Black, Antony P.B., Ardern-Jones, Michael R., Kasprowicz, Victoria, Bowness, Paul, Jones, Louise, Bailey, Abigail S., ...
The ability of human keratinocytes to present antigen to T cells is controversial and, indeed, it has been suggested that keratinocytes may promote T cell hyporesponsiveness. Furthermore, it is...
Bacterial superantigen facilitates epithelial presentation of allergen to T helper 2 cells. (2007)
Ardern-Jones, Michael R., Black, Anthony P., Bateman, Elizabeth A., Ogg, Graham S.
Although clinical and laboratory evidence support roles for both staphylococcal infection and environmental allergens in the pathogenesis of atopic dermatitis, human studies have largely considered...
Bacterial superantigen facilitates epithelial presentation of allergen to T helper 2 cells (2007)
Ardern-Jones, Michael R., Black, Antony P., Bateman, Elizabeth A., Ogg, Graham S.
Although clinical and laboratory evidence support roles for both staphylococcal infection and environmental allergens in the pathogenesis of atopic dermatitis, human studies have largely considered...
BLDSC reference no.: D203797.
Jeffery, Katie J. M., Usuku, Koichiro, Hall, Sarah E., Matsumoto, Wataru, Taylor, Graham P., Procter, Jeanette, ...
The risk of disease associated with persistent virus infections such as HIV-I, hepatitis B and C, and human T-lymphotropic virus-I (HTLV-I) is strongly determined by the virus load. However, it is...
Dyer, Wayne B., Ogg, Graham S., Demoitie, Marie-Ange, Jin, Xia, Geczy, Andrew F., Rowland-Jones, Sarah L., ...
Proposals for the use of live attenuated human immunodeficiency virus (HIV) type 1 (HIV-1) as a vaccine candidate in humans have been based on the protection afforded by attenuated simian...
Dorrell, Lucy, Dong, Tao, Ogg, Graham S., Lister, Simon, McAdam, Steve, Rostron, Tim, ...
We present detailed studies of human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTL) responses to clade A or C HIV type 1 in three donors infected in East Africa. We define several...
Spiegel, Hans M. L., Ogg, Graham S., DeFalcon, Elizabeth, Sheehy, Megan E., Monard, Simon, Haslett, Patrick A. J., ...
CD4+ T cells are thought to be critical in the maintenance of virus-specific CD8+ cytotoxic T-cell (CTL) responses. In human immunodeficiency virus type 1 (HIV-1) infection, a selective decline in...
Kalams, Spyros A., Goulder, Philip J., Shea, Amy K., Jones, Norman G., Trocha, Alicja K., Ogg, Graham S., ...
Therapeutic suppression of human immunodeficiency virus type 1 (HIV-1) replication may help elucidate interactions between the host cellular immune responses and HIV-1 infection. We performed a...
Ogg, Graham S., Kostense, Stefan, Klein, Michel R., Jurriaans, Suzanne, Hamann, Dörte, McMichael, Andrew J., ...
Few studies have examined longitudinal changes in human immunodeficiency virus type 1 (HIV)-specific cytotoxic T lymphocytes (CTL). To more closely define the natural history of HIV-specific CTL, we...
Allergen-specific CD8+ T cells and atopic disease
Seneviratne, Suranjith L., Jones, Louise, King, Abigail S., Black, Antony, Powell, Sheila, McMichael, Andrew J., ...
Considerable evidence suggests that IL-10 may have a role in the manifestation of atopic disease. We sought to test the hypothesis that at the single cell level, allergen-specific T cells have...
TLR2 is expressed on activated T cells as a costimulatory receptor
Komai-Koma, Mousa, Jones, Louise, Ogg, Graham S., Xu, Damo, Liew, Foo Y.
Toll is the founder of a group of pattern recognition receptors that play a critical role in the innate immunity in Drosophila. At least 10 distinct Toll-like receptors (TLRs), recognizing...
Webster, George J. M., Reignat, Stephanie, Brown, David, Ogg, Graham S., Jones, Louise, Seneviratne, Suranjith L., ...
The cytotoxic T-cell response in chronic hepatitis B virus (HBV) infection has been described as weak and mono- or oligospecific in comparison to the more robust virus-specific T-cell response...
Jeffery, Katie J. M., Usuku, Koichiro, Hall, Sarah E., Matsumoto, Wataru, Taylor, Graham P., Procter, Jeanette, ...
The risk of disease associated with persistent virus infections such as HIV-I, hepatitis B and C, and human T-lymphotropic virus-I (HTLV-I) is strongly determined by the virus load. However, it is...
Dyer, Wayne B., Ogg, Graham S., Demoitie, Marie-Ange, Jin, Xia, Geczy, Andrew F., Rowland-Jones, Sarah L., ...
Proposals for the use of live attenuated human immunodeficiency virus (HIV) type 1 (HIV-1) as a vaccine candidate in humans have been based on the protection afforded by attenuated simian...
Dorrell, Lucy, Dong, Tao, Ogg, Graham S., Lister, Simon, McAdam, Steve, Rostron, Tim, ...
We present detailed studies of human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTL) responses to clade A or C HIV type 1 in three donors infected in East Africa. We define several...
Spiegel, Hans M. L., Ogg, Graham S., DeFalcon, Elizabeth, Sheehy, Megan E., Monard, Simon, Haslett, Patrick A. J., ...
