Adam A. Margolin, Teresa Palomero, Pavel Sumazin, Andrea Califano, Adolfo Ferrando, Gustavo A. Stolovitzky
ChIP-on-chip has emerged as a powerful tool to dissect the complex network of regulatory interactions between transcription factors and their targets. However, most ChIP-on-chip analysis methods use...
Transcriptional analysis of the B cell germinal center reaction
Klein, Ulf, Tu, Yuhai, Stolovitzky, Gustavo A., Keller, Jeffrey L., Haddad, Joseph, Miljkovic, Vladan, ...
The germinal center (GC) reaction is crucial for T cell-dependent immune responses and is targeted by B cell lymphomagenesis. Here we analyzed the transcriptional changes that occur in B cells during...
Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling
Küppers, Ralf, Klein, Ulf, Schwering, Ines, Distler, Verena, Bräuninger, Andreas, Cattoretti, Giorgio, ...
Hodgkin lymphoma (HL) is a malignancy of unknown pathogenesis. The malignant Hodgkin and Reed/Sternberg (HRS) cells derive from germinal center B cells (or rarely, T cells) but have a heterogeneous...
A plausible model for the digital response of p53 to DNA damage
Ma, Lan, Wagner, John, Rice, John Jeremy, Hu, Wenwei, Levine, Arnold J., Stolovitzky, Gustavo A.
Recent observations show that the single-cell response of p53 to ionizing radiation (IR) is “digital” in that it is the number of oscillations rather than the amplitude of p53 that shows...
Transcriptional analysis of the B cell germinal center reaction
Klein, Ulf, Tu, Yuhai, Stolovitzky, Gustavo A., Keller, Jeffrey L., Haddad, Joseph, Miljkovic, Vladan, ...
The germinal center (GC) reaction is crucial for T cell-dependent immune responses and is targeted by B cell lymphomagenesis. Here we analyzed the transcriptional changes that occur in B cells during...
Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling
Küppers, Ralf, Klein, Ulf, Schwering, Ines, Distler, Verena, Bräuninger, Andreas, Cattoretti, Giorgio, ...
Hodgkin lymphoma (HL) is a malignancy of unknown pathogenesis. The malignant Hodgkin and Reed/Sternberg (HRS) cells derive from germinal center B cells (or rarely, T cells) but have a heterogeneous...
A plausible model for the digital response of p53 to DNA damage
Ma, Lan, Wagner, John, Rice, John Jeremy, Hu, Wenwei, Levine, Arnold J., Stolovitzky, Gustavo A.
Recent observations show that the single-cell response of p53 to ionizing radiation (IR) is “digital” in that it is the number of oscillations rather than the amplitude of p53 that shows...
Roach, Jared C., Smith, Kelly D., Strobe, Katie L., Nissen, Stephanie M., Haudenschild, Christian D., Zhou, Daixing, ...
Transcription factors play a key role in integrating and modulating biological information. In this study, we comprehensively measured the changing abundances of mRNAs over a time course of...
Klein, Ulf, Tu, Yuhai, Stolovitzky, Gustavo A., Mattioli, Michela, Cattoretti, Giorgio, Husson, Hervé, ...
B cell–derived chronic lymphocytic leukemia (B-CLL) represents a common malignancy whose cell derivation and pathogenesis are unknown. Recent studies have shown that >50% of CLLs display...