@TOME-2: a new pipeline for comparative modeling of protein-ligand complexes (2009)
Pons, Jean-Luc, Labesse, Gilles
@TOME 2.0 is new web pipeline dedicated to protein structure modeling and small ligand docking based on comparative analyses. @TOME 2.0 allows fold recognition, template selection, structural...
Monnier, Carine, Dodé, Catherine, Fabre, Ludovic, Teixeira, Luis, Labesse, Gilles, Pin, Jean-Philippe, ...
Kallmann syndrome (KS) combines hypogonadism due to gonadotropin-releasing hormone deficiency, and anosmia or hyposmia, related to defective olfactory bulb morphogenesis. In a large series of KS...
Rondard, Philippe, Huang, Siluo, Monnier, Carine, Tu, Haijun, Blanchard, Bertrand, Oueslati, Nadia, ...
The G-protein-coupled receptor (GPCR) activated by the neurotransmitter GABA is made up of two subunits, GABA(B1) and GABA(B2). GABA(B1) binds agonists, whereas GABA(B2) is required for trafficking...
Rondard, Philippe, Huang, Siluo, Monnier, Carine, Tu, Haijun, Blanchard, Bertrand, Oueslati, Nadia, ...
The G-protein-coupled receptor (GPCR) activated by the neurotransmitter GABA is made up of two subunits, GABA(B1) and GABA(B2). GABA(B1) binds agonists, whereas GABA(B2) is required for trafficking...
Rondard, Philippe, Huang, Siluo, Monnier, Carine, Tu, Haijun, Blanchard, Bertrand, Oueslati, Nadia, ...
The G-protein-coupled receptor (GPCR) activated by the neurotransmitter GABA is made up of two subunits, GABA(B1) and GABA(B2). GABA(B1) binds agonists, whereas GABA(B2) is required for trafficking...
Rondard, Philippe, Huang, Siluo, Monnier, Carine, Tu, Haijun, Blanchard, Bertrand, Oueslati, Nadia, ...
The G-protein-coupled receptor (GPCR) activated by the neurotransmitter GABA is made up of two subunits, GABA(B1) and GABA(B2). GABA(B1) binds agonists, whereas GABA(B2) is required for trafficking...
ROP18 Is a Rhoptry Kinase Controlling the Intracellular Proliferation of Toxoplasma gondii (2007)
Hiba El Hajj, Maryse Lebrun, Stefan T. Arold, Henri Vial, Gilles Labesse, Jean François Dubremetz
Toxoplasma gondii is an obligate intracellular parasite for which the discharge of apical organelles named rhoptries is a key event in host cell invasion. Among rhoptry proteins, ROP2, which is the...
Binet, Virginie, Duthey, Béatrice, Lecaillon, Jennifer, Vol, Claire, Quoyer, Julie, Labesse, Gilles, ...
G protein-coupled receptors (GPCRs) are key players in cell communication. Several classes of such receptors have been identified. Although all GPCRs possess a heptahelical domain directly activating...
Binet, Virginie, Duthey, Béatrice, Lecaillon, Jennifer, Vol, Claire, Quoyer, Julie, Labesse, Gilles, ...
G protein-coupled receptors (GPCRs) are key players in cell communication. Several classes of such receptors have been identified. Although all GPCRs possess a heptahelical domain directly activating...
Binet, Virginie, Duthey, Béatrice, Lecaillon, Jennifer, Vol, Claire, Quoyer, Julie, Labesse, Gilles, ...
G protein-coupled receptors (GPCRs) are key players in cell communication. Several classes of such receptors have been identified. Although all GPCRs possess a heptahelical domain directly activating...
kinDOCK: a tool for comparative docking of protein kinase ligands (2006)
Martin, Laetitia, Catherinot, Vincent, Labesse, Gilles
KinDOCK is a new web server for the analysis of ATP-binding sites of protein kinases. This characterization is based on the docking of ligands already co-crystallized with other protein kinases. A...
