Burnett, James C., Opsenica, Dejan, Sriraghavan, Kamaraj, Panchal, Rekha G., Ruthel, Gordon, Hermone, Ann R., ...
We previously identified structurally diverse small molecule (non-peptidic) inhibitors (SMNPIs) of the botulinum neurotoxin serotype A (BoNT/A) light chain (LC). Of these, several (including...
Ribot, Wilson J., Panchal, Rekha G., Brittingham, Katherine C., Ruthel, Gordon, Kenny, Tara A., Lane, Douglas, ...
Alveolar macrophages (AM) are very important for pulmonary innate immune responses against invading inhaled pathogens because they directly kill the organisms and initiate a cascade of innate and...
Time-Lapse Confocal Imaging of Development of Bacillus anthracis in Macrophages (1998)
Ruthel, Gordon, Ribot, Wilson J., Bavari, Sina, Hoover, Timothy A.
Macrophages attempt to battle infection with Bacillus anthracis spores by phagocytosis of the spores. However, it is believed that B. anthracis spores may survive phagocytosis and may actually use...
Ebola and Marburg Virus-Like Particles Activate Human Myeloid Dendritic Cells (1998)
Bosio, Catherine M., Moore, Brian D., Warfield, Kelly L., Ruthel, Gordon, Mohamadzadeh, Mansour
The filoviruses, Ebola (EBOV) and Marburg (MARV) viruses are potential global threats and cause deadly hemorrhagic fevers. Although, both EBOV and MARV exponentially replicate in dendritic cells...
Bosio, Catharine M., Aman, M. J., Grogan, Case, Hogan, Robert, Ruthel, Gordon
Ebola virus (EBOV) and Marburg virus (MARV) cause rapidly progressive hemorrhagic fever with high mortality and may possess specialized mechanisms to evade immune destruction. We postulated that...
Association of Ebola Virus Matrix Protein VP40 with Microtubules (1998)
Ruthel, Gordon, Demmin, Gretchen L., Kallstrom, George, Javid, Melodi P., Badie, Shirin S., Will, Amy B., ...
Viruses exploit a variety of cellular components to complete their life cycles, and it has become increasingly clear that use of host cell microtubules is a vital part of the infection process for...
Dendritic Cells Endocytose Bacillus Anthracis Spores: Implications for Anthrax Pathogenesis (1998)
Brittingham, Katherine C., Ruthel, Gordon, Panchal, Rekha G., Fuller, Claudette L., Ribot, Wilson J.
Phagocytosis of inhaled Bacillus anthracis spores and subsequent trafficking to lymph nodes are decisive events in the progression of inhaled anthrax because they initiate germination and...
Analysis of Ebola Virus and VLP Release Using an Immunocapture Assay (1998)
Kallstrom, George, Warfield, Kelly L., Swenson, Dana L., Mort, Shannon, Panchal, Rekha G., Ruthel, Gordon, ...
Ebola virus (EBOV), an emerging pathogen, is the causative agent of a rapidly progressive hemorrhagic fever with high mortality rates. There are currently no approved vaccines or treatments available...
Pless, Dorothy D., Ruthel, Gordon, Reinke, Emily K., Ulrich, Robert G., Bavari, Sina
Bacterial superantigen intoxication causes massive overactivation of T cells, which can result in potentially lethal toxic shock. Superantigens fall into two groups: superantigens such as...
Lactobacilli Activate Human Dendritic Cells that Skew T Cells Toward T Helper 1 Polarization (1998)
Mohamadzadeh, Mansour, Olson, Scott, Kalina, Warren V., Ruthel, Gordon, Demmin, Gretchen L., Warfield, Kelly L., ...
Professional antigen-presenting dendritic cells (DCs) are critical in regulating T cell immune responses at both systemic and mucosal sites. Many Lactobacillus species are normal members of the human...
Mohamadzadeh, Mansour, Coberley, Sadie S., Olinger, Gene G., Kalina, Warren V., Ruthel, Gordon, Fullter, Claudette L., ...
Marburg virus (MARV) and Ebola virus (EBOV), members of the viral family Filoviridae, cause fatal hemorrhagic fevers in humans and nonhuman primates. High viral burden is coincident with inadequate...
In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding
Panchal, Rekha G., Ruthel, Gordon, Kenny, Tara A., Kallstrom, George H., Lane, Douglas, Badie, Shirin S., ...
The matrix protein VP40 plays a critical role in Ebola virus assembly and budding, a process that utilizes specialized membrane domains known as lipid rafts. Previous studies with purified protein...
Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization
Mohamadzadeh, Mansour, Olson, Scott, Kalina, Warren V., Ruthel, Gordon, Demmin, Gretchen L., Warfield, Kelly L., ...
Professional antigen-presenting dendritic cells (DCs) are critical in regulating T cell immune responses at both systemic and mucosal sites. Many Lactobacillus species are normal members of the human...
