Inoue, H., Tani, S., Hosoya, S., Inokuchi, K., Fujiwara, T., Saito, T., ...
$^{63/65}$Cu- and $^{35/37}$Cl-NMR experiments were performed to investigate triplet localization in the $S=1/2$ dimer compound NH$_4$CuCl$_3$, which shows magnetization plateaus at one-quarter and...
X-Ray Spectral Variability of the Seyfert Galaxy NGC 4051 Observed with Suzaku (2008)
Terashima, Y., Gallo, L. C., Inoue, H., Markowitz, A. G., Reeves, J. N., Anabuki, N., ...
We report results from a Suzaku observation of the narrow-line Seyfert 1 NGC 4051. During our observation, large amplitude rapid variability is seen and the averaged 2--10 keV flux is 8.1x10^-12 erg...
M. F. Adziman, S. Deshp, M. Omiya, H. Inoue, K. Kishimoto
Abstract. The stochastic nature of aluminum foam structure, having a random distribution of voids, makes it difficult to model its compressive deformation behavior accurately. In this paper, a...
Intrabasement reflections of the Ontong Java Plateau: implications for plateau construction (2008)
Inoue, H., Coffin, M.F., Nakamura, Y., Mochizuki, K., Kroenke, L.W.
Subscriptions: Information about subscribing to Circulation is online at
Fast Manipulation Path Planning for Humanoid Robots (2007)
Ptfe}ga?h?%r%e H $g$n, James Kuffner, Koichi Nishiwaki, Satoshi Kagami, H. Inoue, Masayuki Inaba, ...
We present an interactive manipulation path planner under development for providing high-level task-based control for humanoid robots. Using a graphical simulation environment, the software is...
observations of the Seyfert 1 galaxies Mrk 1040 and MS 0225.5+3121 (2007)
Reynolds Fabian, C. S. Reynolds, A. C. Fabian, H. Inoue
We present ASCA observations of the Seyfert 1 galaxies Mrk 1040 and MS 0225.5+3121. Mrk 1040 was found to have decreased in flux by almost a factor of 4 since an EXOSAT observation 10 years ago. The...
C. S. Reynolds, A. C. Fabian, K. Nandra, H. Inoue, H. Kunieda, K. Iwasawa
ASCA PV observations of the Seyfert 1 galaxy MCG\Gamma6\Gamma30\Gamma15: rapid variability of the warm absorber.
NMR Study on the Vortex Slush Phase in Organic Superconductor \kappa-(BEDT-TTF)2Cu(NCS)2 (2007)
Urano, M., Tonishi, J., Inoue, H., Saito, T., Fujiwara, T., Chiku, H., ...
The vortex state in a single crystal of the layered organic superconductor \kappa-(BEDT-TTF2Cu(NCS)2, where BEDT-TTF (or ET) is bis(ethylenedithio)tetrathiafulvalene, was studied by 1H-NMR. Under a...
Commission 44: space & high energy astrophysics (2007)
Okuda, Haruyuki, Hasinger, Günther, Arnaud, M. D., Bludman, S., Braga, J., Brosch, N., ...
Hard X-ray Detector (HXD) on Board Suzaku (2006)
Takahashi, T., Abe, K., Endo, M., Endo, Y., Ezoe, Y., Fukazawa, Y., ...
The Hard X-ray Detector (HXD) on board Suzaku covers a wide energy range from 10 keV to 600 keV by combination of silicon PIN diodes and GSO scintillators. The HXD is designed to achieve an extremely...
Ishisaki, Y., Maeda, Y., Fujimoto, R., Ozaki, M., Ebisawa, K., Takahashi, T., ...
We have developed a framework for the Monte-Carlo simulation of the X-Ray Telescopes (XRT) and the X-ray Imaging Spectrometers (XIS) onboard Suzaku, mainly for the scientific analysis of spatially...
Cu-NMR study on the disordered quantum spin magnet with the Bose-glass ground state (2006)
Fujiwara, T., Inoue, H., Oosawa, A., Tsunoda, R., Goto, T., Suzuki, T., ...
Cu-NMR study has been performed on the disordered spin-gap system Tl1-xKxCuCl3 In the high-field H > HC=\Delta/\mu_B, where \Delta is the spin-gap, the hyperfine field becomes extremely inhomogeneous...
Optically driven micropump produced by three-dimensional two-photon microfabrication (2006)
Maruo, Shoji, Inoue, H., 丸尾, 昭二, マルオ, シヨウジ
An optically driven lobed micropump was developed using three-dimensional two-photon microfabrication. The two built-in rotors, 9 mu m in diameter, are cooperatively driven by means of time-divided...
Technique for cladding of poison sheets for Cd-poisoned moderator (2005)
Kawai, M, Kobayashi, Y, Miyake, Y, Inoue, H, Harada, M, Teshigawara, M, ...
Development of Uniform CdTe Pixel Detectors Based on Caltech ASIC (2004)
Oonuki, K., Inoue, H., Nakazawa, K., Mitani, T., Tanaka, T., Takahashi, T., ...
We have developed a large CdTe pixel detector with dimensions of 23.7 x 13.0 mm and a pixel size of 448 x 448 um^2. The detector is based on recent technologies of an uniform CdTe single crystal, a...
Science with XEUS - the X-ray Evolving Universe Spectroscopy Mission (2004)
Parmar, A. N., Arnaud, M., Barcons, X., Bleeker, J., Hasinger, G., Inoue, H., ...
Mimori, K., Tanaka, Y., Yoshinaga, K., Masuda, T., Yamashita, K., Okamoto, M., ...
Background: By using array comparative genomic hybridization (CGH), the increased copy number of CYP24 (which encodes vitamin D 24-hydroxylase) at 20q13.2 was previously reported, leading to the...
The origin of X-ray flux from the galactic ridge (2003)
Dogiel, V. A., Masai, K., Inoue, H., Schönfelder, V., Strong, A. W.
Study of the Largest Multiwavelength Campaign of the Microquasar GRS 1915+105 (2002)
Ueda, Y., Yamaoka, K., Sanchez-Fernandez, C., Dhawan, V., Chaty, S., Grove, J. E., ...
