Aguet, M., Salgam, P., Gutte, B., Arnheiter, H.
The antigenic determinant recognized by the monoclonal antibody that had been raised against synthetic human interferon-alpha 1 (IFN-alpha 1) fragment 111-166 [Arnheiter, H., Thomas, R.M., Leist, T.,...
Antiviral determinants of rat Mx GTPases map to the carboxy-terminal half.
Johannes, L, Kambadur, R, Lee-Hellmich, H, Hodgkinson, C A, Arnheiter, H, Meier, E
Rat Mx2 and rat Mx3 are two alpha/beta interferon-inducible cytoplasmic GTPases that differ in three residues in the amino-terminal third, which also contains the tripartite GTP-binding domain, and...
Takebayashi, K, Chida, K, Tsukamoto, I, Morii, E, Munakata, H, Arnheiter, H, ...
In the DNA binding domain of microphthalmia-associated transcription factor (MITF), four mutations are reported: mi, Mi wh, mi ew, and mi or. MITFs encoded by the mi, Mi wh, mi ew, and Mi or mutant...
Switch in antiviral specificity of a GTPase upon translocation from the cytoplasm to the nucleus.
Johannes, L, Arnheiter, H, Meier, E
The Mx2 protein of rats is a cytoplasmic GTPase that protects cells against vesicular stomatitis virus but not against influenza virus. Since vesicular stomatitis virus replicates in the cytoplasm...
Herpes simplex virus pathogenesis in transgenic mice is altered by the homeodomain protein Hox 1.3.
Mitchell, W J, De Santo, R J, Zhang, S D, Odenwald, W F, Arnheiter, H
The DNA sequence TAAT is the core binding motif for the mouse homeodomain protein Hox 1.3 (proposed new name, Hoxa-5). These sequences are present within the multiple TAATGARAT regulatory motifs in...
Activity of rat Mx proteins against a rhabdovirus.
Meier, E, Kunz, G, Haller, O, Arnheiter, H
Upon stimulation with alpha/beta interferon, rat cells synthesize three Mx proteins. Sequence analysis of corresponding cDNAs reveals that these three proteins are derived from three distinct genes....
Stereo images of vesicular stomatitis virus assembly.
Odenwald, W F, Arnheiter, H, Dubois-Dalcq, M, Lazzarini, R A
Viral assembly was studied by viewing platinum replicas of cytoplasmic and outer plasma membrane surfaces of baby hamster kidney cells infected with vesicular stomatitis virus. Replicas of the...
Vesicular stomatitis virus N and NS proteins form multiple complexes.
Davis, N L, Arnheiter, H, Wertz, G W
The vesicular stomatitis virus nucleocapsid protein, N, associated specifically with the viral phosphoprotein, NS, in an in vitro system which supported vesicular stomatitis virus RNA replication....
Affinity-purified polyclonal antibodies directed against human lymphoblastoid interferon (IFN), Escherichia coli-derived human IFN-alpha 2, or two synthetic fragments of human IFN-alpha 1 all...
Measles virus P gene codes for two proteins.
Bellini, W J, Englund, G, Rozenblatt, S, Arnheiter, H, Richardson, C D
The entirety of the phosphoprotein gene of measles virus has been sequenced. The gene is composed of 1,657 nucleotides and specifies a 507-amino-acid protein (P). A second overlapping reading frame...
Greenspan, D, Krystal, M, Nakada, S, Arnheiter, H, Lyles, D S, Palese, P
The nonstructural NS2 protein of influenza A/PR/8/34 virus was efficiently expressed in bacteria, and monospecific antisera were prepared against the bacterially synthesized polypeptide. These...
The allele Mx regulates the extent to which interferon alpha/beta inhibits the growth of influenza viruses in mouse cells such as peritoneal macrophages. The time course of induction of the antiviral...
Expression of a recombinant DNA gene coding for the vesicular stomatitis virus nucleocapsid protein.
Sprague, J, Condra, J H, Arnheiter, H, Lazzarini, R A
A cDNA clone containing the entire vesicular stomatitis virus nucleocapsid gene was assembled by fusing portions of two partial clones. When the cDNA clone was inserted into a new general-purpose...
Interferon independence of genetically controlled resistance to flaviviruses.
Brinton, M A, Arnheiter, H, Haller, O
Flavivirus-resistant C3H/RV mice injected with sheep anti-interferon globulin and then infected with either West Nile or yellow fever virus survived and displayed no disease symptoms. Also, treatment...
Modulation of epidermal growth factor receptors by human alpha interferon.
Zoon, K C, Karasaki, Y, Zur Nedden, D L, Hu, R Q, Arnheiter, H
Treatment of Madin-Darby bovine kidney (MDBK) cells with human interferon (IFN)-alpha 2 at 37 degrees C results in a dose-dependent inhibition of cell growth and a reduction of the subsequent binding...
Arnheiter, H, Ohno, M, Smith, M, Gutte, B, Zoon, K C
An 125I-labeled monoclonal antibody made against a synthetic 56-residue fragment of human leukocyte interferon (IFN) alpha 1 recognizes human, Escherichia coli-derived IFN alpha A bound to the...
Haller, O, Arnheiter, H, Lindenmann, J
Mice carrying the gene Mx were resistant to the lethal action of a hepatotropic line of avian influenza A virus. In resistant animals, foci of liver necrosis were self-limiting, and maximal virus...
