Ginger L. Milne

Inherited human cPLA2α deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction

Adler, David H., Cogan, Joy D., Phillips, John A., Schnetz-Boutaud, Nathalie, Milne, Ginger L., Iverson, Tina, ...

Cytosolic phospholipase A2α (cPLA2α) hydrolyzes arachidonic acid from cellular membrane phospholipids, thereby providing enzymatic substrates for the synthesis of eicosanoids, such as...

Formation of Highly Reactive Cyclopentenone Isoprostane Compounds (A3/J3-Isoprostanes) in Vivo from Eicosapentaenoic Acid*

Brooks, Joshua D., Milne, Ginger L., Yin, Huiyong, Sanchez, Stephanie C., Porter, Ned A., Morrow, Jason D.

Omega-3 (ω-3) polyunsaturated fatty acids (PUFAs) found in marine fish oils are known to suppress inflammation associated with a wide variety of diseases. Eicosapentaenoic acid (EPA) is one of the...

Human Biochemistry of the Isoprostane Pathway*

Milne, Ginger L., Yin, Huiyong, Morrow, Jason D.

Development of Oxidative Stress by Cytochrome P450 Induction in Rodents Is Selective for Barbiturates and Related to Loss of Pyridine Nucleotide-dependent Protective Systems*S⃞

Dostalek, Miroslav, Hardy, Klarissa D., Milne, Ginger L., Morrow, Jason D., Chen, Chi, Gonzalez, Frank J., ...

Reactive oxygen species (ROS) and oxidative stress have been considered in a variety of disease models, and cytochrome P450 (P450) enzymes have been suggested to be a source of ROS. Induction of...

Electrophilic Cyclopentenone Neuroprostanes Are Anti-inflammatory Mediators Formed from the Peroxidation of the ω-3 Polyunsaturated Fatty Acid Docosahexaenoic Acid*

Musiek, Erik S., Brooks, Joshua D., Joo, Myungsoo, Brunoldi, Enrico, Porta, Alessio, Zanoni, Giuseppe, ...

The ω-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) possesses potent anti-inflammatory properties and has shown therapeutic benefit in numerous inflammatory diseases. However, the...

Drugs Used in the Treatment of Rheumatoid Arthritis: Relationship between Current Use and Cardiovascular Risk Factors

Rho, Young Hee, Oeser, Annette, Chung, Cecilia P, Milne, Ginger L, Stein, C Michael

Increased dietary NaCl induces renal medullary PGE2 production and natriuresis via the EP2 receptor

Chen, Jian, Zhao, Min, He, Wenjuan, Milne, Ginger L., Howard, Jocelyn R. H., Morrow, Jason, ...

A high-NaCl diet induces renal medullary cyclooxygenase (COX)2 expression, and selective intramedullary infusion of a COX2 inhibitor increases blood pressure in rats on a high-salt diet. The present...

Inherited human cPLA2α deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction

Adler, David H., Cogan, Joy D., Phillips, John A., Schnetz-Boutaud, Nathalie, Milne, Ginger L., Iverson, Tina, ...