Gregory J. Kirkner

Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma (2008)

Kawasaki, Takako, Nosho, Katsuhiko, Ohnishi, Mutsuko, Suemoto, Yuko, Glickman, Jonathan N, Chan, Andrew T, ...

Abstract Background Cyclooxygenase-2 (COX-2, PTGS2 ) plays an important role in colorectal carcinogenesis. COX-2 overexpression in colorectal cancer is inversely associated with microsatellite...

A Cohort Study of Tumoral LINE-1 Hypomethylation and Prognosis in Colon Cancer (2008)

Ogino, Shuji, Nosho, Katsuhiko, Kirkner, Gregory J., Kawasaki, Takako, Chan, Andrew T., Schernhammer, Eva S., ...

Genome-wide DNA hypomethylation plays has an important role in genomic instability and colorectal carcinogenesis. However, the relationship between cellular DNA methylation level and patient outcome...

MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer (2007)

Ogino, Shuji, Hazra, Aditi, Tranah, Gregory J., Kirkner, Gregory J., Kawasaki, Takako, Nosho, Katsuhiko, ...

O-6-methylguanine-DNA methyltransferase (MGMT) repairs inappropriately methylated guanine residues in DNA. MGMT promoter methylation and gene silencing are common events in colorectal cancer, and may...

18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high (2007)

Ogino, Shuji, Kawasaki, Takako, Kirkner, Gregory J, Ohnishi, Mutsuko, Fuchs, Charles S

Abstract Background: The CpG island methylator phenotype (CIMP) with widespread promoter methylation is a distinct epigenetic phenotype in colorectal cancer, associated with microsatellite...

Metabolic Predictors of 5-Year Change in Weight and Waist Circumference in a Triethnic Population: The Insulin Resistance Atherosclerosis Study (2003)

Mayer-Davis, Elizabeth J., Kirkner, Gregory J., Karter, Andrew J., Zaccaro, Daniel J.

Insulin resistance, insulin secretion, and glucose tolerance may predict weight change. A total of 1,194 adults aged 39–69 years at baseline (46% with normal glucose tolerance according to...

Combined Analysis of COX-2 and p53 Expressions Reveals Synergistic Inverse Correlations with Microsatellite Instability and CpG Island Methylator Phenotype in Colorectal Cancer1

Ogino, Shuji, Brahmandam, Mohan, Kawasaki, Takako, Kirkner, Gregory J, Loda, Massimo, Fuchs, Charles S

Cyclooxygenase-2 (COX-2) overexpression and mutations of p53 (a known COX-2 regulator) are inversely associated with microsatellite instability—high (MSI-H) and CpG island methylator phenotype...

Combined Analysis of COX-2 and p53 Expressions Reveals Synergistic Inverse Correlations with Microsatellite Instability and CpG Island Methylator Phenotype in Colorectal Cancer1

Ogino, Shuji, Brahmandam, Mohan, Kawasaki, Takako, Kirkner, Gregory J, Loda, Massimo, Fuchs, Charles S

Cyclooxygenase-2 (COX-2) overexpression and mutations of p53 (a known COX-2 regulator) are inversely associated with microsatellite instability—high (MSI-H) and CpG island methylator phenotype...

18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high

Ogino, Shuji, Kawasaki, Takako, Kirkner, Gregory J, Ohnishi, Mutsuko, Fuchs, Charles S

Precision and Performance Characteristics of Bisulfite Conversion and Real-Time PCR (MethyLight) for Quantitative DNA Methylation Analysis

Ogino, Shuji, Kawasaki, Takako, Brahmandam, Mohan, Cantor, Mami, Kirkner, Gregory J., Spiegelman, Donna, ...

Assays to measure DNA methylation, which are important in epigenetic research and clinical diagnostics, typically rely on conversion of unmethylated cytosine to uracil by sodium bisulfite. However,...

