The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease (2004)
Bandopadhyay, R., Kingsbury, A.E., Cookson, M.R., Reid, A.R., Evans, I.M., Hope, A.D., ...
Two mutations in the DJ-1 gene on chromosome1p36 have been identified recently to cause early-onset, autosomal recessive Parkinson’s disease. As no information is available regarding the...
Kimura, K, Saga, H, Hayashi, K, Obata, H, Chimori, Y, Ariga, H, ...
Cloning and characterization of the genomic DNA of the human MSSP genes.
Haigermoser, C, Fujimoto, M, Iguchi-Ariga, S M, Ariga, H
MSSP proteins have been identified by their binding to an upstream element of c-myc. Independently, two different approaches yielded two cDNA clones highly homologous to the MSSP cDNAs, suggesting an...
A novel G1-specific enhancer identified in the human heat shock protein 70 gene.
Taira, T, Narita, T, Iguchi-Ariga, S M, Ariga, H
Expression of the human heat shock protein 70 gene (hsp70) is induced by various kinds of stress and by oncogenes. In the absence of stress, hsp70 is mainly expressed in the G1and S phases of the...
Kimura, K, Saga, H, Hayashi, K, Obata, H, Chimori, Y, Ariga, H, ...
The expression of alpha-smooth muscle actin is coordinately regulated by positive and negative cis- elements in the promoter region. Although cis -elements and trans -acting factors involved in the...
Shiroki, K, Ohshima, K, Fukui, Y, Ariga, H
An E1B 58K mutant of adenovirus type 12 (Ad12), dl207, was constructed by the deletion of 852 base pairs in the E1B 58K coding region. The mutant could grow efficiently in 293E1 cells but not in...
Initiation of simian virus 40 DNA replication in vitro.
Exogenously added simian virus 40 (SV40) DNA can be replicated semiconservatively in vitro by a mixture of a soluble extract of HeLa cell nuclei and the cytoplasm from SV40-infected CosI cells. When...
c-myc protein can be substituted for SV40 T antigen in SV40 DNA replication.
Iguchi-Ariga, S M, Itani, T, Yamaguchi, M, Ariga, H
Replicating activity of SV40 origin-containing plasmid was tested in human cells as well as in monkey CosI cells. All the plasmids possessing SV40 ori sequences could replicate, even in the absence...
Takai, T, Nishita, Y, Iguchi-Ariga, S M, Ariga, H
We have previously reported the human cDNA encoding MSSP-1, a sequence-specific double- and single-stranded DNA binding protein [Negishi, Nishita, Saëgusa, Kakizaki, Galli, Kihara, Tamai, Miyajima,...
We have previously developed simian virus 40 (SV40) DNA replication system in vitro (Ariga and Sugano, J. Virol. 48, 481, 1983). This system is composed of human HeLa or mouse FM3A nuclear extract...
Adenovirus DNA synthesized in the presence of aphidicolin.
Oguro, M, Yamashita, T, Ariga, H, Nagano, H
Adenovirus types 2 and 5 DNA synthesized in vivo and in vitro in the presence of aphidicolin were studied. Inhibition of adenoviral DNA synthesis by aphidicolin was only 70% even at a concentration...
Identification of the replicative intermediates in SV40 DNA replication in vitro.
The soluble replication system is which the exogenously added simian virus 40 (SV40) DNA can be replicated semiconservatively in vitro, has been developed (Ariga and Sugano, J.Virol. 48, 481, 1983)....
Sudo, K, Ogata, M, Sato, Y, Iguchi-Ariga, S M, Ariga, H
The c-myc protein has recently been shown to interact with a region possessing putative origin of DNA replication and enhancer activities located 2 kb upstream of the c-myc gene itself. Transgenic...
Effect of silencer on polyomavirus DNA replication.
Ariizumi, K, Takahashi, H, Nakamura, M, Ariga, H
We have cloned the cellular sequence termed box DNA from the enhancer region of polyomavirus F9 mutant fPyF9. Box DNA functions as a negative transcriptional element (silencer) in undifferentiated F9...
Negative transcriptional regulatory element that functions in embryonal carcinoma cells.
Ariizumi, K, Takahashi, H, Nakamura, M, Ariga, H
We have cloned the polyomavirus mutant fPyF9, which persists in an episomal state in F9 embryonal carcinoma cells (K. Ariizumi and H. Ariga, Mol. Cell. Biol. 6:3920-3927, 1986). fPyF9 carries three...
BOX DNA: a novel regulatory element related to embryonal carcinoma cell differentiation.
Kihara-Negishi, F, Tsujita, R, Negishi, Y, Ariga, H
BOX DNA was previously isolated from the DNA sequence inserted in the enhancer B domain of mutant polyomavirus (fPyF9) DNA. We also reported that BOX DNA functioned negatively on DNA replication and...
Ariga, H, Itani, T, Iguchi-Ariga, S M
We have already reported that the cloned mouse DNA fragment (pMU65) could replicate in a simian virus 40 T antigen-dependent system in vivo and in vitro (H. Ariga, Z. Tsuchihashi, M. Naruto, and M....
