Heinzer, S, Kuhn, G, Krucker, T, Meyer, E, Ulmann-Schuler, A, Stampanoni, M, ...
To adequately supply tissues with oxygen and nutrients, the formation of functional vascular networks requires generation of normal, healthy vessels and their arrangement into an effective network...
Flt-1, but not Flk-1 mediates hyperpermeability through activation of the PI3-K/Akt pathway (2007)
Vogel, C., Bauer, A., Wiesnet, M., Preissner, K. T., Schaper, W., Marti, H. H., ...
Vascular endothelial growth factor (VEGF), a potent mediator of endothelial proliferation and migration, has an important role also in brain edema formation during hypoxia and ischemia. VEGF binds to...
Schäffer, L, Scheid, A, Spielmann, P, Breymann, C, Zimmermann, R, Meuli, M, ...
The transforming growth factor-beta 3 (TGF-beta 3) is involved in oxygen-dependent differentiation processes during placental development and pregnancy disorders. However, the importance of oxygen...
Targeted disruption of the mouse PAS domain serine/threonine kinase PASKIN. (2003)
Katschinski, D M, Marti, H H, Wagner, K F, Shibata, J, Eckhardt, K, Martin, F, ...
Copyright © 2007, the American Society for Microbiology. All rights reserved
p38 MAPK - a molecular switch between angiogenesis and vascular permeability (2002)
Ißbrücker, K., Marti, H.H., Hippenstiel, S., Springmann, G., Vosswinkel, R., Gaumann, A., ...
Marti, H H, Katschinski, D M, Wagner, K F, Schäffer, L, Stier, B, Wenger, R H
The heterodimeric hypoxia-inducible factor (HIF)-1 is a transcriptional master regulator of several genes involved in mammalian oxygen homeostasis, including erythropoietin, vascular endothelial...
Pavlicek, V, Marti, H H, Grad, S, Gibbs, J S, Kol, C, Wenger, R H, ...
In order to investigate whether vascular endothelial growth factor (VEGF) and inflammatory pathways are activated during acute hypobaric hypoxia in subjects who are susceptible to high-altitude...
Wenger, R H, Marti, H H, Bauer, C, Gassmann, M
Hypoxia is thought to be a common precursor of coronary artery disease and malignant tumors, both diseases representing the leading causes of death in industrial nations. So far, investigations of...
The hypoxia-inducible factor-1 DNA recognition site is cAMP-responsive. (1997)
Kvietikova, I, Wenger, R H, Marti, H H, Gassmann, M
The hypoxia-inducible factor-1 (HIF-1) was first described as a DNA binding activity that specifically recognizes an 8 bp hypoxia response element (HRE) known to be essential for oxygen-regulated...
Hypoxia-inducible factor-1 alpha is regulated at the post-mRNA level. (1997)
Wenger, R H, Kvietikova, I, Rolfs, A, Gassmann, M, Marti, H H
The hypoxia-inducible factor-1 (HIF-1) is involved in the induction of oxygen regulated genes such as erythropoietin and vascular endothelial growth factor (VEGF). HIF-1 is a heterodimeric...
Marti, H H, Gassmann, M, Wenger, R H, Kvietikova, I, Morganti-Kossmann, M C, Kossmann, T, ...
Until now, erythropoietin (EPO) was thought to be produced exclusively in fetal liver and adult kidney and to regulate mammalian erythropoiesis. However, we recently showed that steady state levels...
Wenger, R H, Rolfs, A, Marti, H H, Guénet, J L, Gassmann, M
The heterodimeric hypoxia-inducible transcription factor HIF-1 is involved in the oxygen-regulated transcription of several genes including erythropoietin. Cloning and sequencing of the alpha-subunit...
Oxygen supply and oxygen-dependent gene expression in differentiating embryonic stem cells. (1996)
Gassmann, M, Fandrey, J, Bichet, S, Wartenberg, M, Marti, H H, Bauer, C, ...
