Zalewski, J, Dubiel, J, Gajos, G, Legutko, J, Dudek, D, ...
The aim of this study was to estimate ischemic and reperfusive release of myocardial adenosine degradation products (MADP) during beta-adrenergic blockade and its relation to infarct size (IS) and...
Dubiel, J, Pieniazek, P, Dudek, D, Kocurek, A, Trebacz, J, ...
To evaluate the extent to which the protective effect of metoprolol was accompanied by changes in myocardial oxygen consumption and metabolism, thrombotic occlusion of coronary artery followed by...
Vanhecke, W, Mertens, D, Timmermans, C, ...
BACKGROUND: The optimal atrioventricular delay in dual-chamber pacing differs from patient to patient. The availability of a portable scintillation probe (VEST) enables noninvasive monitoring of left...
Three-dimensional correction for spillover and recovery of myocardial PET images (1996)
Vrolix, M, Schiepers, C, Schelbert, H, Kuhle, W, ...
PET permits the quantification of myocardial blood flow, but is hampered by the limited spatial resolution of PET images. METHODS: We evaluated two methods for the correction of resolution effects in...
The aim of this study was to evaluate the usefulness of dobutamine echocardiography (DE) in distinguishing necrotic from ischemic myocardium in infarct zones. We performed DE in 39 patients, 3 to 5...
Wilczek, K L, Vandorpe, J, Lan, P N, Schacht, E, ...
PURPOSE: To investigate the neointimal response to poly(organo)phosphazene- and amphiphilic polyurethane-coated, oversized, stainless steel stents implanted in porcine peripheral arteries. METHODS:...
Right atrial tumor arising on an atrial septal aneurysm. Assessment by MR imaging (1995)
De Man, F, Weemaes, K, De Geest, H, ...
An elderly women presenting with transient ischemic events underwent transesophageal echocardiography, which detected an aneurysm of the interatrial septum. A tumor protruding from the right atrial...
In vivo comparison between two tip pressure transducer systems (1995)
Experimental findings are presented of an in vivo comparison between a Sentron catheter and another tip transducer manometer: a Millar microtip catheter. Both catheters have been used simultaneously...
Platypnoea syndrome caused by atrial septal aneurysm (1995)
Timmermans, C, De Geest, H, Delanote, M, ...
A patient with platypnoea after right pneumonectomy and radiotherapy is described. On transoesophageal contrast echocardiography and cardiac catheterization, an atrial septal aneurysm with...
Wilczek, K L, Vandorpe, J, Lan, P N, Schacht, E, ...
Polymer coatings have been suggested to decrease the thrombogenicity of metallic intravascular stents. The purpose of the present study was to investigate the intimal response to two different...
Determinants of transmitral inflow pattern 10-14 days after acute myocardial infarction (1995)
Jang, I K, Brzostek, T, De Geest, H
AIM: The administration of thrombolytic therapy after an acute myocardial infarction can reduce the size of the infarct and improve left ventricular function. We used pulsed Doppler to assess left...
Wilczek, K V, Barios, L, De Geest, H
RATIONALE AND OBJECTIVES: We tested deployment feasibility and intraarterial biocompatibility of polyethylene terephthalate (PET) self-expandable vascular stents in a porcine peripheral artery model....
Scheys, I, Dubiel, J S, ...
This study examines possible covariates of left ventricular function two weeks and sixteen months after an acute infarction. It was performed in a group of 312 patients randomized double blindly to...
Dobutamine stress echocardiography after heart transplantation (1994)
Anastassiou, I, De Geest, H, ...
Dobutamine stress echocardiography was performed in 28 heart transplant recipients to study its value in the detection and staging of transplant vasculopathy. Fourteen patients had angiographic...
Ventricular electrograms and intramyocardial pressure signals were recorded in 11 dogs during sinus rhythm, during paced ventricular tachycardia, and at the onset of and during ventricular...
Vandommele, J, ...
A case is reported of recurrent intracerebral abscesses occurring in a patient with isolated drainage of a persistent left superior vena cava to the left atrium without causing cardiac symptoms or...
Intravenous (i.v.) metoprolol preceding thrombolysis in an anesthetized dog model of thrombotic occlusion of the anterior descending coronary artery helps limit infarct size (IS). We wished to...
Hyperlipidemia is common in heart transplant patients. Lipid-lowering therapy poses special problems, yet may be important because accelerated graft atherosclerosis is the major factor limiting...
OBJECTIVES. To study the effects of oral pretreatment with metoprolol over 3 days on hemodynamics, left ventricular function, regional myocardial blood flow, and infarct size in an anesthetized dog...
Scheys, I, Dubiel, J S, ...
Thrombolytic therapy salvages jeopardized myocardium and preserves left ventricular function. Therefore, a beneficial effect on exercise tolerance and haemodynamic adaptation to exercise can be...
Dubiel, J, Kaczmarek, J, ...
OBJECTIVES. We studied the effects of beta 1-adrenergic blockade preceding thrombolysis on hemodynamic variables, myocardial blood flow and infarct size in a canine model of thrombotic occlusion of...
