Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm (2008)
Abstract Enveloped viruses encode specialized fusion proteins which promote the merger of viral and cell membranes, permitting the cytosolic release of the viral cores. Understanding the molecular...
Imaging individual retroviral fusion events: From hemifusion to pore formation and growth
Melikyan, Gregory B., Barnard, Richard J. O., Abrahamyan, Levon G., Mothes, Walther, Young, John A. T.
Viral fusion proteins catalyze merger of viral and cell membranes through a series of steps that have not yet been well defined. To elucidate the mechanism of virus entry, we have imaged fusion...
Mkrtchyan, Samvel R., Markosyan, Ruben M., Eadon, Michael T., Moore, John P., Melikyan, Gregory B., Cohen, Fredric S.
Human immunodeficiency virus (HIV) Env-induced fusion is highly temperature dependent. When effector and target cells were coincubated at 37°C, there was a kinetic delay before fusion commenced....
Melikyan, Gregory B., Egelhofer, Marc, Von Laer, Dorothee
Soluble peptides derived from the C-terminal heptad repeat domain of human immunodeficiency virus type 1 (HIV-1) gp41 are potent inhibitors of HIV-1 entry and gp41-induced fusion. Target...
Imaging individual retroviral fusion events: From hemifusion to pore formation and growth
Melikyan, Gregory B., Barnard, Richard J. O., Abrahamyan, Levon G., Mothes, Walther, Young, John A. T.
Viral fusion proteins catalyze merger of viral and cell membranes through a series of steps that have not yet been well defined. To elucidate the mechanism of virus entry, we have imaged fusion...
Mkrtchyan, Samvel R., Markosyan, Ruben M., Eadon, Michael T., Moore, John P., Melikyan, Gregory B., Cohen, Fredric S.
Human immunodeficiency virus (HIV) Env-induced fusion is highly temperature dependent. When effector and target cells were coincubated at 37°C, there was a kinetic delay before fusion commenced....
Melikyan, Gregory B., Egelhofer, Marc, Von Laer, Dorothee
Soluble peptides derived from the C-terminal heptad repeat domain of human immunodeficiency virus type 1 (HIV-1) gp41 are potent inhibitors of HIV-1 entry and gp41-induced fusion. Target...
Heredia, Alonso, Gilliam, Bruce, Latinovic, Olga, Le, Nhut, Bamba, Douty, DeVico, Anthony, ...
The CCR5 chemokine receptor plays a pivotal role in human immunodeficiency virus type 1 (HIV-1) infection. Several studies have suggested that CCR5 density levels in individuals are rate limiting for...
Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm
Enveloped viruses encode specialized fusion proteins which promote the merger of viral and cell membranes, permitting the cytosolic release of the viral cores. Understanding the molecular details of...
Miyauchi, Kosuke, Kozlov, Michael M., Melikyan, Gregory B.
The HIV envelope (Env) glycoprotein mediates membrane fusion through sequential interactions with CD4 and coreceptors, followed by the refolding of the transmembrane gp41 subunit into the stable...