Conservation of Nef function across highly diverse lineages of SIVsmm (2009)
Schmökel, Jan, Li, Hui, Bailes, Elizabeth, Schindler, Michael, Silvestri, Guido, Hahn, Beatrice H, ...
Abstract Background SIVsmm is a simian immunodeficiency virus that persists efficiently without causing disease in naturally infected sooty mangabeys (SMs) but induces AIDS upon cross-species...
Understanding the benign nature of SIV infection in natural hosts. (2007)
Silvestri, Guido, Paiardini, Mirko, Pandrea, Ivona, Lederman, Michael M., Sodora, Donald L.
In striking contrast to HIV infection, natural SIV infection of African nonhuman primates is asymptomatic and usually does not induce significant CD4+ T cell depletion despite high levels of virus...
Staprans, Silvija, Klucking, Sara, Silvestri, Guido, Chavan, Rahul, Barry, Ashley, Feinberg, Mark
No abstract available.
Understanding the benign nature of natural SIV infection: Implications for AIDS pathogenesis (2006)
No abstract available.
Schindler, Michael, Münch, Jan, Kutsch, Olaf, Li, Hui, Santiago, Mario L, Bibollet-Ruche, Frederic, ...
No abstract available.
Paiardini, Mirko, Galati, Domenico, Cervasi, Barbara, Cannavo, Giuseppe, Galluzzi, Luca, Montroni, Maria, ...
Human immunodeficiency virus (HIV)-induced immunodeficiency is characterized by progressive loss of CD4+ T cells associated with functional abnormalities of the surviving lymphocytes. Increased...
Turnover of lymphocytes and conceptual paradigms in HIV infection
Silvestri, Guido, Feinberg, Mark B.
Prevailing views concerning the pathogenic mechanisms of AIDS have shifted from models that focus primarily on direct HIV-mediated killing of CD4+ T cells to models that emphasize the pathogenic role...
Garber, David A., Silvestri, Guido, Barry, Ashley P., Fedanov, Andrew, Kozyr, Natalia, McClure, Harold, ...
In vivo blockade of CD28 and CD40 T cell costimulation pathways during acute simian immunodeficiency virus (SIV) infection of rhesus macaques was performed to assess the relative contributions of...
Regoes, Roland R., Antia, Rustom, Garber, David A., Silvestri, Guido, Feinberg, Mark B., Staprans, Silvija I.
There is an ongoing debate on whether acute human immunodeficiency virus infection is controlled by target cell limitation or by virus-specific cellular immunity. To resolve this question, we...
Staprans, Silvija I., Barry, Ashley P., Silvestri, Guido, Safrit, Jeffrey T., Kozyr, Natalia, Sumpter, Beth, ...
Given the dual role of CD4 T cells as both immune effectors and targets for HIV infection, the balance of CD4 versus CD8 T cell-mediated responses induced by candidate AIDS vaccines may be critical...
Silvestri, Guido, Fedanov, Andrew, Germon, Stephanie, Kozyr, Natalia, Kaiser, William J., Garber, David A., ...
To understand how natural sooty mangabey hosts avoid AIDS despite high levels of simian immunodeficiency virus (SIV) SIVsm replication, we inoculated mangabeys and nonnatural rhesus macaque hosts...
Chahroudi, Ann, Chavan, Rahul, Koyzr, Natalia, Waller, Edmund K., Silvestri, Guido, Feinberg, Mark B.
The presumed broad tropism of poxviruses has stymied attempts to identify both the cellular receptor(s) and the viral determinant(s) for binding. Detailed studies of poxvirus binding to and infection...
Chahroudi, Ann, Chavan, Rahul, Kozyr, Natalia, Waller, Edmund K., Silvestri, Guido, Feinberg, Mark B.
Paiardini, Mirko, Galati, Domenico, Cervasi, Barbara, Cannavo, Giuseppe, Galluzzi, Luca, Montroni, Maria, ...
Human immunodeficiency virus (HIV)-induced immunodeficiency is characterized by progressive loss of CD4+ T cells associated with functional abnormalities of the surviving lymphocytes. Increased...