Platypnea-orthodeoxia syndrome: a report of two cases (1994)
Two cases of orthostatic dyspnea and arterial desoxygenation, as a postpneumonectomy complication, are reported. In one patient, echocardiography and cardiac catheterization revealed the presence of...
Diagnostic value of transesophageal echocardiography in platypnea (1994)
Platypnea is a rare syndrome of orthostatic dyspnea frequently caused by an interatrial right-to-left shunt. The diagnosis is difficult. Assessment of arterial blood gases reveals orthostatic...
De Man, F, Wilczek, K, Barrios, L, Raymenants, E, ...
Quantitation of coronary luminal diameter with a 20 MHz mechanically rotating intravascular ultrasound (IVUS) catheter was compared with orthogonal-view cineangiography by use of a semiautomated...
Cardiac transplantation in giant cell myocarditis. A case report (1994)
Laruelle, C, Vanhaecke, Johan; U0011502, Van De Werf, Frans; U0009589, Flameng, Willem; U0018951, Verbeken, Eric; U0018420, Meyns, Bart; U0011101, ...
The present report describes a 15-year-old boy who underwent an urgent cardiac transplantation for giant cell myocarditis because of fulminant progressive heart failure, complicated by ventricular...
Role of intravascular ultrasound in coronary artery disease: a new gold standard? An overview (1994)
Although selective contrast coronary arteriography has been the gold standard approach for coronary imaging since more than 30 years, new coronary imaging techniques are currently under development....
Scheys, I, Dubiel, J, De Geest, H
The incidence of recurrent ischemia, congestive heart failure and death during the first year after discharge were analysed prospectively in a group of 312 patients randomized double blindly to rt-PA...
DE PAEP, G., BUNENS, B., BOGAERT, J. G., RADEMAKERS, F. E., BOSMANS, H. T., ...
Left ventricular volume was determined in 12 healthy volunteers using a newly developed two-dimensional echocardio-graphic delineation method. The results were compared with those of magnetic...
BRZOSTEK, T., DE WERF, F. VAN, MORTELMANS, L., SCHEYS, I., LESAFFRE, E., DUBIEL, J. S., ...
Thrombolytic therapy salvages jeopardized myocardium and preserves left ventricular function. Therefore, a beneficial effect on exercise tolerance and haemodynamic adaptation to exercise can be...
Scheys, I, Wackers, F, Brzostek, T, ...
In this study a new method for assessment of perfusion defects (PDs) derived from myocardial perfusion tomograms was evaluated in patients treated with thrombolytic therapy. Using global constraints...
Usefulness of echocardiography and Doppler in the detection of segmental myocardial ischemia (1993)
Echocardiography and Doppler was performed in 20 patients during percutaneous transluminal coronary angioplasty of a right coronary artery to evaluate the usefulness of echocardiography and Doppler...
Classification of death in patients under antiarrhythmic treatment (1993)
Rogers, R, Rubens, A, De Geest, H
In the evaluation of antiarrhythmic treatment, total mortality and total cardiac mortality are the only endpoints difficult to misclassify. End-stage cardiac failure competes with "suddenness" in...
Two patients with large pericardial thrombi following cardiac surgery presented as having right cardiac tamponade. Transesophageal echocardiography (TEE) identified a large pericardial hematoma...
De Geest, H, ...
Using global constraints and dynamic programming, a new model-based segmentation algorithm was developed to determine myocardial borders and basal plane. The segmented image is transformed to a...
Changes in left ventricular filling after valve replacement for aortic stenosis (1993)
In order to evaluate the short- and long-term effects of aortic valve replacement on the pattern of left ventricular inflow velocity, pulsed wave Doppler analysis was performed in 20 patients with...
Department of Cardiology, University Hospital Gasthuisberg, Leuven, Belgium.
Brzostek, T, Wackers, F J, Willems, G M, ...
OBJECTIVES. This study was conducted to explore mechanisms that could explain the possible clinical benefit of early administration of a beta 1-selective adrenoreceptor blocking agent or a...
We reviewed the coronary angiographic findings of 19 patients with a cardiac myxoma, who underwent cardiac catheterization before surgery. Seventeen myxomas were localized in the left atrium and...
Scheys, I, Brzostek, T, ...
The aim of the study was the functional re-evaluation of 296 patients 12 to 18 months after a double-blind trial evaluating the effect of tissue plasminogen activator (rt-PA) versus placebo given...
Vrolix, M, ...
The usefulness of echocardiography and Doppler for the detection of acute myocardial ischemia was evaluated during right coronary artery occlusion in 20 patients. The echocardiographic findings were...
Clinical applications of echocardiography in patients with acute myocardial infarction (1993)
The ability of echocardiography to visualize ventricular wall motion abnormalities induced by ischaemia and infarction makes it an ideal tool in the assessment of patients with acute myocardial...
Aubert, A E, Jordaens, L, Waleffe, A, De Geest, H, ...
Ninety-three patients, who underwent DC shock ablation were reviewed over a mean follow-up period of 54 months (range 3 to 84 months). These patients (46 male and 47 female, mean age: 58 years) had...
