H. Itoh

Publication List Details

Period

1977 - 9999

Number

181

Co-Authors

A Unified Approach to Composite MVL (Multiple-Valued Logic) with Monotonic Subfunction, (9999)

Nakamichi,M., Itoh,H.

The concept of composite multiple-valued logic (CMVL) is introduced. The CMVL has subfunctions in the subsets of logical values. The subfunctions, especially monotonic ones play role to make the...

Properties of electron swarms in CF3I (2009)

Hasegawa, H., Date, H., Shimozuma, M., Itoh, H.

We report the electron swarm parameters, the drift velocity, and the ionization coefficients in CF3I gas for relatively wide ranges of reduced electric fields (E/N). The drift velocity is measured...

Epitaxial-strain effect on charge/orbital order in Pr0.5Ca0.5MnO3 films (2009)

Okuyama, D., Nakamura, M., Wakabayashi, Y., Itoh, H., Kumai, R., Yamada, H., ...

Effect of growth orientation on charge- and orbital-ordering (CO-OO) phenomena has been studied for Pr0.5Ca0.5MnO3 epitaxial thin films fabricated on (LaAlO3)0.3-(SrAl0.5Ta0.5O3)0.7 (LSAT) substrates...

Ferromagnetism and Electronic Structures of Nonstoichiometric Heusler-Alloy Fe_3-xMn_xSi Epilayers Grown on Ge(111) (2009)

Hamaya, K., Itoh, H., Nakatsuka, O., Ueda, K., Yamamoto, K., Itakura, M., ...

For the study of ferromagnetic materials which are compatible with group-IV semiconductor spintronics, we demonstrate control of the ferromagnetic properties of Heusler-alloys Fe_3-xMn_xSi...

Expression of ATP sensitive K+ channel subunit Kir6.1 in rat kidney (2009)

M Zhou, HJ He, R Suzuki, O Tanaka, M Sekiguchi, Y Yasuoka, ...

ATP-sensitive K+ (KATP) channels in kidney are considered to play roles in regulating membrane potential during the change in intracellular ATP concentration. They are composed of channel subunits...

Spin polarization control through resonant states in an Fe/GaAs Schottky barrier (2008)

Honda, S., Itoh, H., Inoue, J., Kurebayashi, H., Trypiniotis, T., Barnes, C. H. W., ...

Spin polarization of the tunnel conductivity has been studied for Fe/GaAs junctions with Schottky barriers.It is shown that band matching of resonant interface states within the Schottky barrier...

Spin polarization control through resonant states in an Fe/GaAs Schottky barrier (2008)

Honda, S., Itoh, H., Inoue, J., Kurebayashi, H., Trypiniotis, T., Barnes, C. H. W., ...

Spin polarization of the tunnel conductivity has been studied for Fe/GaAs junctions with Schottky barriers. It is shown that band matching of resonant interface states within the Schottky barrier...

Downloaded from (2008)

H Itoh, K Nakao, M Mukoyama, S Shiono, N Morii, A Sugawara, ...

Effects of intravenously administered beta-human atrial natriuretic polypeptide in humans

Effect of the Schottky barrier height on the detection of midgap levels in 4H-SiC by deep level transient spectroscopy (2007)

Reshanov, S. A., Pensl, G., Danno, K., Kimoto, T., Hishiki, S., Ohshima, T., ...

The effect of the Schottky barrier height on the detection of the concentration of midgap defects using deep level transient spectroscopy (DLTS) is experimentally and theoretically studied for EH6...

Human oviductal epithelial cells express Toll-like receptor 3 and respond to double-stranded RNA: Fallopian tube-specific mucosal immunity against viral infection (2007)

Nasu, K., Itoh, H., Yuge, A., Nishida, M., Narahara, H.

BACKGROUND: The aim of this study was to evaluate the site-specific immunoregulatory mechanisms against viral infection in human Fallopian tubes. METHODS: We therefore investigated the effects of...

Human oviductal epithelial cells express Toll-like receptor 3 and respond to double-stranded RNA: Fallopian tube-specific mucosal immunity against viral infection (2006)

Nasu, K., Itoh, H., Yuge, A., Nishida, M., Narahara, H.

BACKGROUND: The aim of this study was to evaluate the site-specific immunoregulatory mechanisms against viral infection in human Fallopian tubes. METHODS: We therefore investigated the effects of...

Human oviductal epithelial cells express Toll-like receptor 3 and respond to double-stranded RNA: Fallopian tube-specific mucosal immunity against viral infection (2006)

Nasu, K., Itoh, H., Yuge, A., Nishida, M., Narahara, H.

BACKGROUND: The aim of this study was to evaluate the site-specific immunoregulatory mechanisms against viral infection in human Fallopian tubes. METHODS: We therefore investigated the effects of...

What determines the likelihood of species discovery in marine holozooplankton: is size, range or depth important? (2005)

Gibbons, M.J., Richardson, A.J., Angel, M.V., Buecher, E., Esnal, G., Fernandez Alamo, M.A., ...

The relationship between date of first description and size, geographic range and depth of occurrence is investigated for 18 orders of marine holozooplankton (comprising over 4000 species). Results...

What determines the likelihood of species discovery in marine holozooplankton: is size, range or depth important? (2005)

Gibbons, M.J., Richardson, A.J., Angel, M.V., Buecher, E., Esnal, G., Alamo, M.A.F., ...

The relationship between date of first description and size, geographic range and depth of occurrence is investigated for 18 orders of marine holozooplankton (comprising over 4000 species). Results...

What determines the likelihood of species discovery in marine holozooplankton: is size, range or depth important? (2005)

Gibbons, M. J., Richardson, A. J., Angel, M. V., Buecher, E., Esnal, G., Alamo, M. A. F., ...

The relationship between date of first description and size, geographic range and depth of occurrence is investigated for 18 orders of marine holozooplankton (comprising over 4000 species). Results...