Resuscitation-promoting factors possess a lysozyme-like domain (2004)
Cohen-Gonsaud, Martin, Keep, Nicholas H., Davies, Angharad P., Ward, John, Henderson, Brian, Labesse, Gilles
The novel bacterial cytokine family – resuscitation-promoting factors (Rpfs) – share a conserved domain of uncharacterized function. Predicting the structure of this domain suggests that Rpfs...
Resuscitation-promoting factors possess a lysozyme-like domain (2004)
Cohen-Gonsaud, Martin, Keep, Nicholas H., Davies, Angharad P., Ward, John, Henderson, Brian, Labesse, Gilles
The novel bacterial cytokine family â resuscitation-promoting factors (Rpfs) â share a conserved domain of uncharacterized function. Predicting the structure of this domain suggests that...
Resuscitation-promoting factors possess a lysozyme-like domain (2004)
Cohen-Gonsaud, Martin, Keep, Nicholas H., Davies, Angharad P., Ward, John, Henderson, Brian, Labesse, Gilles
The novel bacterial cytokine family – resuscitation-promoting factors (Rpfs) – share a conserved domain of uncharacterized function. Predicting the structure of this domain suggests that Rpfs...
Resuscitation-promoting factors possess a lysozyme-like domain (2004)
Cohen-Gonsaud, Martin, Keep, Nicholas H., Davies, Angharad P., Ward, John, Henderson, Brian, Labesse, Gilles
The novel bacterial cytokine family – resuscitation-promoting factors (Rpfs) – share a conserved domain of uncharacterized function. Predicting the structure of this domain suggests that Rpfs...
ViTO: tool for refinement of protein sequence-structure alignments (2004)
Catherinot, Vincent, Labesse, Gilles
Summary: ViTO is a graphical application, including an editor, of multiple sequence alignment and a three-dimensional (3D) structure viewer. It is possible to manipulate alignments containing...
ViTO, a tool for refinement of protein sequence-structure alignments (2004)
Catherinot, Vincent, Labesse, Gilles
Summary: ViTO is a graphical application including an editor of multiple sequence alignment and a 3D structure viewer. It is possible to manipulate alignments containing hundreds of sequences and to...
Delaunay, Jérôme, Mée, Gwenn Le, Ezzeddine, Nader, Labesse, Gilles, Terzian, Christophe, Capri, Michèle, ...
We reported in our previous work that the EDEN‐dependent translational repression of maternal mRNAs was conserved between Drosophila and Xenopus. In Xenopus, this repression is achieved through...
ViTO, a tool for refinement of protein sequence-structure alignments (2004)
Catherinot, Vincent, Labesse, Gilles
Summary: ViTO is a graphical application including an editor of multiple sequence alignment and a 3D structure viewer. It is possible to manipulate alignments containing hundreds of sequences and to...
Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain (2003)
Hoellerer, Maria K., Noble, Martin E.M., Labesse, Gilles, Campbell, Iain D., Werner, Jörn M., Arold, Stefan T.
Focal adhesions (FAs) are large submembrane signaling complexes formed at sites of cellular attachment to the extracellular matrix. The interaction of LD motifs with their targets plays an important...
Pochet, Sylvie, Dugué, Laurence, Labesse, Gilles, Delepierre, Muriel, Munier-Lehmann, Hélène
Thymidine monophosphate kinase (TMPK) from Mycobacterium tuberculosis (TMPKmt) is an attractive target for the design of specific inhibitors. This fact is the result of its key role in the thymidine...
Pochet, Sylvie, Dugué, Laurence, Labesse, Gilles, Delepierre, Muriel, Munier-Lehmann, Hélène
Thymidine monophosphate kinase (TMPK) from Mycobacterium tuberculosis (TMPKmt) is an attractive target for the design of specific inhibitors. This fact is the result of its key role in the thymidine...
Stéphanie Ducasse-cabanot, Martin Cohen-gonsaud, Hedia Marrakchi, Michel Nguyen, Didier Zerbib, Jean Bernadou, ...
The first-line specific antituberculous drug isoniazid inhibits the fatty acid elongation system (FAS) FAS-II involved in the biosynthesis of mycolic acids, which are major lipids of the...
