Rose, Giuseppina, Passarino, Giuseppe, Scornaienchi, Vittorio, Romeo, Giuseppe, Dato, Serena, Bellizzi, Dina, ...
Abstract Background Studies on heteroplasmy occurring in the mitochondrial DNA (mtDNA) control region (CR) in leukocytes of centenarians and younger subjects have shown that the C150T somatic...
Genetics of healthy aging in europe (2007)
Franceschi, Claudio, Bezrukov, Vladyslav, Blanché, Hélène, Bolund, Lars, Christensen, Kaare, De Benedictis, Giovanna, ...
The aim of the 5-year European Union (EU)-Integrated Project GEnetics of Healthy Aging (GEHA), constituted by 25 partners (24 from Europe plus the Beijing Genomics Institute from China), is to...
Garasto, Sabrina, Berardelli, Maurizio, DeRango, Francesco, Mari, Vincenzo, Feraco, Emidio, De Benedictis, Giovanna
Abstract Background In studies on the genetics of human aging, we observed an age-related variation of the 3'APOB-VNTR genotypic pool (alleles: Short , S , 39 repeats) with the homozygous SS genotype...
Multidisciplinary approaches in genetic studies of human aging and longevity (2004)
Tan, Qihua, Yashin, Anatoli I., Christensen, Kaare, Jeune, Bernard, De Benedictis, Giovanna, Kruse, Torben A., ...
The amount of research on human aging and longevity has been growing rapidly in recent years. Multidisciplinary approaches, which integrate classic population genetics methods with the principles of...
Assessing genetic association with human survival at multi-allelic loci (2004)
Tan, Qihua, De Benedictis, Giovanna, Yashin, Anatoli I., Bathum, Lise, Christiansen, Lene, Dahlgaard, Jesper, ...
Genetic variation plays an important role in natural selection and population evolution. However, it also presents geneticists interested in aging research with problems in data analysis because of...
Zhang, Jin, Asin-Cayuela, Jordi, Fish, Jennifer, Michikawa, Yuichi, Bonafé, Massimiliano, Olivieri, Fabiola, ...
The presence of a genetic component in longevity is well known. Here, the association of a mtDNA mutation with a prolonged life span in humans was investigated. Large-scale screening of the mtDNA...
Rose, Guiseppina, Dato, Serena, Altomare, Katia, Bellizzi, Dina, Garasto, Sabrina, Greco, Valentina, ...
The human sirtuin 3 (SIRT3) gene encodes a putative mitochondrial NAD-dependent deacetylase (SIRT3) which belongs to the evolutionary conserved family of sirtuin 2 proteins. Studies in model...
Tan, Qihua, Bathum, Lise, Christiansen, Lene, De Benedictis, Giovanna, Dahlgaard, Jesper, Frizner, N, ...
In this paper, we apply logistic regression models to measure genetic association with human survival for highly polymorphic and pleiotropic genes. By modelling genotype frequency as a function of...
A centenarian-only approach for assessing gene-gene interaction in human longevity (2002)
Tan, Qihua, De Benedictis, Giovanna, Ukraintseva, Svetlana V., Franceschi, Claudio, Vaupel, James W., Yashin, Anatoli I.
Tan, Qihua, Bellizzi, Dina, Rose, Guiseppina, Garasto, S., Franceschi, Claudio, Kruse, Torben, ...
A new method based on the recently developed relative risk approach is introduced, and applied to data from Italian centenarian study (965 subjects aged from 13 to 109 years old) for investigating...
Male/female ratio in centenarians: a possible role played by population genetic structure (2002)
Passarino, Guiseppe, Calignano, Cinzia, Vallone, Adriana, Franceschi, Claudio, Jeune, Bernard, Robine, Jean-M., ...
Bonafe, Maximilliano, Barbi, Cristina, Olivieri, Fabiola, Yashin, Anatoli I., Andreev, Kirill F., Vaupel, James W., ...
Passarino, Giuseppe, Underhill, Peter A., Cavalli-Sforza, Luca, Baggio, Giovannella, Semino, Ornella, Pes, Giovanni Mario, ...
We have analyzed a sample of 40 centenarians and 116 young controls from Sardinia, with a set of new Y chromosome binary markers, to evaluate if Y chromosome genes are involved in the high prevalence...
Bonafè, Massimiliano, Olivieri, Fabiola, Mari, Daniela, Baggio, Giovannella, Mattace, Rosario, Berardelli, Maurizio, ...
In a previous letter (Bonafè et al. 1999) we tested the hypothesis that polymorphic variants of p53 have an impact on human longevity, by comparing p53 codon 72 allelic and genotypic frequency...
Zhang, Jin, Asin-Cayuela, Jordi, Fish, Jennifer, Michikawa, Yuichi, Bonafé, Massimiliano, Olivieri, Fabiola, ...
The presence of a genetic component in longevity is well known. Here, the association of a mtDNA mutation with a prolonged life span in humans was investigated. Large-scale screening of the mtDNA...
Garasto, Sabrina, Berardelli, Maurizio, DeRango, Francesco, Mari, Vincenzo, Feraco, Emidio, De Benedictis, Giovanna
Zhang, Jin, Asin-Cayuela, Jordi, Fish, Jennifer, Michikawa, Yuichi, Bonafé, Massimiliano, Olivieri, Fabiola, ...
The presence of a genetic component in longevity is well known. Here, the association of a mtDNA mutation with a prolonged life span in humans was investigated. Large-scale screening of the mtDNA...