We present the results from a multiwavelength campaign of GRS 1915+105 performed from 2000 April 16 to 25. This is one of the largest coordinated set of observations ever performed for this source,...
Ozaki, T., Wai, D., Yokoyama, R., Ahrens, S., Diallo, R., ...
Background: The incidence of Ewing’s tumors (ETs) is lower in Asians or African-Americans than in Caucasians. Patients and methods: Japanese ETs were available for analysis of chromosomal...
Glinghammar, B., Inoue, H., Rafter, J.J.
Evidence is accumulating that bile acids induce apoptosis in colonic cells. Therefore, it becomes important to study the underlying molecular mechanisms and the role of this phenomenon in tumor...
Analytical Studies on the Structure and Emission of the SS433 Jets (2000)
Inoue, H., Shibazaki, N., Hoshi, R.
We study the structure and emission of the SS 433 jets in the X-ray emitting region and in the inner and hotter portion inside the X-ray emitting region. In order to consider the jet structure from...
The X-ray Spectrum and Light Curve of Supernova 1995N (2000)
Fox, D. W., Lewin, W. H. G., Fabian, A., Iwasawa, K., Terlevich, R., Zimmermann, H. U., ...
We report on multi-epoch X-ray observations of the Type IIn (narrow emission line) supernova SN 1995N with the ROSAT and ASCA satellites. The January 1998 ASCA X-ray spectrum is well fitted by a...
Development of Superconducting Linac for the Kek/Jaeri Joint Project (2000)
Mizumoto, M., Ouchi, N., Kusano, J., Chishiro, E., Hasegawa, K., Akaoka, N., ...
The JAERI/KEK Joint Project for the high-intensity proton accelerator facility has been proposed with a superconducting (SC) linac option from 400 MeV to 600MeV. System design of the SC linac has...
X-ray absorption and rapid variability of the dwarf Seyfert nucleus of NGC4395 (2000)
Iwasawa, K., Fabian, A. C., Almaini, O., Lira, P., Lawrence, A., Hayashida, K., ...
We report the detection of an absorbed central X-ray source and its strong, rapid variability in NGC4395, the least luminous Seyfert nucleus known. The X-ray source exhibits a number of flares with...
The X-ray evolving universe spectroscopy mission (XEUS) (2000)
Bavdaz, M, Bleeker, J A M, Hasinger, G, Inoue, H, Palumbo, G, Peacock, A, ...
Simulating High-Level Robot Behaviors (2000)
J. Kuffner, Tokyo J. Kuffner, S. Kagami, M. Inaba, H. Inoue
Physically-based simulation software is commonly used for developing and testing low-level robot control algorithms. In order to facilitate the development and evaluation of higher-level robot...
Dynamically-stable Motion Planning for Humanoid Robots (2000)
Ptfe}ga?h?%r%e H $g$n, James Kuffner, Koichi Nishiwaki, Satoshi Kagami, H. Inoue, Masayuki Inaba, ...
We present an algorithm for computing stable collision-free motions for humanoid robots given full-body posture goals. Given a robot's internal model of the environment and a statically-stable...
Automating Object Manipulation Tasks for Humanoid Robots (2000)
James Kuffner, M. Inaba, H. Inoue
This paper presents an experimental interactive path planner for automatically generating manipulation trajectories for humanoid robots. There are many potential uses for such software, with the...
Genetic variants of IL-13 signalling and human asthma and atopy (2000)
Heinzmann, A., Akaiwa, M., Kreomer, R.T., Ohshima, K., ...
Asthma and atopy show epidemiological association and are biologically linked by T-helper type 2 (Th2) cytokine-driven inflammatory mechanisms. IL-4 operates through the IL-4 receptor (IL-4R, a...
Superiority of electropolishing over chemical polishing on high gradients (1999)
Saitô, K, Inoue, H, Kako, E, Fujino, T, Noguchi, S, Ono, M, ...
Variation of the broad X-ray iron line in MCG-6-30-15 during a flare (1999)
Iwasawa, K., Fabian, A. C., Young, A. J., Inoue, H., Matsumoto, C.
We report results on the broad iron emission line of the Seyfert galaxy MCG-6-30-15, obtained from the second long ASCA observation in 1997. The time-averaged profile of the broad line is very...
Development of 1.3 GHz medium-$\beta$ structure with high gradient (1999)
Saitô, K, Noguchi, S, Inoue, H, Ono, M, Shishido, T, Yamazaki, Y, ...
Ueda, Y., Takahashi, T., Inoue, H., Tsuru, T., Sakano, M., Ishisaki, Y., ...
We carried out the first wide-area unbiased survey with the ASCA satellite in the 0.7-10 keV band around a north Galactic-pole region covering a continuous area of 7 square degrees (Large Sky Survey;...
ASCA Observations of GRO J1744-28 (1998)
Nishiuchi, M., Koyama, K., Maeda, Y., Asai, K., Dotani, T., Inoue, H., ...
We report the ASCA results of the bursting X-ray pulsar \gro, which was observed in February 1996 and March 1997. The source flux in the 2--10 keV band was $2.0\times10^{-8}$ erg/sec/cm$^2$ in 1996...
ASCA Observation of the Galactic Jet Source XTE J0421+560 (CI Cam) in Outburst (1998)
Ueda, Y., Ishida, M., Inoue, H., Dotani, T., Greiner, J., Lewin, W. H. G.
We observed the newly discovered Galactic jet source XTE J0421+560 (= CI Cam) with ASCA from 1998 April 3.3 to April 4.1 (UT), three days after the beginning of the outburst. The X-ray intensity in...
Simple Photoelectric Absorption during Dipping in the ASCA Observation of XB1916-053 (1997)
Church, M. J., Dotani, T., Balucinska-Church, M., Mitsuda, K., Takahashi, T., Inoue, H., ...
We report results of analysis of the ASCA observation of the Low Mass X-ray Binary dipping source XB1916-053 made on 1993, May 2nd. We have shown that the spectra can be well fitted by the same...
Fluctuations in the diffuse X-ray background observed with Ginga (1997)
Butcher, J. A., Stewart, G. C., Warwick, R. S., Fabian, A. C., Carrera, F. J., Barcons, X., ...