Turnover of lymphocytes and conceptual paradigms in HIV infection
Silvestri, Guido, Feinberg, Mark B.
Prevailing views concerning the pathogenic mechanisms of AIDS have shifted from models that focus primarily on direct HIV-mediated killing of CD4+ T cells to models that emphasize the pathogenic role...
Garber, David A., Silvestri, Guido, Barry, Ashley P., Fedanov, Andrew, Kozyr, Natalia, McClure, Harold, ...
In vivo blockade of CD28 and CD40 T cell costimulation pathways during acute simian immunodeficiency virus (SIV) infection of rhesus macaques was performed to assess the relative contributions of...
Regoes, Roland R., Antia, Rustom, Garber, David A., Silvestri, Guido, Feinberg, Mark B., Staprans, Silvija I.
There is an ongoing debate on whether acute human immunodeficiency virus infection is controlled by target cell limitation or by virus-specific cellular immunity. To resolve this question, we...
Staprans, Silvija I., Barry, Ashley P., Silvestri, Guido, Safrit, Jeffrey T., Kozyr, Natalia, Sumpter, Beth, ...
Given the dual role of CD4 T cells as both immune effectors and targets for HIV infection, the balance of CD4 versus CD8 T cell-mediated responses induced by candidate AIDS vaccines may be critical...
Silvestri, Guido, Fedanov, Andrew, Germon, Stephanie, Kozyr, Natalia, Kaiser, William J., Garber, David A., ...
To understand how natural sooty mangabey hosts avoid AIDS despite high levels of simian immunodeficiency virus (SIV) SIVsm replication, we inoculated mangabeys and nonnatural rhesus macaque hosts...
Chahroudi, Ann, Chavan, Rahul, Koyzr, Natalia, Waller, Edmund K., Silvestri, Guido, Feinberg, Mark B.
The presumed broad tropism of poxviruses has stymied attempts to identify both the cellular receptor(s) and the viral determinant(s) for binding. Detailed studies of poxvirus binding to and infection...
Chahroudi, Ann, Chavan, Rahul, Kozyr, Natalia, Waller, Edmund K., Silvestri, Guido, Feinberg, Mark B.
Schindler, Michael, Münch, Jan, Kutsch, Olaf, Li, Hui, Santiago, Mario L, Bibollet-Ruche, Frederic, ...
Muthukumar, Alagarraju, Zhou, Dejiang, Paiardini, Mirko, Barry, Ashley P., Cole, Kelly S., McClure, Harold M., ...
Sooty mangabeys, the natural host of simian immunodeficiency virus (SIVsm), generally avoid progressive depletion of CD4+ T cells and opportunistic infections associated with infection of humans...
Dunham, Richard, Pagliardini, Paola, Gordon, Shari, Sumpter, Beth, Engram, Jessica, Moanna, Abeer, ...
In contrast to human immunodeficiency virus (HIV)-infected humans, natural hosts for simian immunodeficiency virus (SIV) very rarely progress to acquired immunodeficiency syndrome (AIDS). While the...
Understanding the benign nature of SIV infection in natural hosts
Silvestri, Guido, Paiardini, Mirko, Pandrea, Ivona, Lederman, Michael M., Sodora, Donald L.
In striking contrast to HIV infection, natural SIV infection of African nonhuman primates is asymptomatic and usually does not induce significant CD4+ T cell depletion despite high levels of virus...
Apetrei, Cristian, Gautam, Rajeev, Sumpter, Beth, Carter, Anders C., Gaufin, Thaidra, Staprans, Silvija I., ...
Simian immunodeficiency virus (SIV) SIVsmm naturally infects sooty mangabeys (SMs) and is the source virus of pathogenic infections with human immunodeficiency virus type 2 (HIV-2) and SIVmac of...
Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hosts
Pandrea, Ivona, Apetrei, Cristian, Gordon, Shari, Barbercheck, Joseph, Dufour, Jason, Bohm, Rudolf, ...
In contrast to lentiviral infections of humans and macaques, simian immunodeficiency virus (SIV) infection of natural hosts is nonpathogenic despite high levels of viral replication. However, the...
