Baraldi, Pier Giovanni, Carrion, Maria Dora, Cruz-Lopez, Olga, Lopez Cara, Carlota, Basso, Giuseppe, ...
The essential role of microtubules in mitosis makes them a major target of compounds useful for cancer therapy. In our search for potent antitumor agents, a novel series of...
Zorzi, Elisa, Mussolin, Lara, Pigazzi, Martina, Basso, Giuseppe, ...
Background
Zangrando, Andrea, Dell'Orto, Marta, Te Kronnie, Geertruy, Basso, Giuseppe
Abstract Background The presence of MLL rearrangements in acute leukemia results in a complex number of biological modifications that still remain largely unexplained. Armstrong et al. proposed MLL...
Guastadisegni, Maria, Lonoce, Angelo, Impera, Luciana, Albano, Francesco, D'Addabbo, Pietro, Caruso, Sebastiano, ...
Abstract Chromosomal translocations play a crucial role in tumorigenesis, often resulting in the formation of chimeric genes or in gene deregulation through position effects. T-cell acute...
Campo Dell'Orto, Marta, Zangrando, Andrea, Trentin, Luca, Li, Rui, Liu, Wei-min, Te Kronnie, Geertruy, ...
Abstract Background Microarray gene expression (MAGE) signatures allow insights into the transcriptional processes of leukemias and may evolve as a molecular diagnostic test. Introduction of MAGE...
Campo Dell'Orto, Marta, Zangrando, Andrea, Trentin, Luca, Li, Rui, Liu, Wei-min, Te Kronnie, Geertruy, ...
Background Microarray gene expression (MAGE) signatures allow insights into the transcriptional processes of leukemias and may evolve as a molecular diagnostic test. Introduction of MAGE into...
Mono- and bi-allelic expression of insulin-like growth factor II gene in human muscle tumors (1994)
Pedone, Paolo V., Tirabosco, Roberto, Cavazzana, Andrea O., Ungaro, Paola, Basso, Giuseppe, Luksch, Roberto, ...
Insulin-like growth factor II (IGF-II) is a mitogen for many cell types and an important modulator of muscle growth and differentiation. IGF-II gene is prevalently expressed during prenatal...
Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
Gallina, Giovanna, Dolcetti, Luigi, Serafini, Paolo, Santo, Carmela De, Marigo, Ilaria, Colombo, Mario P., ...
Active suppression of tumor-specific T lymphocytes can limit the efficacy of immune surveillance and immunotherapy. While tumor-recruited CD11b+ myeloid cells are known mediators of tumor-associated...
Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
Gallina, Giovanna, Dolcetti, Luigi, Serafini, Paolo, Santo, Carmela De, Marigo, Ilaria, Colombo, Mario P., ...
Active suppression of tumor-specific T lymphocytes can limit the efficacy of immune surveillance and immunotherapy. While tumor-recruited CD11b+ myeloid cells are known mediators of tumor-associated...
Campo Dell'Orto, Marta, Zangrando, Andrea, Trentin, Luca, Li, Rui, Liu, Wei-min, Te Kronnie, Geertruy, ...
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
Thompson, Benjamin J., Buonamici, Silvia, Sulis, Maria Luisa, Palomero, Teresa, Vilimas, Tomas, Basso, Giuseppe, ...
Recent studies have shown that activating mutations of NOTCH1 are responsible for the majority of T cell acute lymphoblastic leukemia (T-ALL) cases. Most of these mutations truncate its C-terminal...
Outcome of treatment in children with hypodiploid acute lymphoblastic leukemia
Nachman, James B., Heerema, Nyla A., Sather, Harland, Camitta, Bruce, Forestier, Erik, Harrison, Christine J., ...
One-hundred thirty-nine patients with acute lymphoblastic leukemia (ALL) and hypodiploidy (fewer than 45 chromosomes) were collected from 10 different national ALL study groups and single...
Guastadisegni, Maria Corsignano, Lonoce, Angelo, Impera, Luciana, Albano, Francesco, D'Addabbo, Pietro, Caruso, Sebastiano, ...
Chromosomal translocations play a crucial role in tumorigenesis, often resulting in the formation of chimeric genes or in gene deregulation through position effects. T-cell acute lymphoblastic...
Dworzak, Michael N., Schumich, Angela, Printz, Dieter, Pötschger, Ulrike, Husak, Zvenyslava, Attarbaschi, Andishe, ...
CD20 is expressed in approximately one- half of pediatric acute lymphoblastic leukemia (ALL) cases with B-cell precursor (BCP) origin. We observed that it is occasionally up-regulated during...
Kohlmann, Alexander, Kipps, Thomas J, Rassenti, Laura Z, Downing, James R, Shurtleff, Sheila A, Mills, Ken I, ...
Gene expression profiling has the potential to enhance current methods for the diagnosis of haematological malignancies. Here, we present data on 204 analyses from an international standardization...
Pistollato, Francesca, Rampazzo, Elena, Abbadi, Sara, Della Puppa, Alessandro, Scienza, Renato, D'Avella, Domenico, ...
Bonvini, Paolo, Zorzi, Elisa, Mussolin, Lara, Monaco, Giovanni, Pigazzi, Martina, Basso, Giuseppe, ...
This study by Bonvini and coworkersd describes in vitro data supporting a role for the CDK inhibitor flavopiridol in the treatment of anaplastic large cell lymphoma. Moreover, their studies establish...