H. Hauser

Publication List Details

Period

1980 - 2008

Number

123

Co-Authors

The genome of the simian and human malaria parasite Plasmodium knowlesi (2008)

Pain, A., Bohme, U., Berry, A.E., Mungall, K., Finn, R.D., Jackson, A.P., ...

Plasmodium knowlesi is an intracellular malaria parasite whose natural vertebrate host is Macaca fascicularis (the 'kra' monkey); however, it is now increasingly recognized as a significant cause of...

Path Line Oriented Topology for Periodic 2D Time-Dependent Vector Fields (2008)

Thomas Ertl, Ken Joy, Beatriz Santos (editors, K. Shi, H. Theisel, T. Weinkauf, ...

This paper presents an approach to extracting a path line oriented topological segmentation for periodic 2D timedependent vector fields. Topological methods aiming in capturing the asymptotic...

Nanoimprint Lithographie mit interferenzlithographisch hergestellten Stempeln (2007)

Hauser, H.

Die Effizienz von Solarzellen kann durch eine Texturierung der Oberfläche gesteigert werden. Die zu Grunde liegenden Effekte hierzu sind eine Reduktion der Reflektivität der Oberfläche und der...

Nanoimprint Lithographie mit interferenzlithographisch hergestellten Stempeln (2007)

Hauser, H.

Die Effizienz von Solarzellen kann durch eine Texturierung der Oberfläche gesteigert werden. Die zu Grunde liegenden Effekte hierzu sind eine Reduktion der Reflektivität der Oberfläche und der...

The genome of Rhizobium leguminosarum has recognizable core and accessory components (2006)

Young, J.P.W., Crossman, L.C., Johnston, A.W.B., Thomson, N.R., Ghazoui, Z.F., Hull, K.H., ...

Background Rhizobium leguminosarum is an α-proteobacterial N2-fixing symbiont of legumes that has been the subject of more than a thousand publications. Genes for the symbiotic interaction with...

The genome of Rhizobium leguminosarum has recognizable core and accessory components (2006)

Young, J.P.W., Crossman, L.C., Johnston, A.W.B., Thomson, N.R., Ghazoui, Z.F., Hull, K.H., ...

Background Rhizobium leguminosarum is an α-proteobacterial N2-fixing symbiont of legumes that has been the subject of more than a thousand publications. Genes for the symbiotic interaction with...

The genome of Rhizobium leguminosarum has recognizable core and accessory components (2006)

Young, J.P.W., Crossman, L.C., Johnston, A.W.B., Thomson, N.R., Ghazoui, Z.F., Hull, K.H., ...

Background Rhizobium leguminosarum is an α-proteobacterial N2-fixing symbiont of legumes that has been the subject of more than a thousand publications. Genes for the symbiotic interaction with...

UFOs -- Unidentified Figurative Objects. A Geometric Challenge (2005)

Bruschek, C., Gann, S., Hauser, H., Wagner, D., Zeillinger, D.

Choose a polynomial in three variables with not more than three or four monomials of moderate degree. Take simple coefficients as 1 and -1. Then draw a picture of the solution variety in real three...

The genome of the African trypanosome Trypanosoma brucei (2005)

Berriman, M., Ghedin, E., Hertz-Fowler, C., Blandin, G., Renauld, H., Bartholomeu, D.C., ...

African trypanosomes cause human sleeping sickness and livestock trypanosomiasis in sub-Saharan Africa. We present the sequence and analysis of the 11 megabase-sized chromosomes of Trypanosoma...

Take-back systems - a logistic and economic comparison (2004)

Hauser, H., Hohaus, C.

For the return of waste from electrical and electronic equipment different take-back systems - depending on the group of appliances - are being discussed in various countries. The design of these...

Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance (2004)

Holden, M. T. G., Feil, E. J., Lindsay, J. A., Peacock, S. J., Day, N. P. J., Enright, M. C., ...

Staphylococcus aureus is an important nosocomial and community-acquired pathogen. Its genetic plasticity has facilitated the evolution of many virulent and drug-resistant strains, presenting a major...