We present Ginga measurements of the spatial fluctuations in the diffuse X-ray background. When combined with earlier results, the new data constrain the extragalactic log N - log S relation in the...
The Cessation of Flickering during Dips in Cygnus X-1 (1997)
Balucinska-Church, M., Takahashi, T., Ueda, Y., Church, M. J., Dotani, T., Mitsuda, K., ...
We report the discovery of the cessation of flickering in dips in the black hole candidate Cygnus X-1, detected for the first time in the ASCA observation of May 9th., 1995. During this observation,...
The ASCA X-ray spectrum of the powerful radio galaxy 3C109 (1997)
Allen, S. W., Fabian, A. C., Idesawa, E., Inoue, H., Kii, T., Otani, C.
We report the results from an ASCA X-ray observation of the powerful Broad Line Radio Galaxy, 3C109. The ASCA spectra confirm our earlier ROSAT detection of intrinsic X-ray absorption associated with...
Describing a modular motion system based on a real time process network model (1997)
The brain of an autonomous robot generates signals to the motors in each situation of the dynamical real world to achieve various tasks. The designer of it has to describe a complex system that maps...
In this paper, we present programming environments for developing real time autonomous agents on multi-processor systems based on a hardware independent description model. BeNet, our model is a...
Describing a Modular Motion System based on a Real Time Process Network Model (1997)
The brain of an autonomous robot generates signals to the motors in each situation of the dynamical real world to achieve various tasks. The designer of it has to describe a complex system that maps...
Benzo[a]pyrene up-regulates cyclooxygenase-2 gene expression in oral epithelial cells (1997)
Kelley, DJ, Mestre, JR, Subbaramaiah, K, Sacks, PG, Schantz, SP, Tanabe, T, ...
Zhang, S. N., Ebisawa, K., Sunyaev, R., Ueda, Y., Harmon, B. A., Sazonov, S., ...
The X-ray/radio transient superluminal jet source GRO J1655-40 was recently suggested to contain a black hole from optical observations. Being a relatively close-by system (d \sim 3.2 kpc), it can...
High Momentum Behavior of Geometric Bremsstrahlung in the Expanding Universe (1996)
Hotta, M., Inoue, H., Joichi, I., Tanaka, M.
We shall discuss various kinds of geometric bremsstrahlung processes in the spatially flat Robertson-Walker universe. Despite that the temperature of the universe is much higher than particle masses...
Brandt, W. N., Fabian, A. C., Dotani, T., Nagase, F., Inoue, H., Kotani, T., ...
We report on ASCA energy spectra of Cir X-1 taken near its zero phase on 1994 August 4-5. The ASCA SIS detectors allow a more detailed study of the iron K complex than has been possible before. We...
The variable iron K emission line in MCG-6-30-15 (1996)
Iwasawa, K., Fabian, A. C., Reynolds, C. S., Nandra, K., Otani, C., Inoue, H., ...
We report on the variability of the iron K emission line in the Seyfert 1 galaxy MCG--6-30-15 during a four-day ASCA observation. The line consists of a narrow core at an energy of about 6.4 keV, and...
Investigation on barrel polishing for superconducting niobium cavities (1996)
Higuchi, T, Saitô, K, Noguchi, S, Ono, M, Kako, E, Shishido, T, ...
Status of the seamless L-band cavity fabrication at KEK (1996)
Fujino, T, Saitô, K, Inoue, H, Noguchi, S, Ono, M, Kako, E, ...
Kako, E, Noguchi, S, Ono, M, Saitô, K, Shishido, T, Fujino, T, ...
Activities of high gradient SC cavities at KEK (1996)
Kako, E, Noguchi, S, Ono, M, Saitô, K, Shishido, T, Wake, M, ...
Designing Asynchronous Parallel Process Networks for Desirable Autonomous Robot Behaviors (1996)
T. Oka, K. Takeda, M. Inaba, H. Inoue
The behavior of an autonomous robot is generated by the dynamics of the interaction between the brain and the environment. The designer of the brain must describe and actualize a system that makes a...
Nestorowicz, A, Wilson, BA, Schoor, KP, Inoue, H, Glaser, B, Landau, H, ...
The variable OVIII Warm Absorber in MCG-6-30-15 (1995)
Otani, C., Kii, T., Reynolds, C. S., Fabian, A. C., Iwasawa, K., Hayashida, K., ...
We present the results of a 4 day ASCA observation of the Seyfert galaxy MCG-6-30-15, focussing on the nature of the X-ray absorption by the warm absorber, characterizd by the K-edges of the...
Geometric Bremsstrahlung in the Early Universe (1995)
Futamase, T., Hotta, M., Inoue, H., Yamaguchi, M.
We discuss photon emission from particles decelerlated by the cosmic expansion. This can be interpretated as a kind of bremsstrahlung induced by the Universe geometry. In the high momentum limit its...
Development of TESLA-type cavity at KEK (1995)
Ono, M, Kako, E, Noguchi, S, Saitô, K, Shishido, T, Wake, M, ...
On broad iron K-alpha lines in Seyfert 1 galaxies (1995)
Fabian, A. C., Nandra, K., Reynolds, C. S., Brandt, W. N., Otani, C., Tanaka, Y., ...
The X-ray spectrum obtained by Tanaka et al from a long observation of the active galaxy MCG$-6-30-15$ shows a broad iron K$\alpha$ line skewed to low energies. The simplest interpretation of the...
ABELL 2163: Temperature, Mass, and Hydrostatic Equilibrium (1995)
Markevitch, M., Mushotzky, R., Inoue, H., Yamashita, K., Furuzawa, A., Tawara, Y.
Using ASCA data, we have measured the electron temperature in A2163 out to 1.5h^{-1} Mpc (10a_x) from the center, in three radial bins. The temperatures are 12.2+1.9-1.2 keV, 11.5+2.7-2.9 keV and...
Reynolds, C. S., Fabian, A. C., Nandra, K., Inoue, H., Kunieda, H., Iwasawa, K.
We present a detailed re-analysis of the two {\it ASCA} Performance Verification observations of the nearby Seyfert 1 galaxy MCG-6-30-15. Confirming the results of Fabian et al. (1994), we find...