Association of Ebola Virus Matrix Protein VP40 with Microtubules
Ruthel, Gordon, Demmin, Gretchen L., Kallstrom, George, Javid, Melodi P., Badie, Shirin S., Will, Amy B., ...
Viruses exploit a variety of cellular components to complete their life cycles, and it has become increasingly clear that use of host cell microtubules is a vital part of the infection process for...
Pless, Dorothy D., Ruthel, Gordon, Reinke, Emily K., Ulrich, Robert G., Bavari, Sina
Bacterial superantigen intoxication causes massive overactivation of T cells, which can result in potentially lethal toxic shock. Superantigens fall into two groups: superantigens such as...
Mohamadzadeh, Mansour, Coberley, Sadie S., Olinger, Gene G., Kalina, Warren V., Ruthel, Gordon, Fuller, Claudette L., ...
Marburg virus (MARV) and Ebola virus (EBOV), members of the viral family Filoviridae, cause fatal hemorrhagic fevers in humans and nonhuman primates. High viral burden is coincident with inadequate...
In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding
Panchal, Rekha G., Ruthel, Gordon, Kenny, Tara A., Kallstrom, George H., Lane, Douglas, Badie, Shirin S., ...
The matrix protein VP40 plays a critical role in Ebola virus assembly and budding, a process that utilizes specialized membrane domains known as lipid rafts. Previous studies with purified protein...
Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization
Mohamadzadeh, Mansour, Olson, Scott, Kalina, Warren V., Ruthel, Gordon, Demmin, Gretchen L., Warfield, Kelly L., ...
Professional antigen-presenting dendritic cells (DCs) are critical in regulating T cell immune responses at both systemic and mucosal sites. Many Lactobacillus species are normal members of the human...
Association of Ebola Virus Matrix Protein VP40 with Microtubules
Ruthel, Gordon, Demmin, Gretchen L., Kallstrom, George, Javid, Melodi P., Badie, Shirin S., Will, Amy B., ...
Viruses exploit a variety of cellular components to complete their life cycles, and it has become increasingly clear that use of host cell microtubules is a vital part of the infection process for...
Pless, Dorothy D., Ruthel, Gordon, Reinke, Emily K., Ulrich, Robert G., Bavari, Sina
Bacterial superantigen intoxication causes massive overactivation of T cells, which can result in potentially lethal toxic shock. Superantigens fall into two groups: superantigens such as...
Mohamadzadeh, Mansour, Coberley, Sadie S., Olinger, Gene G., Kalina, Warren V., Ruthel, Gordon, Fuller, Claudette L., ...
Marburg virus (MARV) and Ebola virus (EBOV), members of the viral family Filoviridae, cause fatal hemorrhagic fevers in humans and nonhuman primates. High viral burden is coincident with inadequate...
Ribot, Wilson J., Panchal, Rekha G., Brittingham, Katherine C., Ruthel, Gordon, Kenny, Tara A., Lane, Douglas, ...
Alveolar macrophages (AM) are very important for pulmonary innate immune responses against invading inhaled pathogens because they directly kill the organisms and initiate a cascade of innate and...
Lipid Raft Microdomains: A Gateway for Compartmentalized Trafficking of Ebola and Marburg Viruses〉
Bavari, Sina, Bosio, Catharine M., Wiegand, Elizabeth, Ruthel, Gordon, Will, Amy B., Geisbert, Thomas W., ...
Spatiotemporal aspects of filovirus entry and release are poorly understood. Lipid rafts act as functional platforms for multiple cellular signaling and trafficking processes. Here, we report the...
Saikh, Kamal U., Kissner, Teri L., Nystrom, Steven, Ruthel, Gordon, Ulrich, Robert G.
Interleukin-15 (IL-15) is generally considered to sustain T-cell memory and to be a growth factor for natural killer cells. Previous data from our laboratory demonstrated that IL-15 is also an...
Mechanical tension can specify axonal fate in hippocampal neurons
Lamoureux, Phillip, Ruthel, Gordon, Buxbaum, Robert E., Heidemann, Steven R.
Here we asked whether applied mechanical tension would stimulate undifferentiated minor processes of cultured hippocampal neurons to become axons and whether tension could induce a second axon in an...
In Vitro Intracellular Trafficking of Virulence Antigen during Infection by Yersinia pestis
DiMezzo, Tracy L., Ruthel, Gordon, Brueggemann, Ernst E., Hines, Harry B., Ribot, Wilson J., Chapman, Carol E., ...
Yersinia pestis, the causative agent of plague, encodes several essential virulence factors on a 70 kb plasmid, including the Yersinia outer proteins (Yops) and a multifunctional virulence antigen...
Swenson, Dana L., Warfield, Kelly L., Warren, Travis K., Lovejoy, Candace, Hassinger, Jed N., Ruthel, Gordon, ...
Phosphorodiamidate morpholino oligomers (PMOs) are uncharged nucleic acid-like molecules designed to inactivate the expression of specific genes via the antisense-based steric hindrance of mRNA...