Nramp1-mediated innate resistance to intraphagosomal pathogens is regulated by IRF-8, PU.1, and Miz-1 (2003)

Alter-Koltunoff, M., Ehrlich, S., Natalie, D., Aviva, A., Eilers, M., Hauser, H., ...

Natural resistance-associated macrophage protein 1 (Nramp1) is a proton/divalent cation antiporter exclusively expressed in monocyte/macrophage cells with a unique role in innate resistance to...

Nramp1-mediated innate resistance to intraphagosomal pathogens is regulated by IRF-8, PU.1, and Miz-1 (2003)

Alter-Koltunoff, M., Ehrlich, S., Dror, N., Azriel, A., Eilers, M., Hauser, H., ...

Natural resistance-associated macrophage protein 1 (Nramp1) is a proton/divalent cation antiporter exclusively expressed in monocyte/macrophage cells with a unique role in innate resistance to...

Strong resolution of singularities in characteristic zero (2002)

Encinas, S., Hauser, H.

We present a concise proof for the existence and construction of a {\it strong resolution of excellent schemes} of finite type over a field of characteristic zero. Our proof is based on earlier work...

Identification of a negative response element in the human inducible nitric oxide synthase (hiNOS) promoter: the role of NF-κB-repressing factor (NRF) in basal repression of the hiNOS gene (2002)

Feng, X, Guo, Z, Nourbakhsh, M, Hauser, H, Ganster, R, Shao, L, ...

Although nuclear factor (NF)-κB plays a central role in mediating cytokine-stimulated human inducible nitric-oxide synthase (hiNOS) gene transcription, very little is known about the factors...

Cytomegalovirus early promoter induced expression of hCD59 in porcine organs provides protection against hyperacute rejection (2001)

Niemann, H., Verhoeyen, E., Wonigeit, K., Lorenz, R., Hecker, J., Schwinzer, R., ...

The critical shortage of human donor organs has generated growing interest for porcine to human xenotransplantation. The major immunological barrier to xenotransplantation is the hyperacute rejection...

The WTO dispute settlement system: a first assessment from an economic perspective (2000)

Bütler, M, Hauser, H

We explore the incentives countries face in trade litigation within the new WTO dispute settlement system. Our analysis yields a number of interesting predictions, First, because sanctions are ruled...

Strukturwandel im Kfz-Gewerbe und der Mobilitätsbranche - Stand und Entwicklung (1999)

Hansen, U., Hauser, H., Kauschke, P.

Der Strukturwandel im Kfz-Gewerbe und der Mobilitätsbranche wird kurz beschrieben und die Konsequenzen aufgezeigt. Ein Entwicklungsbereich ist die Integration von ökoeffizienten Dienstleistungen in...

Ökologischer Strukturwandel im Bereich Kfz/Mobilität durch öko-effiziente Dienstleistungen? Identifikation des Handlungsbedarfs (1999)

Hansen, U., Hauser, H., Kauschke, P.

Der Strukturwandel der Gesellschaft wird sich auch auf dem Bereich der Kraftfahrzeuge und dem Mobilitätsbedürfnis niederschlagen. Gerade im Bereich der Mobilität existieren vielfältige...

"Öko-effizienz-verdächtige" Dienstleistungen - Mögliche Dienstleistungsinnovationen für Kfz-Handwerk, Kfz-Gewerbe sowie Mobilitätsdienstleister (1999)

Hansen, U., Hauser, H., Kauschke, P.

Im Rahmen dieses Beitrages werden vorhandene und mögliche Dienstleistungen für das Kfz-Handwerk, das Kfz-Gewerbe sowie Mobilitätsdienstleister aufgeführt. Ein besonderer Schwerpunkt liegt dabei...

Marktchancen für öko-effiziente Dienstleistungen - Prioritäre Dienstleistungsinnovationen und ihre Potentiale : Fallstudie "Kfz-Zuliefergewerbe und Kfz-Entsorger/Verwerter" (1999)

Hansen, U., Hauser, H., Kauschke, P.

Im Rahmen dieses Beitrages werden die Branchen Kfz-Zuliefergewerbe und Kfz-Entsorgung / -verwertung genauer untersucht, inwieweit für ökoeffiziente Dienstleistungen Marktchancen bestehen. Besonders...

