H. C. J. Hoefsloot

Marangoni convection around a ventilated air bubble under microgravity conditions (2008)

Hoefsloot, H.C.J., Hoogstraten, H.W.

Under microgravity conditions in both parabolic and sounding rocket flights, the mass-transfer-induced Marangoni convection around an air bubble was studied. To prevent the bubble from becoming...

Growth factors for Marangoni instability in a spherical liquid layer under zero-gravity conditions (2008)

Hoefsloot, H.C.J., Hoogstraten, H.W., Knobbe, J.W.

The neutral-stability analysis presented earlier is completed by computing the growth factors β for the normal modes and by showing that the neutral states (Re(β)=0) are stationary (Im(β)=0)...

Marangoni convection in V-shaped containers (2008)

Hoogstraten, H.W., Hoefsloot, H.C.J.

This paper presents a numerical study of the time evolution of Marangoni convection in two V-shaped containers involved in the microgravity experiments reported earlier. First the case of the...

Marangoni instability in a liquid layer bounded by two coaxial cylinder surfaces (2008)

Hoefsloot, H.C.J., Hoogstraten, H.W., Hoven, A.

A liquid layer, confined between two coaxial cylinder surfaces, has either a gas-liquid interface on the inside and is heated from the outer (solid) boundary, or it has a gas-liquid interface on the...

Marangoni instability in a liquid layer confined between two concentric spherical surfaces under zero-gravity conditions (2008)

Hoefsloot, H.C.J., Hoogstraten, H.W.

A liquid layer containing a single solute is bounded on the outside by a rigid spherical surface and on the inside by a concentric gas/liquid interface. The solute evaporates from the liquid to the...

Assessment of PLSDA cross validation (2008)

Westerhuis, J.A., Hoefsloot, H.C.J., Smit, S., Vis, D.J., Smilde, A.K., ...

Classifying groups of individuals based on their metabolic profile is one of the main topics in metabolomics research. Due to the low number of individuals compared to the large number of variables,...

Variable selection methods as a tool to find sensor locations for distributed parameter systems (2008)

Stanimirovic, O., Hoefsloot, H.C.J., Bokx, P.K. De, Smilde, A.K.

The problem of finding suitable sensor locations for distributed parameter systems (DPS) is tackled as a variable selection problem. Two existing variable selection methods are used: one is based on...

Optimized time alignment algorithm for LC-MS data: Correlation optimized warping using component detection algorithm-selected mass chromatograms (2008)

Christin, C., Smilde, A.K., Hoefsloot, H.C.J., Suits, F., Bischoff, R., Horvatovich, P.L.

Correlation optimized warping (COW) based on the total ion current (TIC) is a widely used time alignment algorithm (COW-TIC). This approach works successfully on chromatograms containing few...

Insights into Sonogashira cross-coupling by high-throughput kinetics and descriptor modeling (2008)

Plenio, H., Immel, S., Burello, E., Rothenberg, G., Hoefsloot, H.C.J.

A method is presented for the high-throughput monitoring of reaction kinetics in homogeneous catalysis, running up to 25 coupling reactions in a single reaction vessel. This method is demonstrated...

Multilevel data analysis of a crossover designed human nutritional intervention study (2008)

Westerhuis, J.A., Dorsten, F.A. Van, Hoefsloot, H.C.J., Jacobs, D.M., ...

A new method is introduced for the analysis of 'omics' data derived from crossover designed drug or nutritional intervention studies. The method aims at finding systematic variations in metabolic...

The geometry of ASCA (2008)

Smilde, A.K., Hoefsloot, H.C.J., Westerhuis, J.A.

For analyzing designed high-dimensional data, no standard methods are currently available. A method that is becoming more and more popular for analyzing such data is ASCA. The mathematics of ASCA are...

A classification model for the Leiden proteomics competition (2008)

Hoefsloot, H.C.J., Smit, S., Smilde, A.K.

A strategy is presented to build a discrimination model in proteomics studies. The model is built using cross-validation. This cross-validation step can simply be combined with a variable selection...

PARAFASCA: ASCA combined with PARAFAC for the analysis of metabolic fingerprinting data (2008)

Jansen, J.J., Bro, R., Hoefsloot, H.C.J., Westerhuis, J.A., Smilde, A.K.

Novel post-genomics experiments such as metabolomics provide datasets that are highly multivariate and often reflect an underlying experimental design, developed with a specific experimental question...

Statistical data processing in clinical proteomics (2008)

Smit, S., Hoefsloot, H.C.J., Smilde, A.K.

