Bridging the gap between systems biology and medicine (2009)
Clermont, Gilles, Auffray, Charles, Moreau, Yves, Rocke, David M, Dalevi, Daniel, Dubhashi, Devdatt, ...
Abstract Systems biology has matured considerably as a discipline over the last decade, yet some of the key challenges separating current research efforts in systems biology and clinically useful...
Computational disease modeling – fact or fiction? (2009)
Tegnér, Jesper N, Compte, Albert, Auffray, Charles, An, Gary, Cedersund, Gunnar, Clermont, Gilles, ...
Abstract Background Biomedical research is changing due to the rapid accumulation of experimental data at an unprecedented scale, revealing increasing degrees of complexity of biological processes....
silico design of clinical trials: A method coming of age. Crit (2009)
Gilles Clermont, Md John, Bartels Rukmini Kumar, Msc Greg Constantine, Phd Yoram Vodovotz, Carson Chow Phd
Objective: To determine the feasibility and potential usefulness of mathematical models in evaluating immunomodulatory strategies in clinical trials of severe sepsis. Design: Mathematical modeling of...
Computational disease modeling - fact or fiction? (2009)
Tegner, Jesper N, Compte, Albert, Auffray, Charles, An, Gary, Cedersund, Gunnar, Clermont, Gilles, ...
Background: Biomedical research is changing due to the rapid accumulation of experimental data at an unprecedented scale, revealing increasing degrees of complexity of biological processes. Life...
From Inverse Problems in Mathematical Physiology to Quantitative Differential Diagnoses (2007)
Sven Zenker, Jonathan Rubin, Gilles Clermont
The improved capacity to acquire quantitative data in a clinical setting has generally failed to improve outcomes in acutely ill patients, suggesting a need for advances in computer-supported data...
From Inverse Problems in Mathematical Physiology to Quantitative Differential Diagnoses (2007)
Sven Zenker, Jonathan Rubin, Gilles Clermont
The improved capacity to acquire quantitative data in a clinical setting has generally failed to improve outcomes in acutely ill patients, suggesting a need for advances in computer supported data...
Modeling longitudinal data in acute illness (2007)
Abstract Biomarkers of sepsis could allow early identification of high-risk patients, in whom aggressive interventions can be life-saving. Among those interventions are the immunomodulatory...
Hoste, Eric AJ, Clermont, Gilles, Kersten, Alexander, Venkataraman, Ramesh, Angus, Derek C, De Bacquer, Dirk, ...
Abstract Introduction The lack of a standard definition for acute kidney injury has resulted in a large variation in the reported incidence and associated mortality. RIFLE, a newly developed...
Predicting late anemia in critical illness (2006)
Milbrandt, Eric B, Clermont, Gilles, Martinez, Javier, Kersten, Alex, Rahim, Malik T, Angus, Derek C
Abstract Introduction Identifying critically ill patients most likely to benefit from pre-emptive therapies will become increasingly important if therapies are to be used safely and cost-effectively....
A MATHEMATICAL SIMULATION OF THE INFLAMMATORY RESPONSE TO ANTHRAX INFECTION (2006)
Rukmini Kumar, Carson C. Chow, John D. Bartels, Gilles Clermont, Yoram Vodovotz
ABSTRACT—Bacillus anthracis (anthrax) can trigger an acute inflammatory response that results in multisystem organ failure and death. Previously, we developed a mathematical model of acute...
Artificial neural networks as prediction tools in the critically ill (2005)
Abstract The past 25 years have witnessed the development of improved tools with which to predict short-term and long-term outcomes after critical illness. The general paradigm for constructing the...
Al-Nakeeb, Sadiq, Clermont, Gilles
No abstract available.
The acute inflammatory response in diverse shock States (2005)
Carson C. Chow, Gilles Clermont, Rukmini Kumar, Claudio Lagoa, Zacharia Tawadrous, David Gallo, ...
ABSTRACT—A poorly controlled acute inflammatory response can lead to organ dysfunction and death. Severe systemic inflammation can be induced and perpetuated by diverse insults such as the...
Dynamics of Acute Inflammation (2004)
Kumar, Rukmini, Clermont, Gilles, Vodovotz, Yoram, Chow, Carson
When the body is infected, it mounts an acute inflammatory response to rid itself of the pathogens and restore health. Uncontrolled acute inflammation due to infection is defined clinically as Sepsis...