Saveanu, Cosmin, Miron, Simona, Borza, Tudor, Craescu, Constantin T., Labesse, Gilles, Gagyi, Cristina, ...
Structural genomics is a new approach in functional assignment of proteins identified via whole-genome sequencing programs. Its rationale is that nonhomologous proteins performing similar or related...
Munier-Lehmann, HÉLÈNE, Chaffotte, Alain, Pochet, Sylvie, Labesse, Gilles
We have overexpressed in Escherichia coli the thymidylate kinase of Mycobacterium tuberculosis (TMPKmt). Biochemical and physico-chemical characterization of TMPKmt revealed distinct structural and...
Easier threading through web-based comparisons and cross-validations (2001)
Douguet, Dominique, Labesse, Gilles
Summary: We have developed a WWW server for the integration and comparison of protein structure predictions performed by five different servers. Users submit an amino acid sequence to a selected set...
Biochemical Characterization of the Helper Component of Cauliflower Mosaic Virus
Hebrard, Eugenie, Drucker, Martin, Leclerc, Denis, Hohn, Thomas, Uzest, Marilyne, Froissart, Remy, ...
The helper component of Cauliflower mosaic virus is encoded by viral gene II. This protein (P2) is dispensable for virus replication but required for aphid transmission. The purification of P2 has...
Ganem, Carine, Devaux, Frédéric, Torchet, Claire, Jacq, Claude, Quevillon-Cheruel, Sophie, Labesse, Gilles, ...
Ssu72 is an essential yeast protein that is involved in transcription. It physically interacts with transcription initiation and termination complexes. In this report, we provide evidence that Ssu72...
Ducasse-Cabanot, Stéphanie, Cohen-Gonsaud, Martin, Marrakchi, Hedia, Nguyen, Michel, Zerbib, Didier, Bernadou, Jean, ...
The first-line specific antituberculous drug isoniazid inhibits the fatty acid elongation system (FAS) FAS-II involved in the biosynthesis of mycolic acids, which are major lipids of the...
The Drosophila Bruno paralogue Bru-3 specifically binds the EDEN translational repression element
Delaunay, Jérôme, Le Mée, Gwenn, Ezzeddine, Nader, Labesse, Gilles, Terzian, Christophe, Capri, Michèle, ...
We reported in our previous work that the EDEN-dependent translational repression of maternal mRNAs was conserved between Drosophila and Xenopus. In Xenopus, this repression is achieved through the...
Internal Point Mutations of the Capsid Modify the Serotype of Rice Yellow Mottle Virus
Hébrard, Eugénie, Pinel-Galzi, Agnès, Catherinot, Vincent, Labesse, Gilles, Brugidou, Christophe, Fargette, Denis
Rice yellow mottle virus is classified in five major serotypes; the molecular diversity of the coat protein (CP) is well established, but the amino acids involved in the recognition by discriminant...
Blanc-Potard, Anne-Béatrice, Labesse, Gilles, Figueroa-Bossi, Nara, Bossi, Lionello
In Salmonella enterica serovar Typhimurium, an S431P substitution in the B subunit of gyrase (allele gyrB651) confers resistance to nalidixic acid and causes reduced DNA superhelicity and...
kinDOCK: a tool for comparative docking of protein kinase ligands
Martin, Laetitia, Catherinot, Vincent, Labesse, Gilles
KinDOCK is a new web server for the analysis of ATP-binding sites of protein kinases. This characterization is based on the docking of ligands already co-crystallized with other protein kinases. A...
Biochemical Characterization of the Helper Component of Cauliflower Mosaic Virus
Hebrard, Eugenie, Drucker, Martin, Leclerc, Denis, Hohn, Thomas, Uzest, Marilyne, Froissart, Remy, ...
The helper component of Cauliflower mosaic virus is encoded by viral gene II. This protein (P2) is dispensable for virus replication but required for aphid transmission. The purification of P2 has...