Is Nef the elusive cause of HIV-associated hematopoietic dysfunction?
Kirchhoff, Frank, Silvestri, Guido
HIV-associated hematological abnormalities involve all lineages of blood cells, thus implying that the virus impairs the function of early HSCs. However, the underlying mechanisms of this defect are...
Kosub, David A., Lehrman, Ginger, Milush, Jeffrey M., Zhou, Dejiang, Chacko, Elizabeth, Leone, Amanda, ...
The objective of this study was to functionally assess gamma/delta (γδ) T cells following pathogenic human immunodeficiency virus (HIV) infection of humans and nonpathogenic simian immunodeficiency...
Klatt, Nichole R., Villinger, Francois, Bostik, Pavel, Gordon, Shari N., Pereira, Lara, Engram, Jessica C., ...
Naturally SIV-infected sooty mangabeys (SMs) remain asymptomatic despite high virus replication. Elucidating the mechanisms underlying AIDS resistance of SIV-infected SMs may provide crucial...
Schindler, Michael, Schmökel, Jan, Specht, Anke, Li, Hui, Münch, Jan, Khalid, Mohammad, ...
Recent data suggest that Nef-mediated downmodulation of TCR-CD3 may protect SIVsmm-infected sooty mangabeys (SMs) against the loss of CD4+ T cells. However, the mechanisms underlying this protective...
Gordon, Shari N., Dunham, Richard M., Engram, Jessica C., Estes, Jacob, Wang, Zichun, Klatt, Nichole R., ...
Sooty mangabeys (SMs) naturally infected with simian immunodeficiency virus (SIV) do not develop AIDS despite high levels of virus replication. At present, the mechanisms underlying this disease...
Simian Immunodeficiency Virus SIVagm Dynamics in African Green Monkeys▿
Pandrea, Ivona, Ribeiro, Ruy M., Gautam, Rajeev, Gaufin, Thaidra, Pattison, Melissa, Barnes, Mary, ...
The mechanisms underlying the lack of disease progression in natural simian immunodeficiency virus (SIV) hosts are still poorly understood. To test the hypothesis that SIV-infected African green...
Pandrea, Ivona, Onanga, Richard, Souquiere, Sandrine, Mouinga-Ondéme, Augustin, Bourry, Olivier, Makuwa, Maria, ...
Simian immunodeficiency virus (SIV) persistence in wild populations of African nonhuman primates (NHPs) may occur through horizontal and vertical transmission. However, the mechanism(s) and timing of...
CCL3L Copy Number Variation and the Co-Evolution of Primate and Viral Genomes
Gornalusse, German, Mummidi, Srinivas, He, Weijing, Silvestri, Guido, Bamshad, Mike, Ahuja, Sunil K.
Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections
Brenchley, Jason M., Paiardini, Mirko, Knox, Kenneth S., Asher, Ava I., Cervasi, Barbara, Asher, Tedi E., ...
Acute HIV infection is characterized by massive loss of CD4 T cells from the gastrointestinal (GI) tract. Th17 cells are critical in the defense against microbes, particularly at mucosal surfaces....
Conservation of Nef function across highly diverse lineages of SIVsmm
Schmökel, Jan, Li, Hui, Bailes, Elizabeth, Schindler, Michael, Silvestri, Guido, Hahn, Beatrice H, ...
Richardson, Max W., Carroll, Richard G., Stremlau, Matthew, Korokhov, Nikolay, Humeau, Laurent M., Silvestri, Guido, ...
Rhesus TRIM5α (rhTRIM5α), but not human TRIM5α (huTRIM5α), potently inhibits human immunodeficiency virus (HIV) infection and is thus a potentially valuable therapeutic tool. Primary human CD4 T...
Muthumani, Karuppiah, Choo, Andrew Y., Shedlock, Devon J., Laddy, Dominick J., Sundaram, Senthil G., Hirao, Lauren, ...
Chronic viral infection is characterized by the functional impairment of virus-specific T-cell responses. Recent evidence has suggested that the inhibitory receptor programmed death 1 (PD-1) is...