In mouse Mx+ cells, interferon alpha/beta induces the synthesis of the nuclear Mx protein, whose accumulation is correlated with specific inhibition of influenza viral protein synthesis. When Mx+...
Antiviral determinants of rat Mx GTPases map to the carboxy-terminal half.
Johannes, L, Kambadur, R, Lee-Hellmich, H, Hodgkinson, C A, Arnheiter, H, Meier, E
Rat Mx2 and rat Mx3 are two alpha/beta interferon-inducible cytoplasmic GTPases that differ in three residues in the amino-terminal third, which also contains the tripartite GTP-binding domain, and...
Takebayashi, K, Chida, K, Tsukamoto, I, Morii, E, Munakata, H, Arnheiter, H, ...
In the DNA binding domain of microphthalmia-associated transcription factor (MITF), four mutations are reported: mi, Mi wh, mi ew, and mi or. MITFs encoded by the mi, Mi wh, mi ew, and Mi or mutant...
Switch in antiviral specificity of a GTPase upon translocation from the cytoplasm to the nucleus.
Johannes, L, Arnheiter, H, Meier, E
The Mx2 protein of rats is a cytoplasmic GTPase that protects cells against vesicular stomatitis virus but not against influenza virus. Since vesicular stomatitis virus replicates in the cytoplasm...
Herpes simplex virus pathogenesis in transgenic mice is altered by the homeodomain protein Hox 1.3.
Mitchell, W J, De Santo, R J, Zhang, S D, Odenwald, W F, Arnheiter, H
The DNA sequence TAAT is the core binding motif for the mouse homeodomain protein Hox 1.3 (proposed new name, Hoxa-5). These sequences are present within the multiple TAATGARAT regulatory motifs in...
Activity of rat Mx proteins against a rhabdovirus.
Meier, E, Kunz, G, Haller, O, Arnheiter, H
Upon stimulation with alpha/beta interferon, rat cells synthesize three Mx proteins. Sequence analysis of corresponding cDNAs reveals that these three proteins are derived from three distinct genes....
Stereo images of vesicular stomatitis virus assembly.
Odenwald, W F, Arnheiter, H, Dubois-Dalcq, M, Lazzarini, R A
Viral assembly was studied by viewing platinum replicas of cytoplasmic and outer plasma membrane surfaces of baby hamster kidney cells infected with vesicular stomatitis virus. Replicas of the...
Vesicular stomatitis virus N and NS proteins form multiple complexes.
Davis, N L, Arnheiter, H, Wertz, G W
The vesicular stomatitis virus nucleocapsid protein, N, associated specifically with the viral phosphoprotein, NS, in an in vitro system which supported vesicular stomatitis virus RNA replication....
Affinity-purified polyclonal antibodies directed against human lymphoblastoid interferon (IFN), Escherichia coli-derived human IFN-alpha 2, or two synthetic fragments of human IFN-alpha 1 all...
Measles virus P gene codes for two proteins.
Bellini, W J, Englund, G, Rozenblatt, S, Arnheiter, H, Richardson, C D
The entirety of the phosphoprotein gene of measles virus has been sequenced. The gene is composed of 1,657 nucleotides and specifies a 507-amino-acid protein (P). A second overlapping reading frame...
Greenspan, D, Krystal, M, Nakada, S, Arnheiter, H, Lyles, D S, Palese, P
The nonstructural NS2 protein of influenza A/PR/8/34 virus was efficiently expressed in bacteria, and monospecific antisera were prepared against the bacterially synthesized polypeptide. These...
The allele Mx regulates the extent to which interferon alpha/beta inhibits the growth of influenza viruses in mouse cells such as peritoneal macrophages. The time course of induction of the antiviral...
Expression of a recombinant DNA gene coding for the vesicular stomatitis virus nucleocapsid protein.
Sprague, J, Condra, J H, Arnheiter, H, Lazzarini, R A
A cDNA clone containing the entire vesicular stomatitis virus nucleocapsid gene was assembled by fusing portions of two partial clones. When the cDNA clone was inserted into a new general-purpose...
Interferon independence of genetically controlled resistance to flaviviruses.
Brinton, M A, Arnheiter, H, Haller, O
Flavivirus-resistant C3H/RV mice injected with sheep anti-interferon globulin and then infected with either West Nile or yellow fever virus survived and displayed no disease symptoms. Also, treatment...
Modulation of epidermal growth factor receptors by human alpha interferon.
Zoon, K C, Karasaki, Y, Zur Nedden, D L, Hu, R Q, Arnheiter, H
Treatment of Madin-Darby bovine kidney (MDBK) cells with human interferon (IFN)-alpha 2 at 37 degrees C results in a dose-dependent inhibition of cell growth and a reduction of the subsequent binding...
Arnheiter, H, Ohno, M, Smith, M, Gutte, B, Zoon, K C
An 125I-labeled monoclonal antibody made against a synthetic 56-residue fragment of human leukocyte interferon (IFN) alpha 1 recognizes human, Escherichia coli-derived IFN alpha A bound to the...
Haller, O, Arnheiter, H, Lindenmann, J
Mice carrying the gene Mx were resistant to the lethal action of a hepatotropic line of avian influenza A virus. In resistant animals, foci of liver necrosis were self-limiting, and maximal virus...
In mouse Mx+ cells, interferon alpha/beta induces the synthesis of the nuclear Mx protein, whose accumulation is correlated with specific inhibition of influenza viral protein synthesis. When Mx+...