Age-associated changes in beta-adrenergic modulation on rat cardiac excitation-contraction coupling.
Xiao, R P, Spurgeon, H A, O'Connor, F, Lakatta, E G
Previous studies have demonstrated that the ability of beta-adrenergic receptor (beta AR) stimulation to increase cardiac contractility declines with aging. In the present study, the control...
Spurgeon, H A, DuBell, W H, Stern, M D, Sollott, S J, Ziman, B D, Silverman, H S, ...
1. Single isolated rat cardiac myocytes were loaded with either the pentapotassium salt form or the acetoxymethyl ester (AM) form of the calcium-sensitive fluorescent probe, Indo-1. The relationship...
The cytosolic calcium transient modulates the action potential of rat ventricular myocytes.
DuBell, W H, Boyett, M R, Spurgeon, H A, Talo, A, Stern, M D, Lakatta, E G
1. The modulation of the action potential by the cytosolic Ca2+ (Cai2+) transient was studied in single isolated rat ventricular myocytes loaded with the acetoxymethyl ester form of the...
Force staircase kinetics in mammalian cardiac muscle: modulation by muscle length
Lakatta, E. G., Spurgeon, H. A.
1. Quiescent cat papillary muscles were stimulated to contract regularly at Lmax, the length at which force production is optimal, and at 0·85 Lmax. The resulting increase in force production (rate...
Age-associated changes in beta-adrenergic modulation on rat cardiac excitation-contraction coupling.
Xiao, R P, Spurgeon, H A, O'Connor, F, Lakatta, E G
Previous studies have demonstrated that the ability of beta-adrenergic receptor (beta AR) stimulation to increase cardiac contractility declines with aging. In the present study, the control...
Spurgeon, H A, DuBell, W H, Stern, M D, Sollott, S J, Ziman, B D, Silverman, H S, ...
1. Single isolated rat cardiac myocytes were loaded with either the pentapotassium salt form or the acetoxymethyl ester (AM) form of the calcium-sensitive fluorescent probe, Indo-1. The relationship...
The cytosolic calcium transient modulates the action potential of rat ventricular myocytes.
DuBell, W H, Boyett, M R, Spurgeon, H A, Talo, A, Stern, M D, Lakatta, E G
1. The modulation of the action potential by the cytosolic Ca2+ (Cai2+) transient was studied in single isolated rat ventricular myocytes loaded with the acetoxymethyl ester form of the...
Force staircase kinetics in mammalian cardiac muscle: modulation by muscle length
Lakatta, E. G., Spurgeon, H. A.
1. Quiescent cat papillary muscles were stimulated to contract regularly at Lmax, the length at which force production is optimal, and at 0·85 Lmax. The resulting increase in force production (rate...