This review discusses data analysis strategies for the discovery of biomarkers in clinical proteomics. Proteomics studies produce large amounts of data, characterized by few samples of which many...

Discriminant Q2 (DQ2) for improved discrimination in PLSDA models (2008)

Westerhuis, J.A., Hoefsloot, H.C.J., Smilde, A.K.

In this paper we introduce discriminant Q2 (DQ2) as an improvement for the Q2 value used in the validation of PLSDA models. DQ2 does not penalize class predictions beyond the class label value. With...

How to distinguish healthy from diseased? Classification strategy for mass spectrometry based clinical proteomics. (2007)

Smit, S., Akkermans, L.M.W., Reijmers, Th.H., Eilers, P.H.C., Hoefsloot, H.C.J., ...

Assessing the statistical validity of proteomics based biomarkers. (2007)

Smit, S., Breemen, M.J. Van, Hoefsloot, H.C.J., Smilde, A.K., Koster, C.G. De

vering gene expression patterns in time course microarray experiments by ANOVA-SCA. (2007)

Nueda, M.J., Conessa, A., Westerhuis, J.A., Hoefsloot, H.C.J., Smilde, A.K., Talon, M., ...

Grey component analysis. (2007)

Westerhuis, J.A., Hoefsloot, H.C.J., Smilde, A.K.

MALS. (2007)

Hoefsloot, H.C.J., Westerhuis, J.A., Verouden, M.P.H., Smilde, A.K.

Conditional Monte Carlo sampling to find branching architectures of polymers from radical polymerizations with transfer to polymer and recombination termination. (2007)

Iedema, P.D., Wulkow, M., Hoefsloot, H.C.J.

Conditional Monte Carlo sampling to find branching architectures of polymers from radical polymerizations with transfer to polymer and recombination termination (2007)

Iedema, P.D., Wulkow, M., Hoefsloot, H.C.J.

MALS. (2007)

Hoefsloot, H.C.J., Westerhuis, J.A., Verouden, M.P.H., Smilde, A.K.

Conditional Monte Carlo sampling to find branching architectures of polymers from radical polymerizations with transfer to polymer and recombination termination. (2007)

Iedema, P.D., Wulkow, M., Hoefsloot, H.C.J.

vering gene expression patterns in time course microarray experiments by ANOVA-SCA. (2007)

Nueda, M.J., Conessa, A., Westerhuis, J.A., Hoefsloot, H.C.J., Smilde, A.K., Talon, M., ...

Grey component analysis. (2007)

Westerhuis, J.A., Hoefsloot, H.C.J., Smilde, A.K.

How to distinguish healthy from diseased? Classification strategy for mass spectrometry based clinical proteomics. (2007)

Smit, S., Akkermans, L.M.W., Reijmers, Th.H., Eilers, P.H.C., Hoefsloot, H.C.J., ...

Assessing the statistical validity of proteomics based biomarkers. (2007)

Smit, S., Breemen, M.J. Van, Hoefsloot, H.C.J., Smilde, A.K., Koster, C.G. De

Centering, scaling and transformations: improving the biological information content of metabolomics data. (2006)

Berg Van Den, R.A., Hoefsloot, H.C.J., Westerhuis, J.A., Smilde, A.K.

Background: Extracting relevant biological information from large data sets is a major challenge in functional genomics research. Different aspects of the data hamper their biological interpretation....

Maximum Likelihood Scalling (MALS). (2006)

Hoefsloot, H.C.J., Westerhuis, J.A., Smilde, A.K.

Linking PCA and time derivatives of dynamic systems. (2006)

Stanimirovic, O., Hoefsloot, H.C.J., Bokx, P. De, Smilde, A.K.

Bagged K-means clustering of metabolome data. (2006)

Hageman, J.A., Westerhuis, J.A., Hoefsloot, H.C.J., Smilde, A.K.

Conditional Monte Carlo sampling to find branching architectures of polymers from radical polymerizations with transfer to polymer. (2006)

Iedema, P.D., Hoefsloot, H.C.J.

Modelling multi-viscosity systems with dissipative particle dynamics. (2006)

Visser, D.C., Hoefsloot, H.C.J., Iedema, P.D.

Maximum Likelihood Scalling (MALS). (2006)

Hoefsloot, H.C.J., Westerhuis, J.A., Smilde, A.K.

Linking PCA and time derivatives of dynamic systems. (2006)

Stanimirovic, O., Hoefsloot, H.C.J., Bokx, P. De, Smilde, A.K.

Bagged K-means clustering of metabolome data. (2006)

Hageman, J.A., Westerhuis, J.A., Hoefsloot, H.C.J., Smilde, A.K.

