Gerry Weinmaster

Basal expression of IκBα is controlled by the mammalian transcriptional repressor RBP-J (CBF1) and its activator Notch1 (2003)

Oakley, Fiona, Mann, Jelena, Ruddell, Richard G., Pickford, Jessica, Weinmaster, Gerry, Mann, Derek A.

By using the hepatic stellate cell (HSC) as a paradigm for cells that undergo long term re-programming of NF-κB-dependent transcription, we have determined a novel mechanism by which mammalian cells...

SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function

Zhou, Sifang, Fujimuro, Masahiro, Hsieh, James J.-D., Chen, Lin, Miyamoto, Alison, Weinmaster, Gerry, ...

Notch proteins are transmembrane receptors that mediate intercell communication and direct individual cell fate decisions. The activated intracellular form of Notch, NotchIC, translocates to the...

The Neural RNA-Binding Protein Musashi1 Translationally Regulates Mammalian numb Gene Expression by Interacting with Its mRNA

Imai, Takao, Tokunaga, Akinori, Yoshida, Tetsu, Hashimoto, Mitsuhiro, Mikoshiba, Katsuhiko, Weinmaster, Gerry, ...

Musashi1 (Msi1) is an RNA-binding protein that is highly expressed in neural progenitor cells, including neural stem cells. In this study, the RNA-binding sequences for Msi1 were determined by in...

Epstein-Barr Virus BamHI-A Rightward Transcript-Encoded RPMS Protein Interacts with the CBF1-Associated Corepressor CIR To Negatively Regulate the Activity of EBNA2 and NotchIC

Zhang, Jinxia, Chen, Honglin, Weinmaster, Gerry, Hayward, S. Diane

The Epstein-Barr virus (EBV) BamHI-A rightward transcripts (BARTs) are expressed in all EBV-associated tumors as well as in latently infected B cells in vivo and cultured B-cell lines. One of the...

Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice

Jiang, Rulang, Lan, Yu, Chapman, Harry D., Shawber, Carrie, Norton, Christine R., Serreze, David V., ...

The Notch signaling pathway is a conserved intercellular signaling mechanism that is essential for proper embryonic development in numerous metazoan organisms. We have examined the in vivo role of...

Influences of Media and Inocula on the In Vitro Susceptibility of Haemophilus influenzae to Co-Trimoxazole, Ampicillin, Penicillin, and Chloramphenicol

Marks, Melvin I., Weinmaster, Gerry

The effects of inocula and media on the activities of ampicillin, penicillin, chloramphenicol and co-trimoxazole against Haemophilus influenzae were examined in vitro. Two inocula and four media were...

Reevaluation of the Disk Diffusion Method for Sulfonamide Susceptibility Testing of Neisseria meningitidis

Hammerberg, Susan, Marks, Melvin I., Weinmaster, Gerry

Lack of correlation between quantitative minimal inhibitory concentration (MIC) determinations and disk diffusion susceptibility tests in our laboratory prompted a study to reevaluate the use of the...

Fringe Glycosyltransferases Differentially Modulate Notch1 Proteolysis Induced by Delta1 and Jagged1

Yang, Liang-Tung, Nichols, James T., Yao, Christine, Manilay, Jennifer O., Robey, Ellen A., Weinmaster, Gerry

Fringe O-fucose-β1,3-N-acetylglucosaminyltransferases modulate Notch signaling by potentiating signaling induced by Delta-like ligands, while inhibiting signaling induced by Serrate/Jagged1 ligands....

SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function

Zhou, Sifang, Fujimuro, Masahiro, Hsieh, James J.-D., Chen, Lin, Miyamoto, Alison, Weinmaster, Gerry, ...

Notch proteins are transmembrane receptors that mediate intercell communication and direct individual cell fate decisions. The activated intracellular form of Notch, NotchIC, translocates to the...

The Neural RNA-Binding Protein Musashi1 Translationally Regulates Mammalian numb Gene Expression by Interacting with Its mRNA

Imai, Takao, Tokunaga, Akinori, Yoshida, Tetsu, Hashimoto, Mitsuhiro, Mikoshiba, Katsuhiko, Weinmaster, Gerry, ...

Musashi1 (Msi1) is an RNA-binding protein that is highly expressed in neural progenitor cells, including neural stem cells. In this study, the RNA-binding sequences for Msi1 were determined by in...

Epstein-Barr Virus BamHI-A Rightward Transcript-Encoded RPMS Protein Interacts with the CBF1-Associated Corepressor CIR To Negatively Regulate the Activity of EBNA2 and NotchIC

Zhang, Jinxia, Chen, Honglin, Weinmaster, Gerry, Hayward, S. Diane

The Epstein-Barr virus (EBV) BamHI-A rightward transcripts (BARTs) are expressed in all EBV-associated tumors as well as in latently infected B cells in vivo and cultured B-cell lines. One of the...

Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice

Jiang, Rulang, Lan, Yu, Chapman, Harry D., Shawber, Carrie, Norton, Christine R., Serreze, David V., ...

The Notch signaling pathway is a conserved intercellular signaling mechanism that is essential for proper embryonic development in numerous metazoan organisms. We have examined the in vivo role of...

Influences of Media and Inocula on the In Vitro Susceptibility of Haemophilus influenzae to Co-Trimoxazole, Ampicillin, Penicillin, and Chloramphenicol

Marks, Melvin I., Weinmaster, Gerry

The effects of inocula and media on the activities of ampicillin, penicillin, chloramphenicol and co-trimoxazole against Haemophilus influenzae were examined in vitro. Two inocula and four media were...

Reevaluation of the Disk Diffusion Method for Sulfonamide Susceptibility Testing of Neisseria meningitidis

Hammerberg, Susan, Marks, Melvin I., Weinmaster, Gerry

Lack of correlation between quantitative minimal inhibitory concentration (MIC) determinations and disk diffusion susceptibility tests in our laboratory prompted a study to reevaluate the use of the...

Fringe Glycosyltransferases Differentially Modulate Notch1 Proteolysis Induced by Delta1 and Jagged1

Yang, Liang-Tung, Nichols, James T., Yao, Christine, Manilay, Jennifer O., Robey, Ellen A., Weinmaster, Gerry

Fringe O-fucose-β1,3-N-acetylglucosaminyltransferases modulate Notch signaling by potentiating signaling induced by Delta-like ligands, while inhibiting signaling induced by Serrate/Jagged1 ligands....

DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur

Nichols, James T., Miyamoto, Alison, Olsen, Samantha L., D'Souza, Brendan, Yao, Christine, Weinmaster, Gerry

Cleavage of Notch by furin is required to generate a mature, cell surface heterodimeric receptor that can be proteolytically activated to release its intracellular domain, which functions in signal...

The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands

Ladi, Ena, Nichols, James T., Ge, Weihong, Miyamoto, Alison, Yao, Christine, Yang, Liang-Tung, ...

Mutations in the DSL (Delta, Serrate, Lag2) Notch (N) ligand Delta-like (Dll) 3 cause skeletal abnormalities in spondylocostal dysostosis, which is consistent with a critical role for N signaling...