Ariga, H, Tsuchihashi, Z, Naruto, M, Yamada, M
Mouse liver DNA was cut out with BamHI and cloned into YIp5, which contained the URA3 gene of Saccharomyces cerevisiae in pBR322. Of the several plasmids isolated, two plasmids, pMU65 and pMU111,...
New class of polyomavirus mutant that can persist as free copies in F9 embryonal carcinoma cells.
A small circular DNA was found extrachromosomally in a clone of F9 embryonal carcinoma (EC) cells at high copy numbers per cell. The DNA was cloned in plasmid pUC19. Restriction endonuclease analyses...
The replicating activity of several cloned DNAs containing putative origin sequences was examined in a cell-free extract that absolutely depends on simian virus 40 (SV40) T antigen promoting...
Ariga, H, Imamura, Y, Iguchi-Ariga, S M
We have previously reported that c-myc protein, or protein(s) complexed with c-myc protein, binds to the region upstream of the first exon of the c-myc gene and that this region contains an origin of...
Complementation of the temperature-sensitive defect in H5ts125 adenovirus DNA replication in vitro.
Kaplan, L M, Ariga, H, Hurwitz, J, Horwitz, M S
Soluble extracts of adenovirus-infected HeLa cell nuclei support DNA replication on exogenous adenovirus DNA templates. Conditions of synthesis using both wild-type and temperature-sensitive extracts...
Iguchi-Ariga, S M, Okazaki, T, Itani, T, Ogata, M, Sato, Y, Ariga, H
We have previously reported that c-myc protein may promote cellular DNA replication by binding to initiation sites of replication. Here we report that a putative origin of human cellular DNA...
Possible function of the c-myc product: promotion of cellular DNA replication.
Iguchi-Ariga, S M, Itani, T, Kiji, Y, Ariga, H
We have recently cloned a plasmid, pARS65, containing the sequences derived from mouse liver DNA which can autonomously replicate in mouse and human cells (Ariga et al., 1987). In this report, we...
Iwata, K, Seya, T, Ueda, S, Ariga, H, Nagasawa, S
Three major membrane cofactor protein (MCP) phenotypes with different serine-threonine (ST)-rich regions, namely STc (L-phenotype), STBC (H or U phenotype) and STABC, and the MCP without the ST...
Galli, I, Iguchi-Ariga, S M, Ariga, H
The SV40 origin of replication comprises a run of thymine and adenine residues. Integrity of this AT-rich sequence is known to be essential for replication. We set out to study whether or not these...
A novel DNA replication origin identified in the human heat shock protein 70 gene promoter.
Taira, T, Iguchi-Ariga, S M, Ariga, H
A general and sensitive method for the mapping of initiation sites of DNA replication in vivo, developed by Vassilev and Johnson, has revealed replication origins in the region of simian virus 40...
Cloning and characterization of the genomic DNA of the human MSSP genes.
Haigermoser, C, Fujimoto, M, Iguchi-Ariga, S M, Ariga, H
MSSP proteins have been identified by their binding to an upstream element of c-myc. Independently, two different approaches yielded two cDNA clones highly homologous to the MSSP cDNAs, suggesting an...
A novel G1-specific enhancer identified in the human heat shock protein 70 gene.
Taira, T, Narita, T, Iguchi-Ariga, S M, Ariga, H
Expression of the human heat shock protein 70 gene (hsp70) is induced by various kinds of stress and by oncogenes. In the absence of stress, hsp70 is mainly expressed in the G1and S phases of the...
Kimura, K, Saga, H, Hayashi, K, Obata, H, Chimori, Y, Ariga, H, ...
The expression of alpha-smooth muscle actin is coordinately regulated by positive and negative cis- elements in the promoter region. Although cis -elements and trans -acting factors involved in the...
Shiroki, K, Ohshima, K, Fukui, Y, Ariga, H
An E1B 58K mutant of adenovirus type 12 (Ad12), dl207, was constructed by the deletion of 852 base pairs in the E1B 58K coding region. The mutant could grow efficiently in 293E1 cells but not in...
Initiation of simian virus 40 DNA replication in vitro.
Exogenously added simian virus 40 (SV40) DNA can be replicated semiconservatively in vitro by a mixture of a soluble extract of HeLa cell nuclei and the cytoplasm from SV40-infected CosI cells. When...
c-myc protein can be substituted for SV40 T antigen in SV40 DNA replication.
Iguchi-Ariga, S M, Itani, T, Yamaguchi, M, Ariga, H
Replicating activity of SV40 origin-containing plasmid was tested in human cells as well as in monkey CosI cells. All the plasmids possessing SV40 ori sequences could replicate, even in the absence...
Takai, T, Nishita, Y, Iguchi-Ariga, S M, Ariga, H
We have previously reported the human cDNA encoding MSSP-1, a sequence-specific double- and single-stranded DNA binding protein [Negishi, Nishita, Saëgusa, Kakizaki, Galli, Kihara, Tamai, Miyajima,...
We have previously developed simian virus 40 (SV40) DNA replication system in vitro (Ariga and Sugano, J. Virol. 48, 481, 1983). This system is composed of human HeLa or mouse FM3A nuclear extract...
