Cancer Incidence in the Families of Children With Ewing's Tumor (1991)
Hartley, A. L., Birch, J. M., Blair, V., Teare, M. D., Marsden, H. B., Harris, M.
N-and c-myc Oncogenes in Childhood Rhabdomyosarcoma (1990)
DIAS, P., KUMAR, P., MARSDEN, H. B., GATTAMANENI, H. R., KUMAR, S.
Isolation of Bacteroides corrodens from infections in children
Six cases of infections in children with Bacteroides corrodens are reported. In five the infection was mixed but in one fatal extradural and subdural empyema the organism was found in pure culture....
Ewing's tumours and neuroblastomas
Marsden, H. B., Steward, J. K.
From a study of 59 cases of neuroblastoma and 21 patients classified as cases of Ewing's tumour there appear to be differences in age incidence, duration of disease, gross and microscopical...
Germ cell tumours of childhood: a review of 137 cases.
Marsden, H B, Birch, J M, Swindell, R
One hundred and thirty-seven germ cell tumours occurring in 134 children included in the Manchester University Children's Tumour Registry over a 25-year period have been studied. The incidence and...
Congenital mesoblastic nephroma: possible prognostic and management value of assessing DNA content.
Barrantes, J C, Toyn, C, Muir, K R, Parkes, S E, Raafat, F, Cameron, A H, ...
The case records and pathology of all children with kidney tumours treated in the West Midlands Health Authority Region (WMHAR) from 1957 to 1986 were reviewed. The histology was reviewed by a panel...
Mesoblastic nephroma contains fibronectin but lacks laminin.
Kumar, S, Marsden, H B, Carr, T, Kodet, R
Non-metastatic mesoblastic nephromas from four young children were shown to contain fibronectin but not laminin using an immunoperoxidase staining procedure. In contrast, one metastasising spindle...
Kumar, S, Carr, T, Marsden, H B, Calabuig-Crespo, M C
Using a peroxidase-antiperoxidase staining procedure, formalin fixed paraffin embedded sections of fetal and normal kidney; benign (mesoblastic nephroma); and malignant tumours (Wilms' tumour, clear...
New look at mesoblastic nephroma.
Thirty eight mesoblastic nephromas were studied. The age range of the patients was between the neonatal period and 18 months. The presence of cartilage is consistent with a mesoblastic origin, but...
Study of childhood renal tumours using peroxidase conjugated lectins.
Kumar, S, Carr, T, Marsden, H B, Morris-Jones, P H
Six peroxidase conjugated lectins were used to compare their ability to bind to formalin fixed paraffin embedded tissue sections of childhood renal tumours (Wilms' tumour, mesoblastic nephroma, renal...
Study of childhood renal tumours using a monoclonal antibody to Tamm-Horsfall protein.
Kumar, S, Marsden, H B, Jasani, B, Kumar, P
A monoclonal antibody to Tamm-Horsfall glycoprotein was used for the immuno-localization of Tamm-Horsfall protein in formalin fixed, paraffin embedded tissue sections of childhood renal tumours,...
Bone marrow fibrosis in acute lymphoblastic leukaemia of childhood.
Hann, I M, Evans, D I, Marsden, H B, Jones, P M, Palmer, M K
A prospective study of bone marrow fibrosis was made in a group of 40 children with acute lymphoblastic leukaemia to see whether it affected the prognosis or course of the disease. Secondary...
Bone metastases in children presenting with renal tumours.
A survey of bone metastases in 132 children presenting with renal tumours has been carried out using material from the Manchester (England) Children's Tumour Registry during the period 1954 to 1976....
Gonadal infiltration in children with leukaemia and lymphoma.
In a postmortem survey of children with leukaemia and lymphoma, the overall incidence of testicular infiltration was 65% and of ovarian infiltration 66%. In acute lymphoblastic leukaemia, testicular...
Isolation of Bacteroides corrodens from infections in children
Six cases of infections in children with Bacteroides corrodens are reported. In five the infection was mixed but in one fatal extradural and subdural empyema the organism was found in pure culture....
Ewing's tumours and neuroblastomas
Marsden, H. B., Steward, J. K.
From a study of 59 cases of neuroblastoma and 21 patients classified as cases of Ewing's tumour there appear to be differences in age incidence, duration of disease, gross and microscopical...
Germ cell tumours of childhood: a review of 137 cases.
Marsden, H B, Birch, J M, Swindell, R
One hundred and thirty-seven germ cell tumours occurring in 134 children included in the Manchester University Children's Tumour Registry over a 25-year period have been studied. The incidence and...
Congenital mesoblastic nephroma: possible prognostic and management value of assessing DNA content.
Barrantes, J C, Toyn, C, Muir, K R, Parkes, S E, Raafat, F, Cameron, A H, ...
