Gregory J. Christianson

Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease (2006)

Petkova, Stefka B., Akilesh, Shreeram, Sproule, Thomas J., Christianson, Gregory J., Al Khabbaz, Hana, Brown, Aaron C., ...

The MHC class I-like Fc receptor FcRn plays an essential role in extending the half-life (t1/2) of IgG antibodies and IgG-Fc-based therapeutics in the circulation. The goal of this study was to...

Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease (2006)

Petkova, Stefka B., Akilesh, Shreeram, Sproule, Thomas J., Christianson, Gregory J., Al Khabbaz, Hana, Brown, Aaron C., ...

The MHC class I-like Fc receptor FcRn plays an essential role in extending the half-life (t1/2) of IgG antibodies and IgG-Fc-based therapeutics in the circulation. The goal of this study was to...

Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor α chain gene rearrangement

DiLorenzo, Teresa P., Graser, Robert T., Ono, Toshiro, Christianson, Gregory J., Chapman, Harold D., Roopenian, Derry C., ...

Nonobese diabetic (NOD) mice develop insulin-dependent diabetes mellitus due to autoimmune T lymphocyte-mediated destruction of pancreatic β cells. Although both major histocompatibility complex...

The MHC class I–like Fc receptor promotes humorally mediated autoimmune disease

Akilesh, Shreeram, Petkova, Stefka, Sproule, Thomas J., Shaffer, Daniel J., Christianson, Gregory J., Roopenian, Derry

The MHC class I family–like Fc receptor, FcRn, is normally responsible for extending the life span of serum IgG Ab’s, but whether this molecule contributes to autoimmune pathogenesis remains...

Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor α chain gene rearrangement

DiLorenzo, Teresa P., Graser, Robert T., Ono, Toshiro, Christianson, Gregory J., Chapman, Harold D., Roopenian, Derry C., ...

Nonobese diabetic (NOD) mice develop insulin-dependent diabetes mellitus due to autoimmune T lymphocyte-mediated destruction of pancreatic β cells. Although both major histocompatibility complex...

The MHC class I–like Fc receptor promotes humorally mediated autoimmune disease

Akilesh, Shreeram, Petkova, Stefka, Sproule, Thomas J., Shaffer, Daniel J., Christianson, Gregory J., Roopenian, Derry

The MHC class I family–like Fc receptor, FcRn, is normally responsible for extending the life span of serum IgG Ab’s, but whether this molecule contributes to autoimmune pathogenesis remains...