What determines the likelihood of species discovery in marine holozooplankton: is size, range or depth important? (2005)

Gibbons, M. J., Richardson, A. J., Angel, M. V., Buecher, E., Esnal, G., Alamo, M. A. F., ...

The relationship between date of first description and size, geographic range and depth of occurrence is investigated for 18 orders of marine holozooplankton (comprising over 4000 species). Results...

T-cell clonality to Porphyromonas gingivalis and human heat shock protein 60s in patients with atherosclerosis and periodontitis (2004)

Yamazaki, K, Ohsawa, Y, Itoh, H, Ueki, K, Tabeta, K, Oda, T, ...

Individuals with periodontitis have been reported to have a significantly increased risk of developing coronary heart disease. Several studies have demonstrated that the immune response to heat shock...

Quantum oscillation of magnetoresistance in tunneling junctions with a nonmagnetic spacer (2003)

Itoh, H., Inoue, J., Umerski, A., Mathon, J.

We make a theoretical study of the quantum oscillations of the tunneling magnetoresistance (TMR) as a function of the spacer layer thickness. Such oscillations were recently observed in tunneling...

Cathodoluminescence characterization of dislocations in gallium nitride using a transmission electron microscope (2003)

Yamamoto, N, Itoh, H, Grillo, V, Chichibu, S F, Keller, S, Speck, J S, ...

Cathodoluminescence technique combined with transmission electron microscopy (TEM-CL) has been used to characterize optical properties of dislocations in GaN epilayers. The dislocations act as...

Influence of impurity-scattering on tunneling conductance in d-wave superconductors with broken time reversal symmetry (2003)

Kitaura, N., Itoh, H., Asano, Y., Tanaka, Y., Inoue, J., Tanuma, Y., ...

Effects of impurity scattering on tunneling conductance in dirty normal-metal/insulator/superconductor junctions are studied based on the Kubo formula and the recursive Green function method. The...

Quantum oscillation of magnetoresistance in tunneling junctions with a nonmagnetic spacer (2002)

Itoh, H., Umerski, J. Inoue A., Mathon, J.

We make a theoretical study of the quantum oscillations of the tunneling magnetoresistance (TMR) as a function of the spacer layer thickness. Such oscillations were recently observed in tunneling...

Tunnel magnetoresistance and interfacial electronic state (2002)

Inoue, J., Itoh, H.

We study the relation between tunnel magnetoresistance (TMR) and interfacial electronic states modified by magnetic impurities introduced at the interface of the ferromagnetic tunnel junctions, by...

Tunneling conductance in normal metal - high $T_{C}$ cuprate junctions in the presence of magnetic field (2001)

Tanaka, Y., Itoh, H., Tsuchiura, H., Inoue, J., Tanuma, Y., Kashiwaya, S.

The magnetic field responses of the zero-bias conductance peak (ZBCP) in tunneling spectra of high $T_{C}$ cuprate junctions are studied theoretically. Our calculation is based on the lattice Green's...

Difference in sensitivity to vecuronium between patients with ocular and generalized myasthenia gravis (2001)

Itoh, H., Shibata, K., Nitta, S.

Patients with myasthenia gravis show sensitivity to non‐depolarizing neuromuscular blocking drugs, but little is known about differences in this sensitivity between types of myasthenia. In 10...

Double Resonance Mechanism of Ferromagnetism and Magnetotransport in (Ga-Mn)As (2000)

Inoue, J., Nonoyama, S., Itoh, H.

We calculate the electronic states of the Mn-doped semiconductors and show that resonant states are formed at the top of the down spin valence band due to magnetic impurities and that they give rise...

Discovery of a New Deeply Eclipsing SU UMa-Type Dwarf Nova, IY UMa (= TmzV85) (2000)

Uemura, M., Kato, T., Matsumoto, K., Takamizawa, K., Schmeer, P., Jensen, L. T., ...

We discovered a new deeply eclipsing SU UMa-type dwarf nova, IY UMa, which experienced a superoutburst in 2000 January. Our monitoring revealed two distinct outbursts, which suggest a superoutburst...

Nucleation Control of Diamond Synthesized by Microwave Palsma CVD on Cemented Carbide Substrate. (1998)

Itoh, H., Osaki, T., Iwahara, H., Sakamoto, H.

Diamond was coated on to cemented carbide substrate by microwave plasma CVD, in which nucleation control of diamond crystals was investigated under constant deposition conditions; total pressure 30...

Microstructure of cBN-Diamond Sintered Compact Prepared by Reaction Sintering. (1998)

Itoh, H., Takao, H., Iwahara, H.

CBN-diamond composite sintered compact (diamond content 15-70 wt%) were prepared by reaction sintering at 7-7.5 GPa and 1400-1700 C for 10-30 min from the starting powder of the hBN-diamond system in...

Microstructure and Properties of the Sintered Composite Prepared by Hot Pressing of TiN-Coated Alumina Powder. (1998)

Itoh, H., Sugimoto, H., Iwahara, H., Otsuka, J., Iio, S.

Alumina powders (average grain size: 50 micron) coated with TiN film of thickness 0.5 and 1.2 micron were prepared by rotary powder-bed chemical vapor deposition for 15 and 90 min, respectively....

Clinical profiles of Chinese patients with diffuse panbronchiolitis (1998)

Tsang, KWT, Ooi, CGC, Ip, MSM, Lam, WK, Ngan, H, Chan, E, ...

BACKGROUND: Diffuse panbronchiolitis (DPB), characterised by progressive sinobronchial sepsis, is well characterised in Japanese subjects but not in other ethnic groups. The experience with DPB in...

The clinical profiles of Chinese patients with diffuse panbronchiolitis (1998)

Tsang, KWT, Ooi, CGC, Ip, MSM, Lam, WK, Ngan, H, Wong, MP, ...

BACKGROUNDDiffuse panbronchiolitis (DPB), characterised by progressive sinobronchial sepsis, is well characterised in Japanese subjects but not in other ethnic groups. The experience with DPB in...

