Protecting role of cosolvents in protein denaturation by SDS: a structural study (2008)
Michaux, Catherine, Pouyez, Jenny, Wouters, Johan, Privé, Gilbert G
Abstract Background Recently, we reported a unique approach to preserve the activity of some proteins in the presence of the denaturing agent, Sodium Dodecyl Sulfate (SDS). This was made possible by...
BMC Structural Biology BioMed Central (2008)
Catherine Michaux, Jenny Pouyez, Johan Wouters, Johan Wouters, Gilbert G Privé
Research article Protecting role of cosolvents in protein denaturation by SDS: a structural study
Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator (2007)
Stogios, Peter J., Chen, Lu, Privé, Gilbert G.
BTB-zinc finger (BTB-ZF) proteins are transcription regulators with roles in development, differentiation, and oncogenesis. In these proteins, the BTB domain (also known as the POZ domain) is a...
Crystal structures of saposins A and C (2006)
Ahn, Victoria E., Leyko, Paul, Alattia, Jean-René, Chen, Lu, Privé, Gilbert G.
Saposins A and C are sphingolipid activator proteins required for the lysosomal breakdown of galactosylceramide and glucosylceramide, respectively. The saposins interact with lipids, leading to an...
Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator (2006)
Stogios, Peter J., Chen, Lu, Privé, Gilbert G.
BTB-zinc finger (BTB-ZF) proteins are transcription regulators with roles in development, differentiation, and oncogenesis. In these proteins, the BTB domain (also known as the POZ domain) is a...
Crystal structures of saposins A and C (2006)
Ahn, Victoria E., Leyko, Paul, Alattia, Jean-René, Chen, Lu, Privé, Gilbert G.
Saposins A and C are sphingolipid activator proteins required for the lysosomal breakdown of galactosylceramide and glucosylceramide, respectively. The saposins interact with lipids, leading to an...
Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator (2006)
Stogios, Peter J., Chen, Lu, Privé, Gilbert G.
BTB-zinc finger (BTB-ZF) proteins are transcription regulators with roles in development, differentiation, and oncogenesis. In these proteins, the BTB domain (also known as the POZ domain) is a...
Sequence and structural analysis of BTB domain proteins (2005)
Stogios, Peter J, Downs, Gregory S, Jauhal, Jimmy JS, Nandra, Sukhjeen K, Privé, Gilbert G
Abstract Background The BTB domain (also known as the POZ domain) is a versatile protein-protein interaction motif that participates in a wide range of cellular functions, including transcriptional...
of a designed alpha helical bundle (1998)
Gg Prive, Dh Anderson, L Wesson, D Cascio, D Eisenberg, Email Alerting, ...
Packed protein bilayers in the 0.90 A resolution structure of a
Crystal structure of the BTB domain from PLZF
Ahmad, K. Farid, Engel, Christian K., Privé, Gilbert G.
The BTB domain (also known as the POZ domain) is an evolutionarily conserved protein–protein interaction motif found at the N terminus of 5–10% of C2H2-type zinc-finger transcription factors, as...
Solution structure and dynamics of the outer membrane enzyme PagP by NMR
Hwang, Peter M., Choy, Wing-Yiu, Lo, Eileen I., Chen, Lu, Forman-Kay, Julie D., Raetz, Christian R. H., ...
The bacterial outer membrane enzyme PagP transfers a palmitate chain from a phospholipid to lipid A. In a number of pathogenic Gram-negative bacteria, PagP confers resistance to certain cationic...
Crystal structure of saposin B reveals a dimeric shell for lipid binding
Ahn, Victoria E., Faull, Kym F., Whitelegge, Julian P., Fluharty, Arvan L., Privé, Gilbert G.
Saposin B is a small, nonenzymatic glycosphingolipid activator protein required for the breakdown of cerebroside sulfates (sulfatides) within the lysosome. The protein can extract target lipids from...
A hydrocarbon ruler measures palmitate in the enzymatic acylation of endotoxin
Ahn, Victoria E, Lo, Eileen I, Engel, Christian K, Chen, Lu, Hwang, Peter M, Kay, Lewis E, ...