Ganem, Carine, Devaux, Frédéric, Torchet, Claire, Jacq, Claude, Quevillon-Cheruel, Sophie, Labesse, Gilles, ...
Ssu72 is an essential yeast protein that is involved in transcription. It physically interacts with transcription initiation and termination complexes. In this report, we provide evidence that Ssu72...
Ducasse-Cabanot, Stéphanie, Cohen-Gonsaud, Martin, Marrakchi, Hedia, Nguyen, Michel, Zerbib, Didier, Bernadou, Jean, ...
The first-line specific antituberculous drug isoniazid inhibits the fatty acid elongation system (FAS) FAS-II involved in the biosynthesis of mycolic acids, which are major lipids of the...
The Drosophila Bruno paralogue Bru-3 specifically binds the EDEN translational repression element
Delaunay, Jérôme, Le Mée, Gwenn, Ezzeddine, Nader, Labesse, Gilles, Terzian, Christophe, Capri, Michèle, ...
We reported in our previous work that the EDEN-dependent translational repression of maternal mRNAs was conserved between Drosophila and Xenopus. In Xenopus, this repression is achieved through the...
Internal Point Mutations of the Capsid Modify the Serotype of Rice Yellow Mottle Virus
Hébrard, Eugénie, Pinel-Galzi, Agnès, Catherinot, Vincent, Labesse, Gilles, Brugidou, Christophe, Fargette, Denis
Rice yellow mottle virus is classified in five major serotypes; the molecular diversity of the coat protein (CP) is well established, but the amino acids involved in the recognition by discriminant...
Blanc-Potard, Anne-Béatrice, Labesse, Gilles, Figueroa-Bossi, Nara, Bossi, Lionello
In Salmonella enterica serovar Typhimurium, an S431P substitution in the B subunit of gyrase (allele gyrB651) confers resistance to nalidixic acid and causes reduced DNA superhelicity and...
kinDOCK: a tool for comparative docking of protein kinase ligands
Martin, Laetitia, Catherinot, Vincent, Labesse, Gilles
KinDOCK is a new web server for the analysis of ATP-binding sites of protein kinases. This characterization is based on the docking of ligands already co-crystallized with other protein kinases. A...
ROP18 Is a Rhoptry Kinase Controlling the Intracellular Proliferation of Toxoplasma gondii
El Hajj, Hiba, Lebrun, Maryse, Arold, Stefan T, Vial, Henri, Labesse, Gilles, Dubremetz, Jean François
Toxoplasma gondii is an obligate intracellular parasite for which the discharge of apical organelles named rhoptries is a key event in host cell invasion. Among rhoptry proteins, ROP2, which is the...
Saveanu, Cosmin, Miron, Simona, Borza, Tudor, Craescu, Constantin T., Labesse, Gilles, Gagyi, Cristina, ...
Structural genomics is a new approach in functional assignment of proteins identified via whole-genome sequencing programs. Its rationale is that nonhomologous proteins performing similar or related...
Munier-Lehmann, HÉLÈNE, Chaffotte, Alain, Pochet, Sylvie, Labesse, Gilles
We have overexpressed in Escherichia coli the thymidylate kinase of Mycobacterium tuberculosis (TMPKmt). Biochemical and physico-chemical characterization of TMPKmt revealed distinct structural and...
Functioning of the dimeric GABAB receptor extracellular domain revealed by glycan wedge scanning
Rondard, Philippe, Huang, Siluo, Monnier, Carine, Tu, Haijun, Blanchard, Bertrand, Oueslati, Nadia, ...
The G-protein-coupled receptor (GPCR) activated by the neurotransmitter GABA is made up of two subunits, GABAB1 and GABAB2. GABAB1 binds agonists, whereas GABAB2 is required for trafficking GABAB1 to...
@TOME-2: a new pipeline for comparative modeling of protein–ligand complexes
Pons, Jean-Luc, Labesse, Gilles
@TOME 2.0 is new web pipeline dedicated to protein structure modeling and small ligand docking based on comparative analyses. @TOME 2.0 allows fold recognition, template selection, structural...