Dioscorea villosa (wild yam) induces chronic kidney injury via pro-fibrotic pathways (2008)
Wojcikowski, Ken, Wohlmuth, Hans, Johnson, David W, Gobe, Glenda
Dioscorea villosa (wild yam) rhizome extract is a medicinal herb that is commonly used to treat symptoms of menopause and rheumatoid arthritis. We had evidence from previous in vitro experiments that...
Dioscorea villosa (wild yam) induces chronic kidney injury via pro-fibrotic pathways (2008)
Wojcikowski, Ken, Wohlmuth, Hans, Johnson, David W, Gobe, Glenda
Dioscorea villosa (wild yam) rhizome extract is a medicinal herb that is commonly used to treat symptoms of menopause and rheumatoid arthritis. We had evidence from previous in vitro experiments that...
Wojcikowski, Ken, Wohlmuth, Hans, Johnson, David W, Rolfe, Margaret, Gobe, Glenda
Aim: Renal fibrosis is central to progression of most chronic renal pathologies. Antioxidants that protect the tubular epithelium and anti-fibrotics that induce apoptosis of pro-fibrotic...
Dioscorea villosa (wild yam) induces chronic kidney injury via pro-fibrotic pathways (2008)
Wojcikowski, Ken, Wohlmuth, Hans, Johnson, David W, Gobe, Glenda
Dioscorea villosa (wild yam) rhizome extract is a medicinal herb that is commonly used to treat symptoms of menopause and rheumatoid arthritis. We had evidence from previous in vitro experiments that...
Dioscorea villosa (wild yam) induces chronic kidney injury via pro-fibrotic pathways (2008)
Wojcikowski, Ken, Wohlmuth, Hans, Johnson, David W, Gobe, Glenda
Dioscorea villosa (wild yam) rhizome extract is a medicinal herb that is commonly used to treat symptoms of menopause and rheumatoid arthritis. We had evidence from previous in vitro experiments that...
Dioscorea villosa (wild yam) induces chronic kidney injury via pro-fibrotic pathways (2008)
Wojcikowski, Ken, Wohlmuth, Hans, Johnson, David W, Gobe, Glenda
Dioscorea villosa (wild yam) rhizome extract is a medicinal herb that is commonly used to treat symptoms of menopause and rheumatoid arthritis. We had evidence from previous in vitro experiments that...
Wojcikowski, Ken, Wohlmuth, Hans, Johnson, David W, Rolfe, Margaret, Gobe, Glenda
Aim: Renal fibrosis is central to progression of most chronic renal pathologies. Antioxidants that protect the tubular epithelium and anti-fibrotics that induce apoptosis of pro-fibrotic...
Dioscorea villosa (wild yam) induces chronic kidney injury via pro-fibrotic pathways (2008)
Wojcikowski, Ken, Wohlmuth, Hans, Johnson, David W, Gobe, Glenda
Dioscorea villosa (wild yam) rhizome extract is a medicinal herb that is commonly used to treat symptoms of menopause and rheumatoid arthritis. We had evidence from previous in vitro experiments that...
Dioscorea villosa (wild yam) induces chronic kidney injury via pro-fibrotic pathways (2008)
Wojcikowski, Ken, Wohlmuth, Hans, Johnson, David W, Gobe, Glenda
Dioscorea villosa (wild yam) rhizome extract is a medicinal herb that is commonly used to treat symptoms of menopause and rheumatoid arthritis. We had evidence from previous in vitro experiments that...
Wojcikowski, Ken, Wohlmuth, Hans, Johnson, David W, Rolfe, Margaret, Gobe, Glenda
Aim: Renal fibrosis is central to progression of most chronic renal pathologies. Antioxidants that protect the tubular epithelium and anti-fibrotics that induce apoptosis of pro-fibrotic...
Stevenson, Lesley M, Wojcikowski, Ken, Leach, David N, Wohlmuth, Hans, Gobe, Glenda
Background: The prevalence of chronic renal disease exceeds 10% in industrialized societies. Oxidative damage is thought to be one of the main mechanisms involved in nearly all chronic renal...
Xu, Jian, Zhang, Bing, Yang, Tao, Gobe, Glenda, Wei, Ming Q., West, Malcolm J.
Objective: Hypertension is a worldwide health problem. The renin-angiotensin system (RAS) is considered to be the major regulator of blood pressure, and the key factor in most essential hypertension....
Stevenson, Lesley M, Wojcikowski, Ken, Leach, David N, Wohlmuth, Hans, Gobe, Glenda
Background: The prevalence of chronic renal disease exceeds 10% in industrialized societies. Oxidative damage is thought to be one of the main mechanisms involved in nearly all chronic renal...
