Gay, Alan P., Ougham, Helen J., Taylor, J., Donnison, Iain S., Wagstaff, C., Stead, A. D., ...
Abstract for talk at Society for Experimental Biology Main Meeting [Session on Imaging Techniques for understanding Plant Responses to Stress], University of Kent, Canterbury, 2-7 April 2006.
Parfitt, D., Herbert, R. J., Rogers, H. J., Francis, D.
If, following an inductive treatment of 2 d of continuous darkness, shoot apices of Pharbitis nil are cultured 1 d later on White's medium supplemented with 2% sucrose, they cannot form carpels, but...
Parfitt, D., Herbert, R. J., Rogers, H. J., Francis, D.
If, following an inductive treatment of 2 d of continuous darkness, shoot apices of Pharbitis nil are cultured 1 d later on White's medium supplemented with 2% sucrose, they cannot form carpels, but...
Herbert, R.J., Vilhar, B., Evett, C., Orchard, C.B., Rogers, H.J., Davies, M.S., ...
It was examined whether ethylene induces programmed cell death in a cell cycle‐specific manner. Following synchronization of the tobacco TBY‐2 cell line with aphidicolin and its...
REVIEW ARTICLE: Transgenic plants and the environment (1995)
With a continued increase in the range of transgenes, and plant species for which genetic modification is possible, this review attempts to bring together some of the factors that will influence the...
Polymorphic N-acetylation capacity in lung cancer (1988)
Philip, P.A., Fitzgerald, D.L., Cartwright, R.A., Peake, M.D., Rogers, H.J.
Hepatic N-acetylation phenotype has been suggested to be an important risk factor in the aetiology of bladder cancer. This study explores the N-acetylation capacity of a series of lung cancer cases...
Genetically determined debrisoquine oxidation capacity in bladder cancer (1984)
Cartwright, R.A., Philip, P.A., Rogers, H.J., Glashan, R.W.
A report is given of a series of bladder cancer cases examined for the oxidation capacity demonstrated by the use of debrisoquine. No overall association of poor and extensive metaboliser exists...
An investigation of some fit statistics for latent trait models / (1983)
Proefschrift University of New England.
Rogers, H.J., Bradbrook, I.D., Morrison, P.J., Spector, R.G., Cox, D.A., Lees, L.J.
Sultamicillin is an orally absorbed double ester of sulbactam (penicillanic acid sulphone, a semisynthetic inhibitor of the &eegr;-lactamases of many Gram-positive and Gram-negative species) and...
Effect of cimetidine on oral absorption of ampicillin and cotrimoxazole (1980)
ROGERS, H. J., JAMES, C. A., MORRISON, P. J., BRADBROOK, I. D.
Stanier, J. B, Rogers , H. J, Ward, J. B
Incluye bibliografía e índice
Antisera against purified autolytic N-acetylmuramyl-L-alanine amidase from Bacillus subtilis 168 were prepared in rabbits. They neutralized the enzymatic action of the purified amidase acting on...
Temperature-sensitive nature of the rodB maturation in Bacillus subtilis.
The Mg2+ requirement of a morphological mutant of Bacillus subtlis, rodB strain 104 was highly temperature sensitive in the presence of halide or nitrate anions. Likewise the morphological change...
Double Mutants of Bacillus subtilis Growing as Helices
Double mutants of Bacillus subtilis, deficient in autolysin and rod in genotype, grow as helical filaments of unseparated cells when changed from the cocci to rods.
Autolysins and shape change in rodA mutants of Bacillus subtilis.
The biochemical phenotype of rodA mutants was not affected by the simultaneous presence in double mutants of the lyt gene which makes them 90 to 95% deficient in autolysin action. The only...
Autolytic enzyme-deficient mutants of Bacillus subtilis 168.
Mutants of Bacillus subtilis strain 168 have been isolated that are at least 90 to 95% deficient in the autolytic enzymes N-acetylmuramyl-L-alanine amidase and endo-beta-N-acetylglucosaminidase....
Formation of cell wall polymers by reverting protoplasts of Bacillus licheniformis.
Elliott, T S, Ward, J B, Rogers, H J
The biosynthesis of peptidoglycan and teichoic acid by reverting protoplasts of Bacillus licheniformis 6346 His-, in cubated at 35 C on medium containing 2.5% agar, is detectable after 40 min. The...
Ultrastructural study of the reversion of protoplasts of Bacillus licheniformis to bacilli.
Elliott, T S, Ward, J B, Wyrick, P B, Rogers, H J
The reversion of protoplasts of Bacillus licheniformis 6346 His- on a medium containing 2.5% agar has been studied in sectioned material after reaction with a ferritin-conjugated antibody specific to...
Magnesium and anion requirements of rodB mutants of Bacillus subtilis.
