Gudmar Thorleifsson

New common variants affecting susceptibility to basal cell carcinoma. (2009)

Stacey, Simon N, Sulem, Patrick, Masson, Gisli, Gudjonsson, Sigurjon A, Thorleifsson, Gudmar, Jakobsdottir, Margret, ...

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Sequence variants at the TERT-CLPTM1L locus associate with many cancer types (2009)

Rafnar, Thorunn, Sulem, Patrick, Stacey, Simon N, Geller, Frank, Gudmundsson, Julius, Sigurdsson, Asgeir, ...

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The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects (2009)

Choquet, Hélène, Cavalcanti-Proença, Christine, Lecoeur, Cécile, Dina, Christian, Cauchi, Stéphane, Vaxillaire, Martine, ...

A recent study reported an association between the brain natriuretic peptide (BNP) promoter T-381C polymorphism (rs198389) and protection against type 2 diabetes (T2D). As replication in several...

Sequence variant on 8q24 confers susceptibility to urinary bladder cancer (2008)

Kiemeney, Lambertus A, Thorlacius, Steinunn, Sulem, Patrick, Geller, Frank, Aben, Katja K H, Stacey, Simon N, ...

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Unsupervised empirical Bayesian multiple testing with external covariates (2008)

Ferkingstad, Egil, Frigessi, Arnoldo, Rue, Håvard, Thorleifsson, Gudmar, Kong, Augustine

In an empirical Bayesian setting, we provide a new multiple testing method, useful when an additional covariate is available, that influences the probability of each null hypothesis being true. We...

Two newly identified genetic determinants of pigmentation in Europeans. (2008)

Sulem, Patrick, Gudbjartsson, Daniel F, Stacey, Simon N, Helgason, Agnar, Rafnar, Thorunn, Jakobsdottir, Margret, ...

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Many sequence variants affecting diversity of adult human height (2008)

Gudbjartsson, Daniel F, Walters, G Bragi, Thorleifsson, Gudmar, Stefansson, Hreinn, Halldorsson, Bjarni V, Zusmanovich, Pasha, ...

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Genetics of gene expression and its effect on disease (2008)

Emilsson, Valur, Thorleifsson, Gudmar, Zhang, Bin, Leonardson, Amy S, Zink, Florian, Zhu, Jun, ...

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Genetic determinants of hair, eye and skin pigmentation in Europeans (2007)

Sulem, Patrick, Gudbjartsson, Daniel F, Stacey, Simon N, Helgason, Agnar, Rafnar, Thorunn, Magnusson, Kristinn P, ...

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. The Hamiltonian (2007)

Mark J. Bowick, Simon M. Catterall, Marco Falcioni, Gudmar Thorleifsson, Konstantinos N. Anagnostopoulos

We present the results of a high-statistics Monte Carlo simulation of a phantom crystalline (fixed-connectivity) membrane with free boundary. We verify the existence of a flat phase by examining...

Variants conferring risk of atrial fibrillation on chromosome 4q25. (2007)

Gudbjartsson, Daniel F, Arnar, David O, Helgadottir, Anna, Gretarsdottir, Solveig, Holm, Hilma, Sigurdsson, Asgeir, ...

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The Association of a SNP Upstream of INSIG2 with Body Mass Index is Reproduced in Several but Not All Cohorts (2007)

Helen N. Lyon, Valur Emilsson, Anke Hinney, Iris M. Heid, Jessica Lasky-Su, Xiaofeng Zhu, ...

A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI...

The association of a SNP upstream of INSIG2 with Body Mass Index is reproduced in several but not all cohorts (2007)

Helen N Lyon, Valur Emilsson, Anke Hinney, Iris M. Heid, Jessica Lasky-Su, Xiaofeng Zhu, ...

A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI)[1]. The association between increased BMI and homozygosity for the...

The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. (2007)

Lyon, Helen N, Emilsson, Valur, Hinney, Anke, Heid, Iris M, Lasky-Su, Jessica, Zhu, Xiaofeng, ...

A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI...

A common variant associated with prostate cancer in European and African populations (2006)

Amundadottir, Laufey T, Sulem, Patrick, Gudmundsson, Julius, Helgason, Agnar, Baker, Adam, Agnarsson, Bjarni A, ...

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CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD. (2006)

Magnusson, Kristinn P, Duan, Shan, Sigurdsson, Haraldur, Petursson, Hjorvar, Yang, Zhenglin, Zhao, Yu, ...

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CFH Y402H Confers Similar Risk of Soft Drusen and Both Forms of Advanced AMD (2006)

Kristinn P. Magnusson, Shan Duan, Haraldur Sigurdsson, Hjorvar Petursson, Zhenglin Yang, Yu Zhao, ...

A common missense variant, Y402H, in the Complement Factor H gene is associated strongly with soft drusen, a precursor of advanced age-related macular degeneration

CFH Y402H Confers Similar Risk of Soft Drusen and Both Forms of Advanced AMD (2006)

Kristinn P. Magnusson, Shan Duan, Haraldur Sigurdsson, Hjorvar Petursson, Zhenglin Yang, Yu Zhao, ...

Background Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment in the developed world. The two forms of advanced AMD, geographic atrophy and neovascular...

Linkage of essential hypertension to chromosome 18q (2002)

Kristjansson, Kristleifur, Manolescu, Andrei, Kristinsson, Arni, Hardarson, Thordur, Knudsen, Helga, Ingason, Sigurdur, ...

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Universality Classes of Self-Avoiding Fixed-Connectivity Membranes (2000)

Bowick, Mark J., Cacciuto, Angelo, Thorleifsson, Gudmar, Travesset, Alex

We present an analysis of extensive large-scale Monte Carlo simulations of self-avoiding fixed-connectivity membranes for sizes (number of faces) ranging from 512 to 17672 (triangular) plaquettes....