Stevenson, Lesley M, Wojcikowski, Ken, Leach, David N, Wohlmuth, Hans, Gobe, Glenda
Background: The prevalence of chronic renal disease exceeds 10% in industrialized societies. Oxidative damage is thought to be one of the main mechanisms involved in nearly all chronic renal...
Morais, Christudas, Pat, Betty, Gobe, Glenda, Johnson, David W., Healy, Helen
Background. The activation of nuclear factor-kappa B (NF-kappa B) has been implicated in the development, progression and metastasis of renal cell carcinoma (RCC). This study investigates the effect...
Protein kinase C activation and its role in kidney disease (2006)
Protein kinase C (PKC) comprises a superfamily of isoenzymes, many of which are activated by cofactors such as diacylglycerol and phosphatidylserine. In order to be capable of activation, PKC must...
Morais, Christudas, Pat, Betty, Gobe, Glenda, Johnson, David W., Healy, Helen
Background. The activation of nuclear factor-kappa B (NF-kappa B) has been implicated in the development, progression and metastasis of renal cell carcinoma (RCC). This study investigates the effect...
Protein kinase C activation and its role in kidney disease (2006)
Protein kinase C (PKC) comprises a superfamily of isoenzymes, many of which are activated by cofactors such as diacylglycerol and phosphatidylserine. In order to be capable of activation, PKC must...
Morais, Christudas, Pat, Betty, Gobe, Glenda, Johnson, David W., Healy, Helen
Background. The activation of nuclear factor-κB (NF-κB) has been implicated in the development, progression and metastasis of renal cell carcinoma (RCC). This study investigates the effect of...
Morais, Christudas, Pat, Betty, Gobe, Glenda, Johnson, David W., Healy, Helen
Background. The activation of nuclear factor-κB (NF-κB) has been implicated in the development, progression and metastasis of renal cell carcinoma (RCC). This study investigates the effect of...
Morais, Christudas, Pat, Betty, Gobe, Glenda, Johnson, David W., Healy, Helen
Background. The activation of nuclear factor-κB (NF-κB) has been implicated in the development, progression and metastasis of renal cell carcinoma (RCC). This study investigates the effect of...
BETTY PAT, TAO YANG, CHUIZE KONG, DIANNE WATTERS, DAVID W JOHNSON, Glenda Gobe
This paper reports key original data on the role of the mitogen activated protein kinase signal transduction proteins, specifically extracellular regulated kinase (ERK), in determining the...
Marsh, Susan, Laursen, Paul, Pat, Betty, Gobe, Glenda, Coombes, Jeff
therosclerotic plaque contains apoptotic endothelial cells with oxidative stress implicated in this process. Vitamin E and α-lipoic acid are a potent antioxidant combination with the potential to...
Pat, Betty, Yang, Tao, Kong, Chuize, Watters, Dianne Josephine, Johnson, David W., Gobe, Glenda, ...
Yes
Marsh, Susan, Laursen, Paul, Pat, Betty, Gobe, Glenda, Coombes, Jeff
Atherosclerotic plaque contains apoptotic endothelial cells with oxidative stress implicated in this process. Vitamin E and a-lipoic acid are a potent antioxidant combination with the potential to...
BETTY PAT, TAO YANG, CHUIZE KONG, DIANNE WATTERS, DAVID W JOHNSON, Glenda Gobe
This paper reports key original data on the role of the mitogen activated protein kinase signal transduction proteins, specifically extracellular regulated kinase (ERK), in determining the...
Marsh, Susan, Laursen, Paul, Pat, Betty, Gobe, Glenda, Coombes, Jeff
Atherosclerotic plaque contains apoptotic endothelial cells with oxidative stress implicated in this process. Vitamin E and a-lipoic acid are a potent antioxidant combination with the potential to...
Caveolins in the repair phase of acute renal failure after oxidative stress (2004)
Percy, Christine, Waters, Michael J., Gobe, Glenda
Ischaemia-reperfusion and toxic injury are leading causes of acute renal failure (ARF). Both of these injury initiators use secondary mediators of damage in oxygen-derived free radicals. Several...
Caveolins in the repair phase of acute renal failure after oxidative stress (2004)
Percy, Christine, Waters, Michael J., Gobe, Glenda
Ischaemia-reperfusion and toxic injury are leading causes of acute renal failure (ARF). Both of these injury initiators use secondary mediators of damage in oxygen-derived free radicals. Several...
Wensheng Pan, Hideaki Ishii, Yoshiro Ebihara, Glenda Gobe
This paper is part of an ongoing collaboration with Prof Hideaki Ishii, Department of Pathology, Tokyo Medical College, Japan. Prof Ishii spent 3 years under my supervision as a Research Fellow at...