CD4+ T cells are thought to be critical in the maintenance of virus-specific CD8+ cytotoxic T-cell (CTL) responses. In human immunodeficiency virus type 1 (HIV-1) infection, a selective decline in...
Kalams, Spyros A., Goulder, Philip J., Shea, Amy K., Jones, Norman G., Trocha, Alicja K., Ogg, Graham S., ...
Therapeutic suppression of human immunodeficiency virus type 1 (HIV-1) replication may help elucidate interactions between the host cellular immune responses and HIV-1 infection. We performed a...
Ogg, Graham S., Kostense, Stefan, Klein, Michel R., Jurriaans, Suzanne, Hamann, Dörte, McMichael, Andrew J., ...
Few studies have examined longitudinal changes in human immunodeficiency virus type 1 (HIV)-specific cytotoxic T lymphocytes (CTL). To more closely define the natural history of HIV-specific CTL, we...
Allergen-specific CD8+ T cells and atopic disease
Seneviratne, Suranjith L., Jones, Louise, King, Abigail S., Black, Antony, Powell, Sheila, McMichael, Andrew J., ...
Considerable evidence suggests that IL-10 may have a role in the manifestation of atopic disease. We sought to test the hypothesis that at the single cell level, allergen-specific T cells have...
TLR2 is expressed on activated T cells as a costimulatory receptor
Komai-Koma, Mousa, Jones, Louise, Ogg, Graham S., Xu, Damo, Liew, Foo Y.
Toll is the founder of a group of pattern recognition receptors that play a critical role in the innate immunity in Drosophila. At least 10 distinct Toll-like receptors (TLRs), recognizing...
Webster, George J. M., Reignat, Stephanie, Brown, David, Ogg, Graham S., Jones, Louise, Seneviratne, Suranjith L., ...
The cytotoxic T-cell response in chronic hepatitis B virus (HBV) infection has been described as weak and mono- or oligospecific in comparison to the more robust virus-specific T-cell response...
Jones, Louise, Black, Antony P., Malavige, Gathsaurie N., Ogg, Graham S.
Open reading frame 4 (ORF4) of varicella-zoster virus (VZV) encodes an immediate-early protein that is believed to be important for viral infectivity and establishing latency. Evidence suggests that...
Bacterial superantigen facilitates epithelial presentation of allergen to T helper 2 cells
Ardern-Jones, Michael R., Black, Antony P., Bateman, Elizabeth A., Ogg, Graham S.
Although clinical and laboratory evidence support roles for both staphylococcal infection and environmental allergens in the pathogenesis of atopic dermatitis, human studies have largely considered...
Interleukin-4 promotes human CD8+ T cell expression of CCR7
Seneviratne, Suranjith L, Black, Antony P, Jones, Louise, Di Gleria, Kati, Bailey, Abigail S, Ogg, Graham S
Despite strong evidence supporting a pathway of human T cell differentiation characterized by changes in the expression of CCR7, CD28, CD27 and CD62L, few studies have addressed the mechanisms of...
HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function
Appay, Victor, Nixon, Douglas F., Donahoe, Sean M., Gillespie, Geraldine M.A., Dong, Tao, King, Abigail, ...
The use of peptide–human histocompatibility leukocyte antigen (HLA) class I tetrameric complexes to identify antigen-specific CD8+ T cells has provided a major development in our understanding of...
Maini, Mala K., Boni, Carolina, Lee, Chun Kyon, Larrubia, Juan R., Reignat, Stephanie, Ogg, Graham S., ...
Hepatitis B virus (HBV) is a noncytopathic virus, and the recognition of infected hepatocytes by HBV-specific CD8 cells has been assumed to be the central mechanism causing both liver damage and...
Reignat, Stephanie, Webster, George J.M., Brown, David, Ogg, Graham S., King, Abigail, Seneviratne, Suranjith L., ...
Deletion, anergy, and a spectrum of functional impairments can affect virus-specific CD8 cells in chronic viral infections. Here we characterize a low frequency population of CD8 cells present in...
Romero, Pedro, Rod Dunbar, P., Valmori, Danila, Pittet, Mikaël, Ogg, Graham S., Rimoldi, Donata, ...
Characterization of cytolytic T lymphocyte (CTL) responses to tumor antigens has been impeded by a lack of direct assays of CTL activity. We have synthesized reagents (“tetramers”) that...
High Frequency of Skin-homing Melanocyte-specific Cytotoxic T Lymphocytes in Autoimmune Vitiligo
Ogg, Graham S., Rod Dunbar, P., Romero, Pedro, Chen, Ji-Li, Cerundolo, Vincenzo
Vitiligo is an autoimmune condition characterized by loss of epidermal melanocytes. Using tetrameric complexes of human histocompatibility leukocyte antigen (HLA) class I to identify antigen-specific...
Oligoclonal Expansions of CD8+ T Cells in Chronic HIV Infection Are Antigen Specific
Wilson, Jamie D.K., Ogg, Graham S., Allen, Rachel L., Goulder, Philip J.R., Kelleher, Anthony, Sewell, Andy K., ...
Acute HIV infection is associated with a vigorous immune response characterized by the proliferation of selected T cell receptor V beta (BV)-expressing CD8+ T cells. These ‘expansions', which are...