H. B. Beverloo

Asparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia (2005)

Stams, W.A., Boer, M.L. Den, Holleman, A., Appel, I.M., Beverloo, H.B., Wering, E.R. Van, ...

Resistance to L-asparaginase in leukemic cells may be caused by an elevated cellular expression of asparagine synthetase (AS). Previously, we reported that high AS expression did not correlate to...

Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia (2005)

Stam, R.W., Sallan, S.E., Pieters, R., Armstrong, S.A., Boer, M.L. Den, Schneider, P., ...

Acute lymphoblastic leukemia (ALL) in infants is characterized by rearrangements of the mixed lineage leukemia (MLL) gene, drug resistance, and a poor treatment outcome. Therefore, novel therapeutic...

Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia (2005)

Holleman, A., Boer, M.L. Den, Kazemier, K.M., Beverloo, H.B., Von Bergh, A.R., Janka-Schaub, G.E., ...

Drug resistance in childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) is associated with impaired ability to induce apoptosis. To elucidate causes of apoptotic defects, we...

The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA insterstrand cross-link-induced double-strand breaks (2004)

Niedernhofer, L.J., Odijk, H., Budzowska, M., Drunen, E. Van, Maas, A., Theil, A.F., ...

Interstrand cross-links (ICLs) are an extremely toxic class of DNA damage incurred during normal metabolism or cancer chemotherapy. ICLs covalently tether both strands of duplex DNA, preventing the...

Randomized comparison of low-dose versus high-dose interferon-alfa in chronic myeloid leukemia: prospective collaboration of 3 joint trials by the MRC and HOVON groups (2004)

Kluin-Nelemans, H.C., Buck, G., Cessie, S. Le, Richards, S., Beverloo, H.B., Falkenburg, J.H.F., ...

Prognostically useful gene-expression profiles in acute myeloid leukemia (2004)

Valk, P.J., Delwel, R., Verhaak, R.G., Beijen, M.A., Erpelinck, C.A., ...

BACKGROUND: In patients with acute myeloid leukemia (AML) a combination of methods must be used to classify the disease, make therapeutic decisions, and determine the prognosis. However, this...

High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients (2003)

Smit, E.M., Beverloo, H.B., Sonneveld, P., Verhoef, G., Ossenkoppele, G.J., ...

The proto-oncogene EVI1 encodes a DNA binding protein and is located on chromosome 3q26. The gene is aberrantly expressed in acute myeloid leukemia (AML) patients carrying 3q26 abnormalities. Two...

Sensitivity to L-asparaginase is not associated with expression levels of asparagine synthetase in t(12;21)+ pediatric ALL (2003)

Stams, W.A., Boer, M.L. Den, Beverloo, H.B., Meijerink, J.P., Stigter, R.L., Wering, E.R. Van, ...

The (12;21) translocation resulting in TEL/AML1 gene fusion is present in about 25% of childhood precursor B-lineage acute lymphoblastic leukemia (ALL) and is associated with a good prognosis and a...

Molecular cytogenetic and clinical findings in ETV6/ABL1-positive leukemia (2001)

Beverloo, H B, Van Drunen, E, Janssens, A, Hählen, K, Poppe, B, ...

Rearrangements of 12p, resulting from deletions or translocations, are common findings in hematologic malignancies. In many cases, these rearrangements target the ETV6 gene (previously called TEL)...

t(7;12)(q36;p13) and t(7;12)(q32;p13) - translocations involving ETV6 in children 18 months of age or younger with myeloid disorders (2001)

Slater, R.M., Drunen, E. Van, Kroes, W.G.M., Olde Weghuis, D., Berg, E. Van Den, Smit, E.M., ...

Fusion of the homeobox gene HLXB9 and the ETV6 gene in infant acute myeloid leukemias with the t(7;12)(q36;p13) (2001)

Beverloo, H.B., Panagopoulos, I., Isaksson, M., Wering, E. Van, Drunen, E. Van, Klein, A. De, ...

Recently, we and others reported a recurrent t(7;12)(q36;p13) found in myeloid malignancies in children < or =18 months of age and associated with a poor prognosis. Fluorescence in situ hybridization...

Mouse Rad54 affects DNA doublestrand break repair and sister chromatid exchange (2000)

Dronkert, M.L.G., Beverloo, H.B., Johnson, R.D., Hoeijmakers, J.H.J., Jasin, M., Kanaar , R.

Cells can achieve error-free repair of DNA double-strand breaks (DSBs) by homologous recombination through gene conversion with or without crossover. In contrast, an alternative homology-dependent...

Mouse RAD54 affects DNA double-strand break repair and sister chromatid exchange (2000)

Dronkert, M.L., Beverloo, H.B., Johnson, R.D., Hoeijmakers, J.H., Jasin, M., Kanaar, R.

Cells can achieve error-free repair of DNA double-strand breaks (DSBs) by homologous recombination through gene conversion with or without crossover. In contrast, an alternative homology-dependent...

Bidirectional differentiation involving a cell with rearrangement of the MLL gene: letter (1998)

Berg, H. Van Den, Caron, H.N., Kroes, W.G.M., ...

Bidirectional differentiation involving a cell with rearrangement of the MLL gene (letter) (1998)

Berg, H. Van Den, Caron, H.N., Theunissen, H.G., Kroes, W.G.M., Beverloo, H.B., ...

Translocation (11;15)(q23;q14) in three patients with acute non-lymphoblastic leukemia (ANLL): clinical, cytogenetic and molecular studies (1995)

Beverloo, H B, Selleri, L, ...

We report on three patients with acute non-lymphoblastic leukemia (ANLL) displaying the same chromosomal translocation t(11;15)(q23;q14). The clinical course of the disease was aggressive, and...

Chromosomal localization of three repair genes: the xeroderma pigmentosum group C gene and two human homologs of yeast RAD23. (1994)

Smit, E.M.E., Beverloo, H.B., Sugasawa, K., Matsutani, C., Hanaoka, F., ...

The nucleotide excision repair (NER) disorder xeroderma pigmentosum (XP) is characterized by sun (UV) sensitivity, predisposition to skin cancer, and extensive genetic heterogeneity. Recently, we...