The ability of enzymes to distinguish between fatty acyl groups can involve molecular measuring devices termed hydrocarbon rulers, but the molecular basis for acyl-chain recognition in any...
Sequence and structural analysis of BTB domain proteins
Stogios, Peter J, Downs, Gregory S, Jauhal, Jimmy JS, Nandra, Sukhjeen K, Privé, Gilbert G
An analysis of the protein architecture, genomic distribution and sequence conservation of BTB domain proteins in 17 fully sequenced eukaryotes reveals a high structural conservation and adaptation...
Crystal structure of the BTB domain from PLZF
Ahmad, K. Farid, Engel, Christian K., Privé, Gilbert G.
The BTB domain (also known as the POZ domain) is an evolutionarily conserved protein–protein interaction motif found at the N terminus of 5–10% of C2H2-type zinc-finger transcription factors, as...
Solution structure and dynamics of the outer membrane enzyme PagP by NMR
Hwang, Peter M., Choy, Wing-Yiu, Lo, Eileen I., Chen, Lu, Forman-Kay, Julie D., Raetz, Christian R. H., ...
The bacterial outer membrane enzyme PagP transfers a palmitate chain from a phospholipid to lipid A. In a number of pathogenic Gram-negative bacteria, PagP confers resistance to certain cationic...
Crystal structure of saposin B reveals a dimeric shell for lipid binding
Ahn, Victoria E., Faull, Kym F., Whitelegge, Julian P., Fluharty, Arvan L., Privé, Gilbert G.
Saposin B is a small, nonenzymatic glycosphingolipid activator protein required for the breakdown of cerebroside sulfates (sulfatides) within the lysosome. The protein can extract target lipids from...
A hydrocarbon ruler measures palmitate in the enzymatic acylation of endotoxin
Ahn, Victoria E, Lo, Eileen I, Engel, Christian K, Chen, Lu, Hwang, Peter M, Kay, Lewis E, ...
The ability of enzymes to distinguish between fatty acyl groups can involve molecular measuring devices termed hydrocarbon rulers, but the molecular basis for acyl-chain recognition in any...
Sequence and structural analysis of BTB domain proteins
Stogios, Peter J, Downs, Gregory S, Jauhal, Jimmy JS, Nandra, Sukhjeen K, Privé, Gilbert G
An analysis of the protein architecture, genomic distribution and sequence conservation of BTB domain proteins in 17 fully sequenced eukaryotes reveals a high structural conservation and adaptation...
Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator
Stogios, Peter J., Chen, Lu, Privé, Gilbert G.
BTB-zinc finger (BTB-ZF) proteins are transcription regulators with roles in development, differentiation, and oncogenesis. In these proteins, the BTB domain (also known as the POZ domain) is a...
Crystal structures of saposins A and C
Ahn, Victoria E., Leyko, Paul, Alattia, Jean-René, Chen, Lu, Privé, Gilbert G.
Saposins A and C are sphingolipid activator proteins required for the lysosomal breakdown of galactosylceramide and glucosylceramide, respectively. The saposins interact with lipids, leading to an...
Molecular imaging of membrane interfaces reveals mode of β-glucosidase activation by saposin C
Alattia, Jean-René, Shaw, James E., Yip, Christopher M., Privé, Gilbert G.
Acid β-glucosidase (GCase) is a soluble lysosomal enzyme responsible for the hydrolysis of glucose from glucosylceramide and requires activation by the small nonenzymatic protein saposin C (sapC) to...
Protecting role of cosolvents in protein denaturation by SDS: a structural study
Michaux, Catherine, Pouyez, Jenny, Wouters, Johan, Privé, Gilbert G
Crystal structure of a self-assembling lipopeptide detergent at 1.20 Å
Ho, Dona N., Pomroy, Neil C., Cuesta-Seijo, José A., Privé, Gilbert G.
Lipopeptide detergents (LPDs) are a new class of amphiphile designed specifically for the structural study of integral membrane proteins. The LPD monomer consists of a 25-residue peptide with fatty...