The value of intracoronary ultrasound for quantitative assessment of minimal coronary arterial diameter and for on-line evaluation of balloon angioplasty result was studied in 42 patients undergoing...
Isolated single coronary artery: a review of 50,000 consecutive coronary angiographies (1992)
Vrolix, M, ...
Single coronary artery is a rare congenital anomaly of the coronary arteries where only one coronary artery arises from the aortic trunk by a single coronary ostium, supplying the entire heart. A...
Glazier, J J, Vrolix, M C, De Geest, H, Willems, J L
The in-hospital and short-term follow-up results of a conservative coronary angioplasty approach in 354 consecutive patients treated after thrombolysis for acute myocardial infarction were compared...
Glazier, J J, Van Lierde, J, Vrolix, M, Willems, J L, ...
To assess the results of a conservative coronary angioplasty strategy in unstable angina pectoris, the records of 1,421 consecutive patients without previous myocardial infarction undergoing a first...
Vrolix, M C, Stammen, F, Vergauwen, B, De Geest, H, ...
In this study, the immediate and short-term outcome of 9 consecutive patients aged 80 years or older undergoing percutaneous transluminal coronary angioplasty (PTCA) are reported. Of these 9...
Denef, B, Aubert, A E, De Geest, H
Atrial transport function and the corresponding transmitral flow and stroke volume depend on the timing of atrial contraction. To study the influence of short atrioventricular delay (AVD) on these...
Benit, E, Vrolix, M C, Rocha, P, De Geest, H
Since its introduction in 1984, percutaneous transvenous mitral balloon valvuloplasty (PTMV) has emerged as an effective technique in the treatment of selected patients with severe mitral stenosis....
Coronary artery disease is frequently associated with disturbed blood lipids and with a deficient blood fibrinolytic capacity. In order to investigate a possible link between hypercholesterolemia and...
Isolated single coronary artery: a review of 50 000 consecutive coronary angiographies (1992)
DESMET, W., VANHAECKE, J., VROLIX, M., PIESSENS, J., WILLEMS, J., ...
Single coronary artery is a rare congenital anomaly of the coronary arteries where only one coronary artery arises from the aortic trunk by a single coronary ostium, supplying the entire heart. A...
Glazier, J J, Vrolix, M, De Geest, H, Willems, J L
The purpose of this study was to determine the long-term prognosis of patients with an isolated total occlusion of the left anterior descending artery (LAD). A total of 173 male patients with a...
Vrolix, M, Sionis, D, Glazier, J J, De Geest, H
The clinical value of intracoronary electrography for the detection of myocardia ischaemia was assessed during coronary angioplasty and compared to a standard technique of surface ECG monitoring. In...
Hemodynamic changes after subselective intracoronary administration of nisoldipine in humans (1991)
Sionis, D, Willems, J L, De Geest, H
Hemodynamic changes after the subselective intracoronary administration of 50 micrograms of nisoldipine were analyzed in 24 nonstenotic coronary arteries using a randomized, placebo-controlled,...
Crosstalk with external bipolar DVI pacing: a case report (1991)
An increase of the basic atrial pacing rate from a preset value of 70 beats/min up to 91 beats/min was recorded in a patient with an external bipolar dual chamber pacing system. This observation...
Ridogrel in the setting of percutaneous transluminal coronary angioplasty (1991)
Vrolix, M, Stammen, F, ...
The safety of the combination of heparin and ridogrel therapy and its antiplatelet efficacy was examined in the setting of percutaneous transluminal coronary angioplasty (PTCA). In 32 patients...
The effects of superoxide dismutase treatment on infarct size, postischemic recovery of contractile function and tissue content of high energy phosphates were examined in a canine model of myocardial...
Geboers, M, Sionis, D, De Geest, H
This report describes a patient with a single coronary artery system, in whom the right coronary artery originated from the distal left circumflex. A significant stenosis was present just at the...
Vrolix, M, Sionis, D, De Geest, H
A patient with chest pain of recent onset, suggestive for angina pectoris, was referred for diagnostic coronary angiography, which showed the typical phenomenon of "slow dye progression" in the...
Janssens, J, Ghillebert, G, De Geest, H
The prevalence of esophageal chest pain was studied prospectively in patients referred on an elective basis to a cardiac unit for suspected myocardial ischemia. A group of 248 consecutive patients...
Immediate and short-term results of a 1988-1989 coronary angioplasty registry (1991)
Vrolix, M, Glazier, J J, De Geest, H, Willems, J L
To determine the relevance of recent refinements in angioplasty technology to our particular practice, the records of 507 consecutive patients undergoing a first percutaneous transluminal coronary...
Torsades de pointes after intracoronary papaverine (1991)
Coronary blood flow velocity and coronary flow reserve can be assessed in humans using a coronary Doppler catheter and the vasodilator papaverine. Although it is a safe, elegant and reproducible...
A single oral dosage of 100, 200 or 300 mg Epanolol or placebo was administered in a randomized double-blind, cross-over fashion to 12 patients with stable effort angina. Symptom limited bicycle...