Monte Carlo Renormalization of 2d Simplicial Quantum Gravity Coupled to Gaussian Matter (1998)

Gregory, Eric B., Catterall, Simon M., Thorleifsson, Gudmar

We extend a recently proposed real-space renormalization group scheme for dynamical triangulations to situations where the lattice is coupled to continuous scalar fields. Using Monte Carlo...

Lattice Gravity and Random Surfaces (1998)

Thorleifsson, Gudmar

I review recent progress in simplicial quantum gravity in three and four dimensions, in particular new results on the phase structure of modified models of dynamical triangulations, the application...

Three-Dimensional Simplicial Gravity and Degenerate Triangulations (1998)

Thorleifsson, Gudmar

I define a model of three-dimensional simplicial gravity using an extended ensemble of triangulations where, in addition to the usual combinatorial triangulations, I allow degenerate triangulations,...

Numerical Observation of a Tubular Phase in Anisotropic Membranes (1997)

Bowick, Mark, Falcioni, Marco, Thorleifsson, Gudmar

We provide the first numerical evidence for the existence of a tubular phase, predicted by Radzihovsky and Toner (RT), for anisotropic tethered membranes without self-avoidance. Incorporating...

The Poisson ratio of crystalline surfaces (1996)

Falcioni, Marco, Bowick, Mark, Guitter, Emmanuel, Thorleifsson, Gudmar

A remarkable theoretical prediction for a crystalline (polymerized) surface is that its Poisson ratio (\sigma) is negative. Using a large scale Monte Carlo simulation of a simple model of such...

The Flat Phase of Crystalline Membranes (1996)

Bowick, Mark, Catterall, Simon, Falcioni, Marco, Thorleifsson, Gudmar, Anagnostopoulos, Konstantinos

We present the results of a hight-statistics Monte Carlo simulation of a phantom crystalline (fixed-connectivity) membrane with free boundary. We verify the existence of a flat phase by examining...

The Flat Phase of Crystalline Membranes (1996)

Bowick, Mark, Catterall, Simon, Falcioni, Marco, Thorleifsson, Gudmar, Anagnostopoulos, Konstantinos

We present the results of a hight-statistics Monte Carlo simulation of a phantom crystalline (fixed-connectivity) membrane with free boundary. We verify the existence of a flat phase by examining...

The Flat Phase of Crystalline Membranes (1996)

Bowick, Mark, Catterall, Simon, Falcioni, Marco, Thorleifsson, Gudmar, Anagnostopoulos, Konstantinos

We present the results of a hight-statistics Monte Carlo simulation of a phantom crystalline (fixed-connectivity) membrane with free boundary. We verify the existence of a flat phase by examining...

The Forgotten Potts Models (1994)

Thorleifsson, Gudmar

The q=10 and q=200 state Potts models coupled to 2d gravity are investigated numerically and shown to have continuous phase transitions, contrary to their behavior on a regular lattice. Critical...

New critical phenomena in 2d quantum gravity (1994)

Ambjorn, Jan, Thorleifsson, Gudmar, Wexler, Mark

We study $q=10$ and $q=200$ state Potts models on dynamical triangulated lattices and demonstrate that these models exhibit continuous phase transitions, contrary to the first order transition...

CFH Y402H Confers Similar Risk of Soft Drusen and Both Forms of Advanced AMD

Magnusson, Kristinn P, Duan, Shan, Sigurdsson, Haraldur, Petursson, Hjorvar, Yang, Zhenglin, Zhao, Yu, ...

A common missense variant, Y402H, in the Complement Factor H gene is associated strongly with soft drusen, a precursor of advanced age-related macular degeneration

Localization of a Susceptibility Gene for Type 2 Diabetes to Chromosome 5q34–q35.2

Reynisdottir, Inga, Thorleifsson, Gudmar, Benediktsson, Rafn, Sigurdsson, Gunnar, Emilsson, Valur, Einarsdottir, Anna Sigurlin, ...

We report a genomewide linkage study of type 2 diabetes (T2D [MIM 125853]) in the Icelandic population. A list of type 2 diabetics was cross-matched with a computerized genealogical database...

CFH Y402H Confers Similar Risk of Soft Drusen and Both Forms of Advanced AMD

Magnusson, Kristinn P, Duan, Shan, Sigurdsson, Haraldur, Petursson, Hjorvar, Yang, Zhenglin, Zhao, Yu, ...

A common missense variant, Y402H, in the Complement Factor H gene is associated strongly with soft drusen, a precursor of advanced age-related macular degeneration

The Association of a SNP Upstream of INSIG2 with Body Mass Index is Reproduced in Several but Not All Cohorts

Lyon, Helen N, Emilsson, Valur, Hinney, Anke, Heid, Iris M, Lasky-Su, Jessica, Zhu, Xiaofeng, ...

A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI...

On the Replication of Genetic Associations: Timing Can Be Everything!

Lasky-Su, Jessica, Lyon, Helen N., Emilsson, Valur, Heid, Iris M., Molony, Cliona, Raby, Benjamin A., ...

The failure of researchers to replicate genetic-association findings is most commonly attributed to insufficient statistical power, population stratification, or various forms of between-study...

Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

Lindgren, Cecilia M., Heid, Iris M., Randall, Joshua C., Lamina, Claudia, Steinthorsdottir, Valgerdur, Qi, Lu, ...

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist...

Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design?

Heid, Iris M., Huth, Cornelia, Loos, Ruth J. F., Kronenberg, Florian, Adamkova, Vera, Anand, Sonia S., ...

The INSIG2 rs7566605 polymorphism was identified for obesity (BMI≥30 kg/m2) in one of the first genome-wide association studies, but replications were inconsistent. We collected statistics from 34...