Interleukin-1 polymorphisms associated with increased risk of gastric cancer (2000)
El Omar, E.M., Carrington, M., Chow, W-H., McColl, K.E.L., Bream, J.H., Young, H.A., ...
Helicobacter pylori infection is associated with a variety of clinical outcomes including gastric cancer and duodenal ulcer disease. The reasons for this variation are not clear, but the gastric...
Kwak, L W, Young, H A, Pennington, R W, Weeks, S D
The idiotype of the Ig expressed by a B-cell malignancy (Id) can serve as a unique tumor-specific antigen and as a model for cancer vaccine development. In murine models of Id vaccination,...
A cyclophilin-related protein involved in the function of natural killer cells.
Anderson, S K, Gallinger, S, Roder, J, Frey, J, Young, H A, Ortaldo, J R
Natural killer cells are non-major histocompatibility complex-restricted large granular lymphocytes that can recognize and destroy tumor cells without prior stimulation. A 150-kDa molecule on the...
Ghosh, P, Tan, T H, Rice, N R, Sica, A, Young, H A
Optimal activation of T cells requires at least two signals. One signal can be delivered by the antigen-specific T-cell receptor, and the second signal is provided by the costimulatory molecule(s)...
Sica, A, Tan, T H, Rice, N, Kretzschmar, M, Ghosh, P, Young, H A
Interferon-gamma (IFN-gamma) is an important immunoregulatory protein that is expressed usually only in large granular lymphocytes and T cells. The gene encoding IFN-gamma was previously found to...
Rat sarcoma virus: further analysis of individual viral isolates and the gene product.
Young, H A, Rasheed, S, Sowder, R, Benton, C V, Henderson, L E
Rasheed rat sarcoma virus, derived by in vitro cocultivation of two rat cell lines (Rasheed et al., Proc. Natl. Acad. Sci. U.S.A. 75:2972-2976, 1978), has been reported to code for a protein of...
Ye, J, Cippitelli, M, Dorman, L, Ortaldo, J R, Young, H A
Our group has previously reported that the nuclear factor Yin-Yang 1 (YY1), a ubiquitous DNA-binding protein, is able to interact with a silencer element (BE) in the gamma interferon (IFN-gamma)...
Xu, L C, Young, H A, Blanco, M, Kessler, S, Roberts, A B, Karlsson, S
The transduction efficiency of human bone marrow CD34+ cells with supernatants from the retrovirus producer cell clone PA317/LGSN 16 was only one-fifth of that with supernatants from GP+ envAm12/LGSN...
Gonda, M A, Young, H A, Elser, J E, Rasheed, S, Talmadge, C B, Nagashima, K, ...
Rasheed rat sarcoma virus (RaSV) has been shown to code for a protein of 29,000 Mr not present in replication-competent rat type C helper virus (RaLV)-infected cells. This protein is a fused gene...
CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.
Thompson, C B, Lindsten, T, Ledbetter, J A, Kunkel, S L, Young, H A, Emerson, S G, ...
CD28 is a 44-kDa glycoprotein expressed as a homodimer on the surface of a major subset of human T cells. Previous studies have demonstrated that the binding of monoclonal antibodies to the CD28...
Identification of a DNA binding site for the nuclear factor YY1 in the human GM-CSF core promoter.
Ye, J, Young, H A, Ortaldo, J R, Ghosh, P
It has been well documented that the repeated CATT(A/T) sequence, localized between -64 and -35 in the human GM-CSF promoter, is required for the promoter activity, and this region likely serves as a...
DeFeo, D, Gonda, M A, Young, H A, Chang, E H, Lowy, D R, Scolnick, E M, ...
Harvey murine sarcoma virus (Ha-MuSV) is a mouse-rat recombinant retrovirus that encodes a protein designated p21, required for virally induced transformation. Using a radiolabeled DNA fragment from...
In order to determine the relationship between the generation of a 1.0 kb mRNA and methylation of the T cell receptor beta chain gene, we have analyzed the methylation state of the T cell receptor...
Shih, T Y, Weeks, M O, Young, H A, Scolnick, E M
We have recently described an intracellular protein, p21, in nonproducer cells transformed by either the Kirsten (Ki-MSV) or Harvey (Ha-MSV) strain of murine sarcoma virus (Shih et al., Virology, in...
Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus.
Ellis, R W, DeFeo, D, Maryak, J M, Young, H A, Shih, T Y, Chang, E H, ...
Detailed restriction endonuclease maps were developed for Harvey murine sarcoma virus (Ha-MuSV) DNA (clone H-1), molecularly closed at its unique EcoRI site in pBR322, for three nonoverlapping...
Steroid induction of mouse mammary tumor virus: effect upon synthesis and degradation of viral RNA.