Changes in human coronary flow reserve after administration of intracoronary diltiazem (1991)
Sionis, D, Van Lierde, J, Willems, J L, De Geest, H
Epicardial coronary artery diameter (ECAD), coronary blood flow velocity (CBFV), and coronary flow velocity reserve (CFVR) were analyzed at baseline and after a 500 micrograms i.c. bolus of diltiazem...
Cabrera, E Z, Dorny, N, Thoeng, J, ...
A miniaturized radionuclide cardiac probe incorporated in a semi-rigid plastic chest garment has made ambulatory left ventricular (LV) function evaluation possible, with gated nuclear data being...
Percutaneous transvenous mitral valvuloplasty (PTMV) was performed with two cylindric pigtail balloon catheters in a 52-year-old woman with symptomatic mitral stenosis. The subvalvular apparatus was...
Outcome following coronary balloon angioplasty in young adults aged 35 years or less (1991)
Vergauwen, B, Stammen, F, Vrolix, M C, De Geest, H, ...
The natural history of symptomatic young patients with coronary artery disease is often far from benign. Follow-up studies of young patients who have undergone coronary bypass graft surgery show...
Vrolix, MC, Geboers, M, Sionis, D, De Geest, H
This report describes a patient with a single coronary artery system, in whom the right coronary artery originated from the distal left circumflex. A significant stenosis was present just at the...
PIESSENS, J., VROLIX, D., SIONIS, D., GLAZIER, J. J., DE GEEST, H., WILLEMS, J.
The clinical value of intracoronarv electrography for the detection ofmyocardial ischaemia was assessed during coronary angioplasty and compared to a standard technique of surface ECG monitoring. In...
PIESSENS, J., VROLIX, D., SIONIS, D., GLAZIER, J. J., DE GEEST, H., WILLEMS, J.
The clinical value of intracoronarv electrography for the detection ofmyocardial ischaemia was assessed during coronary angioplasty and compared to a standard technique of surface ECG monitoring. In...
The severity of the infarct-related residual coronary stenosis after spontaneous or therapeutic thrombolysis was quantitatively assessed in 91 patients with an acute myocardial infarction who were...
Effect of short atrioventricular delay on cardiac output (1990)
Denef, B, Aubert, A E, De Werf, V, De Geest, H
Short atrioventricular (AV) delay modifies late diastolic filling dynamics. The effect of this change on cardiac output (CO) was studied in closed chest, AV blocked canine preparations (N:10), during...
STUDY OBJECTIVE--The aim was to record diastolic transmitral pressure gradients at high sensitivity to quantitate the effect on transmitral pressure gradients of changing the heart rate....
Evidence for decreased coronary flow reserve in viable postischemic myocardium (1990)
Borgers, M, Jang, I K, De Geest, H
To try to unravel the complexity and heterogeneity of the "no-reflow" phenomenon and its underlying mechanisms, we studied tissue perfusion in reperfused heart muscle by using tracer microspheres in...
Infarction was provoked in the dog by introducing a copper coil into the left anterior descending coronary artery. Eight groups, each of 6 dogs, were studied which received various treatments and...
Arnold, A, Urbain, J L, Hermens, W, ...
In a double-blind trial of the European Cooperative Study Group, 721 patients with acute myocardial infarction of less than 5 hours' duration were given either 100 mg recombinant tissue-type...
Ochronosis and alkaptonuria: report of a new case with calcified aortic valve stenosis (1990)
Van Parijs, G, Bayart, M, Lauwerijns, J, De Geest, H
A patient with calcified aortic valve disease secondary to ochronosis and alkaptonuria is presented. Urgent aortic valve replacement was necessary. The cardiovascular complications of this disease...
Between October 1986 and January 1989, 57 attempts of percutaneous transluminal valvuloplasty were made in 51 elderly patients, mean age 76.7 +/- 6.2 years, with symptomatic aortic stenosis; this...
Between April 1988 and October 1989, 22 adult patients with isolated or predominant severe mitral stenosis underwent Percutaneous Transvenous Mitral Valvuloplasty (PTMV). In 20 patients, a...
The effects of beta-adrenergic blockade, thrombolysis and their combination on infarct size and left ventricular function were investigated in a canine model of thrombotic occlusion of the left...
Extracorporeal shock wave lithotripsy and cardiac arrhythmias (1989)
Holter monitoring was performed in 400 patients undergoing extracorporeal shock wave lithotripsy (ESWL). The highest heart rate occurred before and after ESWL. During respiratory-triggered ESWL, 30%...
Brzostek, T, Stammen, F, Vrolix, M, De Geest, H
To investigate the antiischemic efficacy of intravenously administered diltiazem, 42 patients were randomly allocated to receive placebo or active treatment before 1-vessel percutaneous transluminal...
Goldreyer, B N, Wyman, M E, Jacquemlyn, E, De Geest, H
The intra-atrial electrograms (P waves) from floating orthogonal atrial electrodes of acutely implanted pacemaker leads (SRT lead) were recorded and the frequency characteristics were determined. The...