Altteile-Netzwerke - Schlüssel für die Etablierung der zeitwertgerechten Kfz-Reparatur (1999)

Hauser, H., Kauschke, P.

Die nachhaltige Dienstleistung der zeitwertgerechten Reparatur setzt gut funktionierende Altteile-Netzwerke voraus. Mit wachsender Größe eine solchen Netzwerkes steigt die Wahrscheinlichkeit, ein...

A New System for Collection and Transportation of Waste Electrical and Electronic Equipment (1998)

Hauser, H., Krawczik, A.

Das System LOBSTER (Logistik bei Sammlung und Transport für das Elektronik-Recycling) ist ein neuartiges Logistiksystem, daß eine neue Fahrzeugtechnik (Aufbautentechnik) mit neuen, speziell...

Neue Dienstleistungen : Innovationsforschung im Kfz-Handwerk und -gewerbe (1998)

Hauser, H., Hansen, U.

Im Rahmen dieses Beitrages wird über eine vom Bundesministerium für Bildung und Wissenschaft, Forschung und Technologie gefördertes Programm "Dienstleistungen für das 21. Jahrhundert" berichtet....

Logistikgerechte Demontagekonzepte in der Kreislaufwirtschaft (1997)

Moukabary, G., Hauser, H.

Um eine qualifizierte Entsorgung gebrauchter Produkte unter Nutzung der ökonomischen Potentiale zu gewährleisten, ist die Planung geeigneter Demontagesysteme erforderlich. Die wesentlichste...

Demonstrationszentrum Produktkreisläufe - Teilprojekt III : Aufbau komplexer Logistiknetzwerke (1997)

Hansen, U., Hauser, H.

Im Rahmen des Demonstrationszentrums Produktkreisläufe - Aufbau komplexer Logistiknetzwerke werden die in den Forschungs- und Industrietätigkeiten des Fraunhofer IML entstandenen Ergebnisse,...

Wie man Altautos umweltgerecht verwertet. Deutschland baut ein Rücknahmesystem auf (1996)

Hansen, U., Hauser, H.

Ausgehend vom Kreislaufwirtschaftsgesetz werden die rechtlichen Rahmenbedingungen und Anforderungen an die Altautoverwertung in Deutschland beschrieben. Im weiteren Verlauf wird auf die Konzeption...

Realisierung einer Kreislaufwirtschaft. Kraftfahrzeuge, Elektro- und Elektronikgeräte (1995)

Hauser, H., Röttchen, P.

Von den jährlich in der BRD rund 2 Mio. endgültig stillgelegten Pkw erfolgt bei nur ca. 10 Prozent eine Altteileverwertung. Während die im Pkw enthaltenen Metalle fast vollständig in die...

Förderketten: Ölschmierung muß nicht sein (1995)

Kauschke, P., Hauser, H.

Der Beitrag thematisiert die Verschleißproblematik von Förderketten sowie die Forschungstätigkeiten des Fraunhofer-Instituts für Materialfluss und Logistik auf diesem Gebiet. Das Ziel der...

Bausteine der Kreislaufwirtschaft. Verwendungs- und Verwertungskonzepte (1995)

Hauser, H., Röttchen, P.

Eine der dringlichsten Aufgaben unserer Zeit ist das Schließen von Stoffkreisläufen, d.h. die Rückführung von Stoffen in den Produktionsprozeß. Die verstärkte Nutzung recyclierter Stoffe als...

Demontage von Elektro- und Elektronikaltgeräten (1994)

Röttchen, P., Hauser, H.

Die Rückführung und die Demontage von Altprodukten sind wichtige Bestandteile heutiger und zukünftiger Recyclingskonzepte. Innerhalb dieses Beitrages wird die Entwicklung und Realisierung einer...

Flexibles Demontagesystem zum Recycling von Elektronikaltgeräten (1994)

Hauser, H., Röttchen, P.

Der Aufsatz beschreibt das Demontagesystem am Beispiel der Zerlegung von Mikrowellenherden. Vornehmliches Ziel bei der Realisierung des Demontagesystems ist die Einbindung der Anlage als Subsystem in...