Galli, I, Iguchi-Ariga, S M, Ariga, H
The SV40 origin of replication comprises a run of thymine and adenine residues. Integrity of this AT-rich sequence is known to be essential for replication. We set out to study whether or not these...
Adenovirus DNA synthesized in the presence of aphidicolin.
Oguro, M, Yamashita, T, Ariga, H, Nagano, H
Adenovirus types 2 and 5 DNA synthesized in vivo and in vitro in the presence of aphidicolin were studied. Inhibition of adenoviral DNA synthesis by aphidicolin was only 70% even at a concentration...
Identification of the replicative intermediates in SV40 DNA replication in vitro.
The soluble replication system is which the exogenously added simian virus 40 (SV40) DNA can be replicated semiconservatively in vitro, has been developed (Ariga and Sugano, J.Virol. 48, 481, 1983)....
Sudo, K, Ogata, M, Sato, Y, Iguchi-Ariga, S M, Ariga, H
The c-myc protein has recently been shown to interact with a region possessing putative origin of DNA replication and enhancer activities located 2 kb upstream of the c-myc gene itself. Transgenic...
A novel DNA replication origin identified in the human heat shock protein 70 gene promoter.
Taira, T, Iguchi-Ariga, S M, Ariga, H
A general and sensitive method for the mapping of initiation sites of DNA replication in vivo, developed by Vassilev and Johnson, has revealed replication origins in the region of simian virus 40...
Effect of silencer on polyomavirus DNA replication.
Ariizumi, K, Takahashi, H, Nakamura, M, Ariga, H
We have cloned the cellular sequence termed box DNA from the enhancer region of polyomavirus F9 mutant fPyF9. Box DNA functions as a negative transcriptional element (silencer) in undifferentiated F9...
Negative transcriptional regulatory element that functions in embryonal carcinoma cells.
Ariizumi, K, Takahashi, H, Nakamura, M, Ariga, H
We have cloned the polyomavirus mutant fPyF9, which persists in an episomal state in F9 embryonal carcinoma cells (K. Ariizumi and H. Ariga, Mol. Cell. Biol. 6:3920-3927, 1986). fPyF9 carries three...
BOX DNA: a novel regulatory element related to embryonal carcinoma cell differentiation.
Kihara-Negishi, F, Tsujita, R, Negishi, Y, Ariga, H
BOX DNA was previously isolated from the DNA sequence inserted in the enhancer B domain of mutant polyomavirus (fPyF9) DNA. We also reported that BOX DNA functioned negatively on DNA replication and...
Ariga, H, Itani, T, Iguchi-Ariga, S M
We have already reported that the cloned mouse DNA fragment (pMU65) could replicate in a simian virus 40 T antigen-dependent system in vivo and in vitro (H. Ariga, Z. Tsuchihashi, M. Naruto, and M....
Ariga, H, Tsuchihashi, Z, Naruto, M, Yamada, M
Mouse liver DNA was cut out with BamHI and cloned into YIp5, which contained the URA3 gene of Saccharomyces cerevisiae in pBR322. Of the several plasmids isolated, two plasmids, pMU65 and pMU111,...
New class of polyomavirus mutant that can persist as free copies in F9 embryonal carcinoma cells.
A small circular DNA was found extrachromosomally in a clone of F9 embryonal carcinoma (EC) cells at high copy numbers per cell. The DNA was cloned in plasmid pUC19. Restriction endonuclease analyses...
The replicating activity of several cloned DNAs containing putative origin sequences was examined in a cell-free extract that absolutely depends on simian virus 40 (SV40) T antigen promoting...
Ariga, H, Imamura, Y, Iguchi-Ariga, S M
We have previously reported that c-myc protein, or protein(s) complexed with c-myc protein, binds to the region upstream of the first exon of the c-myc gene and that this region contains an origin of...
Complementation of the temperature-sensitive defect in H5ts125 adenovirus DNA replication in vitro.
Kaplan, L M, Ariga, H, Hurwitz, J, Horwitz, M S
Soluble extracts of adenovirus-infected HeLa cell nuclei support DNA replication on exogenous adenovirus DNA templates. Conditions of synthesis using both wild-type and temperature-sensitive extracts...
Iguchi-Ariga, S M, Okazaki, T, Itani, T, Ogata, M, Sato, Y, Ariga, H
We have previously reported that c-myc protein may promote cellular DNA replication by binding to initiation sites of replication. Here we report that a putative origin of human cellular DNA...
Possible function of the c-myc product: promotion of cellular DNA replication.
Iguchi-Ariga, S M, Itani, T, Kiji, Y, Ariga, H
We have recently cloned a plasmid, pARS65, containing the sequences derived from mouse liver DNA which can autonomously replicate in mouse and human cells (Ariga et al., 1987). In this report, we...
Iwata, K, Seya, T, Ueda, S, Ariga, H, Nagasawa, S
Three major membrane cofactor protein (MCP) phenotypes with different serine-threonine (ST)-rich regions, namely STc (L-phenotype), STBC (H or U phenotype) and STABC, and the MCP without the ST...