Gordon Smyth

Regression Analysis Of Quantity Data With Exact Zeroes (2008)

Gordon Smyth

Measurements of the magnitude or duration of physical phenomenon have the property that they are positive and continuous, except for the possibility of exact zeroes when the phenomenon does not...

Optimization and Nonlinear Equations (2007)

Gordon Smyth

This article discusses unconstrained optimization. Sometimes however x must satisfy one or more constraints. An example is some of the components of x being known a priori to be positive. In some...

Numerical Analysis (2007)

Gordon Smyth

This article discusses the basic ideas of accuracy and describes briefly key topics in numerical analysis which are treated at more depth in separate articles. Pointers to available software are...

Bioconductor: open software development for computational biology and bioinformatics (2004)

Gentleman, Robert C, Carey, Vincent J, Bates, Douglas M, Bolstad, Ben, Dettling, Marcel, Dudoit, Sandrine, ...

Abstract The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering...

The Matrix Exponential (1997)

Gordon Smyth

onal to the concentration in the supplying compartment. In this case, x j (t) is the concentration of the drug in the jth compartment at time t, while the elements of A are the transfer rates between...

A comparative analysis of transcribed genes in the mouse hypothalamus and neocortex reveals chromosomal clustering

Boon, Wee-Ming, Beissbarth, Tim, Hyde, Lavinia, Smyth, Gordon, Gunnersen, Jenny, Denton, Derek A., ...

The hypothalamus and neocortex are subdivisions of the mammalian forebrain, and yet, they have vastly different evolutionary histories, cytoarchitecture, and biological functions. In an attempt to...

Bioconductor: open software development for computational biology and bioinformatics

Gentleman, Robert C, Carey, Vincent J, Bates, Douglas M, Bolstad, Ben, Dettling, Marcel, Dudoit, Sandrine, ...

A detailed description of the aims and methods of the Bioconductor project, an initiative for the collaborative creation of extensible software for computational biology and bioinformatics.

A comparative analysis of transcribed genes in the mouse hypothalamus and neocortex reveals chromosomal clustering

Boon, Wee-Ming, Beissbarth, Tim, Hyde, Lavinia, Smyth, Gordon, Gunnersen, Jenny, Denton, Derek A., ...

The hypothalamus and neocortex are subdivisions of the mammalian forebrain, and yet, they have vastly different evolutionary histories, cytoarchitecture, and biological functions. In an attempt to...

Bioconductor: open software development for computational biology and bioinformatics

Gentleman, Robert C, Carey, Vincent J, Bates, Douglas M, Bolstad, Ben, Dettling, Marcel, Dudoit, Sandrine, ...

A detailed description of the aims and methods of the Bioconductor project, an initiative for the collaborative creation of extensible software for computational biology and bioinformatics.

Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

Gordon Smyth

The problem of identifying differentially expressed genes in designed microarray experiments is considered. Lonnstedt and Speed (2002) derived an expression for the posterior odds of differential...

Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

Gordon Smyth

The problem of identifying differentially expressed genes in designed microarray experiments is considered. Lonnstedt and Speed (2002) derived an expression for the posterior odds of differential...