H. H. J. Backus

5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients (2001)

Backus, H. H. J., Dukers, D. F., Van Groeningen, C. J., Vos, W., Bloemena, E., Wouters, D., ...

Background: In vitro, thymidylate synthase (TS) inhibition by 5-fluorouracil (5-FU) induces thymineless apoptosis possibly via Fas receptor–Fas ligand interactions and cell-cycle arrest. In...

Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer (2001)

Backus, H. H. J., Van Groeningen, C. J., Vos, W., Dukers, D. F., Bloemena, E., ...

Background: Thymidylate synthase (TS) has been associated with clinical outcome in disseminated colorectal cancer. However, many patients with lowTS expression still fail to respond to treatment....

Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels

Giovannetti, E, Backus, H H J, Wouters, D, Ferreira, C G, Brakenhoff, R H, ...

Colorectal cancer (CRC) resistance to fluoropyrimidines and other inhibitors of thymidylate synthase (TS) is a serious clinical problem often associated with increased intracellular levels of TS....