Govind Chandra

Transposon Express, a software application to report the identity of insertions obtained by comprehensive transposon mutagenesis of sequenced genomes: analysis of the preference for in vitro Tn5 transposition into GC-rich DNA (2004)

Herron, Paul R., Hughes, Gareth, Chandra, Govind, Fielding, Susan, Dyson, Paul J.

Comprehensive mutant libraries can be readily constructed by transposon mutagenesis. To systematically mutagenise the genome of the Gram-positive bacterium Streptomyces coelicolor A3(2), we have...

Genomics of Actinobacteria: Tracing the Evolutionary History of an Ancient Phylum†

Ventura, Marco, Canchaya, Carlos, Tauch, Andreas, Chandra, Govind, Fitzgerald, Gerald F., Chater, Keith F., ...

Summary: Actinobacteria constitute one of the largest phyla among Bacteria and represent gram-positive bacteria with a high G+C content in their DNA. This bacterial group includes microorganisms...

The Transcriptional Repressor Protein NsrR Senses Nitric Oxide Directly via a [2Fe-2S] Cluster

Tucker, Nicholas P., Hicks, Matthew G., Clarke, Thomas A., Crack, Jason C., Chandra, Govind, Le Brun, Nick E., ...

The regulatory protein NsrR, a member of the Rrf2 family of transcription repressors, is specifically dedicated to sensing nitric oxide (NO) in a variety of pathogenic and non-pathogenic bacteria. It...