ASCA observations of the Seyfert 1 galaxies Mrk1040 and MS0225.5+3121 (1995)
Reynolds, C. S., Fabian, A. C., Inoue, H.
We present {\it ASCA} observations of the Seyfert 1 galaxies Mrk~1040 and MS~0225.5+3121. Mrk~1040 was found to have decreased in flux by almost a factor of 4 since an {\it EXOSAT} observation...
T. Ganbo, H. Inoue, K. Kikushima, A. Mizukoshi, Y. Murakami
We measured sIL-2R, TNF-α and sICAM-1 in the sera and middle ear effusions (MEEs) of patients with otitis media with effusion (OME). Although there was no signmcant difference between the sIL-2R...
Inoue, H., Saito, I., Nakazawa, R., Mukaida, N., Matsushima, K., Azuma, N., ...
Background. The occurrence of various arthropathies including carpal-tunnel syndrome (CTS) in dialysis-associated amyloidosis, a condition caused by the deposition of β2 microglobulin (β2MG), has...
The Effect of Lyso-PAF on Ciliary Activity of Human Paranasal Sinus Mucosa in vitro (1994)
T. Ganbo, K. Hisamatsu, H. Inoue, T. Nakajima, Y. Murakami
The effect of lyso-PAF on ciliated cells was investigated in vitro. Normal mucosa was surgically obtained from human paranasal sinuses and incubated in the form of tissue culture. Ciliated epithelium...
Changes in the 11 minute period of 4U 1820-30 (1991)
Tan, J., Morgan, E., Lewin, W.H.G., Penninx, W., Klis, M. Van Der, Paradijs, J. Van, ...
Texture Formation in the Surfaces of Ground Tetragonal Zirconia Polycrystals (1991)
Texture development, changes in crystal structure and residual stress in the surface layers of yttria-doped tetragonal zirconia polycrystalline (Y-TZP) ceramics unidirectionally ground with SiC...
Effects of Precipitation on Recrystallization Textures in Al-Ge Alloy (1991)
Y. Kaneno, H. Inoue, N. Inakazu
The recrystallization textures of Al-4.0wt%Ge alloys with the different states of precipitation before cold rolling were determined by means of orientation distribution functions (ODFs)....
Effects of iron and Silicon on Recrystallization Textures of Drawn Aluminium (1991)
N. Inakazu, Y. Kaneno, H. Inoue
The recrystallization textures of cold drawn aluminium alloys were determined by means of the orientation distribution functions (ODFs). The changes in texture with annealing temperature were...
GINGA observations of quasi-periodic oscillations in type II bursts from teh Rapid Burster (1990)
Dotani, T., Mitsuda, K., Inoue, H., Tanaka, Y., Kawai, N., Tawara, Y., ...
The decreasing 11-minute period of 4U1820-30: evidence of gravitational acceleration (1990)
Morgan, E., Tan, J., Penninx, W., Klis, M. Van Der, Paradijs, J. Van, Makishima, K., ...
The Landstuhl Project aims at a broad application of energy saving construction and solar energy use. 22 solar and three reference houses were measured to obtain results on energy efficiency of the...
Kawase, Y., Iwai, S., Inoue, H., Miura, K., Ohtsuka, E.
The thermal stability of DNA duplexes containing deoxyinosine in a pairing position in turn with each of the four major deoxynucleotides has been investigated by measuring ultraviolet-absorbance at...
Inoue, H., Imura, A., Ohtsuka, E.
Partially self-complementary dodecadeoxyribonucleotides containing a fluorescent nucleoside, 3-β-D-2′-deoxyribofuranosyl-2, 7-dioxopyrido [2, 3-d] pyrimidine (pyridopyrimidine deoxynucleoside, dF)...
Yamamoto, A., Inoue, H., Hirabayashi, H.
A new fabrication method of a thin and large solenoids is presented. The solenoid is wound with NbTi/Cu/Al superconductor, which is wound on the inner surface of an aluminum cylinder. The fabrication...
Yamamoto, A., Inoue, H., Hirabayashi, H.
A new fabrication method of a thin and large solenoids is presented. The solenoid is wound with NbTi/Cu/Al superconductor, which is wound on the inner surface of an aluminum cylinder. The fabrication...
Yamamoto, A., Inoue, H., Hirabayashi, H.
A new fabrication method of a thin and large solenoids is presented. The solenoid is wound with NbTi/Cu/Al superconductor, which is wound on the inner surface of an aluminum cylinder. The fabrication...
MÖSSBAUER SPECTROSCOPIC CHARACTERIZATION OF PRUSSIAN BLUE ANALOGUES (1979)
Inoue, H., Shirai, T., Yanagisawa, S.
Prussian blue analogues of the types Fe[MB(CN)6] (MB = Pd and Pt) and Fe3[MB(CN)6]2.xH2O (MB=Cr, Co, Rh and Ir) show a single absorption line and a relatively large quadrupole splitting respectively....
MÖSSBAUER SPECTROSCOPIC CHARACTERIZATION OF PRUSSIAN BLUE ANALOGUES (1979)
Inoue, H., Shirai, T., Yanagisawa, S.
Prussian blue analogues of the types Fe[MB(CN)6] (MB = Pd and Pt) and Fe3[MB(CN)6]2.xH2O (MB=Cr, Co, Rh and Ir) show a single absorption line and a relatively large quadrupole splitting respectively....
MÖSSBAUER SPECTROSCOPIC CHARACTERIZATION OF PRUSSIAN BLUE ANALOGUES (1979)
Inoue, H., Shirai, T., Yanagisawa, S.
Prussian blue analogues of the types Fe[MB(CN)6] (MB = Pd and Pt) and Fe3[MB(CN)6]2.xH2O (MB=Cr, Co, Rh and Ir) show a single absorption line and a relatively large quadrupole splitting respectively....
Guiding a robot by visual feedback in assembling tasks (1973)
Abstraet--A system whereby a robot puts a block into a box using visual feedback is described. In this experiment, the difference between the desired position and the actual position of the object is...
How does RNase H recognize a DNA.RNA hybrid?