A case report complicated by a perforation of the ascending aorta during percutaneous balloon valvuloplasty for acquired aortic stenosis in a bicuspid aortic valve is presented. The clinical and...
A consecutive series of 192 patients (121 men and 71 women, mean age 59 years, range 28 to 82) with isolated, severe valvular aortic stenosis was with isolated, severe valvular aortic stenosis was...
In a canine model of acute occlusion of the left anterior descending artery (LAD), left ventriculography was performed before and immediately after occlusion and also one and three weeks later....
Thrombo-embolic complication after streptokinase therapy of pulmonary emboli (1988)
A 58-year old patient is reported who developed an ischaemic cerebrovascular accident 22 hours after successful thrombolysis with streptokinase for life-threatening pulmonary emboli. Despite...
Angina pectoris and coronary artery disease in severe aortic regurgitation (1988)
A consecutive series of 198 patients (148 men and 50 women, mean age 51 years, range 18 to 76) with pure, isolated, severe aortic regurgitation was retrospectively studied to determine the prevalence...
New high-frequency catheter technique for His bundle ablation in dogs (1988)
Gewillig, M, Witters, E, ...
A new method is presented for the production of complete atrioventricular heart block. It consists of a special catheter, which is inserted into the right atrium via a femoral vein and positioned in...
Intravenous streptokinase during acute myocardial infarction. A prospective open study (1988)
To evaluate the efficacy of intravenous streptokinase in acute myocardial infarction (AMI) 108 patients received a high-dose (1.5 million units), short-term infusion (60 minutes) within 6 hours after...
An unusual case of guide wire fracture during percutaneous transluminal coronary angioplasty (1988)
We report a case of guide wire fracture during percutaneous transluminal coronary angioplasty, using one of the newer catheter systems. The broken free end of the guide wire remained within the...
Bajcsy-Zs. Hospital, Department of Cardiology, Budapest, Hungary.
Hyperparathyroidism is a rare, recently recognized cause of hypertrophic cardiomyopathy. Elevated serum levels of parathyroid hormone, rather than a rise in the extracellular calcium concentration,...
Recombinant tissue-type plasminogen activator (rt-PA) was administered intravenously to a 64-years old female with thrombotic malfunction of a Björk-Shiley prosthetic tricuspid valve. 150 mg of...
Minten, J, Cornelissen, F, De Geest, H
A technique is described which allows quantification of specifically stained, intermingled vessel wall components in paraffin-embedded tissue. The dissociation of elastic, muscular and connective...
The effect of beta-adrenergic blockade on the salvage and functional recovery of reperfused myocardium was investigated in anesthetized dogs. Immediately after thrombotic occlusion of the left...
A Caucasian female patient with repetitive attacks of ventricular tachycardia and fibrillation caused by annular submitral left ventricular aneurysm is reported. During a follow-up period of six...
Goldreyer, B N, Wyman, M G, Denys, B G, De Geest, H
To compare the sensing characteristics of a solid tip, target tip (Medtronic) and orthogonal electrodes within the right atrial appendage, atrial electrograms were simultaneously recorded from 2...
The dimensional variations of the superior vena cava throughout the cardiac cycle were investigated by means of angiographic and ultrasonic techniques. Results obtained by both methods were largely...
Sensing and pacing with floating electrodes in the right atrium and right atrial appendage (1987)
Goldreyer, B N, Wyman, M G, Denys, B G, De Geest, H
Unipolar and bipolar floating atrial electrograms from 58 pacemaker patients were recorded and compared. Twenty-four floating unipolar electrodes and 29 floating bipolar electrodes were used at...
An unexpected Q fever endocarditis. Report of a case (1987)
A man with blood culture negative endocarditis since 1983 received in October 1984 a mitral valve bioprosthesis. Reintervention in April 1985 was performed because of a paravalvular leak. In...
Complete occlusion of the main left coronary artery. A clinical study (1987)
Between 1975 and 1985, 12 patients with complete occlusion of the main left coronary artery (MLCA) were seen. The historical, clinical, biochemical, radiological, electrocardiographic,...
Unexplained chest pain with normal coronary arteriograms. A follow-up study (1987)
One hundred and forty-two consecutive patients with unexplained chest pain and normal coronary arteries were followed up for a mean period of 49.3 +/- 13.1 months. No cardiac deaths and one...
Effects of betaxolol on heart rate in patients with a recent transmural myocardial infarction (1987)
A randomized double-blind trial was performed with betaxolol, a beta 1-selective and long-acting beta-blocker, in patients with a recent first uncomplicated acute myocardial infarction (AMI)....
GEUKENS, R., ECTOR, H., STALPAERT, G., DE GEEST, H.
A Caucasian female patient with repetitive attacks of ventricular tachycardia and fibrillation caused by annular submitral left ventricular aneurysm is reported. During a follow-up period of six...
Cambier, P, Mombaerts, P, De Geest, H, Collen, D
Recombinant tissue-type plasminogen activator (rt-PA) was administered intravenously to a 64-years old female with thrombotic malfunction of a Bjork-Shiley prosthetic tricuspid valve. 150 mg of...