Young, H A, Shih, T Y, Scolnick, E M, Parks, W P
Steroid hormones have been demonstrated to induce in tissue culture the production of mouse mammary tumor viral (MMTV) RNA, proteins, and particles 10-fold compared with constitutive levels. However,...
Shih, T Y, Young, H A, Coffin, J M, Scolnick, E M
From analysis of the large RNase T1-resistant oligonucleotides of Kirsten sarcoma virus (Ki-SV), a physical map of the virus genome was deduced. Kirsten murine leukemia virus (Ki-MuLV) sequences were...
In vitro transcription of mouse mammary tumor virus RNA into DNA.
Taylor, J M, Illmensee, R, Young, H A
The in vitro transcription of the B-type mouse mammary tumor virus RNA into DNA is similar to that obtained with certain C-type viruses: synthesis can be initiated on an RNA primer molecule...
Tan, T H, Huang, G P, Sica, A, Ghosh, P, Young, H A, Longo, D L, ...
The cis-acting control elements of the interleukin-2 receptor alpha-chain (IL-2R alpha) gene contain a potent kappa B-like enhancer whose activity can be induced by various mitogenic stimuli. Recent...
Brownell, E, Mathieson, B, Young, H A, Keller, J, Ihle, J N, Rice, N R
A portion of the human cellular homolog of v-rel, the transforming gene of the leukemogenic retrovirus reticuloendotheliosis virus, strain T, was used to survey RNAs from several mouse tissues,...
Young, H A, Varesio, L, Hwu, P
Human gamma interferon genomic DNA was introduced into NIH 3T3 fibroblasts by calcium phosphate precipitation and was not expressed in these cells at the cytoplasmic mRNA or protein level. Treatment...
Young, H A, Shih, T Y, Scolnick, E M, Rasheed, S, Gardner, M B
Kirsten sarcoma virus (Ki-MSV) and Harvey sarcoma virus (Ha-MSV) are mouse-rat recombinant viruses that were originally isolated by experimental inoculation of rats with helper-independent mouse type...
Young, H A, Parks, W P, Scolnick, E M
The ffect of N-ethylmaleimide and iodoacetamide on the glucocorticoid receptor activity extracted from the cytosol of either mouse of hamster cells has been investigated. Treatment of mouse or...
Kwak, L W, Young, H A, Pennington, R W, Weeks, S D
The idiotype of the Ig expressed by a B-cell malignancy (Id) can serve as a unique tumor-specific antigen and as a model for cancer vaccine development. In murine models of Id vaccination,...
A cyclophilin-related protein involved in the function of natural killer cells.
Anderson, S K, Gallinger, S, Roder, J, Frey, J, Young, H A, Ortaldo, J R
Natural killer cells are non-major histocompatibility complex-restricted large granular lymphocytes that can recognize and destroy tumor cells without prior stimulation. A 150-kDa molecule on the...
Ghosh, P, Tan, T H, Rice, N R, Sica, A, Young, H A
Optimal activation of T cells requires at least two signals. One signal can be delivered by the antigen-specific T-cell receptor, and the second signal is provided by the costimulatory molecule(s)...
Sica, A, Tan, T H, Rice, N, Kretzschmar, M, Ghosh, P, Young, H A
Interferon-gamma (IFN-gamma) is an important immunoregulatory protein that is expressed usually only in large granular lymphocytes and T cells. The gene encoding IFN-gamma was previously found to...
Rat sarcoma virus: further analysis of individual viral isolates and the gene product.
Young, H A, Rasheed, S, Sowder, R, Benton, C V, Henderson, L E
Rasheed rat sarcoma virus, derived by in vitro cocultivation of two rat cell lines (Rasheed et al., Proc. Natl. Acad. Sci. U.S.A. 75:2972-2976, 1978), has been reported to code for a protein of...
Ye, J, Cippitelli, M, Dorman, L, Ortaldo, J R, Young, H A
Our group has previously reported that the nuclear factor Yin-Yang 1 (YY1), a ubiquitous DNA-binding protein, is able to interact with a silencer element (BE) in the gamma interferon (IFN-gamma)...
Xu, L C, Young, H A, Blanco, M, Kessler, S, Roberts, A B, Karlsson, S
The transduction efficiency of human bone marrow CD34+ cells with supernatants from the retrovirus producer cell clone PA317/LGSN 16 was only one-fifth of that with supernatants from GP+ envAm12/LGSN...
Gonda, M A, Young, H A, Elser, J E, Rasheed, S, Talmadge, C B, Nagashima, K, ...
Rasheed rat sarcoma virus (RaSV) has been shown to code for a protein of 29,000 Mr not present in replication-competent rat type C helper virus (RaLV)-infected cells. This protein is a fused gene...
CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.
Thompson, C B, Lindsten, T, Ledbetter, J A, Kunkel, S L, Young, H A, Emerson, S G, ...