Nakamura, H, Oda, Y, Iwai, S, Inoue, H, Ohtsuka, E, Kanaya, S, ...
The mechanism of RNase H substrate recognition is proposed from a model of a chemically modified DNA.RNA hybrid Escherichia coli RNase H complex. Site-directed mutagenesis of the enzyme and substrate...
Neighboring base damage induced by permanganate oxidation of 8-oxoguanine in DNA.
Koizume, S, Inoue, H, Kamiya, H, Ohtsuka, E
We found that single-stranded DNA oligomers containing a 7, 8-dihydro-8-oxoguanine (8-oxo-G) residue have high reactivity toward KMnO4; the oxidation of 8-oxo-G induces damage to the neighboring...
Fukunaga, M, Hamase, A, Okada, K, Inoue, H, Tsuruta, Y, Miyamoto, K, ...
Ixodes persulcatus serves as a tick vector for Borrelia garinii and Borrelia afzelii in Japan; however, unidentified spirochetes have been isolated from other species of ticks. In this study, 13...
Characterization of DNA polymerase from Pyrococcus sp. strain KOD1 and its application to PCR.
Takagi, M, Nishioka, M, Kakihara, H, Kitabayashi, M, Inoue, H, Kawakami, B, ...
The DNA polymerase gene from the archaeon Pyrococcus sp. strain KOD1 (KOD DNA polymerase) contains a long open reading frame of 5,013 bases that encodes 1,671 amino acid residues (GenBank accession...
Fukuizumi, T, Inoue, H, Tsujisawa, T, Uchiyama, C
When Streptococcus mutans cells are injected into the skeletal muscle of rabbits, an antibody against human cardiac muscle, as well as an anti-S. mutans antibody, is induced in blood plasma. Our...
Inoue, H, Inagaki, K, Eriguchi, S I, Tamura, T, Esaki, N, Soda, K, ...
A 15-kb region of Pseudomonas putida chromosomal DNA containing the mde operon and an upstream regulatory gene (mdeR) has been cloned and sequenced. The mde operon contains two structural genes...
Placental transfer of disodium sulbenicillin.
Miyakawa, I, Taniyama, K, Inoue, H, Lee, H C, Mori, N
The concentrations of sulbenicillin in maternal and fetal blood and in the amniotic fluid compartment were measured in 27 women at parturition. With an intramuscular injection of 2,000 mg of...
Placental transfer of cefotiam dihydrochloride.
Miyakawa, I, Inoue, H, Kuroki, T, Lee, H C, Azegami, M, Mori, N
The concentrations of cefotiam dihydrochloride (CTM) in maternal and fetal blood and in amniotic fluid were determined by bioassay in 38 women at parturition. With an intravenous infusion of 1 g of...
Shimizu, Y, Yamaji, K, Masuho, Y, Yokota, T, Inoue, H, Sudo, K, ...
In addition to NS3 protease, the NS4A protein is required for efficient cleavage of the nonstructural protein region of the hepatitis C virus polyprotein. To investigate the function and the sequence...
Cellular aging is a critical determinant of primary cell resistance to v-src transformation.
Primary cell cultures are in general resistant to the transforming effect of a single oncogene, a finding considered consistent with the multistage theory of carcinogenesis. In the present studies,...
Human T-cell leukemia virus type 1 Tax protein transforms rat fibroblasts via two distinct pathways.
Matsumoto, K, Shibata, H, Fujisawa, J I, Inoue, H, Hakura, A, Tsukahara, T, ...
The human T-cell leukemia virus type 1 (HTLV-1) Tax protein activates the transcription of several cellular genes. This function is thought to play a critical role in the Tax-dependent transformation...
Identification of dimethyl disulfide-forming bacteria isolated from activated sludge.
Tomita, B, Inoue, H, Chaya, K, Nakamura, A, Hamamura, N, Ueno, K, ...
Twenty-four strains with high dimethyl disulfide (DMDS)-forming ability were isolated from activated sludge and identified to the genus level. These bacteria were classified into four groups (A, B,...
Isolation and characterization of a laccase-derepressed mutant of Neurospora crassa.
Laccase from the ascomycete Neurospora crassa is an inducible secretory enzyme. Production of this enzyme is repressed in vegetative cultures but can be induced by treatment with low concentrations...
Kyo, S, Inoue, M, Nishio, Y, Nakanishi, K, Akira, S, Inoue, H, ...
The expression of human papillomavirus type 16 (HPV16) early genes, including E6 and E7 transforming genes, is regulated by several cellular factors binding to the noncoding region (NCR), such as the...
Miyasaka, M, Takami, Y, Inoue, H, Hakura, A
The E6 and E7 genes of human papillomavirus type 16 (HPV-16) transform established lines of rat cells but not rat cells in primary culture irrespective of the expression of the two genes. The reason...
Temperature-sensitive cellular mutant for expression of mRNA from murine retrovirus.
Inoue, H, Kizaka, S, Yutsudo, M, Hakura, A
The cellular mutant B812 isolated from a Fisher rat cell line shows temperature sensitivity of focus formation induced by various retroviruses such as recombinant murine retrovirus containing the...
Higashi, Y, Tanae, A, Inoue, H, Hiromasa, T, Fujii-Kuriyama, Y
Four steroid 21-hydroxylase B [P-450(C21)B] genes (designated P.7, P.10-1, P.10-2, and P.3) from three P-450(C21)-deficient patients were isolated to analyze their structures and functions. Several...
Novel Pseudomonas product stimulates interleukin-8 production in airway epithelial cells in vitro.
Massion, P P, Inoue, H, Richman-Eisenstat, J, Grunberger, D, Jorens, P G, Housset, B, ...
Because high concentrations of IL-8 are found in the sputum of cystic fibrosis patients, we hypothesized that Pseudomonas aeruginosa (PA) induces the production of IL-8 in airway epithelial cells and...
In vivo stimulation of granulopoiesis by recombinant human granulocyte colony-stimulating factor.
Cohen, A M, Zsebo, K M, Inoue, H, Hines, D, Boone, T C, Chazin, V R, ...
Osmotic pumps containing Escherichia coli-derived recombinant human granulocyte colony-stimulating factor (rhG-CSF) were attached to indwelling jugular vein catheters and implanted subcutaneously...