In a double-blind, placebo-controlled, randomized trial the long-term (+/- 3 months) effects of intravenous administration of recombinant tissue-type plasminogen activator (rt-PA) versus placebo were...
Axial pressure gradient in the canine superior vena cava (1986)
In the superior vena cava of anaesthetised open chest dogs the axial pressure gradient was measured simultaneously with the blood flow velocity under different preload conditions. Both pressure...
Verheyen, A, Cornelissen, F, De Geest, H
The mechanical properties (modulus of elasticity and stress-relaxation) of different venous segments of the canine superior vena cava were determined as well as the composition of the vessel wall by...
The automatic termination of malignant tachyarrhythmias and of ventricular fibrillation by an implantable device requires a reliable sensing of these episodes of abnormal ECG. Therefore, we induced...
Seventeen patients with acute transmural myocardial infarction and angiographically confirmed complete coronary occlusion were treated with heparin combined with intravenous single-chain...
In the superior vena cava of anaesthetized open chest dogs the axial pressure gradient (delta P) was measured simultaneously with the blood flow velocity (V) under a variety of preload conditions....
Coronary artery fistulas in an adult population (1986)
A consecutive series of 14 708 coronary arteriograms, performed between 1 April 1975 and 1 August 1983 was examined for the presence of coronary artery fistulas. The incidence was 0.13. There was 1...
The mechanism of disappearance of the physiologic third heart sound with age (1986)
Geboers, J, De Geest, H, Barrios, L
To study the mechanism of disappearance of the physiologic third heart sound (S3) with advancing age, combined phonoechocardiographic and phonomechanocardiographic recordings from 165 normal subjects...
We investigated wave morphology and spectral energy distributions of signals picked up by floating atrial unipolar and bipolar orthogonal sensing electrodes. Our data show that atrial P and QRS waves...
Aortic and mitral valve replacement in osteogenesis imperfecta. Report of a case (1986)
Stalpaert, J, Goddeeris, P, De Geest, H
A patient with osteogenesis imperfecta and mitral and aortic insufficiency, who underwent valve replacement, is described. The post-operative course was complicated by mitral valve dehiscence due to...
Closed chest myocardial biopsies: clinical uses and related problems (1986)
De Geest, H, Borgers, M, ...
Denef, B, Denys, B G, Jongeneel, F, De Geest, H
In order to study the influence of sudden left ventricular pressure rise on the calibrated apexcardiogram, 181 acute aortic occlusions were performed during systole in 7 dog experiments. For each...
Surgical treatment of acute, massive lung embolism. Results and follow-up (1986)
Stalpaert, Georges; U0013701, Suy, R, Daenen, Willem; U0018285, Flameng, Willem; U0018951, Nevelsteen, André; U0014280, ...
Between 1970 and 1984 the diagnosis of acute, massive lung embolism was made 30 times in our department. In 29 patients the clinical diagnosis was correct and a Trendelenburg operation under...
GILLEBERT, C., VAN HOOF, R., PIESSENS, J., DE GEEST, H.
A consecutive series of 14 708 coronary arteriograms, performed between 1 April 1975 and 1 August 1983 was examined for the presence of coronary artery fistulas. The incidence was 0.13. There was 1...
Intramyocardial pressure in the canine heart. An experimental study (1985)
During 11 acute open-chest experiments with dogs, intramyocardial pressure was measured in the anterior wall of the left ventricle with a miniature pressure transducer mounted on a 1.6 mm diameter...
Catheter technique for electrical ablation of the atrioventricular conduction system (1985)
Holvoet, G, Witters, E, De Geest, H
Seven patients with recurrent supraventricular arrhythmias, resistant to conventional drug therapy, were treated with electrical ablation of the atrioventricular (AV) conduction system. Permanent AV...
Twenty-one and a half per cent of the patients with acute myocardial infarction, admitted consecutively to the coronary care unit of the University Hospitals of Leuven in the period 1973-1979, died...
Emergency bypass surgery: late effects on size of infarction and ventricular function (1985)
Holvoet, G, Suy, R, ...
Using thallium myocardial scintigraphy and radionuclide ventriculography, we assessed size of infarction and left ventricular function at late follow-up (greater than 2 months) in 13 patients who...
Fourteen children had a permanent pacemaker implanted between May 1967 and July 1983. Postoperative complete heart block was the indication in nine cases, congenital complete heart block in three,...
Three cases of pseudoaneurysms of the left ventricle after aneurysmectomy are presented. Pseudoaneurysm formation was evidently caused by infection in one case. In the 2 other cases the pathogenetic...
Measurement of pacing threshold (1985)
Witters, E, Tanghe, L, De Geest, H
Thresholds in constant current and constant voltage are reported for 405 CPI 4118 (Cardiac Pacemakers, Inc.) tined leads. In 98% of the cases, the constant current threshold was equal to or lower...
PARDAENS, J., LESAFFRE, E., WILLEMS, J. L., DE GEEST, H.