CD28 is a 44-kDa glycoprotein expressed as a homodimer on the surface of a major subset of human T cells. Previous studies have demonstrated that the binding of monoclonal antibodies to the CD28...
Identification of a DNA binding site for the nuclear factor YY1 in the human GM-CSF core promoter.
Ye, J, Young, H A, Ortaldo, J R, Ghosh, P
It has been well documented that the repeated CATT(A/T) sequence, localized between -64 and -35 in the human GM-CSF promoter, is required for the promoter activity, and this region likely serves as a...
DeFeo, D, Gonda, M A, Young, H A, Chang, E H, Lowy, D R, Scolnick, E M, ...
Harvey murine sarcoma virus (Ha-MuSV) is a mouse-rat recombinant retrovirus that encodes a protein designated p21, required for virally induced transformation. Using a radiolabeled DNA fragment from...
In order to determine the relationship between the generation of a 1.0 kb mRNA and methylation of the T cell receptor beta chain gene, we have analyzed the methylation state of the T cell receptor...
Shih, T Y, Weeks, M O, Young, H A, Scolnick, E M
We have recently described an intracellular protein, p21, in nonproducer cells transformed by either the Kirsten (Ki-MSV) or Harvey (Ha-MSV) strain of murine sarcoma virus (Shih et al., Virology, in...
Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus.
Ellis, R W, DeFeo, D, Maryak, J M, Young, H A, Shih, T Y, Chang, E H, ...
Detailed restriction endonuclease maps were developed for Harvey murine sarcoma virus (Ha-MuSV) DNA (clone H-1), molecularly closed at its unique EcoRI site in pBR322, for three nonoverlapping...
Steroid induction of mouse mammary tumor virus: effect upon synthesis and degradation of viral RNA.
Young, H A, Shih, T Y, Scolnick, E M, Parks, W P
Steroid hormones have been demonstrated to induce in tissue culture the production of mouse mammary tumor viral (MMTV) RNA, proteins, and particles 10-fold compared with constitutive levels. However,...
Shih, T Y, Young, H A, Coffin, J M, Scolnick, E M
From analysis of the large RNase T1-resistant oligonucleotides of Kirsten sarcoma virus (Ki-SV), a physical map of the virus genome was deduced. Kirsten murine leukemia virus (Ki-MuLV) sequences were...
In vitro transcription of mouse mammary tumor virus RNA into DNA.
Taylor, J M, Illmensee, R, Young, H A
The in vitro transcription of the B-type mouse mammary tumor virus RNA into DNA is similar to that obtained with certain C-type viruses: synthesis can be initiated on an RNA primer molecule...
Tan, T H, Huang, G P, Sica, A, Ghosh, P, Young, H A, Longo, D L, ...
The cis-acting control elements of the interleukin-2 receptor alpha-chain (IL-2R alpha) gene contain a potent kappa B-like enhancer whose activity can be induced by various mitogenic stimuli. Recent...
Brownell, E, Mathieson, B, Young, H A, Keller, J, Ihle, J N, Rice, N R
A portion of the human cellular homolog of v-rel, the transforming gene of the leukemogenic retrovirus reticuloendotheliosis virus, strain T, was used to survey RNAs from several mouse tissues,...
Young, H A, Varesio, L, Hwu, P
Human gamma interferon genomic DNA was introduced into NIH 3T3 fibroblasts by calcium phosphate precipitation and was not expressed in these cells at the cytoplasmic mRNA or protein level. Treatment...
Young, H A, Shih, T Y, Scolnick, E M, Rasheed, S, Gardner, M B
Kirsten sarcoma virus (Ki-MSV) and Harvey sarcoma virus (Ha-MSV) are mouse-rat recombinant viruses that were originally isolated by experimental inoculation of rats with helper-independent mouse type...
Young, H A, Parks, W P, Scolnick, E M
The ffect of N-ethylmaleimide and iodoacetamide on the glucocorticoid receptor activity extracted from the cytosol of either mouse of hamster cells has been investigated. Treatment of mouse or...
Care of HIV-infected pregnant women in maternal-fetal medicine programs.
Sklar, P A, Bathgate, S L, Young, H A, Parenti, D M
OBJECTIVE: To survey the evolution over the past decade of attitudes and practices of obstetricians in maternal-fetal medicine fellowship programs regarding the management of human immunodeficiency...
Adachi, M, Kurotani, R, Morimura, K, Shah, Y, Sanford, M, Madison, B B, ...
Clark, L. J., Edington, K., Swan, I. R., McLay, K. A., Newlands, W. J., Wills, L. C., ...
We have examined the incidence of Harvey ras mutations in human squamous cell carcinomas (SCC) of the upper aerodigestive tract using the polymerase chain reaction (PCR) followed by direct...