Correlation of β-Catenin Localization with Cyclooxygenase-2 Expression and CpG Island Methylator Phenotype (CIMP) in Colorectal Cancer1

Kawasaki, Takako, Nosho, Katsuhiko, Ohnishi, Mutsuko, Suemoto, Yuko, Kirkner, Gregory J, Dehari, Reiko, ...

The WNT/β-catenin (CTNNB1) pathway is commonly activated in the carcinogenic process. Cross-talks between the WNT and cyclooxygenase-2 (COX-2 or PTGS2)/prostaglandin pathways have been suggested....

CpG Island Methylator Phenotype-Low (CIMP-Low) in Colorectal Cancer: Possible Associations with Male Sex and KRAS Mutations

Ogino, Shuji, Kawasaki, Takako, Kirkner, Gregory J., Loda, Massimo, Fuchs, Charles S.

The CpG island methylator phenotype (CIMP or CIMP-high) with extensive promoter methylation seems to be a distinct epigenotype of colorectal cancer. However, no study has comprehensively examined...

IGFBP3 Promoter Methylation in Colorectal Cancer: Relationship with Microsatellite Instability, CpG Island Methylator Phenotype, and p531

Kawasaki, Takako, Nosho, Katsuhiko, Ohnishi, Mutsuko, Suemoto, Yuko, Kirkner, Gregory J, Fuchs, Charles S, ...

Insulin-like growth factor binding protein 3 (IGFBP3), which is induced by wild-type p53, regulates IGF and interacts with the TGF-β pathway. IGFBP3 promoter methylation may occur in colorectal...

Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma

Kawasaki, Takako, Nosho, Katsuhiko, Ohnishi, Mutsuko, Suemoto, Yuko, Glickman, Jonathan N, Chan, Andrew T, ...

PIK3CA Mutation in Colorectal Cancer: Relationship with Genetic and Epigenetic Alterations1

Nosho, Katsuhiko, Kawasaki, Takako, Ohnishi, Mutsuko, Suemoto, Yuko, Kirkner, Gregory J, Zepf, Dimity, ...

Somatic PIK3CA mutations are often present in colorectal cancer. Mutant PIK3CA activates AKT signaling, which up-regulates fatty acid synthase (FASN). Microsatellite instability (MSI) and CpG island...

Evaluation of Markers for CpG Island Methylator Phenotype (CIMP) in Colorectal Cancer by a Large Population-Based Sample

Ogino, Shuji, Kawasaki, Takako, Kirkner, Gregory J., Kraft, Peter, Loda, Massimo, Fuchs, Charles S.

The CpG island methylator phenotype (CIMP or CIMP-high) with extensive promoter methylation is a distinct phenotype in colorectal cancer. However, a choice of markers for CIMP has been controversial....

Comprehensive Biostatistical Analysis of CpG Island Methylator Phenotype in Colorectal Cancer Using a Large Population-Based Sample

Nosho, Katsuhiko, Irahara, Natsumi, Shima, Kaori, Kure, Shoko, Kirkner, Gregory J., Schernhammer, Eva S., ...

JC Virus T-Antigen in Colorectal Cancer Is Associated with p53 Expression and Chromosomal Instability, Independent of CpG Island Methylator Phenotype1

Nosho, Katsuhiko, Shima, Kaori, Kure, Shoko, Irahara, Natsumi, Baba, Yoshifumi, Chen, Li, ...

JC virus has a transforming gene encoding JC virus T-antigen (JCVT). JCVT may inactivate wild-type p53, cause chromosomal instability (CIN), and stabilize β-catenin. A link between JCVT and CpG...

Aurora-A Expression Is Independently Associated with Chromosomal Instability in Colorectal Cancer1

Baba, Yoshifumi, Nosho, Katsuhiko, Shima, Kaori, Irahara, Natsumi, Kure, Shoko, Toyoda, Saori, ...

AURKA (the official symbol for Aurora-A, STK15, or BTAK) regulates the function of centrosomes, spindles, and kinetochores for proper mitotic progression. AURKA overexpression is observed in various...