Sittler, Taylor, Zhou, Jun, Park, Joosang, Yuen, Noah K., Sarantopoulos, Stefanie, Mollick, Joseph A., ...
PURPOSE: The therapeutic importance of immune responses against single versus multiple antigens is poorly understood. There also remains insufficient understanding whether responses to one subset of...
Modeling genomic diversity and tumor dependency in malignant melanoma (2008)
Lin, William M., Baker, Alissa C., Beroukhim, Rameen, Winckler, Wendy, Feng, Whei, Marmion, Jennifer M., ...
Corrigendum: High-throughput oncogene mutation profiling in human cancer. (2007)
Thomas, Roman K, Baker, Alissa C, Debiasi, Ralph M, Winckler, Wendy, Laframboise, Thomas, Lin, William M, ...
Systematic efforts are underway to decipher the genetic changes associated with tumor initiation and progression1, 2. However, widespread clinical application of this information is hampered by an...
High-throughput oncogene mutation profiling in human cancer (2007)
Thomas, Roman K., Baker, Alissa C., Debiasi, Ralph M., Winckler, Wendy, Laframboise, Thomas, Lin, William M., ...
Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors
Sampson, John H., Crotty, Laura E., Lee, Samson, Archer, Gary E., Ashley, David M., Wikstrand, Carol J., ...
The epidermal growth factor receptor (EGFR) is often amplified and rearranged structurally in tumors of the brain, breast, lung, and ovary. The most common mutation, EGFRvIII, is characterized by an...
Soiffer, Robert, Lynch, Thomas, Mihm, Martin, Jung, Ken, Rhuda, Catherine, Schmollinger, Jan C., ...
We conducted a Phase I clinical trial investigating the biologic activity of vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage...
Yang, Xiao-Feng, Wu, Catherine J., McLaughlin, Stephen, Chillemi, Antoinette, Wang, Kathy S., Canning, Christine, ...
This report describes a tumor-associated antigen, termed CML66, initially cloned from a chronic myelogenous leukemia (CML) cDNA expression library. CML66 encodes a 583-aa protein with a molecular...
ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction
Hodi, F. Stephen, Schmollinger, Jan C., Soiffer, Robert J., Salgia, Ravi, Lynch, Thomas, Ritz, Jerome, ...
An important goal of cancer immunology is the identification of antigens associated with tumor destruction. Vaccination with irradiated tumor cells engineered to secrete granulocyte/macrophage...
Melanoma inhibitor of apoptosis protein (ML-IAP) is a target for immune-mediated tumor destruction
Schmollinger, Jan C., Vonderheide, Robert H., Hoar, Kara M., Maecker, Britta, Schultze, Joachim L., Hodi, F. Stephen, ...
The identification of antigens associated with tumor destruction is a major goal of cancer immunology. Vaccination with irradiated tumor cells engineered to secrete granulocyte–macrophage colony...
Hodi, F. Stephen, Mihm, Martin C., Soiffer, Robert J., Haluska, Frank G., Butler, Marcus, Seiden, Michael V., ...
A large number of cancer-associated gene products evoke immune recognition, but host reactions rarely impede disease progression. The weak immunogenicity of nascent tumors contributes to this failure...
Gillessen, Silke, Naumov, Yuri N., Nieuwenhuis, Edward E. S., Exley, Mark A., Lee, Frederick S., Mach, Nicolas, ...
CD1d-restricted T cells contribute to tumor protection, but their precise roles remain unclear. Here we show that tumor cells engineered to secrete granulocyte–macrophage colony-stimulating factor...
Wu, Catherine J., Yang, Xiao-Feng, McLaughlin, Stephen, Neuberg, Donna, Canning, Christine, Stein, Brady, ...
The effectiveness of donor-lymphocyte infusion (DLI) for treatment of relapsed chronic myelogenous leukemia (CML) after allogeneic bone marrow transplantation is a clear demonstration of the...
Jinushi, Masahisa, Hodi, F. Stephen, Dranoff, Glenn
The activation of NKG2D on innate and adaptive cytotoxic lymphocytes contributes to immune-mediated tumor destruction. Nonetheless, tumor cell shedding of NKG2D ligands, such as MHC class I...
Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors
Sampson, John H., Crotty, Laura E., Lee, Samson, Archer, Gary E., Ashley, David M., Wikstrand, Carol J., ...
The epidermal growth factor receptor (EGFR) is often amplified and rearranged structurally in tumors of the brain, breast, lung, and ovary. The most common mutation, EGFRvIII, is characterized by an...
Soiffer, Robert, Lynch, Thomas, Mihm, Martin, Jung, Ken, Rhuda, Catherine, Schmollinger, Jan C., ...
We conducted a Phase I clinical trial investigating the biologic activity of vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage...
Yang, Xiao-Feng, Wu, Catherine J., McLaughlin, Stephen, Chillemi, Antoinette, Wang, Kathy S., Canning, Christine, ...
This report describes a tumor-associated antigen, termed CML66, initially cloned from a chronic myelogenous leukemia (CML) cDNA expression library. CML66 encodes a 583-aa protein with a molecular...
ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction
Hodi, F. Stephen, Schmollinger, Jan C., Soiffer, Robert J., Salgia, Ravi, Lynch, Thomas, Ritz, Jerome, ...
An important goal of cancer immunology is the identification of antigens associated with tumor destruction. Vaccination with irradiated tumor cells engineered to secrete granulocyte/macrophage...
Melanoma inhibitor of apoptosis protein (ML-IAP) is a target for immune-mediated tumor destruction
Schmollinger, Jan C., Vonderheide, Robert H., Hoar, Kara M., Maecker, Britta, Schultze, Joachim L., Hodi, F. Stephen, ...
The identification of antigens associated with tumor destruction is a major goal of cancer immunology. Vaccination with irradiated tumor cells engineered to secrete granulocyte–macrophage colony...
Hodi, F. Stephen, Mihm, Martin C., Soiffer, Robert J., Haluska, Frank G., Butler, Marcus, Seiden, Michael V., ...
A large number of cancer-associated gene products evoke immune recognition, but host reactions rarely impede disease progression. The weak immunogenicity of nascent tumors contributes to this failure...
Gillessen, Silke, Naumov, Yuri N., Nieuwenhuis, Edward E. S., Exley, Mark A., Lee, Frederick S., Mach, Nicolas, ...
CD1d-restricted T cells contribute to tumor protection, but their precise roles remain unclear. Here we show that tumor cells engineered to secrete granulocyte–macrophage colony-stimulating factor...
Wu, Catherine J., Yang, Xiao-Feng, McLaughlin, Stephen, Neuberg, Donna, Canning, Christine, Stein, Brady, ...
The effectiveness of donor-lymphocyte infusion (DLI) for treatment of relapsed chronic myelogenous leukemia (CML) after allogeneic bone marrow transplantation is a clear demonstration of the...
Jinushi, Masahisa, Hodi, F. Stephen, Dranoff, Glenn
The activation of NKG2D on innate and adaptive cytotoxic lymphocytes contributes to immune-mediated tumor destruction. Nonetheless, tumor cell shedding of NKG2D ligands, such as MHC class I...
Wynn, Aye Aye, Miyakawa, Kazuhisa, Miyata, Emi, Dranoff, Glenn, Takeya, Motohiro, Takahashi, Kiyoshi
To examine the role of granulocyte/macrophage colony-stimulating factor (GM-CSF) in inflammatory granuloma formation, we injected GM-CSF-deficient (GM-CSF−/−) mice and wild-type (GM-CSF+/+) mice...
Jinushi, Masahisa, Nakazaki, Yukoh, Dougan, Michael, Carrasco, Daniel R., Mihm, Martin, Dranoff, Glenn
Granulocyte-macrophage colony-stimulating factor (GM-CSF) enhances protection against tumors and infections, but GM-CSF–deficient mice develop inflammatory disease. Here we show that GM-CSF is...
Katsumoto, Tamiko R., Duda, Jennifer, Kim, Andrew, Wardak, Zabihullah, Dranoff, Glenn, Clapp, D. Wade, ...
Granulocyte/macrophage colony-stimulating factor (GM-CSF) promotes the survival, proliferation, and differentiation of myeloid lineage cells and regulates chemotaxis and adhesion. However, mice in...
Deficiencies of GM-CSF and Interferon γ Link Inflammation and Cancer
Enzler, Thomas, Gillessen, Silke, Manis, John P., Ferguson, David, Fleming, James, Alt, Frederick W., ...
Chronic inflammation contributes to carcinogenesis, but the underlying mechanisms are poorly understood. We report that aged granulocyte-macrophage colony stimulating factor (GM-CSF)-deficient mice...
Jinushi, Masahisa, Vanneman, Matthew, Munshi, Nikhil C., Tai, Yu-Tzu, Prabhala, Rao H., Ritz, Jerome, ...
Monoclonal gammopathy of undetermined significance (MGUS) is a common disorder of aging and a precursor lesion to full-blown multiple myeloma (MM). The mechanisms underlying the progression from MGUS...
Enzler, Thomas, Gillessen, Silke, Dougan, Michael, Allison, James P., Neuberg, Donna, Oble, Darryl A., ...
The pathogenesis of type 1 diabetes (T1D) involves the immune-mediated destruction of insulin-producing β cells in the pancreatic islets of Langerhans. Genetic analysis of families with a high...
Inciting inflammation: the RAGE about tumor promotion
Dougan, Michael, Dranoff, Glenn
Mechanisms of innate and adaptive immunity play a pivotal role in the development of cancer. Chronic inflammation can drive tumor development, but antitumor immunity can also restrict or even prevent...
Hodi, F. Stephen, Butler, Marcus, Oble, Darryl A., Seiden, Michael V., Haluska, Frank G., Kruse, Andrea, ...
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) functions as a negative regulator of endogenous and vaccine-induced antitumor immunity. The administration of fully human anti-CTLA-4 blocking...