Predicting ICU mortality: A comparison of stationary and nonstationary temporal models (2000)
Mehmet Kayaalp, Gregory F. Cooper, Ph. D, Gilles Clermont, M. Sc
Objective: This study evaluates the effectiveness of the stationarity assumption in predicting the mortality of intensive care unit (ICU) patients at the ICU discharge. Design: This is a comparative...
Théorie formelle des systèmes et applications aux systèmes physiques [microforme] / (1981)
Thèse (M. Sc.)--Université de Montréal, 1981.
Théorie formelle des systèmes et applications aux systèmes physiques / (1981)
Thèse (M. Sc.)--Université de Montréal, 1981.
Artificial neural networks as prediction tools in the critically ill
The past 25 years have witnessed the development of improved tools with which to predict short-term and long-term outcomes after critical illness. The general paradigm for constructing the best known...
Predicting late anemia in critical illness
Milbrandt, Eric B, Clermont, Gilles, Martinez, Javier, Kersten, Alex, Rahim, Malik T, Angus, Derek C
Hoste, Eric AJ, Clermont, Gilles, Kersten, Alexander, Venkataraman, Ramesh, Angus, Derek C, De Bacquer, Dirk, ...
In Silico and In Vivo Approach to Elucidate the Inflammatory Complexity of CD14-deficient Mice
Prince, Jose M, Levy, Ryan M, Bartels, John, Baratt, Arie, Kane, John M, Lagoa, Claudio, ...
The inflammatory phenotype of genetically modified mice is complex, and the role of Gram-negative lipopolysaccharide (LPS) in acute inflammation induced by surgical cannulation trauma, alone or in...
Artificial neural networks as prediction tools in the critically ill
The past 25 years have witnessed the development of improved tools with which to predict short-term and long-term outcomes after critical illness. The general paradigm for constructing the best known...
Predicting late anemia in critical illness
Milbrandt, Eric B, Clermont, Gilles, Martinez, Javier, Kersten, Alex, Rahim, Malik T, Angus, Derek C
Hoste, Eric AJ, Clermont, Gilles, Kersten, Alexander, Venkataraman, Ramesh, Angus, Derek C, De Bacquer, Dirk, ...
In Silico and In Vivo Approach to Elucidate the Inflammatory Complexity of CD14-deficient Mice
Prince, Jose M, Levy, Ryan M, Bartels, John, Baratt, Arie, Kane, John M, Lagoa, Claudio, ...
The inflammatory phenotype of genetically modified mice is complex, and the role of Gram-negative lipopolysaccharide (LPS) in acute inflammation induced by surgical cannulation trauma, alone or in...
From Inverse Problems in Mathematical Physiology to Quantitative Differential Diagnoses
Zenker, Sven, Rubin, Jonathan, Clermont, Gilles
The improved capacity to acquire quantitative data in a clinical setting has generally failed to improve outcomes in acutely ill patients, suggesting a need for advances in computer-supported data...
Modeling longitudinal data in acute illness
Biomarkers of sepsis could allow early identification of high-risk patients, in whom aggressive interventions can be life-saving. Among those interventions are the immunomodulatory therapies, which...
A Patient-Specific in silico Model of Inflammation and Healing Tested in Acute Vocal Fold Injury
Li, Nicole Y. K., Verdolini, Katherine, Clermont, Gilles, Mi, Qi, Rubinstein, Elaine N., Hebda, Patricia A., ...
The development of personalized medicine is a primary objective of the medical community and increasingly also of funding and registration agencies. Modeling is generally perceived as a key enabling...
Computational disease modeling – fact or fiction?
Tegnér, Jesper N, Compte, Albert, Auffray, Charles, An, Gary, Cedersund, Gunnar, Clermont, Gilles, ...
Bridging the gap between systems biology and medicine
Clermont, Gilles, Auffray, Charles, Moreau, Yves, Rocke, David M, Dalevi, Daniel, Dubhashi, Devdatt, ...
Systems biology has matured considerably as a discipline over the last decade, yet some of the key challenges separating current research efforts in systems biology and clinically useful results are...