Rogers, H J, Thurman, P F, Buxton, R S
rodB mutants of Bacillus subtilis have been found to require several hundred-fold more Mg2+ in a minimal growth medium than the wild type to achieve rapid growth. In the presence of all...
Characterization of Bacillus licheniformis 6346 Mutants Which Have Altered Lytic Enzyme Activities
Forsberg, C. W., Rogers, H. J.
Two groups of mutants altered in lytic enzyme activities have been isolated from Bacillus licheniformis 6346 MH-1 by screening clones for halo production in agar plates containing cell wall...
Role of Autolysins in the Killing of Bacteria by Some Bactericidal Antibiotics
Rogers, H. J., Forsberg, C. W.
The rapid lysis of Bacillus licheniformis NCTC 6346 and B. subtilis 168 trp caused by vancomycin and d-cycloserine can be inhibited by stopping protein synthesis. Protein synthesis must be stopped...
Mapping of rod Mutants of Bacillus subtilis
Karamata, D., McConnell, M., Rogers, H. J.
Nine class A salt-dependent rod mutants were mapped on the Bacillus subtilis genome by PBS1-mediated transduction. They are distributed into two small linkage groups designated rod B and rod C;...
MacLeod, Robert A., Thurman, Paul, Rogers, H. J.
Sodium ion was shown to stimulate strongly the transport of l-glutamic acid into cells of Bacillus licheniformis 6346 His−. Lithium ion had a slight capacity to replace Na+ in this capacity, but K+...
Antibacterial effect of scandium and indium complexes of enterochelin on Klebsiella pneumoniae.
Rogers, H J, Synge, C, Woods, V E
A number of studies point to the conclusion that enterochelin, the iron chelator produced by a number of pathogenic enterobacteria, may be an essential metabolite for bacterial multiplication within...
Forsberg, C. W., Wyrick, P. B., Ward, J. B., Rogers, H. J.
Two very poorly lytic mutants of Bacillus licheniformis 6346 that had no teichuronic acid or glucose in their walls were phosphoglucomutase deficient. The walls of the mutants were less autolytic,...
Three-Dimensional Molecular Models of Bacterial Cell Wall Mucopeptides (Peptidoglycans)
Molecular models have been built of mucopeptides (peptidoglycans) from various species of bacteria. If pairs of glycan chains are hydrogen-bonded as are those of chitin, the carboxyl groups of...
Bacteriostatic effect of serum: role of antibody to lipopolysaccharide.
Previous work has shown that antibody and transferrin, acting together, exert a bacteriostatic effect on certain pathogenic Escherichia coli. This effect may be due to the ability of the antibody to...
Reaveley, D. A., Rogers, H. J.
1. The liberation of the vesicles of the mesosomes from protoplasts of Bacillus licheniformis strain 6346 is controlled by the Mg2+ concentration present during the removal of the walls by lysozyme....
Physicochemical properties of hyaluronic acid formed by Streptococcus haemolyticus
Blumberg, B. S., Ogston, A. G., Lowther, D. A., Rogers, H. J.
1. The biosynthesis of teichoic acid in cell suspensions of two strains of Staphylococcus aureus is partially inhibited by the same low concentrations of penicillin that inhibit mucopeptide synthesis...
1. Benzylpenicillin is irreversibly fixed to staphyloccoci by a reaction that obeys second-order kinetics, whereas the progress of inhibition of mucopeptide synthesis obeys first-order kinetics after...
Further effects of chlorpromazine on the hexose permeability of the human erythrocyte
1. The effect of chlorpromazine on hexose transfer across the human erythrocyte membrane was investigated by optical and isotopic techniques in intact erythrocytes.
Is repeated flushing of Hickman catheters necessary?
Gillies, H, Rogers, H J, Johnston, J, Harper, P G, Rudge, C J
Rifampicin reduces effectiveness and bioavailability of prednisolone.
McAllister, W A, Thompson, P J, Al-Habet, S M, Rogers, H J
Rifampicin is an inducer of hepatic drug metabolising enzymes. This results in interactions with several drugs including oral anticoagulants, hypoglycaemics, and contraceptives. Concurrent treatment...
Antisera against purified autolytic N-acetylmuramyl-L-alanine amidase from Bacillus subtilis 168 were prepared in rabbits. They neutralized the enzymatic action of the purified amidase acting on...
Temperature-sensitive nature of the rodB maturation in Bacillus subtilis.
The Mg2+ requirement of a morphological mutant of Bacillus subtlis, rodB strain 104 was highly temperature sensitive in the presence of halide or nitrate anions. Likewise the morphological change...
Double Mutants of Bacillus subtilis Growing as Helices
Double mutants of Bacillus subtilis, deficient in autolysin and rod in genotype, grow as helical filaments of unseparated cells when changed from the cocci to rods.
Autolysins and shape change in rodA mutants of Bacillus subtilis.
