Gilbert H. Smith

Selective segregation of DNA strands persists in long label retaining mammary cells during pregnancy (2008)

Booth, Brian W, Boulanger, Corinne A, Smith, Gilbert H

Abstract Introduction During pregnancy the mammary epithelial compartment undergoes extreme proliferation and differentiation, facilitated by stem/progenitor cells. Mouse mammary epithelium in...

Re-evaluation of mammary stem cell biology based on in vivotransplantation (2008)

Smith, Gilbert H, Medina, Daniel

Abstract Over nearly half a century, transplantation methods have been employed to regenerate the mammary gland in vivo . Recent highly cited reports claim to have demonstrated the regeneration of an...

Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis (2007)

Mack, David L, Boulanger, Corinne A, Callahan, Robert, Smith, Gilbert H

Abstract Introduction Int6 has been shown to be an interactive participant with the protein translation initiation complex eIF3, the COP9 signalosome and the regulatory lid of the 26S proteasome....

Estrogen receptor-α and progesterone receptor are expressed in label-retaining mammary epithelial cells that divide asymmetrically and retain their template DNA strands (2006)

Booth, Brian W, Smith, Gilbert H

Abstract Introduction Stem cells of somatic tissues are hypothesized to protect themselves from mutation and cancer risk through a process of selective segregation of their template DNA strands...

A New Common Integration Site, Int7, for the Mouse Mammary Tumor Virus in Mouse Mammary Tumors Identifies a Gene Whose Product Has Furin-Like and Thrombospondin-Like Sequences (2005)

William Lowther, Korah Wiley, Gilbert H. Smith, Robert Callahan

A novel common integration site for the mouse mammary tumor virus (MMTV) was identified (designated Int7) in five independently arising mouse mammary tumors. The insertion sites all cluster within a...

Mammary cancer and epithelial stem cells: a problem or a solution? (2002)

Smith, Gilbert H

Abstract The existing paradigms for stem cells in adult tissues include the integument, the alimentary canal, the lung, the liver, skeletal muscle and bone marrow. The mammary gland, by contrast, is...

Identification of Stem Cell Units in the Terminal End Bud and Duct of the Mouse Mammary Gland (2001)

Nicholas J. Kenney, Gilbert H. Smith, Erin Lawrence, J. Carl Barrett, David S. Salomon

The mouse mammary gland may undergo cycles of proliferation, terminal differentiation, tissue remodeling, and more importantly malignant transformation.Mammary epithelial stem cells and their progeny...

The lioness : a play in two acts / (1982)

Smith, Gilbert H.

Thesis (M.A.)--University of Wyoming, 1982.

Identification of stem cell units in the terminal end bud and duct of the mouse mammary gland

Kenney, Nicholas J, Smith, Gilbert H, Lawrence, Erin, Barrett, J. Carl, Salomon, David S

The mouse mammary gland may undergo cycles of proliferation, terminal differentiation, tissue remodeling, and more importantly malignant transformation. Mammary epithelial stem cells and their...

Mammary cancer and epithelial stem cells: a problem or a solution?

Smith, Gilbert H

The existing paradigms for stem cells in adult tissues include the integument, the alimentary canal, the lung, the liver, skeletal muscle and bone marrow. The mammary gland, by contrast, is the 'new...

Notch signaling is essential for vascular morphogenesis in mice

Krebs, Luke T., Xue, Yingzi, Norton, Christine R., Shutter, John R., Maguire, Maureen, Sundberg, John P., ...

The Notch gene family encodes large transmembrane receptors that are components of an evolutionarily conserved intercellular signaling mechanism. To assess the role of the Notch4 gene, we generated...

Intracytoplasmic A Particles: Mouse Mammary Tumor Virus Nucleoprotein Cores?

Smith, Gilbert H., Wivel, Nelson A.

A rapid method for the isolation of intracytoplasmic A particles, the putative intracellular nucleoprotein cores of mouse mammary tumor virus (MTV), is presented. Spontaneous C3H/He mouse mammary...

A New Common Integration Site, Int7, for the Mouse Mammary Tumor Virus in Mouse Mammary Tumors Identifies a Gene Whose Product Has Furin-Like and Thrombospondin-Like Sequences

Lowther, William, Wiley, Korah, Smith, Gilbert H., Callahan, Robert

A novel common integration site for the mouse mammary tumor virus (MMTV) was identified (designated Int7) in five independently arising mouse mammary tumors. The insertion sites all cluster within a...

Identification of stem cell units in the terminal end bud and duct of the mouse mammary gland

Kenney, Nicholas J, Smith, Gilbert H, Lawrence, Erin, Barrett, J. Carl, Salomon, David S

The mouse mammary gland may undergo cycles of proliferation, terminal differentiation, tissue remodeling, and more importantly malignant transformation. Mammary epithelial stem cells and their...

Mammary cancer and epithelial stem cells: a problem or a solution?

Smith, Gilbert H

The existing paradigms for stem cells in adult tissues include the integument, the alimentary canal, the lung, the liver, skeletal muscle and bone marrow. The mammary gland, by contrast, is the 'new...

Notch signaling is essential for vascular morphogenesis in mice

Krebs, Luke T., Xue, Yingzi, Norton, Christine R., Shutter, John R., Maguire, Maureen, Sundberg, John P., ...

The Notch gene family encodes large transmembrane receptors that are components of an evolutionarily conserved intercellular signaling mechanism. To assess the role of the Notch4 gene, we generated...

Intracytoplasmic A Particles: Mouse Mammary Tumor Virus Nucleoprotein Cores?

Smith, Gilbert H., Wivel, Nelson A.

A rapid method for the isolation of intracytoplasmic A particles, the putative intracellular nucleoprotein cores of mouse mammary tumor virus (MTV), is presented. Spontaneous C3H/He mouse mammary...

A New Common Integration Site, Int7, for the Mouse Mammary Tumor Virus in Mouse Mammary Tumors Identifies a Gene Whose Product Has Furin-Like and Thrombospondin-Like Sequences

Lowther, William, Wiley, Korah, Smith, Gilbert H., Callahan, Robert

A novel common integration site for the mouse mammary tumor virus (MMTV) was identified (designated Int7) in five independently arising mouse mammary tumors. The insertion sites all cluster within a...

Interaction with the mammary microenvironment redirects spermatogenic cell fate in vivo

Boulanger, Corinne A., Mack, David L., Booth, Brian W., Smith, Gilbert H.

Previously, we characterized a parity-induced mammary epithelial cell population that possessed the properties of pluripotency and self-renewal upon transplantation. These cells were lineally marked...

Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium

Miyoshi, Keiko, Shillingford, Jonathan M., Smith, Gilbert H., Grimm, Sandra L., Wagner, Kay-Uwe, Oka, Takami, ...

Functional development of mammary epithelium during pregnancy depends on prolactin signaling. However, the underlying molecular and cellular events are not fully understood. We examined the specific...

Re-evaluation of mammary stem cell biology based on in vivo transplantation

Smith, Gilbert H, Medina, Daniel

Over nearly half a century, transplantation methods have been employed to regenerate the mammary gland in vivo. Recent highly cited reports claim to have demonstrated the regeneration of an entire...

The mammary microenvironment alters the differentiation repertoire of neural stem cells

Booth, Brian W., Mack, David L., Androutsellis-Theotokis, Andreas, McKay, Ronald D. G., Boulanger, Corinne A., Smith, Gilbert H.

A fundamental issue in stem cell biology is whether adult somatic stem cells are capable of accessing alternate tissue sites and continue functioning as stem cells in the new microenvironment. To...