H. H. Schmidt

Publication List Details

Period

1981 - 1987

Number

34

Co-Authors

Nitric oxide synthase in macula densa regulates glomerular capillary pressure.

Wilcox, C S, Welch, W J, Murad, F, Gross, S S, Taylor, G, Levi, R, ...

Tubular-fluid reabsorption by specialized cells of the nephron at the junction of the ascending limb of the loop of Henle and the distal convoluted tubule, termed the macula densa, releases compounds...

Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.

Schmidt, H H, Pollock, J S, Nakane, M, Gorsky, L D, Förstermann, U, Murad, F

The soluble form of guanylyl cyclase-activating-factor (GAF) synthase from rat cerebellum was purified to homogeneity by sequential affinity chromatographic steps on adenosine 2',5'-bisphosphate...

Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.

Förstermann, U, Pollock, J S, Schmidt, H H, Heller, M, Murad, F

Endothelium-derived relaxing factor/nitric oxide (EDRF/NO) synthesized by bovine aortic endothelial cells and subcellular fractions thereof was assayed by its stimulating effect on soluble guanylyl...

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.

Pollock, J S, Förstermann, U, Mitchell, J A, Warner, T D, Schmidt, H H, Nakane, M, ...

The particulate enzyme responsible for the synthesis of endothelium-derived relaxing factor has been purified from cultured and native (noncultured) bovine aortic endothelial cells. Purification of...

Functional coupling of a Ca2+/calmodulin-dependent nitric oxide synthase and a soluble guanylyl cyclase in vertebrate photoreceptor cells.

Koch, K W, Lambrecht, H G, Haberecht, M, Redburn, D, Schmidt, H H

Electrophysiological recordings on retinal rod cells, horizontal cells and on-bipolar cells indicate that exogenous nitric oxide (NO) has neuromodulatory effects in the vertebrate retina. We report...

Human soluble guanylate cyclase: functional expression and revised isoenzyme family.

Zabel, U, Weeger, M, La, M, Schmidt, H H

Soluble guanylate cyclase (sGC), a heterodimeric (alpha/beta) haem protein that converts GTP to the second messenger cGMP, functions as the receptor for nitric oxide (NO) and nitrovasodilator drugs....

Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity.

Kotsonis, P, Frey, A, Fröhlich, L G, Hofmann, H, Reif, A, Wink, D A, ...

Nitric oxide (NO) synthases (NOSs), which catalyse the oxidation of L-arginine to L-citrulline and an oxide of nitrogen, possibly NO or nitroxyl (NO-), are subject to autoinhibition by a mechanism...

Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide.

Kotsonis, P, Fröhlich, L G, Shutenko, Z V, Horejsi, R, Pfleiderer, W, Schmidt, H H

The underlying mechanisms regulating the activity of the family of homodimeric nitric oxide synthases (NOSs) and, in particular, the requirement for (6R)-5,6,7,8-tetrahydro-L-biopterin (H(4)Bip) are...

Pterin interactions with distinct reductase activities of NO synthase.

Pantke, M M, Reif, A, Valtschanoff, J G, Shutenko, Z, Frey, A, Weinberg, R J, ...

Besides oxidizing L-arginine, neuronal NO synthase (NOS) NADPH-dependently reduces various electron acceptors, including cytochrome c and tetrazolium salts. The latter NADPH diaphorase reaction is...

Nitric oxide synthase in macula densa regulates glomerular capillary pressure.

Wilcox, C S, Welch, W J, Murad, F, Gross, S S, Taylor, G, Levi, R, ...

Tubular-fluid reabsorption by specialized cells of the nephron at the junction of the ascending limb of the loop of Henle and the distal convoluted tubule, termed the macula densa, releases compounds...

Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.

Schmidt, H H, Pollock, J S, Nakane, M, Gorsky, L D, Förstermann, U, Murad, F

The soluble form of guanylyl cyclase-activating-factor (GAF) synthase from rat cerebellum was purified to homogeneity by sequential affinity chromatographic steps on adenosine 2',5'-bisphosphate...

Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.