Altautodemontage - Alte Autos - Neue Konzepte (1993)

Hauser, H., Röttchen, P., Rinschede, A.

Das Fraunhofer-Institut für Materialfluss und Logistik, Abteilung Entsorgungslogistik, führt eine Konzeptplanung einer großtechnischen Demontageanlage für PKW durch. Das aus dem von der...

Altautodemontage (1992)

Röttchen, P., Hauser, H.

Die Abteilung Entsorgungslogistik des IML führt derzeit die Konzeptplanung einer großtechnischen Demontageanlage für Pkw durch. Die Initiative zur Durchführung der Planung ging von der Hertener...

Translation of NRF mRNA Is Mediated by Highly Efficient Internal Ribosome Entry

Oumard, A., Hennecke, M., Hauser, H., Nourbakhsh, M.

The ubiquitous transcription factor NRF (NF-κB repressing factor) is a constitutive transcriptional silencer of the multifunctional cytokine interferon-β. NRF mRNA contains a long 5′ untranslated...

On the use of double FLP recognition targets (FRTs) in the LTR of retroviruses for the construction of high producer cell lines.

Karreman, S, Hauser, H, Karreman, C

A pilot experiment for the construction of a hamster derived, high producer cell line using site specific recombination is described. In the experiment chromosomal loci with intrinsic high expression...

Screening retroviral packaging cells for highly efficient virus production by using a combined selection procedure.

Wirth, M, Grannemann, R, Klehr, D, Hauser, H

To facilitate the screening for clones of transfected packaging cells producing a high yield of recombinant retrovirus, we present a fast and simple method for the isolation of overexpressing cells....

The sequences of and distance between two cis-acting signals determine the efficiency of ribosomal frameshifting in human immunodeficiency virus type 1 and human T-cell leukemia virus type II in vivo.

Kollmus, H, Honigman, A, Panet, A, Hauser, H

We have analyzed in cell culture the sequence elements that control the level of ribosomal frameshifting in the human T-cell leukemia virus type II (HTLV-2) gag-pro junction. The slippery sequence of...

A heptanucleotide sequence mediates ribosomal frameshifting in mammalian cells.

Reil, H, Kollmus, H, Weidle, U H, Hauser, H

Ribosomal frameshifting is an essential requirement for replication of many viruses and retrovirus-like elements. It is regarded as a potential target for antiretroviral therapy. It has been shown...

DNA-mediated gene transfer in Friend leukemia cells by cotransfection of simian virus 40 DNA with herpes simplex virus thymidine kinase DNA.

Steinheider, G, Greiser-Wilke, I, Hauser, H, Bumke-Vogt, C, Moelling, K, Graessmann, A

Thymidine kinase-negative Friend leukemia cells were cotransfected with simian virus 40 (SV40) DNA and thymidine kinase gene DNA of herpes simplex virus type 1. The transfected thymidine...

Mechanism of spontaneous vesiculation.

Hauser, H

Both naturally occurring and synthetic phosphatidic acid (PtdOH) molecules show the phenomenon of spontaneous vesiculation on jump in pH value. This method involves a transient increase in pH of...

The actin-related protein Act3p of Saccharomyces cerevisiae is located in the nucleus.

Weber, V, Harata, M, Hauser, H, Wintersberger, U

Actin-related proteins, a group of protein families that exhibit about 50% sequence identity among each other and to conventional actin, have been found in a variety of eukaryotic organisms. In the...

Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes.

Kirchhoff, S, Schaper, F, Hauser, H

Interferon regulatory factor 1 (IRF-1) is a DNA-binding factor which recognizes regulatory elements in the promoters of interferon (IFN)-beta and some IFN-inducible genes. We observed that expression...

Gene shuttling: moving of cloned DNA into and out of eukaryotic cells.

Lindenmaier, W, Hauser, H, De Wilke, I G, Schütz, G

Successful shuttling of cloned DNA in eukaryotic cells should allow isolation of expressed genes. We tested the utility of cosmids for moving DNA into and out of eukaryotic cells. The unique cleavage...

Stabilization of lipid bilayer vesicles by sucrose during freezing

Strauss, G., Hauser, H.

