Glória R. Franco

Drosophila melanogaster and Caenorhabditis elegans efficiently annotate Schistosoma mansoni sequences (2007)

Francisco Prosdocimi, Depto De, Biologia Geral, Glória R. Franco, J. Miguel Ortega

similarity to Dm is consistently greater than that to Ce, we The genomes of several organisms have been completely have compared the score values obtained when the same sequenced in the last decade...

Microarray analysis of gene expression induced by sexual contact in Schistosoma mansoni (2007)

Waisberg, Michael, Lobo, Francisco P, Cerqueira, Gustavo C, Passos, Liana KJ, Carvalho, Omar S, Franco, Glória R, ...

Abstract Background The parasitic trematode Schistosoma mansoni is one of the major causative agents of Schistosomiasis, a disease that affects approximately 200 million people, mostly in developing...

Production of full-length cDNA sequences by sequencing and analysis of expressed sequence tags from Schistosoma mansoni   (2007)

Fernanda S Moratelli, Isabella K Mendes, Paula L Ortolani, Guilherme C Oliveira, ...

The number of sequences generated by genome projects has increased exponentially, but gene characterization has not followed at the same rate. Sequencing and analysis of full-length cDNAs is an...

Functional complementation of a yeast knockout strain by Schistosoma mansoni   Rho1 GTPase in the presence of caffeine, an agent that affects mutants defective in the protein kinase C signal transduction pathway (2007)

Débora N Santos, Francisco P Lobo, Túlio M Santos, Andréa M Macedo, Sérgio DJ Pena, ...

In a previous study, the Schistosoma mansoni   Rho1 protein was able to complement Rho1 null mutant Saccharomyces cerevisiae   cells at restrictive temperatures and under osmotic stress (low...

Production of full-length cDNA sequences by sequencing and analysis of expressed sequence tags from Schistosoma mansoni (2006)

Faria-Campos,Alessandra C, Moratelli,Fernanda S, Mendes,Isabella K, Ortolani,Paula L, Oliveira,Guilherme C, Campos,Sérgio V A, ...

The number of sequences generated by genome projects has increased exponentially, but gene characterization has not followed at the same rate. Sequencing and analysis of full-length cDNAs is an...

Functional complementation of a yeast knockout strain by Schistosoma mansoni Rho1 GTPase in the presence of caffeine, an agent that affects mutants defective in the protein kinase C signal transduction pathway (2006)

Aguiar,Pedro HN De, Santos,Débora N, Lobo,Francisco P, Santos,Túlio M, Macedo,Andréa M, Pena,Sérgio DJ, ...

In a previous study, the Schistosoma mansoni Rho1 protein was able to complement Rho1 null mutant Saccharomyces cerevisiae cells at restrictive temperatures and under osmotic stress (low calcium...

Clustering of Schistosoma mansoni   mRNA Sequences and Analysis of the Most Transcribed Genes: Implications in Metabolism and Biology of Different Developmental Stages (2002)

Francisco Prosdocimi, Fabiano C Peixoto, Sérgio DJ Pena, José M Ortega, Glória R Franco

The study of the Schistosoma mansoni   genome, one of the etiologic agents of human schistosomiasis, is essential for a better understanding of the biology and development of this parasite. In order...

Cloning and Molecular Characterization of the Schistosoma mansoni   Genes RbAp48 and Histone H4 (2002)

Patrícia P Souza, Débora N Santos, Glória R Franco

The human nuclear protein RbAp48 is a member of the tryptophan/aspartate (WD) repeat family, which binds to the retinoblastoma (Rb) protein. It also corresponds to the smallest subunit of the...

Clustering of Schistosoma mansoni mRNA sequences and analysis of the most transcribed genes: implications in metabolism and biology of different developmental stages (2002)

Prosdocimi,Francisco, Faria-Campos,Alessandra C, Peixoto,Fabiano C, Pena,Sérgio DJ, Ortega,José M, Franco,Glória R

The study of the Schistosoma mansoni genome, one of the etiologic agents of human schistosomiasis, is essential for a better understanding of the biology and development of this parasite. In order to...