ANOVA-simultaneous component analysis (ASCA): a new tool for analyzing designed metabolomics data. (2005)

Smilde, A.K., Jansen, J.J., Hoefsloot, H.C.J., Greef, J. Van Der, Timmerman, M.E.

Motivation: Datasets resulting from metabolomics or metabolic profiling experiments are becoming increasingly complex. Such datasets may contain underlying factors, such as time (time-resolved or...

Poiseuille flow to measure the viscosity of particle model fluids. (2005)

Backer, J.A., Lowe, C.P., Hoefsloot, H.C.J., Iedema, P.D.

The most important property of a fluid is its viscosity, it determines the flow properties. If one simulates a fluid using a particle model, calculating the viscosity accurately is difficult because...

Profiling of liquid crystal displays with Raman spectroscopy: Preprocessing of spectra. (2005)

Stanimirovic, O., Boelens, H.F.M., Mank, A.J.G., Hoefsloot, H.C.J., Smilde, A.K.

Raman spectroscopy is applied for characterizing paintable displays. Few other options than Raman spectroscopy exist for doing so because of the liquid nature of functional materials. The challenge...

ASCA: analysis of multivariate data obtained from an experimental design. (2005)

Jansen, J.J., Hoefsloot, H.C.J., Greef, J. Van Der, Timmerman, M.E., Westerhuis, J.A., Smilde, A.K.

Computing the trivariate chain length/degree of branching/number of combination point distribution for radical polymerization with transfer to polymer and recombination termination. (2005)

Iedema, P.D., Hoefsloot, H.C.J.

Molecular architecture of ldPE (2005)

Iedema, P.D., Hoefsloot, H.C.J.

Combined length scales in dissipative particle dynamics (2005)

Backer, J.A., Lowe, C.P., Hoefsloot, H.C.J., Iedema, P.D.

Comprehensive boundary method for solid walls in dissipative particle dynamics. (2005)

Visser, D.C., Hoefsloot, H.C.J., Iedema, P.D.

Multilevel component analysis of time-resolved metabolic fingerprinting data. (2005)

Jansen, J.J., Hoefsloot, H.C.J., Greef, J. Van Der, Timmerman, M.E., Smilde, A.K.

Lattice BGK of flow in a symmetric bifurcation (2004)

Artoli, A.M.M., Kandhai, D., Hoefsloot, H.C.J., Hoekstra, A.G., Sloot, P.M.A.

A conditional monte carlo method to predict branched architectures from MWD and branching of polyethylene for systems with a constrained geometry metallocene catalyst in continuous reactors (2004)

Iedema, P.D., Hoefsloot, H.C.J.

The role of polyradicals in predicting chain length distribution and gelation for radical polymerization with transfer to polymer (2004)

Iedema, P.D., Hoefsloot, H.C.J.

Molecular weight distribution modeling in low-density polyethylene polymerization; impact of scission mechanisms in the case of CSTR (2004)

Kim, D.M., Busch, M., Hoefsloot, H.C.J., Iedema, P.D.

Predicting the molecular weight distribution of polyethylene for mixed systems with a constrained-geometry metallocene catalyst in a semibatch reactor (2004)

Iedema, P.D., Hoefsloot, H.C.J., Smit, J.

On growth patterns of branched polymer architectures (2004)

Iedema, P.D., Hoefsloot, H.C.J.

Detailed mechanistic studies using in situ spectroscopic analysis: A look at little-known regions of the heck reaction (2004)

Rothenberg, G., Cruz, S.C., Hoefsloot, H.C.J.

The mechanism of the Heck reaction using palladium complexes with large phosphoramidite ligands is investigated. The catalyst precursor is an inactive dimer that equilibrates with the active...

Analysis of Longitudinal Metabolomics Data (2004)

Jansen, J.J., Hoefsloot, H.C.J., Boelens, H.F.M., Greef, J. Van Der, Smilde, A.K.

MOTIVATION: Metabolomics datasets are generally large and complex. Using principal component analysis (PCA), a simplified view of the variation in the data is obtained. The PCA model can be...

A conditional Monte Carlo method to predict branched architectures from molecular weight and degree of branching distribution of polyethylene for single and mixed systems with a constrained geometry metallocene catalyst in continuous reactors (2004)

Iedema, P.D., Hoefsloot, H.C.J.

Any two polymer molecules of the same length (n) and the same number of branch points (N) can have different properties, since they may possess distinct architectures. In this paper we present...

