Ware, Lisa J., Jackson, Akil G.A., Wootton, Stephen A., Burdge, Graham C., Morlese, John F., Moyle, Graeme J., ...
Mechanisms underlying the lipodystrophy syndrome associated with antiretroviral therapy (ART) for HIV infection are not completely understood. We investigated the effect of ART on blood lipid...
Burdge, Graham C., Powell, Jonathan, Dadd, Tony, Talbot, Duncan, Civil, Jacqueline, Calder, Philip C.
Dietary supplementation with fish oil induces beneficial changes in the size and concentration of plasma lipoproteins, although the underlying mechanism is unclear. We have investigated the effect of...
Burdge, Graham C., Lillycrop, Karen A., Phillips, Emma S., Slater-Jefferies, Joanne L., Jackson, Alan A., Hanson, Mark A.
Prenatal nutritional constraint is associated with increased risk of metabolic dysregulation in adulthood contingent on adult diet. In rats, folic acid supplementation of a protein-restricted (PR)...
Burdge, Graham C., Lillycrop, Karen A., Jackson, Alan A.
There is substantial evidence which shows that constraints in the early life environment are an important determinant of risk of metabolic disease and CVD. There is emerging evidence that higher...
Extreme physical inactivity differentially alters dietary oleate and palmitate trafficking (2009)
Bergouignan, Audrey, Trudel, Guy, Simon, Chantal, Chopard, Angèle, Schoeller, Dale A., Momken, Iman, ...
OBJECTIVE: obesity and diabetes are characterized by the incapacity to use fat as fuel. We hypothesized that this reduced fat oxidation is secondary to a sedentary lifestyle. RESEARCH DESIGN AND...
Gender differences in the n-3 fatty acid content of tissues (2008)
Childs, Caroline E., Romeu-Nadal, Meritxell, Burdge, Graham C., Calder, Philip C.
Dietary n-3 PUFA have many beneficial effects on cell and tissue function and on human health. In mammals the n-3 essential fatty acid alpha-linolenic acid (ALNA) can be converted into longer-chain...
Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...
Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...
Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...
Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...
Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...
Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...
Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...
Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...
Godfrey, Keith M., Lillycrop, Karen A., Burdge, Graham C., Gluckman, Peter D., Hanson, Mark A.
There is now considerable evidence that elements of the heritable or familial component of disease susceptibility are transmitted by nongenomic means, and that environmental influences acting during...
Burdge, Graham C., Slater-Jefferies, Jo, Torrens, Christopher, Phillips, Emma S., Hanson, Mark A., Lillycrop, Karen A.
Epidemiological studies and experimental models show that maternal nutritional constraint during pregnancy alters the metabolic phenotype of the offspring and that this can be passed to subsequent...
Heath, Richard B., Karpe, Fredrik, Milne, Ross W., Burdge, Graham C., Wootton, Stephen A., Frayn, Keith N.
Exaggerated postprandial lipemia is associated with coronary heart disease and type II diabetes, yet few studies have examined the effect of sequential meals on lipoprotein metabolism. We have used...
Mayes, Clifford, Burdge, Graham C., Bingham, Anne, Murphy, Jane L., Tubman, Richard, Wootton, Stephen A.
Docosahexaenoic acid (DHA) is an integral component of neural cell membranes and is critical to the development and function of the CNS. A premature delivery interrupts normal placental supply of DHA...
Dietary alpha-linolenic acid and health-related outcomes: a metabolic perspective (2006)
Burdge, Graham C., Calder, Philip C.
alpha-Linolenic acid (alpha LNA; 18 : 3n-3) is essential in the human diet, probably because it is the substrate for the synthesis of longer-chain, more unsaturated n-3 fatty acids, principally EPA...
Burdge, Graham C., Sherman, Rachel C., Ali, Zulaika, Wootton, Stephen A., Jackson, Alan A.
The fetal demand for docosahexaenoic acid (DHA) has to be satisfied by the mother. We determined the fatty acids in maternal plasma non-esterified fatty acid (NEFA), triacylglycerol (TAG) and...
Lillycrop, Karen A., Phillips, Emma S., Jackson, Alan A., Hanson, Mark A., Burdge, Graham C.
Environmental constraints during early life result in phenotypic changes that can be associated with increased disease risk in later life. This suggests persistent alteration of gene transcription....
Burdge, Graham C., Calder, Philip C.
This review summarises and evaluates current knowledge of α-linolenic acid (LNA) metabolism in adult humans. The principal biological role of αLNA appears to be as a precursor for the synthesis of...
Conversion of α-linolenic acid to longer-chain polyunsaturated fatty acids in human adults (2005)
Burdge, Graham C., Calder, Philip C.