Synthesis and hybridization studies on two complementary nona(2'-O-methyl)ribonucleotides.
Inoue, H, Hayase, Y, Imura, A, Iwai, S, Miura, K, Ohtsuka, E
2'-O-Methyl derivatives of the common ribonucleosides except for guanosine were synthesized via the 2'-O-methylation of appropriately-protected nucleosides with CH3I in the presence of Ag2O. The...
Kamiya, H, Miura, H, Murata-Kamiya, N, Ishikawa, H, Sakaguchi, T, Inoue, H, ...
An oligodeoxyribonucleotide containing 8-hydroxyadenine (OH8Ade) was chemically synthesized and single- and double-stranded c-Ha-ras gene fragments with OH8Ade at the second position of codon 61 were...
Kawase, Y, Iwai, S, Inoue, H, Miura, K, Ohtsuka, E
The thermal stability of DNA duplexes containing deoxyinosine in a pairing position in turn with each of the four major deoxynucleotides has been investigated by measuring ultraviolet-absorbance at...
Antisense oligodeoxyribonucleotides (15mers), containing a 2-(N-iodoacetylaminoethyl)thio-adenine, were synthesized and tested for their ability to cleave complementary DNAs (21mers). Cleavage of the...
Design of RNA enzymes distinguishing a single base mutation in RNA.
Koizumi, M, Hayase, Y, Iwai, S, Kamiya, H, Inoue, H, Ohtsuka, E
RNA enzymes (ribozymes) which can cleave RNA by recognizing sequences of 9-15 bases are described. Substrates must contain UX (X = U, C or A). A ribozyme consisting of two oligoribonucleotides (19...
Inoue, H, Imura, A, Ohtsuka, E
Partially self-complementary dodecadeoxyribonucleotides containing a fluorescent nucleoside, 3-beta-D-2'-deoxyribofuranosyl-2, 7-dioxopyrido[2, 3-d]pyrimidine (pyridopyrimidine deoxynucleoside, dF)...
Cloning and functional characterization of a eucaryotic DNA photolyase gene from Neurospora crassa.
Yajima, H, Inoue, H, Oikawa, A, Yasui, A
We cloned a genomic fragment of a photolyase gene from Neurospora crassa by polymerase chain reaction using synthesized oligonucleotide primers designed from the most conserved amino acid sequences...
NMR studies of a DNA containing 8-hydroxydeoxyguanosine.
Oda, Y, Uesugi, S, Ikehara, M, Nishimura, S, Kawase, Y, Ishikawa, H, ...
The effects of hydroxylation at the C8 of a deoxyguanosine residue in DNA were studied by NMR analysis of a self-complementary dodecanucleotide, d(C1-G2-C3-oh8G4-A5-A6-T7-T8-C9-G10-C11-G12), which...
Iwai, S, Yamada, E, Asaka, M, Hayase, Y, Inoue, H, Ohtsuka, E
Six nonaribonucleotides containing the 5'-splice site, one complementary nonamer and an octadecamer containing the 3'-splice site have been synthesized on a polymer support using the...
Site-directed cleavage of RNA.
Shibahara, S, Mukai, S, Nishihara, T, Inoue, H, Ohtsuka, E, Morisawa, H
Using complementary chimeric oligonucleotides containing deoxyribonucleotides and 2'-O-methylribonucleotides (1), enzymatically synthesized RNA (90 mer) were cleaved at a single site with Escherichia...
Yajima, H, Takao, M, Yasuhira, S, Zhao, J H, Ishii, C, Inoue, H, ...
Many eukaryotic organisms, including humans, remove ultraviolet (UV) damage from their genomes by the nucleotide excision repair pathway, which requires more than 10 separate protein factors....
Yamaoka, S, Inoue, H, Sakurai, M, Sugiyama, T, Hazama, M, Yamada, T, ...
Human T-cell leukemia virus type I (HTLV-I) encodes a 40 kDa trans-acting protein, Tax, that regulates transcription of both the proviral and cellular genes, and can transform rat fibroblasts. To...
Possible involvement of IL-12 expression by Epstein-Barr virus in Sjögren syndrome.
Horiuchi, M, Yamano, S, Inoue, H, Ishii, J, Nagata, Y, Adachi, H, ...
AIM: To determine the correlation between interleukin 12 (IL-12) expression and Epstein-Barr virus (EBV) in Sjögren syndrome. METHODS: Indirect immunohistochemical technique, enzyme linked...
Hayase, Y, Jahn, M, Rogers, M J, Sylvers, L A, Koizumi, M, Inoue, H, ...
The fidelity of protein biosynthesis rests largely on the correct aminoacylation of transfer RNAs by their cognate aminoacyl-tRNA synthetases. Previous studies have demonstrated that the interaction...
A distinct terminal structure in newly synthesized chondroitin sulphate chains.
Otsu, K, Inoue, H, Tsuzuki, Y, Yonekura, H, Nakanishi, Y, Suzuki, S
A method was developed for the analysis of non-reducing terminal structure of radiolabelled chondroitin sulphate chains with the aid of N-acetylgalactosamine 4-sulphatase ('terminal 4-sulphatase'),...
Quantitative tissue isolation from Drosophila freeze-dried in acetone.
Fujita, S C, Inoue, H, Yoshioka, T, Hotta, Y
Freeze-drying procedures were developed to enable collection of tissues from Drosophila flies. The flies were frozen in acetone at -86 or -94 degrees C, and dehydrated therein. After drying, many...
Kawabata, M, Inoue, H, Hanyu, A, Imamura, T, Miyazono, K
Smad proteins are signal transducers for the members of the transforming growth factor-beta (TGF-beta) superfamily. Here we show that, in the absence TGF-beta stimulation, Smads exist as monomers in...
Athauda, S. P. B., Matsumoto, K., Rajapakshe, S., Kuribayashi, M., Kojima, M., Kubomura-Yoshida, N., ...
Yokota, H, Iwano, H, Endo, M, Kobayashi, T, Inoue, H, Ikushiro, S, ...
