Gregory J. Tranah

MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer (2007)

Ogino, Shuji, Hazra, Aditi, Tranah, Gregory J., Kirkner, Gregory J., Kawasaki, Takako, Nosho, Katsuhiko, ...

O-6-methylguanine-DNA methyltransferase (MGMT) repairs inappropriately methylated guanine residues in DNA. MGMT promoter methylation and gene silencing are common events in colorectal cancer, and may...

Genetic Variants in the UGT1A6 Enzyme, Aspirin Use, and the Risk of Colorectal Adenoma (2005)

Chan, Andrew T., Tranah, Gregory J., Giovannucci, Edward L., Hunter, David J., Fuchs, Charles S.

Genetic variation in the uridine diphosphate glucuronosyltransferase 1A6 (UGT1A6) enzyme is associated with impaired metabolism of aspirin. To determine whether polymorphisms in the UGT1A6 enzyme...

Hemochromatosis Gene Mutations, Body Iron Stores, Dietary Iron, and Risk of Colorectal Adenoma in Women (2005)

Chan, Andrew T., Ma, Jing, Tranah, Gregory J., Giovannucci, Edward L., Rifai, Nader, Hunter, David J., ...

Background: Some experimental evidence suggests that iron may play a role in colorectal carcinogenesis, but human data for this role have been conflicting, possibly because of problems related to...

Epoxide hydrolase polymorphisms, cigarette smoking, and risk of colorectal adenoma in the Nurses' Health Study and the Health Professionals Follow-Up Study (2004)

Tranah, Gregory J., Giovannucci, Edward, Ma, Jing, Fuchs, Charles, Hankinson, Susan E., Hunter, David J.

Microsomal epoxide hydrolase (mEH) is involved the bioactivation and detoxification of polycyclic aromatic hydrocarbons derived from tobacco smoke and charred meat intake. Two coding-region mEH...

Epoxide hydrolase polymorphisms, cigarette smoking and risk of colorectal adenoma in the Nurses' Health Study and the Health Professionals Follow-up Study (2004)

Tranah, Gregory J., Giovannucci, Edward, Ma, Jing, Fuchs, Charles, Hankinson, Susan E., Hunter, David J.

Microsomal epoxide hydrolase (mEH) is involved in the bioactivation and detoxification of polycyclic aromatic hydrocarbons derived from tobacco smoke and charred meat intake. Two coding region mEH...