Förstermann, U, Pollock, J S, Schmidt, H H, Heller, M, Murad, F

Endothelium-derived relaxing factor/nitric oxide (EDRF/NO) synthesized by bovine aortic endothelial cells and subcellular fractions thereof was assayed by its stimulating effect on soluble guanylyl...

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.

Pollock, J S, Förstermann, U, Mitchell, J A, Warner, T D, Schmidt, H H, Nakane, M, ...

The particulate enzyme responsible for the synthesis of endothelium-derived relaxing factor has been purified from cultured and native (noncultured) bovine aortic endothelial cells. Purification of...

Functional coupling of a Ca2+/calmodulin-dependent nitric oxide synthase and a soluble guanylyl cyclase in vertebrate photoreceptor cells.

Koch, K W, Lambrecht, H G, Haberecht, M, Redburn, D, Schmidt, H H

Electrophysiological recordings on retinal rod cells, horizontal cells and on-bipolar cells indicate that exogenous nitric oxide (NO) has neuromodulatory effects in the vertebrate retina. We report...

Human soluble guanylate cyclase: functional expression and revised isoenzyme family.

Zabel, U, Weeger, M, La, M, Schmidt, H H

Soluble guanylate cyclase (sGC), a heterodimeric (alpha/beta) haem protein that converts GTP to the second messenger cGMP, functions as the receptor for nitric oxide (NO) and nitrovasodilator drugs....

Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity.

Kotsonis, P, Frey, A, Fröhlich, L G, Hofmann, H, Reif, A, Wink, D A, ...

Nitric oxide (NO) synthases (NOSs), which catalyse the oxidation of L-arginine to L-citrulline and an oxide of nitrogen, possibly NO or nitroxyl (NO-), are subject to autoinhibition by a mechanism...

Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide.

Kotsonis, P, Fröhlich, L G, Shutenko, Z V, Horejsi, R, Pfleiderer, W, Schmidt, H H

The underlying mechanisms regulating the activity of the family of homodimeric nitric oxide synthases (NOSs) and, in particular, the requirement for (6R)-5,6,7,8-tetrahydro-L-biopterin (H(4)Bip) are...

Pterin interactions with distinct reductase activities of NO synthase.

Pantke, M M, Reif, A, Valtschanoff, J G, Shutenko, Z, Frey, A, Weinberg, R J, ...

Besides oxidizing L-arginine, neuronal NO synthase (NOS) NADPH-dependently reduces various electron acceptors, including cytochrome c and tetrazolium salts. The latter NADPH diaphorase reaction is...

Human brain contains a metalloprotease that converts big endothelin-1 to endothelin-1 and is inhibited by phosphoramidon and EDTA.

Warner, T. D., Schmidt, H. H., Kuk, J., Mitchell, J. A., Murad, F.

Incubation of big endothelin-1 (bET-1) with protein derived from the detergent-extracted 100,000 g pellet prepared from human brain tissue resulted in the formation of endothelin-1 (ET-1) at a rate...

Characterization and localization of nitric oxide synthase in non-adrenergic non-cholinergic nerves from bovine retractor penis muscles.

Sheng, H., Schmidt, H. H., Nakane, M., Mitchell, J. A., Pollock, J. S., Föstermann, U., ...

1. Partially purified soluble nitric oxide (NO) synthase was isolated from the bovine retractor penis muscle (BRP), a tissue in which the inhibitory response to non-adrenergic non-cholinergic nerve...

Nitric oxide synthase in ferret brain: localization and characterization.

Matsumoto, T., Mitchell, J. A., Schmidt, H. H., Kohlhaas, K. L., Warner, T. D., Förstermann, U., ...

1. In the present study, we have investigated the distribution of nitric oxide synthase in the ferret brain. Nitric oxide synthase was determined biochemically and immunochemically. 2. In the rat...

L-arginine and arginine analogues: effects on isolated blood vessels and cultured endothelial cells.

Schmidt, H. H., Baeblich, S. E., Zernikow, B. C., Klein, M. M., Böhme, E.

1. The present study examined effects of arginine (Arg) and various Arg analogues on the vascular tone of rabbit and rat aortic rings, the release of nitrite from cultured bovine aortic endothelial...