Doping of SiC by implantation of Boron and Aluminum (1997)

Troffer, T., Schadt, M., Frank, T., Itoh, H., Pensl, G., Heindl, J., ...

Experimental studies on aluminum (Al) and boron (B) implantation in 4H/6H SiC are reported; the implantation is conducted at room temperature or elevated temperatures (500 to 700 degrees C). Both Al...

EHMO CALCULATION FOR HYDROGEN ADSORPTION ON NI AND CU ATOM CLUSTERS (1977)

Itoh, H.

The extended Hückel molecular orbital theory is applied to adsorption of atomic hydrogen on (111), (110) and (100) surfaces of Ni and Cu atom clusters containing up to ten atoms. The edge (or...

EHMO CALCULATION FOR HYDROGEN ADSORPTION ON NI AND CU ATOM CLUSTERS (1977)

Itoh, H.

The extended Hückel molecular orbital theory is applied to adsorption of atomic hydrogen on (111), (110) and (100) surfaces of Ni and Cu atom clusters containing up to ten atoms. The edge (or...

EHMO CALCULATION FOR HYDROGEN ADSORPTION ON NI AND CU ATOM CLUSTERS (1977)

Itoh, H.

The extended Hückel molecular orbital theory is applied to adsorption of atomic hydrogen on (111), (110) and (100) surfaces of Ni and Cu atom clusters containing up to ten atoms. The edge (or...

Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing.

Tsukamoto, T, Toyama, R, Itoh, H, Kozasa, T, Matsuoka, M, Kaziro, Y

Go is a specific class ("other") of signal-transducing heterotrimeric GTP-binding proteins (G proteins) that is expressed in high levels in mammalian brain. We have cloned two different rat cDNAs...

Analysis of stress-induced or salicylic acid-induced expression of the pathogenesis-related 1a protein gene in transgenic tobacco.

Ohshima, M, Itoh, H, Matsuoka, M, Murakami, T, Ohashi, Y

The cis-acting elements for regulating gene expression of the tobacco pathogenesis-related 1a protein gene were analyzed in transgenic plants. The 5'-flanking 2.4-kilobase fragment from the...

Detection of Methylobacterium species by 16S rRNA gene-targeted PCR.

Nishio, T, Yoshikura, T, Itoh, H

We designed PCR primers for specific amplification of the 16S rRNA genes of seven species of the genus Methylobacterium. All of the pairwise species tested were successfully differentiated by PCR...

Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy. Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload.

Nakagawa, O, Ogawa, Y, Itoh, H, Suga, S, Komatsu, Y, Kishimoto, I, ...

We previously demonstrated that brain natriuretic peptide (BNP) is a cardiac hormone mainly produced in the ventricle, while the major production site of atrial natriuretic peptide (ANP) is the...

Genetic analysis of the attenuation phenotype of poliovirus type 1.

Omata, T, Kohara, M, Kuge, S, Komatsu, T, Abe, S, Semler, B L, ...

Seven different recombinant viruses from the virulent Mahoney and the attenuated Sabin parental strains of type 1 poliovirus were constructed in vitro by using infectious cDNA clones. Monkey...

In vitro phenotypic markers of a poliovirus recombinant constructed from infectious cDNA clones of the neurovirulent Mahoney strain and the attenuated Sabin 1 strain.

Kohara, M, Omata, T, Kameda, A, Semler, B L, Itoh, H, Wimmer, E, ...

Infectious cDNA corresponding to the entire genome of the attenuated Sabin strain of type 1 poliovirus has been inserted into EcoRI site of bacterial plasmid pBR325. Two consecutive PstI fragments...

Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions.

Nakafuku, M, Obara, T, Kaibuchi, K, Miyajima, I, Miyajima, A, Itoh, H, ...

In a previous paper, we demonstrated that a gene coding for a protein homologous to the alpha subunit of mammalian guanine nucleotide-binding regulatory (G) proteins occurs in Saccharomyces...

Isolation and characterization of the human Gs alpha gene.

Kozasa, T, Itoh, H, Tsukamoto, T, Kaziro, Y

The gene for Gs alpha (the alpha subunit of the guanine nucleotide-binding protein Gs) was isolated from human genomic libraries using rat Gs alpha cDNA as a probe. Comparison of the nucleotide...

Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit.

Matsuoka, M, Itoh, H, Kozasa, T, Kaziro, Y

We have isolated cDNA clones from rat C6 glioma cells coding for several guanine nucleotide-binding regulatory protein (G protein) alpha subunits (G alpha). The cDNA clones were then used to isolate...

Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II.

Itoh, H, Mukoyama, M, Pratt, R E, Gibbons, G H, Dzau, V J

Angiotensin (Ang) II stimulates hypertrophic growth of vascular smooth muscle cells (VSMC). Accompanying this growth is the induction of the expression of growth-related protooncogenes (c-fos, c-jun,...

Molecular cloning of the complementary DNA and gene that encode mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide gene.

Ogawa, Y, Itoh, H, Tamura, N, Suga, S, Yoshimasa, T, Uehira, M, ...

Brain natriuretic peptide (BNP) is a cardiac hormone that occurs predominantly in the ventricle. To study the roles of BNP in chronic cardiovascular regulation, we isolated mouse BNP cDNA and genomic...

Molecular cloning of hamster brain and atrial natriuretic peptide cDNAs. Cardiomyopathic hamsters are useful models for brain and atrial natriuretic peptides.

Tamura, N, Ogawa, Y, Itoh, H, Arai, H, Suga, S, Nakagawa, O, ...

Brain and atrial natriuretic peptides (BNP and ANP) are cardiac hormones with diuretic, natriuretic, and vasodilatory activities. Cardiomyopathic hamsters are widely used animal models of heart...

Atrial natriuretic polypeptide inhibits hypertrophy of vascular smooth muscle cells.

