H. A. Kretzschmar

Identification of Anti-prion Compounds as Efficient Inhibitors of Polyglutamine Protein Aggregation in a Zebrafish Model (2007)

Schiffer, N.W., Broadley, S.A., Hirschberger, T., Tavan, P., Kretzschmar, H.A., Giese, A., ...

The configuration of the Cu2+ binding region in full-length human prion protein (2007)

Del Pino, P., Weiss, A., Bertsch, U., Renner, C., Mentler, M., Grantner, K., ...

The configuration of the Cu2+ binding region in full-length human prion protein compared with the isolated octapeptide (2007)

Weiss, A., Del Pino, P., Bertsch, U., Renner, C., Mentler, M., Grantner, K., ...

A refined method for molecular typing reveals that co-occurrence of PrPSc types in Creutzfeldt-Jakob disease is not the rule (2007)

Notari, S., Capellari, S., Langeveld, J.P.M., Giese, A., Strammiello, R., Gambetti, P., ...

Molecular typing in Creutzfeldt¿Jakob disease (CJD) relies on the detection of distinct protease-resistant prion protein (PrPSc) core fragments, which differ in molecular mass or glycoform ratio....

Analysis of the HUPO Brain Proteome reference samples using 2-d DIGE and 2-d LC-MS/MS (2006)

Frohlich, T., Helmstetter, D., Zobawa, M., Crecelius, A. C., Arzberger, T., Kretzschmar, H. A., ...

Genetic prion disease: the EUROCJD experience. (2005)

Kovács, G G, Puopolo, M, Ladogana, A, Pocchiari, M, Budka, H, Van Duijn, C M, ...

A total of 10-15% of human transmissible spongiform encephalopathies (TSEs) or prion diseases are characterised by disease-specific mutations in the prion protein gene (PRNP). We examined the...

Single molecule analysis of protein aggregation and prions by SIFT (2005)

Bertsch,U., Winklhofer,K. F., Hirschberger,T., Bieschke,J., Weber,P., Hartl,F. U., ...

Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets (2005)

Bertsch,U., Winklhofer,K. F., Hirschberger,T., Bieschke,J., Weber,P., Hartl,F. U., ...

Mortality from Creutzfeldt-Jakob disease and related disorders in Europe, Australia, and Canada. (2005)

Ladogana, A, Puopolo, M, Croes, E A, Budka, H, Jarius, C, Collins, S, ...

BACKGROUND: An international study of the epidemiologic characteristics of Creutzfeldt-Jakob disease (CJD) was established in 1993 and included national registries in France, Germany, Italy, the...

Single molecule analysis of protein aggregation and prions by sift. (2005)

Kretzschmar,H. A., Bertsch,U., Winklhofer,K. F., Hirschberger,T., Bieschke,J., Weber,P., ...

Breaking an absolute species barrier: Transgenic mice expressing the mink PrP gene are susceptible to transmissible mink encephalopathy (2005)

Windl, O., Buchholz, M., Neubauer, A., Schulz-Schaeffer, W., Groschup, M., Walter, S., ...

Single molecule analysis of protein aggregation and prions by SIFT (2005)

Bertsch, U., Winklhofer, K. F., Hirschberger, T., Bieschke, J., Weber, P., Hartl, F. U., ...

Single molecule analysis of protein aggregation and prions by sift (2005)

Kretzschmar, H. A., Bertsch, U., Winklhofer, K. F., Hirschberger, T., Bieschke, J., Weber, P., ...

Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets (2005)

Bertsch, U., Winklhofer, K. F., Hirschberger, T., Bieschke, J., Weber, P., Hartl, F. U., ...

Predictors of survival in sporadic Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies. (2004)

Pocchiari, M, Puopolo, M, Croes, E A, Budka, H, Gelpi, E, Collins, S, ...

A collaborative study of human transmissible spongiform encephalopathies has been carried out from 1993 to 2000 and includes data from 10 national registries, the majority in Western Europe. In this...