Twenty one and a half per cent of the patients with acute myocardial infarction, admitted consecutively to the coronary care unit of the University Hospitals of Leuven in the period 1973–1979, died...
The influence of intrathoracic and intraluminal pressure on venous pressure pulse propagation velocity in the superior vena cava was investigated in acute canine experiments. The propagation velocity...
Grauwels, R, De Geest, H, Amery, A
Systolic time intervals (STIs) were measured in recumbency at rest and in the sitting position at rest and during exercise, before and after a physical training program, in 28 patients with coronary...
Bradycardia, ventricular pauses, syncope, and sports (1984)
Bourgois, J, Verlinden, M, Hermans, L, Vanden Eynde, E, ...
16 athletic patients were examined because of syncope, Stokes-Adams attacks, or both. The life-threatening condition required pacemaker implantation in 7 patients. 8 of the 9 other subjects became...
Thirteen patients with intractable ventricular arrhythmias were studied; they underwent long-term treatment by a combination of antiarrhythmic drugs and ventricular pacing. Eleven patients had a...
The genesis of the third and fourth heart sounds. A pressure-flow study in dogs (1984)
To examine the mechanism of mitral flow deceleration in diastole and its potential influence on the genesis of third (S3) and fourth (S4) heart sounds, we simultaneously recorded left atrial and left...
Boel, A, Geboers, J, Minten, J, De Geest, H, ...
To explore the pathogenesis of the third heart sound (S3), left ventricular hemodynamics in early diastole were studied during catheterization in normal adults without S3S (group I, n = 12) and in...
Ludbrook, P A, Bergmann, S R, Tiefenbrunn, A J, Fox, K A A, De Geest, H, ...
Tissue-type plasminogen activator is a naturally occurring, clot-selective activator of fibrinolysis. We recently reported that human tissue-type plasminogen activator isolated from a...
Bergmann, S R, Fox, K A A, De Geest, H, Hoyng, C F, Sobel, B E, ...
Coronary thrombolysis was induced by intravenous infusion of human tissue-type plasminogen activator (recombinant human t-PA or rt-PA) obtained by expression of the cloned gene in a mammalian cell...
Moerman, E, De Geest, H, Amery, A
Eighteen patients with ischaemic heart disease were trained for 3 months, three times a week. The effectiveness of the training programme was demonstrated by increases of 27% in peak oxygen uptake...
Grauwels, R, De Geest, H, Amery, A
Systolic time intervals (STI) were measured at rest before and after an exercise training programme in 37 patients with ischemic heart disease; 17 patients were treated with a beta-blocking drug...
Coronary artery surgery in patients with myxoedema (1984)
Thyroid replacement therapy in patients with myxoedema associated with coronary atherosclerosis often exacerbates angina or occasionally precipitates myocardial infarction. Coronary revascularization...
WlLLEMS, J.L., PARDAENS, J., DE GEEST, H.
The value of non-invasive, clinical variables in predicting short-term outcome after acute myocardial infarction has been prospectively studied using multivariate analysis in a learning population of...
The disappearance of the physiological third heart sound with age (1984)
Barrios, L, Aubert, André; U0004142, Geboers, J, De Geest, H, Van De Werf, Frans; U0009589
Apparent pulse wave velocity in the canine superior vena cava (1983)
In order to evaluate clinically recorded jugular vein pulses it is necessary to understand the transmission process of the right atrial pressure pulse through the caval veins up to the jugular veins....
Angiographic evolution of coronary atherosclerosis in non-operated patients (1983)
Repeat coronary arteriography was performed in 100 patients with angiographically proven coronary artery disease, because of worsening symptoms (n = 67), persistent stable angina (n = 22) or other...
Transfer characteristics of an ink-jet writer for cardiovascular studies (1983)
The transfer characteristic of a 16 channel ink-jet writer used in a cardiovascular laboratory is described. The test method for measuring linearity, gain and phase response is described and results...
A total of 2350 consecutive Holter recordings revealed that 53 patients had ventricular asystole of 3 seconds or more. The diagnoses based on the longest pauses were: sinus arrest in 19; AV block in...
Aubert, A E, Denef, B, De Geest, H
In order to compare an invasive with a noninvasive index of left ventricular stiffness during late diastole, M-mode echocardiogram, left ventricular pressure (LVP) and apexcardiogram (QLAC) were...
Evaluation of bedside myocardial scintigraphy with 201Tl in acute myocardial infarction (1982)
Bedside myocardial scintigraphy was performed on 149 patients admitted to the Coronary Care Unit (CCU), after IV injection of 74 MBq 201Tl, using a mobile gamma camera (Dynamo). The study was...
Comparative effects of alinidine and propranolol in ischaemic heart disease (1982)
The effects of single oral doses of alinidine 40 mg, propranolol 40 mg or placebo during a maximal exercise test on a bicycle ergometer in patients with angina pectoris were studied in a randomised,...
Relationship between apexcardiogram, left ventricular pressure and wall stress (1982)
Aubert, A E, Denef, B, De Geest, H
Simultaneous measurement of left ventricular dimension and wall thickness by M-mode echocardiography, of left ventricular pressure by a tip-transducer manometer, and of the calibrated apexcardiogram...
