Longitudinally Profiling Neutralizing Antibody Response to SARS (2008)
Coronavirus Pseudotypes, Nigel J. Temperton, Paul K. Chan, Graham Simmons, Maria C. Zambon, Richard S. Tedder, ...
The severe acute respiratory syndrome–associated coronavirus (SARS-CoV) spike protein (S) is a major target for neutralizing antibodies. Retroviral SARS-CoV S pseudotypes have been constructed and...
Peters, Paul J., Bhattacharya, Jayanta, Hibbitts, Samantha, Dittmar, Matthias T., Simmons, Graham, Bell, Jeanne E., ...
Complete envelope genes were amplified from autopsy brain tissue of five individuals who had died of AIDS and had neurological complications. Lymph node samples were included for two of the patients....
Thesis (Ph. D.)--University of London, 2000.
Reeves, Jacqueline D., Hibbitts, Sam, Simmons, Graham, McKnight, Áine, Azevedo-Pereira, José M., Moniz-Pereira, José, ...
Cell surface receptors exploited by human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) for infection are major determinants of tropism. HIV-1 usually requires two receptors to...
Dejucq, Nathalie, Simmons, Graham, Clapham, Paul R.
Human immunodeficiency virus type 1 (HIV-1) non-syncytium-inducing (NSI) strains predominantly use the chemokine receptor CCR5, while syncytium-inducing (SI) strains use CXCR4. In vitro, SI isolates...
Simmons, Graham, Reeves, Jacqueline D., McKnight, Áine, Dejucq, Nathalie, Hibbitts, Sam, Power, Christine A., ...
The coreceptors used by primary syncytium-inducing (SI) human immunodeficiency virus type 1 isolates for infection of primary macrophages were investigated. SI strains using only CXCR4 replicated...
Lin, George, Simmons, Graham, Pöhlmann, Stefan, Baribaud, Frédéric, Ni, Houping, Leslie, George J., ...
The C-type lectins DC-SIGN and DC-SIGNR [collectively referred to as DC-SIGN(R)] bind and transmit human immunodeficiency virus (HIV) and simian immunodeficiency virus to T cells via the viral...
Ebola Virus Glycoproteins Induce Global Surface Protein Down-Modulation and Loss of Cell Adherence
Simmons, Graham, Wool-Lewis, Rouven J., Baribaud, Frédéric, Netter, Robert C., Bates, Paul
The Ebola virus envelope glycoprotein (GP) derived from the pathogenic Zaire subtype mediates cell rounding and detachment from the extracellular matrix in 293T cells. In this study we provide...
Simmons, Graham, Rennekamp, Andrew J., Chai, Ning, Vandenberghe, Luk H., Riley, James L., Bates, Paul
Folate receptor alpha (FRα) has been described as a factor involved in mediating Ebola virus entry into cells (6). Furthermore, it was suggested that interaction with FRα results in internalization...
Simmons, Graham, Reeves, Jacqueline D., Rennekamp, Andrew J., Amberg, Sean M., Piefer, Andrew J., Bates, Paul
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is a rapidly emerging pathogen with potentially serious consequences for public health. Here we describe conditions that result not...
Peters, Paul J., Bhattacharya, Jayanta, Hibbitts, Samantha, Dittmar, Matthias T., Simmons, Graham, Bell, Jeanne, ...
Complete envelope genes were amplified from autopsy brain tissue of five individuals who had died of AIDS and had neurological complications. Lymph node samples were included for two of the patients....
Marzi, Andrea, Gramberg, Thomas, Simmons, Graham, Möller, Peggy, Rennekamp, Andrew J., Krumbiegel, Mandy, ...
The lectins DC-SIGN and DC-SIGNR can augment viral infection; however, the range of pathogens interacting with these attachment factors is incompletely defined. Here we show that DC-SIGN and DC-SIGNR...
Peters, Paul J., Bhattacharya, Jayanta, Hibbitts, Samantha, Dittmar, Matthias T., Simmons, Graham, Bell, Jeanne, ...
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry
Simmons, Graham, Gosalia, Dhaval N., Rennekamp, Andrew J., Reeves, Jacqueline D., Diamond, Scott L., Bates, Paul
Severe acute respiratory syndrome (SARS) is caused by an emergent coronavirus (SARS-CoV), for which there is currently no effective treatment. SARS-CoV mediates receptor binding and entry by its...
Amberg, Sean M., Netter, Robert C., Simmons, Graham, Bates, Paul
The envelope of class I viruses can be a target for potent viral inhibitors, such as the human immunodeficiency virus type 1 (HIV-1) inhibitor enfuvirtide, which are derived from the C-terminal...
Qiu, Zhaozhu, Hingley, Susan T., Simmons, Graham, Yu, Christopher, Das Sarma, Jayasri, Bates, Paul, ...
Most strains of murine coronavirus mouse hepatitis virus (MHV) express a cleavable spike glycoprotein that mediates viral entry and pH-independent cell-cell fusion. The MHV type 2 (MHV-2) strain of...
Marzi, Andrea, Akhavan, Armin, Simmons, Graham, Gramberg, Thomas, Hofmann, Heike, Bates, Paul, ...
The C-type lectins DC-SIGN and DC-SIGNR (collectively referred to as DC-SIGN/R) bind to the ebolavirus glycoprotein (EBOV-GP) and augment viral infectivity. DC-SIGN/R strongly enhance infection...
Reeves, Jacqueline D., Hibbitts, Sam, Simmons, Graham, McKnight, Áine, Azevedo-Pereira, José M., Moniz-Pereira, José, ...