The principal biological role of α-linolenic acid (αLNA; 18:3n-3) appears to be as a precursor for the synthesis of longer chain n-3 polyunsaturated fatty acids (PUFA). Increasing αLNA intake for...
Burdge, Graham C., Derrick, Peter R., Russell, Jennifer J., Tricon, Sabine, Kew, Samantha, Banerjee, Tapati, ...
The purpose of this study was to determine the incorporation into erythrocytes of cis (c)-9,trans (t)-11 conjugated linoleic acid (CLA) and t10,c12 CLA consumed as supplements highly enriched in...
Burdge, Graham C., Tricon, Sabine, Morgan, Rebecca, Kliem, Kirsty E., Childs, Caroline, Jones, Emma, ...
The present study investigated whether consuming dairy products naturally enriched in cis-9, trans-11 (c9,t11) conjugated linoleic acid (CLA) by modification of cattle feed increases the...
Burdge, Graham C., Calder, Philip C.
Chronic inflammation of the vascular endothelium produces endothelial dysfunction and ultimately atherogenesis. Postprandial hyperlipidaemia is an independent risk factor for cardiovascular disease....
Trebble, Timothy M., Arden, Nigel K., Wootton, Stephen A., Mullee, Mark A., Calder, Philip C., Burdge, Graham C., ...
Background & aims: Crohn's disease (CD) is associated with nutritional deficiencies, altered plasma concentrations of polyunsaturated fatty acids (PUFA) and an anti-inflammatory response to fish oil...
Burdge, Graham C., Phillips, Emma S., Dunn, Rebecca L., Jackson, Alan A., Lillycrop, Karen A.
The effect of protein consumption during pregnancy on peroxisomal proliferator-activated receptor (PPAR) expression and plasma lipid concentrations in the offspring were determined in the rat. Rats...
Burdge, Graham C., Lupoli, Berit, Russell, Jennifer J., Tricon, Sabine, Kew, Samantha, Banerjee, Tapati, ...
This study investigated the incorporation of cis-9,trans-11 conjugated linoleic acid (c9,t11 CLA) and trans-10,cis-12-CLA (t10,c12 CLA) into plasma and peripheral blood mononuclear cell (PBMC) lipids...
Burdge, Graham C., Postle, Anthony D.
The molecular species composition of membrane phospholipids influences the activities of integral proteins and cell signalling pathways. We determined the effect of increasing gestational age on...
Burdge, Graham C., Dunn, Rebecca L., Jackson, Alan A.
The objective of this study was to determine whether consumption of a maternal low-protein (MLP) diet during pregnancy alters placental lipid composition, and whether this was prevented by...
Masding, Michael G., Stears, Anna J., Burdge, Graham C., Wootton, Stephen A., Sandeman, Derek D.
Objective: Women with type 2 diabetes appear to lose the protection against cardiovascular disease afforded by estrogens. We examined the effects of menopausal status on postprandial clearance of...
Trebble, Timothy M., Wootton, Stephen A., Miles, Elizabeth A., Mullee, Mark, Arden, Nigel K., Ballinger, Anne B., ...
Background: prostaglandin E2 (PGE2) inhibits lymphocyte proliferation and the production of interferon-{gamma} (IFN-{gamma}) by peripheral blood mononuclear cells, but the effect of PGE2 on...
Trebble, Timothy M., Wootton, Stephen A., Miles, Elizabeth A., Mullee, Mark, Arden, Nigel K., Ballinger, Anne B., ...
BACKGROUND: Prostaglandin E(2) (PGE(2)) inhibits lymphocyte proliferation and the production of interferon-gamma (IFN-gamma) by peripheral blood mononuclear cells, but the effect of PGE(2) on...
Trebble, Timothy M., Wootton, Stephen A., Miles, Elizabeth A., Mullee, Mark, Arden, Nigel K., Ballinger, Anne B., ...
BACKGROUND: Prostaglandin E(2) (PGE(2)) inhibits lymphocyte proliferation and the production of interferon-gamma (IFN-gamma) by peripheral blood mononuclear cells, but the effect of PGE(2) on...
Heath, Richard B., Karpe, Fredrik, Milne, Ross W., Burdge, Graham C., Wootton, Stephen A., Frayn, Keith N.
Circulating triacylglycerol (TG) arises mainly from dietary fat. However, little is known about the entry of dietary fat into the major TG pool, very low-density lipoprotein (VLDL) TG. We used a...
Evans, Kevin, Burdge, Graham C., Wootton, Stephen A., Clark, Mo L., Frayn, Keith N.
Using stable isotopic labeling of dietary fatty acids in conjunction with arteriovenous difference measurements, we have assessed the regulation of lipoprotein lipase-derived fatty acid entrapment in...
Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...
Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...