Lattice BGK simulations of flow in a symmetric bifurcation (2004)

Artoli, A.M.M., Kandhai, D., Hoefsloot, H.C.J., Hoekstra, A.G., Sloot, P.M.A.

Lattice Boltzmann, a robust and accurate solver for interactive computational hemodynamics (2003)

Artoli, A.M.M., Kandhai, B.D., Hoefsloot, H.C.J., Hoekstra, A.G., Sloot, P.M.A.

A conditional Monte Carlo method to determine the architectures of metallocene catalysed polyethylene (2003)

Iedema, P.D., Hoefsloot, H.C.J.

Predicting Molecular Weight Distribution of Polyethylene for Mixed Systems with a Constrained Geometry Metallocene Catalyst in a Semi-Batch Reactor (2003)

Iedema, P.D., Hoefsloot, H.C.J.

Predicting Molecular Weight and Degree of Branching Distribution of Polyethylene for Mixed Systems with a Constrained Geometry Metallocene Catalyst in Semibatch and Continuous Reactors (2003)

Iedema, P.D., Hoefsloot, H.C.J.

Molecular weight distribution modeling of radical polymerization in a CSTR with long chain branching through transfer to polymer and terminal double bond (TDB) propagation (2003)

Iedema, P.D., Grcev, S., Hoefsloot, H.C.J.

Mesoscopic simulation of polymer-solvent phase separation: linear chain behaviour and branching effects (2003)

Vliet, R.E. Van, Hoefsloot, H.C.J., Iedema, P.D.

Lattice Boltzmann: a robust and accurate solver for interactive computational hymodynamics (2003)

Artoli, A.M.M., Kandhai, B.D., Hoefsloot, H.C.J., Hoekstra, A.G., Sloot, P.M.A.

Surgical planning as a treatment for vascular diseases requires fast blood flow simulations that are efficient in handling changing geometry. It is, for example, necessary to try different paths of a...

Dynamics of Liquid-Liquid Demixing: Mesoscopic Simulations of Polymer Solutions (2002)

Vliet, R.E. Van, Dreischor, M.W., Hoefsloot, H.C.J., Iedema, P.D.

MWD Modeling of radical polymerization in batch and continuous reactors with transfer to polymer leading to gel formation (2002)

Iedema, P.D., Hoefsloot, H.C.J.

Mesoscopic Simulation of Polymers in Fluid Dynamics Problems (2002)

Willemsen, S.M., Hoefsloot, H.C.J., Iedema, P.D.

Constrained least squares methods for estimating reaction rate constants from spectroscopic data (2002)

Bijlsma, S., Boelens, H.F.M., Hoefsloot, H.C.J., Smilde, A.K.

How to choose the right process analyzer (2002)

Smilde, A.K., Hoefsloot, H.C.J.

Selection of optimal process analyzers for plant-wide monitoring (2002)

Hoefsloot, H.C.J., Smilde, A.K.

On-line Determination of the Conversion in a Styrene Bulk Polymerization Batch Reactor using Near-Infrared Spectroscopy (2002)

Lousberg, H.H.A., Boelens, H.F.M., Comte, E.P. Le, Hoefsloot, H.C.J., Smilde, A.K.

Development and validation of a fast size exclusion chromatographic method for at-line determination of the conversion of a polymerization reaction (2002)

Lousberg, H.H.A., Hoefsloot, H.C.J., Boelens, H.F.M., Schoenmakers, P.J., Smilde, A.K.

Constrained least squares methods for estimating reaction rate constants from spectroscopic data (2001)

Bijlsma, S., Boelens, H.F.M., Hoefsloot, H.C.J., Smilde, A.K.

The Influence of Micromixing on Molecular Weight Distribution during Controlled Polypropylene Degradation in a Static Mixer Reactor (2001)

Iedema, P.D., Fourcade, E., Hoefsloot, H.C.J., Vliet, G. Van, Bunge, W., Mutsers, S.M.P.

Transient gas-liquid flow in horizontal T-junctions (2001)

Ottens, M., Hoefsloot, H.C.J., Hamersma, P.J.

Correlations predicting liquid hold-up and pressure gradient in steady-state (nearly) horizontal co-current gas-liquid pipe flow (2001)

Ottens, M., Hoefsloot, H.C.J., Hamersma, P.J.

Sufficient conditions for unique solutions within a certain class of curve resolution models (2001)

Smilde, A.K., Hoefsloot, H.C.J., Kiers, H.A.L., Bijlsma, S., Boelens, H.F.M.

Process analyzer location and performance assessment for optimal process monitoring in a tubular reactor (2001)

Boelens, H.F.M., Smilde, A.K., Hoefsloot, H.C.J.