Cloning and Molecular Characterization of the Schistosoma mansoni Genes RbAp48 and Histone H4 (2002)

Souza,Patrícia P, Santos,Débora N, Pena,Sérgio D J, Franco,Glória R

The human nuclear protein RbAp48 is a member of the tryptophan/aspartate (WD) repeat family, which binds to the retinoblastoma (Rb) protein. It also corresponds to the smallest subunit of the...

Cloning and Characterization of SmZF1, a Gene Encoding a Schistosoma mansoni   Zinc Finger Protein (2001)

Analina F Valadão, Glória R Franco, Frederico GC Abath

The zinc finger motifs (Cys2His2) are found in several proteins playing a role in the regulation of transcripton. SmZF1, a Schistosoma mansoni gene encoding a zinc finger protein was initially...

Cloning and characterization of SmZF1, a gene encoding a Schistosoma mansoni zinc finger protein (2001)

Valadão,Analina F, Calzavara-Silva,Carlos E, Franco,Glória R, Abath,Frederico GC

The zinc finger motifs (Cys2His2) are found in several proteins playing a role in the regulation of transcripton. SmZF1, a Schistosoma mansoni gene encoding a zinc finger protein was initially...

RESEARCH NOTE - Characterization of an Abundant Schistosoma mansoni Transcript with No Homologs in the Databases (1998)

Wendell SF Meira, Glória R Franco, Élida ML Rabelo, Sérgio DJ Pena

The expressed sequence tag (EST) approach that we have used in the Schistosoma mansoni Genome Project is a powerful technique for the discovery of new genes of the parasite. In a recent comparative...

Evaluation of cDNA Libraries from Different Developmental Stages of Schistosoma mansoni for Production of Expressed Sequence Tags (ESTs) (1997)

Franco, Glória R., Rabelo, Élida M. L., Azevedo, Vasco, Pena, Heloisa B., Ortega, J. Miguel, Santos, Túlio M., ...

A comparative study of the gene expression profile in different developmental stages of Schistosoma mansoni has been initiated based on the expressed sequence tag(EST) approach. A total of 1401 ESTs...

Virus-Host Coevolution: Common Patterns of Nucleotide Motif Usage in Flaviviridae and Their Hosts

Lobo, Francisco P., Mota, Bruno E. F., Pena, Sérgio D. J., Azevedo, Vasco, Macedo, Andréa M., Tauch, Andreas, ...

Virus-host biological interaction is a continuous coevolutionary process involving both host immune system and viral escape mechanisms. Flaviviridae family is composed of fast evolving RNA viruses...

Phenotypic Screen of Early-Developing Larvae of the Blood Fluke, Schistosoma mansoni, using RNA Interference

De Moraes Mourão, Marina, Dinguirard, Nathalie, Franco, Glória R., Yoshino, Timothy P.

RNA interference (RNAi) represents the only method currently available for manipulating gene-specific expression in Schistosoma spp., although application of this technology as a functional genomic...

Molecular Characterization of the Schistosoma mansoni Zinc Finger Protein SmZF1 as a Transcription Factor

Drummond, Marcela G., Calzavara-Silva, Carlos E., D'Astolfo, Diego S., Cardoso, Fernanda C., Rajão, Matheus A., Mourão, Marina M., ...

Schistosomes are parasites that exhibit a complex life cycle during which they progress through many morphological and physiological transformations. These transformations are likely accompanied by...

Role of the Endogenous Antioxidant System in the Protection of Schistosoma mansoni Primary Sporocysts against Exogenous Oxidative Stress

De Moraes Mourão, Marina, Dinguirard, Nathalie, Franco, Glória R., Yoshino, Timothy P.

Antioxidants produced by the parasite Schistosoma mansoni are believed to be involved in the maintenance of cellular redox balance, thus contributing to larval survival in their intermediate snail...