Bisphenol A, an environmental oestrogenic chemical, was found to conjugate highly with glucuronic acid in male rat liver microsomes studied in vitro. In the various isoforms tested (1A1, 1A3, 1A5,...
Expression of MAGE genes in human colorectal carcinoma.
Mori, M, Inoue, H, Mimori, K, Shibuta, K, Baba, K, Nakashima, H, ...
OBJECTIVE: The human genes MAGE-1 and -3 encode tumor-specific peptide antigens, which are recognized by autologous cytotoxic T lymphocytes. The antigens coded by those genes may be useful for cancer...
Thermal imaging of receptor-activated heat production in single cells.
Zohar, O, Ikeda, M, Shinagawa, H, Inoue, H, Nakamura, H, Elbaum, D, ...
Changes in enthalpy (i.e., heat content) occur during the diverse intracellular chemical and biophysical interactions that take place in the life cycle of biological cells. Such changes have...
Resection of the trachea infiltrated by thyroid carcinoma.
Ishihara, T, Yamazaki, S, Kobayashi, K, Inoue, H, Fukai, S, Ito, K, ...
Twenty-four thyroid carcinoma patients with infiltration of the trachea were treated surgically. The histological diagnosis in these cases included papillary adenocarcinoma in 22 different patients,...
Higashi, Y, Tanae, A, Inoue, H, Fujii-Kuriyama, Y
Oligonucleotide probes specific for the deleterious mutations harbored in the P-450(C21)A pseudogene and oligonucleotide probes specific for the corresponding sequences in the B gene were prepared to...
Inoue, H, Hisamatsu, K I, Yamauchi, M, Kumagai, N
A rapid, simple and low-cost assay method of histamine-N-methyltransferase activity was developed. Methylhistamine, which was separated from the enzymatic reaction system on reversed-phase...
Nishida, K, Inoue, H, Murakami, T
OBJECTIVE--To locate fibronectin ultrastructurally in the most superficial layer of normal articular cartilage of rabbits, in order to clarify its role in joint physiology. METHODS--Articular...
Endoscopic treatment of early oesophageal or gastric cancer.
Takeshita, K, Tani, M, Inoue, H, Saeki, I, Hayashi, S, Honda, T, ...
BACKGROUND AND AIMS: Endoscopic treatment has become increasingly popular in recent years as an alternative to surgical treatment with the hope of offering superior quality of life (QOL) for the...
Elongation factor 1 gamma mRNA expression in oesophageal carcinoma.
Mimori, K, Mori, M, Inoue, H, Ueo, H, Mafune, K, Akiyoshi, T, ...
Elongation factor 1 gamma (EF1 gamma) is known to be a subunit of EF1, one of the G proteins that mediate the transport of aminoacyl tRNA to 80S ribosomes during translation. As little is known...
Etoh, T, Inoue, H, Yoshikawa, Y, Barnard, G, Kitano, S, Mori, M
BACKGROUND—Collagenase-3 (matrix metalloproteinase-13, MMP-13) is a recently identified human MMP with broad substrate specificity which can be activated by membrane type 1 (MT1) matrix...
Visapää, J P, Götte, K, Benesova, M, Li, J, Homann, N, Conradt, C, ...
Background: Chronic ethanol consumption is associated with an increased risk of upper aerodigestive tract cancer. As acetaldehyde seems to be a carcinogenic factor associated with chronic alcohol...
Toda, I, Kawahara, T, Murakawa, Y, Nozaki, A, Kawakubo, K, Inoue, H, ...
Electrophysiological studies were performed in eight patients (four men and four women, mean (SD) age 24 (5) years with paroxysmal attacks of palpitation during or immediately after exercise. Five...
Treatment of dry eye by autologous serum application in Sjögren's syndrome
Tsubota, K., Goto, E., Fujita, H., Ono, M., Inoue, H., Saito, I., ...
AIM—To evaluate the efficacy of autologous serum application for the treatment of dry eye in Sjögren's syndrome. METHODS—The stability of essential components (EGF, vitamin A, and TGF-β) in...
Karimine, N, Arinaga, S, Inoue, H, Nanbara, S, Ueo, H, Akiyoshi, T
Lymphokine-activated killer (LAK) cells generated by culture of peripheral blood mononuclear cells (PBMC), spleen cells (SPC) and regional lymph node cells (LNC) with IL-2 for 4 days were examined...
Inoue, H, Takeuchi, M, Tanaka, T, Usui, M, Ando, S, Taguchi, O
IRBP is a glycolipoprotein with a four-fold partially homologous repeat structure approximately 300 residues in length, and is one of the retinal antigens capable of inducing experimental autoimmune...
Kaneko, M, Inoue, H, Nakazawa, R, Azuma, N, Suzuki, M, Yamauchi, S, ...
Pirfenidone has been shown to modify some cytokine regulatory actions and inhibit fibroblast biochemical reactions resulting in inhibition of proliferation and collagen matrix synthesis by...
F. Furuta, DESY Maschinenphysik, Y. Higashi, T. Higo, H. Inoue, ...
Poster
Modulation by glycyrrhetinic acid derivatives of TPA-induced mouse ear oedema.
Inoue, H., Mori, T., Shibata, S., Koshihara, Y.
1. The anti-inflammatory effects of glycyrrhetinic acid and its derivatives on TPA (12-O-tetradecanoylphorbol-13-acetate)-induced mouse ear oedema were studied. The mechanisms of TPA-induced ear...
1. The longitudinal muscle from the uterus of oestrogen-treated rats was quiescent in Mg-free Krebs solution. Electrical stimulation generated phasic contraction, which was depressed to 35% and 18%...
Involvement of apamin-sensitive K+ channels in antigen-induced spasm of guinea-pig isolated trachea.
Yamauchi, H., Miura, M., Ichinose, M., Ishikawa, J., Nakajima, N., Tomaki, M., ...
1. In order to examine whether K+ channels play a role in antigen-induced airway responses, the effect of K+ channel blockers on antigen-induced airway smooth muscle contraction and mediator release...
Inoue, H., Nagata, N., Koshihara, Y.
1. We have investigated the mechanism of capsaicin-induced mouse ear oedema compared with that of arachidonic acid (AA)-induced ear oedema, and evaluated the possible involvement of neuropeptides in...