Itoh, H, Pratt, R E, Dzau, V J

Vascular remodeling is central to the pathophysiology of hypertension and atherosclerosis. Recent evidence suggests that vasoconstrictive substances, such as angiotensin II (AII), may function as a...

Molecular cloning and sequence analysis of chum salmon gonadotropin cDNAs.

Sekine, S, Saito, A, Itoh, H, Kawauchi, H, Itoh, S

cDNAs encoding alpha and beta subunits of salmon gonadotropins, sGTHI and sGTHII, have been isolated from the cDNA library prepared from salmon pituitary mRNA. sGTHI alpha, sGTHI beta, and sGTHII...

Chronic blockade of endogenous atrial natriuretic polypeptide (ANP) by monoclonal antibody against ANP accelerates the development of hypertension in spontaneously hypertensive and deoxycorticosterone acetate-salt-hypertensive rats.

Itoh, H, Nakao, K, Mukoyama, M, Yamada, T, Hosoda, K, Shirakami, G, ...

To explain the pathophysiological significance of endogenous atrial natriuretic polypeptide (ANP) in the development of hypertension, we examined the effect of chronic, repetitive administrations of...

Occurrence in Saccharomyces cerevisiae of a gene homologous to the cDNA coding for the alpha subunit of mammalian G proteins.

Nakafuku, M, Itoh, H, Nakamura, S, Kaziro, Y

From cross-hybridization studies with cDNAs that code for the alpha subunits of rat brain guanine nucleotide-binding regulatory (G) proteins, we have isolated a gene from yeast Saccharomyces...

Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain.

Itoh, H, Kozasa, T, Nagata, S, Nakamura, S, Katada, T, Ui, M, ...

We have cloned cDNAs encoding alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go and determined their nucleotide sequences. Purified preparations of Gi and Go alpha subunits (Gi...

Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-beta. Possible existence of "vascular natriuretic peptide system".

Suga, S, Nakao, K, Itoh, H, Komatsu, Y, Ogawa, Y, Hama, N, ...

C-type natriuretic peptide (CNP), the third member of the natriuretic peptide family, is thus far known to be distributed mainly in the central nervous system and is considered to act as a...

Liver enriched transcription factors and differentiation of hepatocellular carcinoma.

Hayashi, Y, Wang, W, Ninomiya, T, Nagano, H, Ohta, K, Itoh, H

The development of a complex organism relies on the precise temporal and spacial expression of its genome in many different cell types. The unique phenotype of hepatocytes arises from the expression...

Synthesis of atrial natriuretic polypeptide in human failing hearts. Evidence for altered processing of atrial natriuretic polypeptide precursor and augmented synthesis of beta-human ANP.

Sugawara, A, Nakao, K, Morii, N, Yamada, T, Itoh, H, Shiono, S, ...

To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, 20 human right auricles obtained at cardiovascular surgery were studied. The concentration of alpha-human...

Expression of intestinal trefoil factor mRNA is downregulated during progression of colorectal carcinomas.

Uchino, H, Kataoka, H, Itoh, H, Koono, M

AIMS: Intestinal trefoil factor is a mucosa associated trefoil peptide expressed predominantly in the goblet cells of the small and large intestine. The aim of this work was to investigate the...

Quantitation of hepatitis C viral RNA in liver and serum samples using competitive polymerase chain reaction.

Sugano, M, Hayashi, Y, Yoon, S, Kinoshita, M, Ninomiya, T, Ohta, K, ...

AIMS--To investigate whether the amount of hepatitis C viral RNA (HCV-RNA) in liver and serum can predict the effectiveness of interferon treatment in patients with chronic hepatitis C. METHODS--The...

Cloning of the cDNA encoding mast cell tryptase of Mongolian gerbil, Meriones unguiculatus, and its preferential expression in the intestinal mucosa.

Murakumo, Y, Ide, H, Itoh, H, Tomita, M, Kobayashi, T, Maruyama, H, ...

By using the combination of reverse-transcription PCR and rapid amplification of cDNA ends methods, a cDNA encoding mast cell tryptase was successfully cloned from the small intestine of Mongolian...

Cloning of the cDNA encoding a novel rat mast-cell proteinase, rMCP-3, and its expression in comparison with other rat mast-cell proteinases.

Ide, H, Itoh, H, Tomita, M, Murakumo, Y, Kobayashi, T, Maruyama, H, ...

A cDNA encoding a novel rat mast-cell proteinase (MCP) named rMCP-3 was successfully cloned and sequenced from the peritoneal cells of Lewis rats infected with the intestinal nematode Nippostrongylus...

Molecular cloning of mouse intestinal trefoil factor and its expression during goblet cell changes.

Tomita, M, Itoh, H, Ishikawa, N, Higa, A, Ide, H, Murakumo, Y, ...

A cDNA encoding mouse intestinal trefoil factor (mITF) was successfully cloned and sequenced from the small intestine of C57BL/6 mouse by using the combination of reverse transcription-PCR and rapid...

Decreased serum apolipoprotein A-I concentrations in cows infected with Salmonella typhimurium.

Oikawa, S, Katoh, N, Itoh, H, Miyamoto, T, Konno, M, Kajita, T

Serum apolipoprotein A-I concentrations in cows infected with Salmonella Typhimurium were evaluated to assess its relevance in salmonellosis. Apolipoprotein A-I has been shown in rats to be secreted...

Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts.

Miyamoto, Y, Yoshimasa, T, Arai, H, Takaya, K, Ogawa, Y, Itoh, H, ...

In order to elucidate the regulatory mechanisms of expression of the human endothelin-A receptor (hET-AR) gene, we characterized hET-AR transcripts using reverse transcriptase (RT)-PCR analysis in a...

Cloning of the cDNAs for mast-cell chymases from the jejunum of Mongolian gerbils, Meriones unguiculatus, and their sequence similarities with chymases expressed in the connective-tissue mast cells of mice and rats.

Itoh, H, Murakumo, Y, Tomita, M, Ide, H, Kobayashi, T, Maruyama, H, ...