Wensheng Pan, Hideaki Ishii, Yoshiro Ebihara, Glenda Gobe
This paper is part of an ongoing collaboration with Prof Hideaki Ishii, Department of Pathology, Tokyo Medical College, Japan. Prof Ishii spent 3 years under my supervision as a Research Fellow at...
Apoptosis and expression of Bcl-2, Bcl-XL, and Bax in renal cell carcinomas. (2002)
Glenda Gobe, Rubin M, Williams G, Sawczuk I, Buttyan R
This paper followed my travel scholarship in 2001 with Prof Ralph Buttyan, a long term collaborator at Department of Molecular Urology, College of Physicians and Surgeons, Columbia University NY. The...
Apoptosis and expression of Bcl-2, Bcl-XL, and Bax in renal cell carcinomas. (2002)
Glenda Gobe, Rubin M, Williams G, Sawczuk I, Buttyan R
This paper followed my travel scholarship in 2001 with Prof Ralph Buttyan, a long term collaborator at Department of Molecular Urology, College of Physicians and Surgeons, Columbia University NY. The...
Apoptosis in the pathogenesis of renal disease with a focus on tubulo-interstitial injury (2002)
Renal cell apoptosis is important not only in normal physiological conditions of the kidney but also in pathological processes. In normal renal development, it removes unwanted, damaged or harmful...
Bing Zhang, HQ Xia, Geoffrey Cleghorn, Glenda Gobe, Malcolm West, Ming Wei
The paper reported the original finding of harvesting gene therapy vector from supernatant using poly-L-lysine (PLL). The new method provides a convenient means for harvesting large volumes of...
Leila Cuttle, Xiao-Ju Zhang, Zoltan Endre, Clay Winterford, Glenda Gobe
This paper followed on from key data generated in testing a new hypothesis on the involvement of the Bcl-2 proteins in determining cell death and survival in the renal tubular epithelium after acute...
Leila Cuttle, Xiao-Ju Zhang, Zoltan Endre, Clay Winterford, Glenda Gobe
This paper followed on from key data generated in testing a new hypothesis on the involvement of the Bcl-2 proteins in determining cell death and survival in the renal tubular epithelium after acute...
Bing Zhang, HQ Xia, Geoffrey Cleghorn, Glenda Gobe, Malcolm West, Ming Wei
The paper reported the original finding of harvesting gene therapy vector from supernatant using poly-L-lysine (PLL). The new method provides a convenient means for harvesting large volumes of...
Renal impairment in deoxycorticosterone acetate-salt hypertensive rats (2000)
Dallemagne, Catherine, Ooi, Sze-Yuan, Brown, Lindsay, Gobe, Glenda, Endre, Zoltan
This study has compared renal function in deoxycorticosterone (DOCA)-salt hypertensive Wistar rats (uninephrectomy followed by administration of DOCA 25 mg subcutaneously every fourth day and 1% NaCl...
Cell survival or death in renal tubular epithelium after ischemia-reperfusion injury (1999)
Gobe, Glenda, Willgoss, Desley, Hogg, Nicole, Schoch, Estelle, Endre, Zoltan
A major contributor to the development and progression of ischemia-reperfusion (IR)-induced acute renal failure (ARF) is the loss of functioning tubular epithelial cells by means of various cell...
Molecular controls of radiation-induced apoptosis in the neonatal rat kidney (1999)
Glenda Gobe, Estelle Schoch, Jennifer Leighton
The incidence of cell death due to radiation was examined in a neonatal in vivo model. Differences in the induction of apoptosis, amount of cell proliferation, S-phase cell death, Bcl-2 and p-53...
Cell survival or death in renal tubular epithelium after ischemia-reperfusion injury (1999)
Gobe, Glenda, Willgoss, Desley, Hogg, Nicole, Schoch, Estelle, Endre, Zoltan
A major contributor to the development and progression of ischemia-reperfusion (IR)-induced acute renal failure (ARF) is the loss of functioning tubular epithelial cells by means of various cell...
Molecular controls of radiation-induced apoptosis in the neonatal rat kidney (1999)
Glenda Gobe, Estelle Schoch, Jennifer Leighton
The incidence of cell death due to radiation was examined in a neonatal in vivo model. Differences in the induction of apoptosis, amount of cell proliferation, S-phase cell death, Bcl-2 and p-53...
Chen, Jun, Li, Houwei, Addabbo, Francesco, Zhang, Fung, Pelger, Edward, Patschan, Daniel, ...
There are conflicting data regarding the effects of transplantation of bone marrow-derived cells (BMDCs) on the severity of diabetes. We therefore inquired whether the competence of BMDCs is...