Inoue, H, Iwashita, A, Kanegae, H, Higuchi, K, Fujinaga, Y, Matsumoto, I
A rare case of a peripheral pulmonary adenoid cystic carcinoma is presented. Histological examination after lobectomy showed pronounced submucosal invasion of the carcinoma to proximal bronchi.
Resection of thyroid carcinoma infiltrating the trachea.
Ishihara, T, Kikuchi, K, Ikeda, T, Inoue, H, Fukai, S, Ito, K, ...
We have treated surgically 11 patients with thyroid carcinoma that had infiltrated into the trachea. Three patients had primary tumours, and eight had recurrent tumours after previous operations....
Ganbo, T., Inoue, H., Kikushima, K., Mizukoshi, A., Murakami, Y.
We measured sIL-2R, TNF-α and sICAM-1 in the sera and middle ear effusions (MEEs) of patients with otitis media with effusion (OME). Although there was no signmcant difference between the sIL-2R...
The Effect of Lyso-PAF on Ciliary Activity of Human Paranasal Sinus Mucosa in vitro
Ganbo, T., Hisamatsu, K., Inoue, H., Nakajima, T., Murakami, Y.
The effect of lyso-PAF on ciliated cells was investigated in vitro. Normal mucosa was surgically obtained from human paranasal sinuses and incubated in the form of tissue culture. Ciliated epithelium...
Nishiyama, T, Mishima, K, Obara, K, Inoue, H, Doi, T, Kondo, S, ...
Regulation of the adhesion of mononuclear cells to endothelial cells is considered to be a critical step for the treatment of inflammatory diseases, including autoimmune diseases. K-13182 was...
Sugao, M, Fujiki, A, Sakabe, M, Nishida, K, Tsuneda, T, Iwamoto, J, ...
Expression of the multidrug resistance-associated protein (MRP) gene in non-small-cell lung cancer.
Ota, E., Abe, Y., Oshika, Y., Ozeki, Y., Iwasaki, M., Inoue, H., ...
We examined the levels of expression of the multidrug resistance-associated protein (MRP) gene quantified by Northern blot analysis in comparison with those of the MDR1 gene determined by reverse...
Tanaka, K., Inoue, H., Miki, H., Masuda, E., Kitaichi, M., Komaki, K., ...
We have demonstrated the expression of thyrotropin receptor (TSH-R) in thyroid neoplasms (13 adenomas, 21 papillary carcinomas, two follicular carcinomas) and adjacent normal thyroid using the...
Nakamura, Y, Tanaka, F, Haraguchi, N, Mimori, K, Matsumoto, T, Inoue, H, ...
Mitotic centromere-associated kinesin (MCAK) is a microtubule (MT) depolymerase necessary for ensuring proper kinetochore MT attachment during spindle formation. To determine MCAK expression status...
Reduced tau expression in gastric cancer can identify candidates for successful Paclitaxel treatment
Mimori, K, Sadanaga, N, Yoshikawa, Y, Ishikawa, K, Hashimoto, M, Tanaka, F, ...
A recent study disclosed that breast cancer cases with low ‘tau' expression can predict susceptibility to Paclitaxel administration. In the current study, the clinical significance of tau...
Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer
Ohta, M, Mimori, K, Fukuyoshi, Y, Kita, Y, Motoyama, K, Yamashita, K, ...
We previously cloned human G protein gamma 7 (GNG7) and demonstrated that it was downregulated in gastrointestinal cancer. The significance of GNG7 expression in oesophageal cancer is unknown. TaqMan...
Clinicopathological significance of EZH2 mRNA expression in patients with hepatocellular carcinoma
Sudo, T, Utsunomiya, T, Mimori, K, Nagahara, H, Ogawa, K, Inoue, H, ...
Enhancer of zeste homologue 2 (EZH2), a member of the polycomb group protein family, plays a crucial role in the regulation of embryonic development and has been associated with the regulation of the...
The clinical significance of MMP-1 expression in oesophageal carcinoma
Yamashita, K, Mori, M, Kataoka, A, Inoue, H, Sugimachi, K
Matrix metalloproteinase-1 (MMP-1) is involved in the degradation of interstitial collagen and thus thought to play a role in invasion of carcinoma. We investigated 51 oesophageal carcinoma patients...
Expression of multiple cancer-testis antigen genes in gastrointestinal and breast carcinomas
Mashino, K, Sadanaga, N, Tanaka, F, Yamaguchi, H, Nagashima, H, Inoue, H, ...
Cancer-testis antigens (CTAs) such as MAGE are selectively expressed in various types of human neoplasms but not in normal tissues other than testis. This characteristic feature of CTAs makes them...
Nishida, K, Furumatsu, T, Takada, I, Kawai, A, Yoshida, A, Kunisada, T, ...
A rare immunohistochemical study using 28 surgical sections of human chondrosarcoma revealed that 67.9% of tumour cells had weak (10-40%) or strong (>40%) positive immunoreaction for peroxisome...
EML4–ALK fusion transcript is not found in gastrointestinal and breast cancers
Fukuyoshi, Y, Inoue, H, Kita, Y, Utsunomiya, T, Ishida, T, Mori, M
Fusion genes have been identified as chromosomal rearrangements in certain cancers, such as leukaemia, lymphoma, and sarcoma. The EML4–ALK (EML4: echinoderm microtubule-associated-protein-like 4;...
Clinical significance of elongation factor-1 delta mRNA expression in oesophageal carcinoma
Ogawa, K, Utsunomiya, T, Mimori, K, Tanaka, Y, Tanaka, F, Inoue, H, ...
Clinical significance of Caveolin-1, Caveolin-2 and HER2/neu mRNA expression in human breast cancer
Sagara, Y, Mimori, K, Yoshinaga, K, Tanaka, F, Nishida, K, Ohno, S, ...
Ishikawa, K, Kamohara, Y, Tanaka, F, Haraguchi, N, Mimori, K, Inoue, H, ...
Mitotic centromere-associated kinesin (MCAK) is a microtubule depolymerase that is essential for proper kinetochore–microtubule attachment during spindle formation. Overexpression of MCAK has been...