Cell surface receptors exploited by human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) for infection are major determinants of tropism. HIV-1 usually requires two receptors to...
Dejucq, Nathalie, Simmons, Graham, Clapham, Paul R.
Human immunodeficiency virus type 1 (HIV-1) non-syncytium-inducing (NSI) strains predominantly use the chemokine receptor CCR5, while syncytium-inducing (SI) strains use CXCR4. In vitro, SI isolates...
Simmons, Graham, Reeves, Jacqueline D., McKnight, Áine, Dejucq, Nathalie, Hibbitts, Sam, Power, Christine A., ...
The coreceptors used by primary syncytium-inducing (SI) human immunodeficiency virus type 1 isolates for infection of primary macrophages were investigated. SI strains using only CXCR4 replicated...
Lin, George, Simmons, Graham, Pöhlmann, Stefan, Baribaud, Frédéric, Ni, Houping, Leslie, George J., ...
The C-type lectins DC-SIGN and DC-SIGNR [collectively referred to as DC-SIGN(R)] bind and transmit human immunodeficiency virus (HIV) and simian immunodeficiency virus to T cells via the viral...
Ebola Virus Glycoproteins Induce Global Surface Protein Down-Modulation and Loss of Cell Adherence
Simmons, Graham, Wool-Lewis, Rouven J., Baribaud, Frédéric, Netter, Robert C., Bates, Paul
The Ebola virus envelope glycoprotein (GP) derived from the pathogenic Zaire subtype mediates cell rounding and detachment from the extracellular matrix in 293T cells. In this study we provide...
Simmons, Graham, Rennekamp, Andrew J., Chai, Ning, Vandenberghe, Luk H., Riley, James L., Bates, Paul
Folate receptor alpha (FRα) has been described as a factor involved in mediating Ebola virus entry into cells (6). Furthermore, it was suggested that interaction with FRα results in internalization...
Simmons, Graham, Reeves, Jacqueline D., Rennekamp, Andrew J., Amberg, Sean M., Piefer, Andrew J., Bates, Paul
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is a rapidly emerging pathogen with potentially serious consequences for public health. Here we describe conditions that result not...
Peters, Paul J., Bhattacharya, Jayanta, Hibbitts, Samantha, Dittmar, Matthias T., Simmons, Graham, Bell, Jeanne, ...
Complete envelope genes were amplified from autopsy brain tissue of five individuals who had died of AIDS and had neurological complications. Lymph node samples were included for two of the patients....
Marzi, Andrea, Gramberg, Thomas, Simmons, Graham, Möller, Peggy, Rennekamp, Andrew J., Krumbiegel, Mandy, ...
The lectins DC-SIGN and DC-SIGNR can augment viral infection; however, the range of pathogens interacting with these attachment factors is incompletely defined. Here we show that DC-SIGN and DC-SIGNR...
Peters, Paul J., Bhattacharya, Jayanta, Hibbitts, Samantha, Dittmar, Matthias T., Simmons, Graham, Bell, Jeanne, ...
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry
Simmons, Graham, Gosalia, Dhaval N., Rennekamp, Andrew J., Reeves, Jacqueline D., Diamond, Scott L., Bates, Paul
Severe acute respiratory syndrome (SARS) is caused by an emergent coronavirus (SARS-CoV), for which there is currently no effective treatment. SARS-CoV mediates receptor binding and entry by its...
Amberg, Sean M., Netter, Robert C., Simmons, Graham, Bates, Paul
The envelope of class I viruses can be a target for potent viral inhibitors, such as the human immunodeficiency virus type 1 (HIV-1) inhibitor enfuvirtide, which are derived from the C-terminal...
Qiu, Zhaozhu, Hingley, Susan T., Simmons, Graham, Yu, Christopher, Das Sarma, Jayasri, Bates, Paul, ...
Most strains of murine coronavirus mouse hepatitis virus (MHV) express a cleavable spike glycoprotein that mediates viral entry and pH-independent cell-cell fusion. The MHV type 2 (MHV-2) strain of...
Marzi, Andrea, Akhavan, Armin, Simmons, Graham, Gramberg, Thomas, Hofmann, Heike, Bates, Paul, ...
The C-type lectins DC-SIGN and DC-SIGNR (collectively referred to as DC-SIGN/R) bind to the ebolavirus glycoprotein (EBOV-GP) and augment viral infectivity. DC-SIGN/R strongly enhance infection...
Hofmann, Heike, Simmons, Graham, Rennekamp, Andrew J., Chaipan, Chawaree, Gramberg, Thomas, Heck, Elke, ...
We have recently demonstrated that the severe acute respiratory syndrome coronavirus (SARS-CoV) receptor angiotensin converting enzyme 2 (ACE2) also mediates cellular entry of the newly discovered...
Proteolysis of the Ebola Virus Glycoproteins Enhances Virus Binding and Infectivity▿
Kaletsky, Rachel L., Simmons, Graham, Bates, Paul
Cellular cathepsins are required for Ebola virus infection and are believed to proteolytically process the Ebola virus glycoprotein (GP) during entry. However, the significance of cathepsin cleavage...
Mack, Matthias, Luckow, Bruno, Nelson, Peter J., Cihak, Josef, Simmons, Graham, Clapham, Paul R., ...
CCR5, a chemokine receptor expressed on T cells and macrophages, is the principal coreceptor for M-tropic HIV-1 strains. Recently, we described an NH2-terminal modification of the CCR5 ligand...