The freeze-induced fusion and leakage of small unilamellar vesicles (SUV) of natural and synthetic phosphatidylcholines and the suppression of these processes by sucrose was studied by electron...

5'-Terminal sequences of eucaryotic mRNA can be cloned with high efficiency.

Land, H, Grez, M, Hauser, H, Lindenmaier, W, Schütz, G

A method for cloning mRNAs has been used which results in a high yield of recombinants containing complete 5'-terminal mRNA sequences. It is not dependent on self-priming to generate double-stranded...

Spontaneous vesiculation of phospholipids: a simple and quick method of forming unilamellar vesicles.

Hauser, H, Gains, N

Phosphatidic acid dispersions in H2O vesiculate when the pH is increased transiently (less than 2 min) from approximately 3 to 10.5-11. The same phenomenon is observed in mixed dispersions of...

Interferon-beta promoters contain a DNA element that acts as a position-independent silencer on the NF-kappa B site.

Nourbakhsh, M, Hoffmann, K, Hauser, H

The human interferon-beta (IFN-beta) promoter contains several functional domains that contribute to its virus-inducible regulation. One of them, PRDII, and NF-kappa B-binding sequence, can function...

Human lysosomal acid phosphatase is transported as a transmembrane protein to lysosomes in transfected baby hamster kidney cells.

Waheed, A, Gottschalk, S, Hille, A, Krentler, C, Pohlmann, R, Braulke, T, ...

BHK cells transfected with human lysosomal acid phosphatase (LAP) cDNA (CT29) expressed 70-fold higher enzyme activities of acid phosphatase than non-transfected BHK cells. The CT29-LAP was...

Genome sequence of the enterobacterial phytopathogen Erwinia carotovora subsp. atroseptica and characterization of virulence factors

Bell, K. S., Sebaihia, M., Pritchard, L., Holden, M. T. G., Hyman, L. J., Holeva, M. C., ...

The bacterial family Enterobacteriaceae is notable for its well studied human pathogens, including Salmonella, Yersinia, Shigella, and Escherichia spp. However, it also contains several plant...

Superinduction of the human interferon-beta promoter.

Dinter, H, Hauser, H

Superinduction, that is induction with simultaneous blocking of mRNA translation, enhances the induction of interferon-beta in response to virus or double-stranded RNA in human fibroblasts....

Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways.

Wong, A H, Tam, N W, Yang, Y L, Cuddihy, A R, Li, S, Kirchhoff, S, ...

The interferon-inducible double-stranded RNA protein kinase PKR controls protein synthesis through the phosphorylation of eukaryotic translation initiation factor (eIF)-2. In addition to its...

Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB.

Nourbakhsh, M, Hauser, H

Transcriptional regulation of the interferon-beta (IFN-beta) gene is characterized by strict constitutive repression and virus-specific activation. Previous studies have shown that the IFN-beta...

Physical studies of the interactions of acetylcholine chloride with membrane constituents

Hauser, H., Phillips, M. C., Marchbanks, R. M.

The binding of acetylcholine to pure lipids, and lipids, proteins and lipoproteins extracted from synaptic membranes, was investigated by monolayer and n.m.r. techniques. No specific binding of...

The displacement of calcium ions from phospholipid monolayers by pharmacologically active and other organic bases

Hauser, H., Dawson, R. M. C.

1. The binding of 45Ca2+ to a monolayer of phosphatidylinositol at the air–water interface was maximal when the separation of the phospholipid head groups approximated to the diameter of a hydrated...

Stability of unimolecular films of 32P-labelled lecithin

Hauser, H., Dawson, R. M. C.

1. The stability of monolayers of a highly unsaturated yeast lecithin labelled with 32P has been investigated by a surface radioactivity technique. 2. Lecithin films on distilled water at all surface...

Functional domains of interferon regulatory factor I (IRF-1).

Schaper, F, Kirchhoff, S, Posern, G, Köster, M, Oumard, A, Sharf, R, ...

Interferon (IFN) regulatory factors (IRFs) are a family of transcription factors among which are IRF-1, IRF-2, and IFN consensus sequence binding protein (ICSBP). These factors share sequence...