By using the combination of reverse-transcription CR and rapid amplification of cDNA ends methods, two distinct cDNAs encoding mast-cell proteases (chymases; MCPs), designated as gMCP-1 and -2, were...

cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis.

Itoh, H, Tomita, M, Uchino, H, Kobayashi, T, Kataoka, H, Sekiya, R, ...

By using a combination of the methods of reverse transcription-PCR and rapid amplification of cDNA ends, a cDNA for rat pS2 peptide (rpS2) was successfully cloned and sequenced from rat stomach. By...

Novel 30 kDa protein possessing ATP-binding and chaperone activities.

Itoh, H, Tashima, Y

A 30 kDa protein was purified from pig liver cytosol by using ATP-Sepharose and Green A column chromatography. The partial amino acid sequences of the protein (95 amino acid residues) had no...

Goblet-cell-specific transcription of mouse intestinal trefoil factor gene results from collaboration of complex series of positive and negative regulatory elements.

Itoh, H, Inoue, N, Podolsky, D K

Intestinal trefoil factor (ITF) is expressed selectively in intestinal goblet cells. Previous studies of the rat ITF gene identified one cis-regulatory element, designated the goblet-cell-response...

A novel chaperone-activity-reducing mechanism of the 90-kDa molecular chaperone HSP90.

Itoh, H, Ogura, M, Komatsuda, A, Wakui, H, Miura, A B, Tashima, Y

The 90-kDa heat shock protein (HSP90) acts as a specific molecular chaperone in the folding and regulates a wide range of associated proteins such as steroid hormone receptors. It is known that HSP90...

Preparation of giant liposomes in physiological conditions and their characterization under an optical microscope.

Akashi, K, Miyata, H, Itoh, H, Kinosita, K

Unilamellar liposomes with diameters of 25-100 microns were prepared in various physiological salt solutions, e.g., 100 mM KCl plus 1 mM CaCl2. Successful preparation of the giant liposomes at high...

Time courses of cell electroporation as revealed by submicrosecond imaging of transmembrane potential.

Hibino, M, Itoh, H, Kinosita, K

Changes in the membrane conductance of sea urchin eggs, during the course of electroporation, were investigated over the time range of 0.5 microsecond to 1 ms by imaging the transmembrane potential...

The influence of age and health status on the serum alpha 1-acid glycoprotein level of conventional and specific pathogen-free pigs.

Itoh, H, Tamura, K, Izumi, M, Motoi, Y, Kidoguchi, K, Funayama, Y

Serum alpha-1-acid glycoprotein (alpha 1AG) was measured in 212 Landrace White pigs between birth and finishing age. The alpha 1AG level of healthy pigs five to ten months of age was 338 +/- 79...

Membrane conductance of an electroporated cell analyzed by submicrosecond imaging of transmembrane potential.

Hibino, M, Shigemori, M, Itoh, H, Nagayama, K, Kinosita, K

Transmembrane potential was induced in a sea urchin egg by applying a microsecond electric pulse across the cell. The potential was imaged at a submicrosecond time resolution by staining the cell...

Spatiotemporal relationships among early events of fertilization in sea urchin eggs revealed by multiview microscopy.

Suzuki, K, Tanaka, Y, Nakajima, Y, Hirano, K, Itoh, H, Miyata, H, ...

Four early events of egg fertilization, changes in intracellular calcium concentration and intracellular pH, reorientation of the surface membrane, and the elevation of the fertilization envelope,...

Formation of giant liposomes promoted by divalent cations: critical role of electrostatic repulsion.

Akashi, K, Miyata, H, Itoh, H, Kinosita, K

Spontaneous formation of giant unilamellar liposomes in a gentle hydration process, as well as the adhesion energy between liposomal membranes, has been found to be dependent on the concentration of...

Electroporation of cell membrane visualized under a pulsed-laser fluorescence microscope.

Kinosita, K, Ashikawa, I, Saita, N, Yoshimura, H, Itoh, H, Nagayama, K, ...

Controlled permeability can be conferred to cell membranes by exposing cells to a microsecond electric pulse of sufficient intensity (electroporation). By constructing a fluorescence microimaging...

Improved visualization of intrahepatic bile ducts by endoscopic retrograde balloon catheter cholangiography.

Ikeda, S, Tanaka, M, Yoshimoto, H, Itoh, H, Nakayama, F

In seven patients with a patulous sphincter of Oddi, choledochoduodenal fistula, previous sphincterotomy, sphincteroplasty or bilioenteric anastomosis in which standard endoscopic retrograde...

Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing.

Tsukamoto, T, Toyama, R, Itoh, H, Kozasa, T, Matsuoka, M, Kaziro, Y

Go is a specific class ("other") of signal-transducing heterotrimeric GTP-binding proteins (G proteins) that is expressed in high levels in mammalian brain. We have cloned two different rat cDNAs...

Analysis of stress-induced or salicylic acid-induced expression of the pathogenesis-related 1a protein gene in transgenic tobacco.

Ohshima, M, Itoh, H, Matsuoka, M, Murakami, T, Ohashi, Y

The cis-acting elements for regulating gene expression of the tobacco pathogenesis-related 1a protein gene were analyzed in transgenic plants. The 5'-flanking 2.4-kilobase fragment from the...

Detection of Methylobacterium species by 16S rRNA gene-targeted PCR.

Nishio, T, Yoshikura, T, Itoh, H

We designed PCR primers for specific amplification of the 16S rRNA genes of seven species of the genus Methylobacterium. All of the pairwise species tested were successfully differentiated by PCR...

Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy. Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload.

Nakagawa, O, Ogawa, Y, Itoh, H, Suga, S, Komatsu, Y, Kishimoto, I, ...

We previously demonstrated that brain natriuretic peptide (BNP) is a cardiac hormone mainly produced in the ventricle, while the major production site of atrial natriuretic peptide (ANP) is the...

Genetic analysis of the attenuation phenotype of poliovirus type 1.