Predictors of survival in sporadic Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies (2004)

Pocchiari M, Puopolo M, Croes, E.A., Collins S, Lewis V, ...

A collaborative study of human transmissible spongiform encephalopathies has been carried out from 1993 to 2000 and includes data from 10 national registries, the majority in Western Europe. In this...

Hohenheim consensus talks on Bovine Spongiform Encephalopathy (BSE) (2002)

Beyreuther,K., Biesalski,H. K., Dingermann,T., Kretzschmar,H. A., Multhaupt,G., Tatzelt,J., ...

Hohenheim consensus talks on Bovine Spongiform Encephalopathy (BSE) (2002)

Beyreuther, K., Biesalski, H. K., Dingermann, T., Kretzschmar, H. A., Multhaupt, G., Tatzelt, J., ...

Ultrasensitive detection of pathological prion protein aggregates by dual-color scanning for intensely fluorescent targets. (2000)

Bieschke, J., Giese, A., Schulz-Schaeffer, W., Zerr, I., Poser, S., Eigen, M., ...

Putting prions into focus: application of single molecule detection to the diagnosis of prion diseases. (2000)

Giese, A., Bieschke, J., Eigen, M., Kretzschmar, H. A.

Diagnosis of Creutzfeldt-Jakob disease by measurement of S100 protein in serum: Prospective case-control study. (1998)

Otto, M., Wiltfang, J., Schuetz, E., Zerr, I., Otto, A., Pfahlberg, A., ...

[Consensus report: tissue handling in suspected Creutzfeldt-Jakob disease and other spongiform encephalopathies (prion diseases) in the human.European Union Biomed-1 Concerted Action] (1996)

Budka, H, Aguzzi, A, Brown, P, Brucher, J M, Bugiani, O, Collinge, J, ...

Despite many sensational and intimidating reports in the mass media, transmissible spongiform encephalopathies (prion diseases) are not contagious in the usual sense. Successful transmission requires...

RNA aptamers specifically interact with the prion protein PrP.

Weiss, S, Proske, D, Neumann, M, Groschup, M H, Kretzschmar, H A, Famulok, M, ...

We have isolated RNA aptamers which are directed against the recombinant Syrian golden hamster prion protein rPrP23-231 (rPrPc) fused to glutathione S-transferase (GST). The aptamers did not...

Breaking an Absolute Species Barrier: Transgenic Mice Expressing the Mink PrP Gene Are Susceptible to Transmissible Mink Encephalopathy

Windl, O., Buchholz, M., Neubauer, A., Schulz-Schaeffer, W., Groschup, M., Walter, S., ...

Transmissible mink encephalopathy (TME) is a rare disease of the North American mink, which has never been successfully transmitted to laboratory mice. We generated transgenic mice expressing the...

RNA aptamers specifically interact with the prion protein PrP.

Weiss, S, Proske, D, Neumann, M, Groschup, M H, Kretzschmar, H A, Famulok, M, ...

We have isolated RNA aptamers which are directed against the recombinant Syrian golden hamster prion protein rPrP23-231 (rPrPc) fused to glutathione S-transferase (GST). The aptamers did not...

Breaking an Absolute Species Barrier: Transgenic Mice Expressing the Mink PrP Gene Are Susceptible to Transmissible Mink Encephalopathy

Windl, O., Buchholz, M., Neubauer, A., Schulz-Schaeffer, W., Groschup, M., Walter, S., ...

Transmissible mink encephalopathy (TME) is a rare disease of the North American mink, which has never been successfully transmitted to laboratory mice. We generated transgenic mice expressing the...

Scrapie prion proteins are synthesized in neurons.

Kretzschmar, H. A., Prusiner, S. B., Stowring, L. E., DeArmond, S. J.

Scrapie is a slow degenerative encephalopathy of animals caused by unusual infectious particles termed prions. A cDNA encoding the only apparent component of the prion, a protein designated PrP...