Kirby, G A, Nakamoto, T, Ostojic, R, Taylor, T M, Terashima, A, Higashi, N, ...
A superconducting insertion quadruple is being developed by KEK in collaboration with CERN for the Large Hadron Collider (LHC) project. The mechanical design of the magnet in which the pre-stress is...
Phlegmonous gastritis in a haemodialysis patient with secondary amyloidosis (1999)
Joko, T, Tanaka, H, Hirakata, H, Henzan, H, Hizawa, K, Hirakata, E, ...
Higashi, H, Suzuki, Y, Mukaida, N, Takahashi, N, Miyamoto, D, Matsushima, K
Accumulating evidence indicates that tumor necrosis factor alpha (TNF-alpha) is a principal mediator of endotoxin shock. We previously reported that the action as well as the production of TNF...
Murayama, T, Ohara, Y, Obuchi, M, Khabar, K S, Higashi, H, Mukaida, N, ...
Cytomegalovirus (CMV) infection induced interleukin-8 (IL-8) gene transcription in a human monocytic cell line, THP-1 cells, leading to IL-8 secretion. The functional analysis of the IL-8 gene...
Yoshimoto, T, Higashi, H, Kanatani, A, Lin, X S, Nagai, H, Oyama, H, ...
The 7 alpha-hydroxysteroid dehydrogenase (EC 1.1.1.159) gene from Escherichia coli HB101 was cloned and expressed in E. coli DH1. The hybrid plasmid pSD1, with a 2.8-kbp insert of chromosomal DNA at...
Kitagawa, M, Higashi, H, Jung, H K, Suzuki-Takahashi, I, Ikeda, M, Tamai, K, ...
Cyclin D-Cdk4/6 and cyclin A/E-Cdk2 are suggested to be involved in phosphorylation of the retinoblastoma protein (pRB) during the G1/S transition of the cell cycle. However, it is unclear why...
Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice.
Yoneyama, H, Harada, A, Imai, T, Baba, M, Yoshie, O, Zhang, Y, ...
Thymus and activation-regulated chemokine (TARC) is a recently identified lymphocyte-directed CC chemokine which specifically chemoattracts T helper type 2 CD4(+) T cells in human. To establish the...
Higashi, H, Inanaga, K, Nishi, S, Uchimura, N
1. Intracellular recordings were made from the nucleus accumbens neurons in brain slices from rats previously treated with saline or methamphetamine. 2. In neurones from both methamphetamine- and...
Changes in spontaneous firing patterns of rat hippocampal neurones induced by volatile anaesthetics.
Fujiwara, N, Higashi, H, Nishi, S, Shimoji, K, Sugita, S, Yoshimura, M
1. The effects of the volatile anaesthetics, halothane, isoflurane and enflurane, on rat hippocampal CA1 and CA3 neurones in in vitro preparations were studied by intracellular recording methods. 2....
Higashi, H, Katayama, Y, Morita, K, North, R A
1. The effects of ouabain (1 nM-100 microM) on the membrane properties of rabbit visceral primary afferent neurones (nodose ganglion cells) were studied with intracellular recordings and...
Effects of hypoxia on rat hippocampal neurones in vitro.
Fujiwara, N, Higashi, H, Shimoji, K, Yoshimura, M
1. The effects of hypoxia on the rat hippocampal CA1 neurones in tissue slices of the rat brain were studied in vitro by intracellular recording. 2. In response to superfusion of a hypoxic medium...
Calcium-dependent after-potentials in visceral afferent neurones of the rabbit.
Higashi, H, Morita, K, North, R A
Intracellular recordings were made from neurones in nodose ganglia excised from rabbits. In C neurones, 1-60 action potentials were followed by an after-hyperpolarization with a peak amplitude of 16...
Voltage-dependent activation of potassium current in Helix neurones by endogenous cellular calcium.
Akaike, N, Brown, A M, Dahl, G, Higashi, H, Isenberg, G, Tsuda, Y, ...
1. The effect of endogenous Ca on potential-dependent K current IKD, was examined in identifiable neurones of Helix aspersa. The suction pipette method of internal perfusion was used along with a...
Effect of barbiturates on the GABA receptor of cat primary afferent neurones
1. The effects of the barbiturate anaesthetics, pentobarbitone and thiopentone, on the membrane properties and the γ-aminobutyric acid (GABA)-induced responses of cat primary afferent neurones were...
5-Hydroxytryptamine receptors of visceral primary afferent neurones on rabbit nodose ganglia
1. The electrophysiological characteristics of 5-hydroxytryptamine (5-HT) receptors distributed on visceral primary afferent neurones (the nodose ganglion cells of the vagus) in rabbits were...
Gallagher, J P, Higashi, H, Nishi, S
1. Responses of single cells in the isolated cat spinal ganglion to GABA applied by superfusion or by iontophoresis were recorded using intracellular micro-electrodes. 2. Of the twelve structurally...
Higashi, H, Suzuki, Y, Mukaida, N, Takahashi, N, Miyamoto, D, Matsushima, K
Accumulating evidence indicates that tumor necrosis factor alpha (TNF-alpha) is a principal mediator of endotoxin shock. We previously reported that the action as well as the production of TNF...
Murayama, T, Ohara, Y, Obuchi, M, Khabar, K S, Higashi, H, Mukaida, N, ...