Omata, T, Kohara, M, Kuge, S, Komatsu, T, Abe, S, Semler, B L, ...

Seven different recombinant viruses from the virulent Mahoney and the attenuated Sabin parental strains of type 1 poliovirus were constructed in vitro by using infectious cDNA clones. Monkey...

In vitro phenotypic markers of a poliovirus recombinant constructed from infectious cDNA clones of the neurovirulent Mahoney strain and the attenuated Sabin 1 strain.

Kohara, M, Omata, T, Kameda, A, Semler, B L, Itoh, H, Wimmer, E, ...

Infectious cDNA corresponding to the entire genome of the attenuated Sabin strain of type 1 poliovirus has been inserted into EcoRI site of bacterial plasmid pBR325. Two consecutive PstI fragments...

Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions.

Nakafuku, M, Obara, T, Kaibuchi, K, Miyajima, I, Miyajima, A, Itoh, H, ...

In a previous paper, we demonstrated that a gene coding for a protein homologous to the alpha subunit of mammalian guanine nucleotide-binding regulatory (G) proteins occurs in Saccharomyces...

Isolation and characterization of the human Gs alpha gene.

Kozasa, T, Itoh, H, Tsukamoto, T, Kaziro, Y

The gene for Gs alpha (the alpha subunit of the guanine nucleotide-binding protein Gs) was isolated from human genomic libraries using rat Gs alpha cDNA as a probe. Comparison of the nucleotide...

Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit.

Matsuoka, M, Itoh, H, Kozasa, T, Kaziro, Y

We have isolated cDNA clones from rat C6 glioma cells coding for several guanine nucleotide-binding regulatory protein (G protein) alpha subunits (G alpha). The cDNA clones were then used to isolate...

Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II.

Itoh, H, Mukoyama, M, Pratt, R E, Gibbons, G H, Dzau, V J

Angiotensin (Ang) II stimulates hypertrophic growth of vascular smooth muscle cells (VSMC). Accompanying this growth is the induction of the expression of growth-related protooncogenes (c-fos, c-jun,...

Molecular cloning of the complementary DNA and gene that encode mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide gene.

Ogawa, Y, Itoh, H, Tamura, N, Suga, S, Yoshimasa, T, Uehira, M, ...

Brain natriuretic peptide (BNP) is a cardiac hormone that occurs predominantly in the ventricle. To study the roles of BNP in chronic cardiovascular regulation, we isolated mouse BNP cDNA and genomic...

Molecular cloning of hamster brain and atrial natriuretic peptide cDNAs. Cardiomyopathic hamsters are useful models for brain and atrial natriuretic peptides.

Tamura, N, Ogawa, Y, Itoh, H, Arai, H, Suga, S, Nakagawa, O, ...

Brain and atrial natriuretic peptides (BNP and ANP) are cardiac hormones with diuretic, natriuretic, and vasodilatory activities. Cardiomyopathic hamsters are widely used animal models of heart...

Atrial natriuretic polypeptide inhibits hypertrophy of vascular smooth muscle cells.

Itoh, H, Pratt, R E, Dzau, V J

Vascular remodeling is central to the pathophysiology of hypertension and atherosclerosis. Recent evidence suggests that vasoconstrictive substances, such as angiotensin II (AII), may function as a...

Molecular cloning and sequence analysis of chum salmon gonadotropin cDNAs.

Sekine, S, Saito, A, Itoh, H, Kawauchi, H, Itoh, S

cDNAs encoding alpha and beta subunits of salmon gonadotropins, sGTHI and sGTHII, have been isolated from the cDNA library prepared from salmon pituitary mRNA. sGTHI alpha, sGTHI beta, and sGTHII...

Chronic blockade of endogenous atrial natriuretic polypeptide (ANP) by monoclonal antibody against ANP accelerates the development of hypertension in spontaneously hypertensive and deoxycorticosterone acetate-salt-hypertensive rats.

Itoh, H, Nakao, K, Mukoyama, M, Yamada, T, Hosoda, K, Shirakami, G, ...

To explain the pathophysiological significance of endogenous atrial natriuretic polypeptide (ANP) in the development of hypertension, we examined the effect of chronic, repetitive administrations of...

Occurrence in Saccharomyces cerevisiae of a gene homologous to the cDNA coding for the alpha subunit of mammalian G proteins.

Nakafuku, M, Itoh, H, Nakamura, S, Kaziro, Y

From cross-hybridization studies with cDNAs that code for the alpha subunits of rat brain guanine nucleotide-binding regulatory (G) proteins, we have isolated a gene from yeast Saccharomyces...

Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain.

Itoh, H, Kozasa, T, Nagata, S, Nakamura, S, Katada, T, Ui, M, ...

We have cloned cDNAs encoding alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go and determined their nucleotide sequences. Purified preparations of Gi and Go alpha subunits (Gi...

Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-beta. Possible existence of "vascular natriuretic peptide system".

Suga, S, Nakao, K, Itoh, H, Komatsu, Y, Ogawa, Y, Hama, N, ...

C-type natriuretic peptide (CNP), the third member of the natriuretic peptide family, is thus far known to be distributed mainly in the central nervous system and is considered to act as a...

Liver enriched transcription factors and differentiation of hepatocellular carcinoma.

Hayashi, Y, Wang, W, Ninomiya, T, Nagano, H, Ohta, K, Itoh, H

The development of a complex organism relies on the precise temporal and spacial expression of its genome in many different cell types. The unique phenotype of hepatocytes arises from the expression...

Synthesis of atrial natriuretic polypeptide in human failing hearts. Evidence for altered processing of atrial natriuretic polypeptide precursor and augmented synthesis of beta-human ANP.

Sugawara, A, Nakao, K, Morii, N, Yamada, T, Itoh, H, Shiono, S, ...

To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, 20 human right auricles obtained at cardiovascular surgery were studied. The concentration of alpha-human...