The case records and pathology of all children with kidney tumours treated in the West Midlands Health Authority Region (WMHAR) from 1957 to 1986 were reviewed. The histology was reviewed by a panel...
Mesoblastic nephroma contains fibronectin but lacks laminin.
Kumar, S, Marsden, H B, Carr, T, Kodet, R
Non-metastatic mesoblastic nephromas from four young children were shown to contain fibronectin but not laminin using an immunoperoxidase staining procedure. In contrast, one metastasising spindle...
Kumar, S, Carr, T, Marsden, H B, Calabuig-Crespo, M C
Using a peroxidase-antiperoxidase staining procedure, formalin fixed paraffin embedded sections of fetal and normal kidney; benign (mesoblastic nephroma); and malignant tumours (Wilms' tumour, clear...
New look at mesoblastic nephroma.
Thirty eight mesoblastic nephromas were studied. The age range of the patients was between the neonatal period and 18 months. The presence of cartilage is consistent with a mesoblastic origin, but...
Study of childhood renal tumours using peroxidase conjugated lectins.
Kumar, S, Carr, T, Marsden, H B, Morris-Jones, P H
Six peroxidase conjugated lectins were used to compare their ability to bind to formalin fixed paraffin embedded tissue sections of childhood renal tumours (Wilms' tumour, mesoblastic nephroma, renal...
Study of childhood renal tumours using a monoclonal antibody to Tamm-Horsfall protein.
Kumar, S, Marsden, H B, Jasani, B, Kumar, P
A monoclonal antibody to Tamm-Horsfall glycoprotein was used for the immuno-localization of Tamm-Horsfall protein in formalin fixed, paraffin embedded tissue sections of childhood renal tumours,...
Bone marrow fibrosis in acute lymphoblastic leukaemia of childhood.
Hann, I M, Evans, D I, Marsden, H B, Jones, P M, Palmer, M K
A prospective study of bone marrow fibrosis was made in a group of 40 children with acute lymphoblastic leukaemia to see whether it affected the prognosis or course of the disease. Secondary...
Bone metastases in children presenting with renal tumours.
A survey of bone metastases in 132 children presenting with renal tumours has been carried out using material from the Manchester (England) Children's Tumour Registry during the period 1954 to 1976....
Gonadal infiltration in children with leukaemia and lymphoma.
In a postmortem survey of children with leukaemia and lymphoma, the overall incidence of testicular infiltration was 65% and of ovarian infiltration 66%. In acute lymphoblastic leukaemia, testicular...
Improvements in survival from childhood cancer: results of a population based survey over 30 years
Birch, J M, Marsden, H B, Jones, P H Morris, Pearson, D, Blair, V
Survival from cancer of children whose cancer was diagnosed during the 30 years 1954-83 was analysed. The study was population based with nearly 3000 cases covering about 30 million child years at...
Hawkins, M. M., Wilson, L. M., Stovall, M. A., Marsden, H. B., Potok, M. H., Kingston, J. E., ...
OBJECTIVE--To investigate the incidence and aetiology of secondary leukaemia after childhood cancer in Britain. DESIGN--Cohort study and a case-control study. SETTING--Britain and population based...
Hartley, A L, Birch, J M, Marsden, H B, Harris, M
Seven cases of malignant melanoma in the close relatives of children with osteosarcoma and chondrosarcoma are described. The association between certain childhood malignancies (adrenal cortical...
Late functioning adrenocortical carcinoma in a 5-year-old girl.
Marsden, H B, Jones, P M, Lees, P D, Hann, I M
A 5-year-old with adrenocortical carcinoma presented with acute paraplegia. The tumour was initially nonfunctioning but finally showed rapid dissemination and the patient then developed Cushingoid...
Aortic thrombosis in the newborn period.
Three cases are reported in which thrombi were found in the aorta at postmortem. In each case the thrombus had originated within the ductus arteriosus. We believe that in recent years the attention...
Purine nucleoside phosphorylase deficiency associated with a fatal lymphoproliferative disorder.
Watson, A R, Evans, D I, Marsden, H B, Miller, V, Rogers, P A
A 2 1/2-year-old boy presented with an illness resembling glandular fever. He was found to have T-cell deficiency with lack of red and white cell purine nucleoside phosphorylase enzyme activity. A...
Renal pseudotumours caused by xanthogranulomatous pyelonephritis
Watson, A R, Marsden, H B, Lendon, M, Jones, P H Morris
Five cases of xanthogranulomatous pyelonephritis are described. Wilms's tumour was suspected preoperatively in 2 of the cases and a renal tumour appeared to be confirmed at laparotomy in three....
Neuronal Ceroid Lipofuscinosis (Batten's Disease)
Gordon, N. S., Marsden, H. B., Noronha, M. J.
