Homeostatic mechanisms in dopamine synthesis and release: a mathematical model (2009)
Best, Janet A, Nijhout, H Frederik, Reed, Michael C
Abstract Background Dopamine is a catecholamine that is used as a neurotransmitter both in the periphery and in the central nervous system. Dysfunction in various dopaminergic systems is known to be...
A mathematical model of glutathione metabolism (2008)
Reed, Michael C, Thomas, Rachel L, Pavisic, Jovana, James, S Jill, Ulrich, Cornelia M, Nijhout, H Frederik
Abstract Background Glutathione (GSH) plays an important role in anti-oxidant defense and detoxification reactions. It is primarily synthesized in the liver by the transsulfuration pathway and...
CHAPTER 8 Stochastic Gene Expression: Dominance, Thresholds and Boundaries (2008)
Butterfly color patterns are built as finely tiles mosaics of colored scales, each the product of a single epidermal cell. The overall pattern is composed of a small number of pigments. Each scale...
In silico experimentation with a model of hepatic mitochondrial folate metabolism (2006)
Nijhout, H Frederik, Reed, Michael C, Lam, Shi-Ling, Shane, Barry, Gregory, Jesse F, Ulrich, Cornelia M
Abstract Background In eukaryotes, folate metabolism is compartmentalized and occurs in both the cytosol and the mitochondria. The function of this compartmentalization and the great changes that...
Propagation of Fluctuations in Biochemical Systems, I: Linear SSC Networks (2005)
Anderson, David, Mattingly, Jonathan, Nijhout, H. Frederik, Reed, Michael
We investigate the propagation of random fluctuations through biochemical networks in which the concentrations of species are large enough so that the unperturbed problem is well-described by...
Davidowitz, Goggy, Roff, Derek A., Nijhout, H. Frederik
Natural selection typically acts on multiple traits simultaneously. Quantitative genetics provides the theory for predicting the response to selection of multiple traits and predicts symmetrical...
Davidowitz, Goggy, Nijhout, H. Frederik
The general effects of temperature and nutritional quality on growth rate and body size are well known. We know little, however, about the physiological mechanisms by which an organism translates...
Armin P. Moczek, H. Frederik Nijhout
Dung beetles of the genus Onthophagus Latreille are used as model systems in behavioral ecology, evolutionary biology, and insect development. In the past, studies on the developmental control of...
Ontogeny, Phylogeny and Evolution of Form: An Algorithmic Approach (1986)
Nijhout, H. Frederik, Wray, Gregory A., Claire, Kremen, Teragawa, Carolyn K.
A computer model that simulates general aspects of ontogeny is presented as a heuristic device for studying the relationship between ontogenetic changes and the evolution of morphologies. The model...
Physiological Control of Molting in Insects (1981)
SYNOPSIS. The initiation of a molting cycle in insects is neither a random nor a strictly periodic event. Insofar as molting can accomplish different things under different circumstances, such as a...
Bombyxin is a growth factor for wing imaginal disks in Lepidoptera
Nijhout, H. Frederik, Grunert, Laura W.
The mechanisms that control the growth rate of internal tissues during postembryonic development are poorly understood. In insects, the growth rate of imaginal disks varies with nutrition and keeps...
Boyles, Abee L., Billups, Ashley V., Deak, Kristen L., Siegel, Deborah G., Mehltretter, Lorraine, Slifer, Susan H., ...
In silico experimentation with a model of hepatic mitochondrial folate metabolism
Nijhout, H Frederik, Reed, Michael C, Lam, Shi-Ling, Shane, Barry, Gregory, Jesse F, Ulrich, Cornelia M
Bombyxin is a growth factor for wing imaginal disks in Lepidoptera
Nijhout, H. Frederik, Grunert, Laura W.
The mechanisms that control the growth rate of internal tissues during postembryonic development are poorly understood. In insects, the growth rate of imaginal disks varies with nutrition and keeps...
Boyles, Abee L., Billups, Ashley V., Deak, Kristen L., Siegel, Deborah G., Mehltretter, Lorraine, Slifer, Susan H., ...
Leduc, Damien, Escartin, Frédéric, Nijhout, H. Frederik, Reed, Michael C., Liebl, Ursula, Skouloubris, Stéphane, ...
Although flavin-dependent ThyX proteins show thymidylate synthase activity in vitro and functionally complement thyA defects in heterologous systems, direct proof of their cellular functions is...