Expression of intestinal trefoil factor mRNA is downregulated during progression of colorectal carcinomas.

Uchino, H, Kataoka, H, Itoh, H, Koono, M

AIMS: Intestinal trefoil factor is a mucosa associated trefoil peptide expressed predominantly in the goblet cells of the small and large intestine. The aim of this work was to investigate the...

Quantitation of hepatitis C viral RNA in liver and serum samples using competitive polymerase chain reaction.

Sugano, M, Hayashi, Y, Yoon, S, Kinoshita, M, Ninomiya, T, Ohta, K, ...

AIMS--To investigate whether the amount of hepatitis C viral RNA (HCV-RNA) in liver and serum can predict the effectiveness of interferon treatment in patients with chronic hepatitis C. METHODS--The...

Cloning of the cDNA encoding mast cell tryptase of Mongolian gerbil, Meriones unguiculatus, and its preferential expression in the intestinal mucosa.

Murakumo, Y, Ide, H, Itoh, H, Tomita, M, Kobayashi, T, Maruyama, H, ...

By using the combination of reverse-transcription PCR and rapid amplification of cDNA ends methods, a cDNA encoding mast cell tryptase was successfully cloned from the small intestine of Mongolian...

Cloning of the cDNA encoding a novel rat mast-cell proteinase, rMCP-3, and its expression in comparison with other rat mast-cell proteinases.

Ide, H, Itoh, H, Tomita, M, Murakumo, Y, Kobayashi, T, Maruyama, H, ...

A cDNA encoding a novel rat mast-cell proteinase (MCP) named rMCP-3 was successfully cloned and sequenced from the peritoneal cells of Lewis rats infected with the intestinal nematode Nippostrongylus...

Molecular cloning of mouse intestinal trefoil factor and its expression during goblet cell changes.

Tomita, M, Itoh, H, Ishikawa, N, Higa, A, Ide, H, Murakumo, Y, ...

A cDNA encoding mouse intestinal trefoil factor (mITF) was successfully cloned and sequenced from the small intestine of C57BL/6 mouse by using the combination of reverse transcription-PCR and rapid...

Decreased serum apolipoprotein A-I concentrations in cows infected with Salmonella typhimurium.

Oikawa, S, Katoh, N, Itoh, H, Miyamoto, T, Konno, M, Kajita, T

Serum apolipoprotein A-I concentrations in cows infected with Salmonella Typhimurium were evaluated to assess its relevance in salmonellosis. Apolipoprotein A-I has been shown in rats to be secreted...

Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts.

Miyamoto, Y, Yoshimasa, T, Arai, H, Takaya, K, Ogawa, Y, Itoh, H, ...

In order to elucidate the regulatory mechanisms of expression of the human endothelin-A receptor (hET-AR) gene, we characterized hET-AR transcripts using reverse transcriptase (RT)-PCR analysis in a...

Cloning of the cDNAs for mast-cell chymases from the jejunum of Mongolian gerbils, Meriones unguiculatus, and their sequence similarities with chymases expressed in the connective-tissue mast cells of mice and rats.

Itoh, H, Murakumo, Y, Tomita, M, Ide, H, Kobayashi, T, Maruyama, H, ...

By using the combination of reverse-transcription CR and rapid amplification of cDNA ends methods, two distinct cDNAs encoding mast-cell proteases (chymases; MCPs), designated as gMCP-1 and -2, were...

cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis.

Itoh, H, Tomita, M, Uchino, H, Kobayashi, T, Kataoka, H, Sekiya, R, ...

By using a combination of the methods of reverse transcription-PCR and rapid amplification of cDNA ends, a cDNA for rat pS2 peptide (rpS2) was successfully cloned and sequenced from rat stomach. By...

Novel 30 kDa protein possessing ATP-binding and chaperone activities.

Itoh, H, Tashima, Y

A 30 kDa protein was purified from pig liver cytosol by using ATP-Sepharose and Green A column chromatography. The partial amino acid sequences of the protein (95 amino acid residues) had no...

Goblet-cell-specific transcription of mouse intestinal trefoil factor gene results from collaboration of complex series of positive and negative regulatory elements.

Itoh, H, Inoue, N, Podolsky, D K

Intestinal trefoil factor (ITF) is expressed selectively in intestinal goblet cells. Previous studies of the rat ITF gene identified one cis-regulatory element, designated the goblet-cell-response...

A novel chaperone-activity-reducing mechanism of the 90-kDa molecular chaperone HSP90.

Itoh, H, Ogura, M, Komatsuda, A, Wakui, H, Miura, A B, Tashima, Y

The 90-kDa heat shock protein (HSP90) acts as a specific molecular chaperone in the folding and regulates a wide range of associated proteins such as steroid hormone receptors. It is known that HSP90...

Preparation of giant liposomes in physiological conditions and their characterization under an optical microscope.

Akashi, K, Miyata, H, Itoh, H, Kinosita, K

Unilamellar liposomes with diameters of 25-100 microns were prepared in various physiological salt solutions, e.g., 100 mM KCl plus 1 mM CaCl2. Successful preparation of the giant liposomes at high...

Time courses of cell electroporation as revealed by submicrosecond imaging of transmembrane potential.

Hibino, M, Itoh, H, Kinosita, K

Changes in the membrane conductance of sea urchin eggs, during the course of electroporation, were investigated over the time range of 0.5 microsecond to 1 ms by imaging the transmembrane potential...

The influence of age and health status on the serum alpha 1-acid glycoprotein level of conventional and specific pathogen-free pigs.

Itoh, H, Tamura, K, Izumi, M, Motoi, Y, Kidoguchi, K, Funayama, Y

Serum alpha-1-acid glycoprotein (alpha 1AG) was measured in 212 Landrace White pigs between birth and finishing age. The alpha 1AG level of healthy pigs five to ten months of age was 338 +/- 79...

Membrane conductance of an electroporated cell analyzed by submicrosecond imaging of transmembrane potential.