Four patients are described, who on clinical, histological, and biochemical criteria are considered to be suffering from neuronal ceroid lipofuscinosis. It is suggested that this may be the commonest...
Adrenal cortical tumours: epidemiological and familial aspects.
Hartley, A L, Birch, J M, Marsden, H B, Reid, H, Harris, M, Blair, V
Epidemiological data on the 14 cases of adrenal cortical tumour registered with the Manchester Children's Tumour Registry from 1954 and 1985 are presented. The incidence of adrenal cortical...
Improvements in survival from childhood cancer: results of a population based survey over 30 years
Birch, J M, Marsden, H B, Jones, P H Morris, Pearson, D, Blair, V
Survival from cancer of children whose cancer was diagnosed during the 30 years 1954-83 was analysed. The study was population based with nearly 3000 cases covering about 30 million child years at...
Excess risk of breast cancer in the mothers of children with soft tissue sarcomas.
Birch, J. M., Hartley, A. L., Marsden, H. B., Harris, M., Swindell, R.
Information was obtained on the health status or cause of death in the mothers of a population-based series of 143 children with soft tissue sarcomas. Among these mothers there were 6 cases of breast...
Breast cancer risk in mothers of children with osteosarcoma and chondrosarcoma.
Hartley, A. L., Birch, J. M., Marsden, H. B., Harris, M.
Mothers of a population-based series of 86 children with osteosarcoma or chondrosarcoma were traced and their health status or cause of death ascertained. There were 6 cases of breast cancer among...
Patterns of multiple primary tumours in patients treated for cancer during childhood.
Kingston, J. E., Hawkins, M. M., Draper, G. J., Marsden, H. B., Kinnier Wilson, L. M.
One hundred and sixty one children who have developed more than one primary neoplasm have been identified. Children with tumours of the central nervous system, retinoblastoma and leukaemia were those...
Dias, P., Kumar, P., Marsden, H. B., Morris-Jones, P. H., Birch, J., Swindell, R., ...
The diagnostic and prognostic relevance of desmin expression in 80 rhabdomyosarcomas (RMS) and 5 embryonal sarcomas (ES) was examined using a peroxidase anti-peroxidase staining procedure. Fifty-nine...
Bone-metastasizing renal tumour of childhood.
A primary renal tumour of childhood with histological appearances different from the nephroblastoma is described. This neoplasm, predominantly seen in boys, has a tendency to metastasize to bone....
Bone metastases in childhood renal tumours.
Marsden, H. B., Lennox, E. L., Lawler, W., Kinnier-Wilson, L. M.
Analysis of data from 1434 children with primary renal tumours revealed 57 who developed bone metastases. Of these, 54 were initially recorded as nephroblastoma. Fifty-two of the 57 cases were...
Birch, J. M., Marsden, H. B., Swindell, R.
The Manchester Children's Tumour Registry data for the period 1954-1977 have been analysed. The overall incidence of malignant disease in children aged 0-14 years in the north-west of England is...
Childhood leukaemia in North West England 1954-1977: epidemiology, incidence and survival.
Birch, J. M., Swindell, R., Marsden, H. B., Morris Jones, P. H.
The annual incidence of leukaemia among children aged up to 14 years as estimated by the Manchester Children's Tumour Registry has been analysed for the 24 years 1954-1977. A significant increase in...
Methods of classifying and ascertaining children's tumours.
Leck, I., Birch, J. M., Marsden, H. B., Steward, J. K.
Several methods of ascertaining and classifying childhood neoplasms for epidemiological study have been evaluated using material from the University of Manchester Children's Tumour Registry (CTR),...
The need for specialist review of pathology in paediatric cancer.
Parkes, S. E., Muir, K. R., Cameron, A. H., Raafat, F., Stevens, M. C., Morland, B. J., ...
A retrospective histopathological review of 2104 cases of solid tumour was carried out to assess the variability in diagnosis of childhood cancer. Cases were subject to three independent, concurrent...
Prognostic relevance of DNA content in childhood renal tumours.
Kumar, S., Marsden, H. B., Cowan, R. A., Barnes, J. M.
The DNA content of paraffin embedded tumour specimens from 100 children with kidney tumours was studied by flow cytometry. Data of adequate quality were obtained from 93 cases comprising 67 Wilms'...
A study of soft tissue sarcomas after childhood cancer in Britain
Jenkinson, H C, Winter, D L, Marsden, H B, Stovall, M A, Stevens, M C G, Stiller, C A, ...
Among 16 541 3-year survivors of childhood cancer in Britain, 39 soft tissue sarcomas (STSs) occurred and 1.1 sarcomas were expected, yielding a standardised incidence ratio (SIR) of 16.1. When...