Blastocyst-derived pluripotent mouse embryonic stem cells can differentiate in vitro to form so-called embryoid bodies (EBs), which recapitulate several aspects of murine embryogenesis. We used this...
Erythropoietin gene expression in human, monkey and murine brain. (1996)
Marti, H H, Wenger, R H, Rivas, L A, Straumann, U, Digicaylioglu, M, Henn, V, ...
The haematopoietic growth factor erythropoietin is the primary regulator of mammalian erythropoiesis and is produced by the kidney and the liver in an oxygen-dependent manner. We and others have...
Wenger, R H, Marti, H H, Schuerer-Maly, C C, Kvietikova, I, Bauer, C, Gassmann, M, ...
“This research was originally published in Blood. [1996,87(2):756-61]. Copyright by the American Society of Hematology“.
Kvietikova, I, Wenger, R H, Marti, H H, Gassmann, M
The hypoxia-inducible factor-1 (HIF-1) was first described as a DNA binding activity that specifically recognizes an 8 bp motif known to be essential for hypoxia-inducible erythropoietin gene...
Hypoxia, a novel inducer of acute phase gene expression in a human hepatoma cell line. (1995)
Wenger, R H, Rolfs, A, Marti, H H, Bauer, C, Gassmann, M
Transcriptional regulation of gene expression by hypoxia is an important, but yet only marginally characterized mechanism by which organisms adapt to low oxygen concentrations. The human hepatoma...
Localization of specific erythropoietin binding sites in defined areas of the mouse brain. (1995)
Digicaylioglu, M, Bichet, S, Marti, H H, Wenger, R H, Rivas, L A, Bauer, C, ...
The main physiological regulator of erythropoiesis is the hematopoietic growth factor erythropoietin (EPO), which is induced in response to hypoxia. Binding of EPO to the EPO receptor (EPO-R), a...
Oxygen supply and oxygen-dependent gene expression in differentiating embryonic stem cells.
Gassmann, M, Fandrey, J, Bichet, S, Wartenberg, M, Marti, H H, Bauer, C, ...
Blastocyst-derived pluripotent mouse embryonic stem cells can differentiate in vitro to form so-called embryoid bodies (EBs), which recapitulate several aspects of murine embryogenesis. We used this...
Localization of specific erythropoietin binding sites in defined areas of the mouse brain.
Digicaylioglu, M, Bichet, S, Marti, H H, Wenger, R H, Rivas, L A, Bauer, C, ...
The main physiological regulator of erythropoiesis is the hematopoietic growth factor erythropoietin (EPO), which is induced in response to hypoxia. Binding of EPO to the EPO receptor (EPO-R), a...
Kvietikova, I, Wenger, R H, Marti, H H, Gassmann, M
The hypoxia-inducible factor-1 (HIF-1) was first described as a DNA binding activity that specifically recognizes an 8 bp motif known to be essential for hypoxia-inducible erythropoietin gene...
Oxygen supply and oxygen-dependent gene expression in differentiating embryonic stem cells.
Gassmann, M, Fandrey, J, Bichet, S, Wartenberg, M, Marti, H H, Bauer, C, ...
Blastocyst-derived pluripotent mouse embryonic stem cells can differentiate in vitro to form so-called embryoid bodies (EBs), which recapitulate several aspects of murine embryogenesis. We used this...
Localization of specific erythropoietin binding sites in defined areas of the mouse brain.
Digicaylioglu, M, Bichet, S, Marti, H H, Wenger, R H, Rivas, L A, Bauer, C, ...
The main physiological regulator of erythropoiesis is the hematopoietic growth factor erythropoietin (EPO), which is induced in response to hypoxia. Binding of EPO to the EPO receptor (EPO-R), a...
Kvietikova, I, Wenger, R H, Marti, H H, Gassmann, M
The hypoxia-inducible factor-1 (HIF-1) was first described as a DNA binding activity that specifically recognizes an 8 bp motif known to be essential for hypoxia-inducible erythropoietin gene...