Hibino, M, Shigemori, M, Itoh, H, Nagayama, K, Kinosita, K

Transmembrane potential was induced in a sea urchin egg by applying a microsecond electric pulse across the cell. The potential was imaged at a submicrosecond time resolution by staining the cell...

Spatiotemporal relationships among early events of fertilization in sea urchin eggs revealed by multiview microscopy.

Suzuki, K, Tanaka, Y, Nakajima, Y, Hirano, K, Itoh, H, Miyata, H, ...

Four early events of egg fertilization, changes in intracellular calcium concentration and intracellular pH, reorientation of the surface membrane, and the elevation of the fertilization envelope,...

Formation of giant liposomes promoted by divalent cations: critical role of electrostatic repulsion.

Akashi, K, Miyata, H, Itoh, H, Kinosita, K

Spontaneous formation of giant unilamellar liposomes in a gentle hydration process, as well as the adhesion energy between liposomal membranes, has been found to be dependent on the concentration of...

Electroporation of cell membrane visualized under a pulsed-laser fluorescence microscope.

Kinosita, K, Ashikawa, I, Saita, N, Yoshimura, H, Itoh, H, Nagayama, K, ...

Controlled permeability can be conferred to cell membranes by exposing cells to a microsecond electric pulse of sufficient intensity (electroporation). By constructing a fluorescence microimaging...

Improved visualization of intrahepatic bile ducts by endoscopic retrograde balloon catheter cholangiography.

Ikeda, S, Tanaka, M, Yoshimoto, H, Itoh, H, Nakayama, F

In seven patients with a patulous sphincter of Oddi, choledochoduodenal fistula, previous sphincterotomy, sphincteroplasty or bilioenteric anastomosis in which standard endoscopic retrograde...

Endothelial constitutive nitric oxide synthase protein and mRNA increased in rabbit atherosclerotic aorta despite impaired endothelium-dependent vascular relaxation.

Kanazawa, K., Kawashima, S., Mikami, S., Miwa, Y., Hirata, K., Suematsu, M., ...

Atherosclerotic arteries are well known to exhibit impaired endothelium-dependent relaxation (EDR), but the exact mechanism of this impairment remains unclear. Recently, endothelial constitutive...

Turcot's syndrome and its mode of inheritance.

Itoh, H, Ohsato, K, Yao, T, Iida, M, Watanabe, H

Two sisters with Turcot's syndrome, in which malignant cerebral neoplasms are associated with colonic polyposis, are presented. Cases reported in the literature, including some familial cases, have...

Urokinase type plasminogen activator receptor expression in colorectal neoplasms

Suzuki, S, Hayashi, Y, Wang, Y, Nakamura, T, Morita, Y, Kawasaki, K, ...

a First Division of Pathology, b First Division of Surgery, c Second Division of Internal Medicine, Kobe University School of Medicine, Kobe, Japan, d Division of Gastroenterology, Kobe Asahi...

Inhibition by anti-inflammatory agents of contraction induced by epidermal growth factor-urogastrone in isolated longitudinal smooth muscle strips from guinea-pig stomach.

Itoh, H., Muramatsu, I., Patel, P., Lederis, K., Hollenberg, M. D.

1. Epidermal growth factor-urogastrone (EGF-URO) caused a concentration-dependent contractile response of longitudinal muscle strips from the gastric body of the guinea-pig stomach. The contractile...

Contraction of rat thoracic aorta strips by endothelin-1 in the absence of extracellular Ca2+.

Itoh, H., Higuchi, H., Hiraoka, N., Ito, M., Konishi, T., Nakano, T., ...

1. Endothelin-1 (ET-1) caused a concentration-dependent contraction of helical strips from rat thoracic aorta in the absence of extracellular Ca2+. The Ca(2+)-depleted muscle strips, prepared by...

Neuronal damage in the interval form of CO poisoning determined by serial diffusion weighted magnetic resonance imaging plus 1H-magnetic resonance spectroscopy

Murata, T, Kimura, H, Kado, H, Omori, M, Onizuka, J, Takahashi, T, ...

In a patient with the interval form of carbon monoxide (CO) poisoning diffusion weighted MRI and proton magnetic resonance spectroscopy (1H-MRS) were serially performed immediately after the...

Clinical profiles of Chinese patients with diffuse panbronchiolitis

Tsang, K., Ooi, C., Ip, M., Lam, W., Ngan, H., Chan, E., ...

BACKGROUND—Diffuse panbronchiolitis (DPB), characterised by progressive sinobronchial sepsis, is well characterised in Japanese subjects but not in other ethnic groups. The experience with DPB in...

Job Design and Incentives in Hierarchies with Team Production.

Itoh, H.

The purpose of this paper is to examine how tasks should be allocated in a simple hierarchy consisting of an organizational designer and subordinates, in the framework of a principal-agent...

Moral Hazard and Size Trade in Agency Contracts

Ishiguro, S., Itoh, H.

The purpose of the paper is to investigate how side track (or collusion) among agents affects the principal's welfare in a hidden action model. We assume that the agent's actions are mutually...

Effort Incentives : Evidence from Japanese Data.

Itoh, H, Teruyama, H

Many attempts have been made to explain practical pay and promotion systems in a firm as a consequence of rational behaviour of both the employer and the employee. Recently the incentive theory has...

Moral Hazard and Renegotiation with Multiple Agents.

Ishiguro, S., Itoh, H.

The purpose of this paper is to investigate contract renegotiation in multi-agent situations where risk averse agents negotiate a contract offer to the principal after they observed a common,...

Pancreatic trypsinogen and cathepsin B in human pancreatic carcinomas and associated metastatic lesions.

Ohta, T., Terada, T., Nagakawa, T., Tajima, H., Itoh, H., Fonseca, L., ...

Expression of pancreatic trypsinogen and cathepsin B in 23 surgically resected pancreatic ductal adenocarcinomas was evaluated immunohistochemically, using a monoclonal antibody against human...