Trace organic compounds in the marine environment (2002)
Moore, MR, Vetter, W, Gaus, C, Shaw, GR, Muller, JF
Trace organic chemicals include a range of compounds which, due to a combination of their physico-chemical properties and toxicological implications, have been described as a serious threat to the...
Hepatic xenobiotic metabolism of cylindrospermopsin in vivo in the mouse (2002)
Norris, RLG, Seawright, AA, Shaw, GR, Senogles, P, Eaglesham, GK, Smith, MJ, ...
Cylindrospermopsin (CYN) is a hepatotoxin isolated from the blue-green alga Cylindrospermopsis raciborskii. The role of both glutathione (GSH) and the cytochrome P450 enzyme system (P450) in the...
Norris, RLG, Eaglesham, GK, Shaw, GR, Senogles, P, Chiswell, RK, Smith, MJ, ...
The hepatotoxin cylindrospermopsin (CYN) has been isolated from the cyanobacterium Cylindrospermopsis raciborskii (C. raci.). Efforts to study this toxin have been hampered by the time-consuming...
Distribution of C-14 Cylindrospermopsin in vivo in the mouse (2001)
Norris, RLG, Seawright, AA, Shaw, GR, Smith, MJ, Chiswell, RK, Moore, MR
Radiolabelled C-14 cylindrospermopsin (CYN) has been prepared and used to investigate the distribution and excretion of CYN in vivo in male Quackenbush mice. At a dose of 0.2 mg/kg (i.e., approx....
Gaus, C, Papke, O, Dennison, N, Haynes, D, Shaw, GR, Connell, DW, ...
Recent studies have demonstrated the occurrence of elevated levels of higher chlorinated PCDDs in the coastal environment of Queensland, Australia. This study presents new data for OCDD contamination...
Norris, RL, Eaglesham, GK, Shaw, GR, Smith, MJ, Chiswell, RK, Seawright, AA, ...
We have utilised the combination of sensitivity and specificity afforded by coupling high-performance liquid chromatography (HPLC) to a tandem mass spectrometer (MS-MS) to produce an assay which is...
Cylindrospermopsin, A cyanobacterial alkaloid: Evaluation of its toxicologic activity (2000)
Shaw, GR, Seawright, AA, Moore, MR, Lam, PKS
This paper describes the natural occurrence of the toxin, cylindrospermopsin, in two species of cyanobacteria found in Australia. The structure and chemical properties of this compound are described...
Seawright, AA, Nolan, CC, Shaw, GR, Chiswell, RK, Norris, RL, Moore, MR, ...
Exposure of humans and domestic animals to Cylindrospermopsis raciborskii and its associated toxin cylindrospermopsin in their drinking water will normally be by ingestion. Studies of the...
Eaglesham, GK, Norris, RL, Shaw, GR, Smith, MJ, Chiswell, RK, Davis, BC, ...
Increasing reports of blooms of the blue-green alga Cylindrospermopsis raciborskii (C. raciborskii), which contains the hepatotoxic alkaloid cylindrospermopsin (CYN), have led to public health...
Chiswell, RK, Shaw, GR, Eaglesham, G, Smith, MJ, Norris, RL, Seawright, AA, ...
Cylindrospermopsin is a powerful hepatotoxin produced by the cyanobacterium Cylindrospermopsis raciborskii. It is considered a potential threat to livestock, wildlife, and humans, and is the...
Shaw, GR, Sukenik, A, Livne, A, Chiswell, RK, Smith, MJ, Seawright, AA, ...
The cyanobacterium, Aphanizomenon ovalisporum (Forti) is reported herein for the first time in Australia. Its distribution appears to be restricted to an isolated subtropical region which has...
Deoxycylindrospermopsin, an analog of cylindrospermopsin from Cylindrospermopsis raciborskii (1999)
Norris, RL, Eaglesham, GK, Pierens, G, Shaw, GR, Smith, MJ, Chiswell, RK, ...
Cylindrospermopsin (CYN) is a hepatotoxic alkaloid found in the blue-green alga Cylindrospermopsis raciborskii (C. raciborskii). Data indicating CYN alone does not account for the toxicity of freeze...