Good laboratory practice: preventing introduction of bias at the bench (2009)
Macleod, Malcolm R.,
Fisher, Marc,
O'Collins, Victoria,
Sena, Emily S.,
Dirnagl, Ulrich,
Bath, Philip M.W.,
...
Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human...
Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach (2008)
Crossley, Nicolas A.,
Sena, Emily S.,
Goehler, Jos,
Horn, Jannekke,
Van Der Worp, H. Bart,
Bath, Philip M.W.,
...
Background and Purpose—At least part of the failure in the transition from experimental to clinical studies in stroke has been attributed to the imprecision introduced by problems in the design of...
Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis (2007)
Van Der Worp, H. Bart,
Sena, Emily S.,
Donnan, Geoffrey A.,
Howells, David W.,
Macleod, Malcolm R.
Induced hypothermia is proposed as a treatment for acute ischaemic stroke, but there have been too few clinical trials involving too few patients to draw any conclusions about the therapeutic benefit...
Hemicraniectomy after middle cerebral artery infarction with life-threatening Edema trial (HAMLET). Protocol for a randomised controlled trial of decompressive surgery in space-occupying hemispheric infarction (2006)
Hofmeijer, Jeannette,
Amelink, G Johan,
Algra, Ale,
Van Gijn, Jan,
Macleod, Malcolm R,
Kappelle, L Jaap,
...
Abstract Background Patients with a hemispheric infarct and massive space-occupying brain oedema have a poor prognosis. Despite maximal conservative treatment, the case fatality rate may be as high...
PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial. [ISCRTN 74418480] (2005)
Van Breda, Eric J,
Van Der Worp, H Bart,
Algra, Ale,
Kappelle, L Jaap,
Van Gijn, Jan,
...
Abstract Background In patients with acute stroke, increased body temperature is associated with large lesion volumes, high case fatality, and poor functional outcome. A 1°C increase in body...
Effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute ischemic stroke PISA, a phase II double-blind, randomized, placebo-controlled trial [ISRCTN98608690] (2003)
Dippel, Diederik WJ,
Van Breda, Eric J,
Van Der Worp, H Bart,
Meijer, Ron J,
Kappelle, L Jaap,
...
Abstract Background Body temperature is a strong predictor of outcome in acute stroke. In a previous randomized trial we observed that treatment with high-dose acetaminophen (paracetamol) led to a...
Effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute ischemic stroke PISA, a phase II double-blind, randomized, placebo-controlled trial [ISRCTN98608690]
Dippel, Diederik WJ,
Van Breda, Eric J,
Van Der Worp, H Bart,
Meijer, Ron J,
Kappelle, L Jaap,
...
PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial. [ISCRTN 74418480]
Van Breda, Eric J,
Van Der Worp, H Bart,
Algra, Ale,
Kappelle, L Jaap,
Van Gijn, Jan,
...
Hemicraniectomy after middle cerebral artery infarction with life-threatening Edema trial (HAMLET). Protocol for a randomised controlled trial of decompressive surgery in space-occupying hemispheric infarction
Hofmeijer, Jeannette,
Amelink, G Johan,
Algra, Ale,
Van Gijn, Jan,
Macleod, Malcolm R,
Kappelle, L Jaap,
...
Effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute ischemic stroke PISA, a phase II double-blind, randomized, placebo-controlled trial [ISRCTN98608690]
Dippel, Diederik WJ,
Van Breda, Eric J,
Van Der Worp, H Bart,
Meijer, Ron J,
Kappelle, L Jaap,
...
PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial. [ISCRTN 74418480]
Van Breda, Eric J,
Van Der Worp, H Bart,
Algra, Ale,
Kappelle, L Jaap,
Van Gijn, Jan,
...
Hemicraniectomy after middle cerebral artery infarction with life-threatening Edema trial (HAMLET). Protocol for a randomised controlled trial of decompressive surgery in space-occupying hemispheric infarction
Hofmeijer, Jeannette,
Amelink, G Johan,
Algra, Ale,
Van Gijn, Jan,
Macleod, Malcolm R,
Kappelle, L Jaap,
...