H. A. Coller

Identification of point mutations in mixtures by capillary electrophoresis hybridization.

Khrapko, K, Coller, H A, Hanekamp, J S, Thilly, W G

We have developed a rapid method for unambiguous identification and mutant fraction determination of individual mutants in mixtures of DNA sequence variants each differing by one or a few...

Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions.

Khrapko, K, Bodyak, N, Thilly, W G, Van Orsouw, N J, Zhang, X, Coller, H A, ...

Quantitative information on the cell-to-cell distribution of all possible mitochondrial DNA (mtDNA) mutations in young and aged tissues is needed to assess the relevance of these mutations to the...

Identification of point mutations in mixtures by capillary electrophoresis hybridization.

Khrapko, K, Coller, H A, Hanekamp, J S, Thilly, W G

We have developed a rapid method for unambiguous identification and mutant fraction determination of individual mutants in mixtures of DNA sequence variants each differing by one or a few...

Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions.

Khrapko, K, Bodyak, N, Thilly, W G, Van Orsouw, N J, Zhang, X, Coller, H A, ...

Quantitative information on the cell-to-cell distribution of all possible mitochondrial DNA (mtDNA) mutations in young and aged tissues is needed to assess the relevance of these mutations to the...