Behavior of cholesterol and spin-labeled cholestane in model bile systems studied by electron spin resonance and synchrotron x-ray.

Sömjen, G J, Lipka, G, Schulthess, G, Koch, M H, Wachtel, E, Gilat, T, ...

The behavior of mixed bile salt micelles consisting of sodium taurocholate, egg phosphatidylcholine, and cholesterol has been studied by ESR spin labeling and synchrotron x-ray scattering. Consistent...

Characterization of an integral protein of the brush border membrane mediating the transport of divalent metal ions.

Knöpfel, M, Schulthess, G, Funk, F, Hauser, H

The transport of Fe(2+) and other divalent transition metal ions across the intestinal brush border membrane (BBM) was investigated using brush border membrane vesicles (BBMVs) as a model. This...

The genome of the social amoeba Dictyostelium discoideum

Eichinger, L., Pachebat, J.A., Glöckner, G., Sucgang, R., Berriman, M., ...

The social amoebae are exceptional in their ability to alternate between unicellular and multicellular forms. Here we describe the genome of the best-studied member of this group, Dictyostelium...

Regulated ribosomal frameshifting by an RNA-protein interaction.

Kollmus, H, Hentze, M W, Hauser, H

Ribosomal frameshifting is a translational mechanism used as an essential step in the replication cycle of retroviruses. Programmed frameshifting in retroviral translation involves two sequence...

Acute pancreatitis and normoamylasemia. Not an uncommon combination.

Clavien, P A, Robert, J, Meyer, P, Borst, F, Hauser, H, Herrmann, F, ...

A consecutive series of 352 attacks of acute pancreatitis (AP) was studied prospectively in 318 patients. AP was ascertained by contrast-enhanced CT scan in all but four cases in which diagnosis was...

Translation of NRF mRNA Is Mediated by Highly Efficient Internal Ribosome Entry

Oumard, A., Hennecke, M., Hauser, H., Nourbakhsh, M.

The ubiquitous transcription factor NRF (NF-κB repressing factor) is a constitutive transcriptional silencer of the multifunctional cytokine interferon-β. NRF mRNA contains a long 5′ untranslated...

On the use of double FLP recognition targets (FRTs) in the LTR of retroviruses for the construction of high producer cell lines.

Karreman, S, Hauser, H, Karreman, C

A pilot experiment for the construction of a hamster derived, high producer cell line using site specific recombination is described. In the experiment chromosomal loci with intrinsic high expression...

Screening retroviral packaging cells for highly efficient virus production by using a combined selection procedure.

Wirth, M, Grannemann, R, Klehr, D, Hauser, H

To facilitate the screening for clones of transfected packaging cells producing a high yield of recombinant retrovirus, we present a fast and simple method for the isolation of overexpressing cells....

The sequences of and distance between two cis-acting signals determine the efficiency of ribosomal frameshifting in human immunodeficiency virus type 1 and human T-cell leukemia virus type II in vivo.

Kollmus, H, Honigman, A, Panet, A, Hauser, H

We have analyzed in cell culture the sequence elements that control the level of ribosomal frameshifting in the human T-cell leukemia virus type II (HTLV-2) gag-pro junction. The slippery sequence of...

A heptanucleotide sequence mediates ribosomal frameshifting in mammalian cells.

Reil, H, Kollmus, H, Weidle, U H, Hauser, H

Ribosomal frameshifting is an essential requirement for replication of many viruses and retrovirus-like elements. It is regarded as a potential target for antiretroviral therapy. It has been shown...

DNA-mediated gene transfer in Friend leukemia cells by cotransfection of simian virus 40 DNA with herpes simplex virus thymidine kinase DNA.

Steinheider, G, Greiser-Wilke, I, Hauser, H, Bumke-Vogt, C, Moelling, K, Graessmann, A

Thymidine kinase-negative Friend leukemia cells were cotransfected with simian virus 40 (SV40) DNA and thymidine kinase gene DNA of herpes simplex virus type 1. The transfected thymidine...

Mechanism of spontaneous vesiculation.