Cytomegalovirus (CMV) infection induced interleukin-8 (IL-8) gene transcription in a human monocytic cell line, THP-1 cells, leading to IL-8 secretion. The functional analysis of the IL-8 gene...
Yoshimoto, T, Higashi, H, Kanatani, A, Lin, X S, Nagai, H, Oyama, H, ...
The 7 alpha-hydroxysteroid dehydrogenase (EC 1.1.1.159) gene from Escherichia coli HB101 was cloned and expressed in E. coli DH1. The hybrid plasmid pSD1, with a 2.8-kbp insert of chromosomal DNA at...
Kitagawa, M, Higashi, H, Jung, H K, Suzuki-Takahashi, I, Ikeda, M, Tamai, K, ...
Cyclin D-Cdk4/6 and cyclin A/E-Cdk2 are suggested to be involved in phosphorylation of the retinoblastoma protein (pRB) during the G1/S transition of the cell cycle. However, it is unclear why...
Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice.
Yoneyama, H, Harada, A, Imai, T, Baba, M, Yoshie, O, Zhang, Y, ...
Thymus and activation-regulated chemokine (TARC) is a recently identified lymphocyte-directed CC chemokine which specifically chemoattracts T helper type 2 CD4(+) T cells in human. To establish the...
Higashi, H, Inanaga, K, Nishi, S, Uchimura, N
1. Intracellular recordings were made from the nucleus accumbens neurons in brain slices from rats previously treated with saline or methamphetamine. 2. In neurones from both methamphetamine- and...
Changes in spontaneous firing patterns of rat hippocampal neurones induced by volatile anaesthetics.
Fujiwara, N, Higashi, H, Nishi, S, Shimoji, K, Sugita, S, Yoshimura, M
1. The effects of the volatile anaesthetics, halothane, isoflurane and enflurane, on rat hippocampal CA1 and CA3 neurones in in vitro preparations were studied by intracellular recording methods. 2....
Higashi, H, Katayama, Y, Morita, K, North, R A
1. The effects of ouabain (1 nM-100 microM) on the membrane properties of rabbit visceral primary afferent neurones (nodose ganglion cells) were studied with intracellular recordings and...
Effects of hypoxia on rat hippocampal neurones in vitro.
Fujiwara, N, Higashi, H, Shimoji, K, Yoshimura, M
1. The effects of hypoxia on the rat hippocampal CA1 neurones in tissue slices of the rat brain were studied in vitro by intracellular recording. 2. In response to superfusion of a hypoxic medium...
Calcium-dependent after-potentials in visceral afferent neurones of the rabbit.
Higashi, H, Morita, K, North, R A
Intracellular recordings were made from neurones in nodose ganglia excised from rabbits. In C neurones, 1-60 action potentials were followed by an after-hyperpolarization with a peak amplitude of 16...
Voltage-dependent activation of potassium current in Helix neurones by endogenous cellular calcium.
Akaike, N, Brown, A M, Dahl, G, Higashi, H, Isenberg, G, Tsuda, Y, ...
1. The effect of endogenous Ca on potential-dependent K current IKD, was examined in identifiable neurones of Helix aspersa. The suction pipette method of internal perfusion was used along with a...
Effect of barbiturates on the GABA receptor of cat primary afferent neurones
1. The effects of the barbiturate anaesthetics, pentobarbitone and thiopentone, on the membrane properties and the γ-aminobutyric acid (GABA)-induced responses of cat primary afferent neurones were...
5-Hydroxytryptamine receptors of visceral primary afferent neurones on rabbit nodose ganglia
1. The electrophysiological characteristics of 5-hydroxytryptamine (5-HT) receptors distributed on visceral primary afferent neurones (the nodose ganglion cells of the vagus) in rabbits were...
Gallagher, J P, Higashi, H, Nishi, S
1. Responses of single cells in the isolated cat spinal ganglion to GABA applied by superfusion or by iontophoresis were recorded using intracellular micro-electrodes. 2. Of the twelve structurally...
Kohno, T, Kumamoto, E, Higashi, H, Shimoji, K, Yoshimura, M
The actions of opioid receptor agonists on synaptic transmission in substantia gelatinosa (SG) neurones in adult (6- to 10-week-old) rat spinal cord slices were examined by use of the blind...
Okamoto, M, Baba, H, Goldstein, P A, Higashi, H, Shimoji, K, Yoshimura, M
Functional reorganization of sensory pathways in the rat spinal dorsal horn following sciatic nerve transection was examined using spinal cord slices with an attached dorsal root. Slices were...
Intrathecal Chemotherapy: Selection of Cytostatic Agents
Hayakawa, T., Yamada, R., Kanai, N., Kuroda, R., Ushio, Y., Higashi, H., ...
Selection of cytostatic agents for intrathecal administration is the subject of this paper.
A loss of c-kit expression is associated with an advanced stage and poor prognosis in breast cancer
Tsutsui, S, Yasuda, K, Suzuki, K, Takeuchi, H, Nishizaki, T, Higashi, H, ...
To evaluate the c-kit expression in breast cancer, 217 invasive ductal carcinomas of the breast were immunohistochemically stained for c-kit protein. The c-kit expression was positive in 59 (27%) of...