The Influence of Mixing on Molecular Weight Distribution During controlled Polymer Degradation in a Static Mixer Reactor (2001)

Hoefsloot, H.C.J., Fourcade, E., Vliet, G. Van, Bunge, W., Mutsers, S.M.P., Iedema, P.D.

The influence of micromixing on molecular weight distribution during controlled Polypropylene degradation in a static mixer reactor (2001)

Fourcade, E., Hoefsloot, H.C.J., Vliet, G. Van, Bunge, W., Mutsers, S.M.P., Iedema, P.D.

CFD calculation of laminar striation thinning in static mixer reactors (2001)

Fourcade, E., Wadley, R., Hoefsloot, H.C.J., Green, A., Iedema, P.D.

Using molecular weight distributions to determine the kinetics of peroxide-induced degradation of Polypropylene (2001)

Iedema, P.D., Willems, C., Vliet, G. Van, Bunge, W., Mutsers, S.M.P., Hoefsloot, H.C.J.

Computing radius of gyration distributions for reactor populations of highly random-branched polymers (2001)

Iedema, P.D., Hoefsloot, H.C.J.

Synthesis of branched polymer architectures from molecular weight and branching distributions for radical polymerization with long chain branching, accounting for topology-controlled random scission (2001)

Iedema, P.D., Hoefsloot, H.C.J.

The influence of branching architecture on scission in modeling free-radical polymerization with long chain branching and scission (2001)

Iedema, P.D., Hoefsloot, H.C.J.

Predicting properties of metallocene-based branched copolymers of propylene and ethylene from kinetics and reactor conditions (2000)

Iedema, P.D., Hoefsloot, H.C.J.

Modelling phase change with DPD using a consistent boundary condition (2000)

Willemsen, S.M., Hoefsloot, H.C.J., Visser, D.C., Hamersma, P.J., Iedema, P.D.

No-slip boundary condition in dissipative particle dynamics (2000)

Willemsen, S.M., Hoefsloot, H.C.J., Iedema, P.D.

Pressure induced phase separation with DPD (2000)

Vliet, R.E. Van, Hoefsloot, H.C.J., Hamersma, P.J., Iedema, P.D.

Modeling Molecular Weight and Degree of Branching Distribution of low density Polyethylene (2000)

Iedema, P.D., Wulkow, M., Hoefsloot, H.C.J.

Mixing of two liquids with different rheological behaviour in a lid driven cavity (2000)

Hoefsloot, H.C.J., Willemsen, S.M., Hamersma, P.J., Iedema, P.D.

Estimating reaction rate constants: comparison between traditional curve fitting and curve resolution (2000)

Bijlsma, S., Boelens, H.F.M., Hoefsloot, H.C.J., Smilde, A.K.

Selection of optimal sensor position in a tubular reactor using robust degrees of observability criteria (2000)

Hoefsloot, H.C.J., Boelens, H.F.M., Smilde, A.K.

Effect of small branch inclination on gas-liquid flow separation in T-junctions (1999)

Ottens, M., Hoefsloot, H.C.J., Hamersma, P.J.

Wave characteristics during co-current gas-liquid pipe flow (1999)

Ottens, M., Klinkspoor, K., Hoefsloot, H.C.J., Hamersma, P.J.

The Effect of Residence Time Distribution and Micromixing on Distributive Properties in Radical (Co)Polymerization with Composition Drift and Long Chain Branching (1998)

Iedema, P.D., Hamersma, P.J., Hoefsloot, H.C.J.

A method for the determination of flow regime transitions in bubble columns (1995)

Altena, R., Schouten, J.G., Hoefsloot, H.C.J., Hamersma, P.J.

Gas-liquid flow splitting in regular, reduced and impacting T junctions (1995)

Ottens, M., Swart, J.A. De, Hoefsloot, H.C.J., Hamersma, P.J.

Influence of increased gas density on the hydrodynamics of bubble column reactors. (1994)

Krishna, R., Hennephof, D.E., Ellenberger, J., Hoefsloot, H.C.J.

Gas-Liquid Flow Splitting in Regular, Reduced and Imparting T-junction. (1994)

Ottens, M., Swart, A., Hoefsloot, H.C.J., Hamersma, P.J.

Gas-Liquid Flow in Pipes and T-junction. (1994)

Ottens, M., Hoefsloot, H.C.J., Hamersma, P.J.

Marangoni Convection round a Ventilated Air Bubble under Microgravity conditions. (1994)

Hoefsloot, H.C.J., Hoogstraten, H.W.