Hauser, H

Both naturally occurring and synthetic phosphatidic acid (PtdOH) molecules show the phenomenon of spontaneous vesiculation on jump in pH value. This method involves a transient increase in pH of...

The actin-related protein Act3p of Saccharomyces cerevisiae is located in the nucleus.

Weber, V, Harata, M, Hauser, H, Wintersberger, U

Actin-related proteins, a group of protein families that exhibit about 50% sequence identity among each other and to conventional actin, have been found in a variety of eukaryotic organisms. In the...

Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes.

Kirchhoff, S, Schaper, F, Hauser, H

Interferon regulatory factor 1 (IRF-1) is a DNA-binding factor which recognizes regulatory elements in the promoters of interferon (IFN)-beta and some IFN-inducible genes. We observed that expression...

Gene shuttling: moving of cloned DNA into and out of eukaryotic cells.

Lindenmaier, W, Hauser, H, De Wilke, I G, Schütz, G

Successful shuttling of cloned DNA in eukaryotic cells should allow isolation of expressed genes. We tested the utility of cosmids for moving DNA into and out of eukaryotic cells. The unique cleavage...

Stabilization of lipid bilayer vesicles by sucrose during freezing

Strauss, G., Hauser, H.

The freeze-induced fusion and leakage of small unilamellar vesicles (SUV) of natural and synthetic phosphatidylcholines and the suppression of these processes by sucrose was studied by electron...

5'-Terminal sequences of eucaryotic mRNA can be cloned with high efficiency.

Land, H, Grez, M, Hauser, H, Lindenmaier, W, Schütz, G

A method for cloning mRNAs has been used which results in a high yield of recombinants containing complete 5'-terminal mRNA sequences. It is not dependent on self-priming to generate double-stranded...

Spontaneous vesiculation of phospholipids: a simple and quick method of forming unilamellar vesicles.

Hauser, H, Gains, N

Phosphatidic acid dispersions in H2O vesiculate when the pH is increased transiently (less than 2 min) from approximately 3 to 10.5-11. The same phenomenon is observed in mixed dispersions of...

Interferon-beta promoters contain a DNA element that acts as a position-independent silencer on the NF-kappa B site.

Nourbakhsh, M, Hoffmann, K, Hauser, H

The human interferon-beta (IFN-beta) promoter contains several functional domains that contribute to its virus-inducible regulation. One of them, PRDII, and NF-kappa B-binding sequence, can function...

Human lysosomal acid phosphatase is transported as a transmembrane protein to lysosomes in transfected baby hamster kidney cells.

Waheed, A, Gottschalk, S, Hille, A, Krentler, C, Pohlmann, R, Braulke, T, ...

BHK cells transfected with human lysosomal acid phosphatase (LAP) cDNA (CT29) expressed 70-fold higher enzyme activities of acid phosphatase than non-transfected BHK cells. The CT29-LAP was...

Genome sequence of the enterobacterial phytopathogen Erwinia carotovora subsp. atroseptica and characterization of virulence factors

Bell, K. S., Sebaihia, M., Pritchard, L., Holden, M. T. G., Hyman, L. J., Holeva, M. C., ...

The bacterial family Enterobacteriaceae is notable for its well studied human pathogens, including Salmonella, Yersinia, Shigella, and Escherichia spp. However, it also contains several plant...

Superinduction of the human interferon-beta promoter.

Dinter, H, Hauser, H

Superinduction, that is induction with simultaneous blocking of mRNA translation, enhances the induction of interferon-beta in response to virus or double-stranded RNA in human fibroblasts....

Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways.

Wong, A H, Tam, N W, Yang, Y L, Cuddihy, A R, Li, S, Kirchhoff, S, ...

The interferon-inducible double-stranded RNA protein kinase PKR controls protein synthesis through the phosphorylation of eukaryotic translation initiation factor (eIF)-2. In addition to its...

Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB.

Nourbakhsh, M, Hauser, H

Transcriptional regulation of the interferon-beta (IFN-beta) gene is characterized by strict constitutive repression and virus-specific activation. Previous studies have shown that the IFN-beta...

Physical studies of the interactions of acetylcholine chloride with membrane constituents

Hauser, H., Phillips, M. C., Marchbanks, R. M.

