Org, Elin, Eyheramendy, Susana, Juhanson, Peeter, Gieger, Christian, Lichtner, Peter, Klopp, Norman, ...
Hypertension is a complex disease that affects a large proportion of adult population. Although approximately half of the inter-individual variance in blood pressure (BP) level is heritable,...
Kääb, Stefan, Darbar, Dawood, Van Noord, Charlotte, Dupuis, Josée, Pfeufer, Arne, Newton-Cheh, Christopher, ...
Aims A recent genome-wide association study identified a haplotype block on chromosome 4q25 associated with atrial fibrillation (AF). We sought to replicate this association in four independent...
Sinner, Moritz F., Pfeufer, Arne, Perz, Siegfried, Schulze-Bahr, Eric, Mönnig, Gerold, Eckardt, Lars, ...
AimsThe Brugada syndrome is a rare, potentially fatal primary cardiomyopathy. Patients are identified by symptoms and typical electrocardiogram (ECG) patterns. Prevalence of spontaneous Brugada ECG...
Sinner, Moritz F., Pfeufer, Arne, Akyol, Mahmut, Beckmann, Britt-Maria, Hinterseer, Martin, Wacker, Annette, ...
Aims Atrial fibrillation (AF) is the most frequent arrhythmia in humans. Rare familial forms exist. Recent evidence indicates a genetic susceptibility to common forms of AF. The α-subunit of the...
Hinterseer, Martin, Thomsen, Morten B., Beckmann, Britt-Maria, Pfeufer, Arne, Schimpf, Rainer, Wichmann, H.-Erich, ...
Aims Torsades de pointes arrhythmias (TdP) occur by definition in the setting of prolonged QT intervals. Animal models of drug induced Long-QT syndrome (dLQTS) have shown higher predictive value for...
Multiple Testing for SNP-SNP Interactions (2007)
Boulesteix, Anne-Laure, Strobl, Carolin, Weidinger, Stefan, Wichmann, H.-Erich, Wagenpfeil, Stefan
Most genetic diseases are complex, i.e. associated to combinations of SNPs rather than individual SNPs. In the last few years, this topic has often been addressed in terms of SNP-SNP interaction...
Multiple Testing for SNP-SNP Interactions (2007)
Boulesteix, Anne-Laure, Strobl, Carolin, Weidinger, Stefan, Wichmann, H.-Erich, Wagenpfeil, Stefan
Most genetic diseases are complex, i.e. associated to combinations of SNPs rather than individual SNPs. In the last few years, this topic has often been addressed in terms of SNP-SNP interaction...
Multiple Testing for SNP-SNP Interactions (2007)
Boulesteix, Anne-Laure, Strobl, Carolin, Weidinger, Stefan, Wichmann, H.-Erich, Wagenpfeil, Stefan
Most genetic diseases are complex, i.e. associated to combinations of SNPs rather than individual SNPs. In the last few years, this topic has often been addressed in terms of SNP-SNP interaction...
Multiple Testing for SNP-SNP Interactions (2007)
Boulesteix, Anne-Laure, Strobl, Carolin, Weidinger, Stefan, Wichmann, H.-Erich, Wagenpfeil, Stefan
Most genetic diseases are complex, i.e. associated to combinations of SNPs rather than individual SNPs. In the last few years, this topic has often been addressed in terms of SNP-SNP interaction...
Gibson, Jane, Tapper, William, Cox, David, Zhang, Weihua, Pfeufer, Arne, Gieger, Christian, ...
Two case/control studies with different phenotypes, marker densities, and microarrays were examined for the most significant single markers in defined regions. They show a pronounced bias toward...
Cigarette Smoking and Cancer Risk: Modeling Total Exposure and Intensity (2007)
Lubin, Jay H., Alavanja, Michael C. R., Caporaso, Neil, Brown, Linda M., Brownson, Ross C., Field, R. William, ...
A recent analysis showed that the excess odds ratio (EOR) for lung cancer due to smoking can be modeled by a function which is linear in total pack-years and exponential in the logarithm of smoking...
Koch, Werner, Hoppmann, Petra, Michou, Elena, Jung, Vanessa, Pfeufer, Arne, Mueller, Jakob C., ...
Single-nucleotide polymorphisms within the BAT1-NFKBIL1-LTA genomic region (6p21.3) and the LGALS2 gene (22q13.1), encoding a regulator for lymphotoxin-α, the product of the LTA gene, have been...