Suy, R, Schwarz, F, Borgers, M, Thone, F, ...
The relationships between structural alterations and left ventricular (LV) contraction abnormalities were studied in patients with coronary artery disease (CAD). Transmural biopsies of the LV...
An analysis was made of clinical and electrocardiographic prognostic determinants of multiple vessel disease in 100 men, aged under 45 years, who survived a myocardial infarction. All patients...
Post-traumatic infarction due to blunt chest trauma. Report of two cases (1980)
A myocardial infarction may be caused by a blunt chest trauma. The myocardium may be directly contused or a coronary artery may be occluded. The present paper describes a patient in whom no...
Dotremont, G, Goddeeris, P, De Geest, H
A 52 years old woman with mitral valve prolapse and a history of 3 cardiac syncopes occurring during antiarrhythmic therapy underwent mitral valve replacement. Antiarrhythmic drugs had to be...
A new test for pacemaker leads: capacitance measurement (1978)
A device has been developed which permits in man the measurement of the capacitance of a chronically implanted pacemaker lead at the moment of battery replacement. A large increase in capacitance...
Value of apexcardiography for the timing of left ventricular events in man (1978)
The time relationship between left apexcardiogram and left ventricular pressure was studied in 56 patients with heart disease. The apexcardiogram was recorded by means of a pressure transducer in 20...
A patient with left atrial myxoma is described. Selective coronary arteriography visualized a cluster of abnormal vessels representing the vascularization of the tumoral mass localized in the left...
Initial experience with coronary artery bypass graft surgery. A follow-up study (1977)
The preoperative, postoperative and late follow-up data of an initial series of two hundred patients with coronary artery disease, who underwent direct coronary artery surgery, were analyzed. With...
The relation between the left displacement apex cardiogram and the left ventricular pressure during isovolumic contraction was studied in 30 patients with cardiac disease. Using the instantaneous...
Results of follow-up study in cardiac pacing at St. Raphael University Hosital in Leuven (1976)
Emmerechts, C, De Schepper, S, De Geest, H
After this follow-up period some data seem important for the future: 1. Sudden failure never occurred for ventricular asynchronous units. Moreover battery survival time of fixed rate units is longer...
Anomalous coronary arterial pattern (1976)
The clinical history of an adult patient with anginal-like pain is described. A coronary angiography revealed the existence of a hypoplastic left coronary artery, a right coronary artery which passed...
In 26 patients a direct comparison was made of systolic time intervals derived from the right and left external carotid pulse tracing and from the central aortic pressure, simultaneously recorded by...
In 38 cardiac patients a direct comparison was made of systolic time intervals derived from the external carotid pulse tracing and from the central aortic pressure curve, simultaneously recorded by...
Experience with the Björk-Shiley valve prosthesis (1973)
Suy, R, Ngalipkina, V, Heerinckx, J, Kesteloot, M, ...
The genesis of the third and fourth heart sounds. A pressure-flow study in dogs.
Minten, J, Carmeliet, P, De Geest, H, Kesteloot, H
To examine the mechanism of mitral flow deceleration in diastole and its potential influence on the genesis of third (S3) and fourth (S4) heart sounds, we simultaneously recorded left atrial and left...
Vandepitte, J, De Geest, H, Jousten, P
A case of subacute bacterial endocarditis due to Actinobacillus actinomycetemcomitans is reported. The patient was successfully treated first by a combination of gentamicin and ampicillin and then,...
The genesis of the third and fourth heart sounds. A pressure-flow study in dogs.
Minten, J, Carmeliet, P, De Geest, H, Kesteloot, H
To examine the mechanism of mitral flow deceleration in diastole and its potential influence on the genesis of third (S3) and fourth (S4) heart sounds, we simultaneously recorded left atrial and left...
Vandepitte, J, De Geest, H, Jousten, P
A case of subacute bacterial endocarditis due to Actinobacillus actinomycetemcomitans is reported. The patient was successfully treated first by a combination of gentamicin and ampicillin and then,...
Ector, H, Dhooghe, G, Daenen, W, Stalpaert, G, De Geest, H
Fourteen children had a permanent pacemaker implanted between May 1967 and July 1983. Postoperative complete heart block was the indication in nine cases, congenital complete heart block in three,...
Comparability and reproducibility of apex cardiogram recorded with six different transducer systems.
Willems, J L, Denef, B, Kesteloot, H, De Geest, H
A comparison was made in 7 dogs of the results obtained by 6 different apex cardiographic transducers applied before, during, and after controlled infusion of angiotensin and isoprenaline. The...
Familial centronuclear myopathy associated with 'cardiomyopathy'.
Verhiest, W, Brucher, J M, Goddeeris, P, Lauweryns, J, De Geest, H
Two cases of familial centronuclear myopathy are described. Both presented features of 'cardiomyopathy and one had signs of slight congenital aortic stenosis. The 'cardiomyopathy' was fatal in one...