The binding of acetylcholine to pure lipids, and lipids, proteins and lipoproteins extracted from synaptic membranes, was investigated by monolayer and n.m.r. techniques. No specific binding of...

The displacement of calcium ions from phospholipid monolayers by pharmacologically active and other organic bases

Hauser, H., Dawson, R. M. C.

1. The binding of 45Ca2+ to a monolayer of phosphatidylinositol at the air–water interface was maximal when the separation of the phospholipid head groups approximated to the diameter of a hydrated...

Stability of unimolecular films of 32P-labelled lecithin

Hauser, H., Dawson, R. M. C.

1. The stability of monolayers of a highly unsaturated yeast lecithin labelled with 32P has been investigated by a surface radioactivity technique. 2. Lecithin films on distilled water at all surface...

Functional domains of interferon regulatory factor I (IRF-1).

Schaper, F, Kirchhoff, S, Posern, G, Köster, M, Oumard, A, Sharf, R, ...

Interferon (IFN) regulatory factors (IRFs) are a family of transcription factors among which are IRF-1, IRF-2, and IFN consensus sequence binding protein (ICSBP). These factors share sequence...

Behavior of cholesterol and spin-labeled cholestane in model bile systems studied by electron spin resonance and synchrotron x-ray.

Sömjen, G J, Lipka, G, Schulthess, G, Koch, M H, Wachtel, E, Gilat, T, ...

The behavior of mixed bile salt micelles consisting of sodium taurocholate, egg phosphatidylcholine, and cholesterol has been studied by ESR spin labeling and synchrotron x-ray scattering. Consistent...

Characterization of an integral protein of the brush border membrane mediating the transport of divalent metal ions.

Knöpfel, M, Schulthess, G, Funk, F, Hauser, H

The transport of Fe(2+) and other divalent transition metal ions across the intestinal brush border membrane (BBM) was investigated using brush border membrane vesicles (BBMVs) as a model. This...

Acute pancreatitis and normoamylasemia. Not an uncommon combination.

Clavien, P A, Robert, J, Meyer, P, Borst, F, Hauser, H, Herrmann, F, ...

A consecutive series of 352 attacks of acute pancreatitis (AP) was studied prospectively in 318 patients. AP was ascertained by contrast-enhanced CT scan in all but four cases in which diagnosis was...

Regulated ribosomal frameshifting by an RNA-protein interaction.

Kollmus, H, Hentze, M W, Hauser, H

Ribosomal frameshifting is a translational mechanism used as an essential step in the replication cycle of retroviruses. Programmed frameshifting in retroviral translation involves two sequence...

Xeroradiographic techniques applied to assessment of Achilles tendon in inflammatory or metabolic diseases.

Gerster, J C, Hauser, H, Fallet, G H

Ten patients with inflammatory disease (rheumatoid arthritis, ankylosing spondylitis, Reiter's disease) or metabolic disease (gout, pseudogout, tendinous xanthomatosis) affecting the Achilles tendons...

Preoperative diagnosis of a pulmonary artery sarcoma.

Velebit, V, Christenson, J T, Simonet, F, Maurice, J, Schmuziger, M, Hauser, H, ...

A pulmonary artery sarcoma was diagnosed preoperatively by magnetic resonance imaging enhanced with gadolinium and confirmed by percutaneous computed tomographic guided needle biopsy. Accurate...

The genome of the simian and human malaria parasite Plasmodium knowlesi

Pain, A., Bohme, U., Berry, A.E., Mungall, K., Finn, R.D., Jackson, A.P., ...

Plasmodium knowlesi is an intracellular malaria parasite whose natural vertebrate host is Macaca fascicularis (the 'kra' monkey); however, it is now increasingly recognized as a significant cause of...

The genome of the African trypanosome Trypanosoma brucei

Berriman, M., Ghedin, E., Hertz-Fowler, C., Blandin, G., Renauld, H., Bartholomeu, D.C., ...

African trypanosomes cause human sleeping sickness and livestock trypanosomiasis in sub-Saharan Africa. We present the sequence and analysis of the 11 megabase-sized chromosomes of Trypanosoma...