Akyol, Mahmut, Jalilzadeh, Shapour, Sinner, Moritz F., Perz, Siegfried, Beckmann, Britt M., Gieger, Christian, ...
Aims The QT interval in the general population is a complex trait with 30–50% heritability. QT prolongation is associated with an increased risk of sudden death. A recent family-based study found...
Hilgers, Ralf-Dieter, Feldmann, Uwe, Jöckel, Karl-Heinz, Klar, Rüdiger, Rienhoff, Otto, Schäfer, Helmut, ...
In the Approbationsordnung für Ärzte (German regulation for the Curriculum in Medicine) of 27th June, 2002 the disciplines Epidemiology, Medical Biometry and Medical Informatics are combined in one...
Are students exposed to tobacco smoke in German schools? (2005)
Thaqi, Agim, Merkel, Günter, Wichmann, H.-Erich, Heinrich, Joachim
The aim of this study was to investigate to which extent 6th grade school children are exposed to tobacco smoke by others. As biomarker for the exposure to tobacco smoke nicotine and cotinine were...
Environmental Tobacco Smoke and Lung Cancer: A Case-Control Study in Germany (2000)
Kreuzer, Michaela, Krauss, Martin, Kreienbrock, Lothar, JÖckel, Karl-Heinz, Wichmann, H.-Erich
To assess the association between exposure to environmental tobacco smoke (ETS) and lung cancer, the authors personally interviewed 292 lifelong nonsmoking lung cancer cases (recruited from 15...
Thesis (doctoral)--Universität Köln, 1976.
Repolarization Changes Induced by Air Pollution in Ischemic Heart Disease Patients
Henneberger, Alexandra, Zareba, Wojciech, Ibald-Mulli, Angela, Rückerl, Regina, Cyrys, Josef, Couderc, Jean-Phillippe, ...
Epidemiologic studies report associations between particulate air pollution and cardiovascular morbidity and mortality, but the underlying pathophysiologic mechanisms are still unclear. We tested the...
Melanocortin-4 Receptor Gene Variant I103 Is Negatively Associated with Obesity
Geller, Frank, Reichwald, Kathrin, Dempfle, Astrid, Illig, Thomas, Vollmert, Caren, Herpertz, Stephan, ...
Several rare mutations in the melanocortin-4 receptor gene (MC4R) predispose to obesity. For the most common missense variant V103I (rs2229616), however, the previously reported similar carrier...
Repolarization Changes Induced by Air Pollution in Ischemic Heart Disease Patients
Henneberger, Alexandra, Zareba, Wojciech, Ibald-Mulli, Angela, Rückerl, Regina, Cyrys, Josef, Couderc, Jean-Phillippe, ...
Epidemiologic studies report associations between particulate air pollution and cardiovascular morbidity and mortality, but the underlying pathophysiologic mechanisms are still unclear. We tested the...
Hinney, Anke, Nguyen, Thuy Trang, Scherag, André, Friedel, Susann, Brönner, Günter, Müller, Timo Dirk, ...
Watanabe, Hiroshi, Koopmann, Tamara T., Le Scouarnec, Solena, Yang, Tao, Ingram, Christiana R., Schott, Jean-Jacques, ...
Brugada syndrome is a genetic disease associated with sudden cardiac death that is characterized by ventricular fibrillation and right precordial ST segment elevation on ECG. Loss-of-function...
Gibson, Jane, Tapper, William, Cox, David, Zhang, Weihua, Pfeufer, Arne, Gieger, Christian, ...
Two case/control studies with different phenotypes, marker densities, and microarrays were examined for the most significant single markers in defined regions. They show a pronounced bias toward...
Linsel-Nitschke, Patrick, Götz, Anika, Erdmann, Jeanette, Braenne, Ingrid, Braund, Peter, Hengstenberg, Christian, ...
Genome-Wide Scan on Total Serum IgE Levels Identifies FCER1A as Novel Susceptibility Locus
Weidinger, Stephan, Gieger, Christian, Rodriguez, Elke, Baurecht, Hansjörg, Mempel, Martin, Klopp, Norman, ...
High levels of serum IgE are considered markers of parasite and helminth exposure. In addition, they are associated with allergic disorders, play a key role in anti-tumoral defence, and are crucial...
Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum
Gieger, Christian, Geistlinger, Ludwig, Altmaier, Elisabeth, Hrabé De Angelis, Martin, Kronenberg, Florian, Meitinger, Thomas, ...
The rapidly evolving field of metabolomics aims at a comprehensive measurement of ideally all endogenous metabolites in a cell or body fluid. It thereby provides a functional readout of the...
Wang-Sattler, Rui, Yu, Yao, Mittelstrass, Kirstin, Lattka, Eva, Altmaier, Elisabeth, Gieger, Christian, ...
Exposure to nicotine during smoking causes a multitude of metabolic changes that are poorly understood. We quantified and analyzed 198 metabolites in 283 serum samples from the human cohort KORA...
Linsel-Nitschke, Patrick, Götz, Anika, Erdmann, Jeanette, Braenne, Ingrid, Braund, Peter, Hengstenberg, Christian, ...
Short-Term Mortality Rates during a Decade of Improved Air Quality in Erfurt, Germany
Breitner, Susanne, Stölzel, Matthias, Cyrys, Josef, Pitz, Mike, Wölke, Gabriele, Kreyling, Wolfgang, ...
Luca, Diana, Ringquist, Steven, Klei, Lambertus, Lee, Ann B., Gieger, Christian, Wichmann, H.-Erich, ...
Resources being amassed for genome-wide association (GWA) studies include “control databases” genotyped with a large-scale SNP array. How to use these databases effectively is an open question....
On the Replication of Genetic Associations: Timing Can Be Everything!
Lasky-Su, Jessica, Lyon, Helen N., Emilsson, Valur, Heid, Iris M., Molony, Cliona, Raby, Benjamin A., ...
The failure of researchers to replicate genetic-association findings is most commonly attributed to insufficient statistical power, population stratification, or various forms of between-study...
Kolz, Melanie, Johnson, Toby, Sanna, Serena, Teumer, Alexander, Vitart, Veronique, Perola, Markus, ...
Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a meta-analysis...
Org, Elin, Eyheramendy, Susana, Juhanson, Peeter, Gieger, Christian, Lichtner, Peter, Klopp, Norman, ...
Hypertension is a complex disease that affects a large proportion of adult population. Although approximately half of the inter-individual variance in blood pressure (BP) level is heritable,...
Lindgren, Cecilia M., Heid, Iris M., Randall, Joshua C., Lamina, Claudia, Steinthorsdottir, Valgerdur, Qi, Lu, ...
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist...
Targeting 160 Candidate Genes for Blood Pressure Regulation with a Genome-Wide Genotyping Array
Sõber, Siim, Org, Elin, Kepp, Katrin, Juhanson, Peeter, Eyheramendy, Susana, Gieger, Christian, ...
The outcome of Genome-Wide Association Studies (GWAS) has challenged the field of blood pressure (BP) genetics as previous candidate genes have not been among the top loci in these scans. We used...
A Genome-wide Association Study Identifies Three Loci Associated with Mean Platelet Volume
Meisinger, Christa, Prokisch, Holger, Gieger, Christian, Soranzo, Nicole, Mehta, Divya, Rosskopf, Dieter, ...
Mean platelet volume (MPV) is increased in myocardial and cerebral infarction and is an independent and strong predictor for postevent morbidity and mortality. We conducted a genome-wide association...
Lindgren, Cecilia M., Heid, Iris M., Randall, Joshua C., Lamina, Claudia, Steinthorsdottir, Valgerdur, Qi, Lu, ...
Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations
Hicks, Andrew A., Pramstaller, Peter P., Johansson, Åsa, Vitart, Veronique, Rudan, Igor, Ugocsai, Peter, ...
Sphingolipids have essential roles as structural components of cell membranes and in cell signalling, and disruption of their metabolism causes several diseases, with diverse neurological,...
Heid, Iris M., Lamina, Claudia, Küchenhoff, Helmut, Fischer, Guido, Klopp, Norman, Kolz, Melanie, ...
Previously, estimation of genotype misclassification of single nucleotide polymorphisms (SNPs) as encountered in epidemiologic practice and involving thousands of subjects was lacking. The authors...
Heid, Iris M., Huth, Cornelia, Loos, Ruth J. F., Kronenberg, Florian, Adamkova, Vera, Anand, Sonia S., ...
The INSIG2 rs7566605 polymorphism was identified for obesity (BMI≥30 kg/m2) in one of the first genome-wide association studies, but replications were inconsistent. We collected statistics from 34...