The biochemical phenotype of rodA mutants was not affected by the simultaneous presence in double mutants of the lyt gene which makes them 90 to 95% deficient in autolysin action. The only...
Autolytic enzyme-deficient mutants of Bacillus subtilis 168.
Mutants of Bacillus subtilis strain 168 have been isolated that are at least 90 to 95% deficient in the autolytic enzymes N-acetylmuramyl-L-alanine amidase and endo-beta-N-acetylglucosaminidase....
Formation of cell wall polymers by reverting protoplasts of Bacillus licheniformis.
Elliott, T S, Ward, J B, Rogers, H J
The biosynthesis of peptidoglycan and teichoic acid by reverting protoplasts of Bacillus licheniformis 6346 His-, in cubated at 35 C on medium containing 2.5% agar, is detectable after 40 min. The...
Ultrastructural study of the reversion of protoplasts of Bacillus licheniformis to bacilli.
Elliott, T S, Ward, J B, Wyrick, P B, Rogers, H J
The reversion of protoplasts of Bacillus licheniformis 6346 His- on a medium containing 2.5% agar has been studied in sectioned material after reaction with a ferritin-conjugated antibody specific to...
Magnesium and anion requirements of rodB mutants of Bacillus subtilis.
Rogers, H J, Thurman, P F, Buxton, R S
rodB mutants of Bacillus subtilis have been found to require several hundred-fold more Mg2+ in a minimal growth medium than the wild type to achieve rapid growth. In the presence of all...
Characterization of Bacillus licheniformis 6346 Mutants Which Have Altered Lytic Enzyme Activities
Forsberg, C. W., Rogers, H. J.
Two groups of mutants altered in lytic enzyme activities have been isolated from Bacillus licheniformis 6346 MH-1 by screening clones for halo production in agar plates containing cell wall...
Role of Autolysins in the Killing of Bacteria by Some Bactericidal Antibiotics
Rogers, H. J., Forsberg, C. W.
The rapid lysis of Bacillus licheniformis NCTC 6346 and B. subtilis 168 trp caused by vancomycin and d-cycloserine can be inhibited by stopping protein synthesis. Protein synthesis must be stopped...
Mapping of rod Mutants of Bacillus subtilis
Karamata, D., McConnell, M., Rogers, H. J.
Nine class A salt-dependent rod mutants were mapped on the Bacillus subtilis genome by PBS1-mediated transduction. They are distributed into two small linkage groups designated rod B and rod C;...
MacLeod, Robert A., Thurman, Paul, Rogers, H. J.
Sodium ion was shown to stimulate strongly the transport of l-glutamic acid into cells of Bacillus licheniformis 6346 His−. Lithium ion had a slight capacity to replace Na+ in this capacity, but K+...
Antibacterial effect of scandium and indium complexes of enterochelin on Klebsiella pneumoniae.
Rogers, H J, Synge, C, Woods, V E
A number of studies point to the conclusion that enterochelin, the iron chelator produced by a number of pathogenic enterobacteria, may be an essential metabolite for bacterial multiplication within...
Forsberg, C. W., Wyrick, P. B., Ward, J. B., Rogers, H. J.
Two very poorly lytic mutants of Bacillus licheniformis 6346 that had no teichuronic acid or glucose in their walls were phosphoglucomutase deficient. The walls of the mutants were less autolytic,...
Three-Dimensional Molecular Models of Bacterial Cell Wall Mucopeptides (Peptidoglycans)
Molecular models have been built of mucopeptides (peptidoglycans) from various species of bacteria. If pairs of glycan chains are hydrogen-bonded as are those of chitin, the carboxyl groups of...
Bacteriostatic effect of serum: role of antibody to lipopolysaccharide.
Previous work has shown that antibody and transferrin, acting together, exert a bacteriostatic effect on certain pathogenic Escherichia coli. This effect may be due to the ability of the antibody to...
Reaveley, D. A., Rogers, H. J.
1. The liberation of the vesicles of the mesosomes from protoplasts of Bacillus licheniformis strain 6346 is controlled by the Mg2+ concentration present during the removal of the walls by lysozyme....
Physicochemical properties of hyaluronic acid formed by Streptococcus haemolyticus
Blumberg, B. S., Ogston, A. G., Lowther, D. A., Rogers, H. J.
1. The biosynthesis of teichoic acid in cell suspensions of two strains of Staphylococcus aureus is partially inhibited by the same low concentrations of penicillin that inhibit mucopeptide synthesis...
1. Benzylpenicillin is irreversibly fixed to staphyloccoci by a reaction that obeys second-order kinetics, whereas the progress of inhibition of mucopeptide synthesis obeys first-order kinetics after...
Further effects of chlorpromazine on the hexose permeability of the human erythrocyte
1. The effect of chlorpromazine on hexose transfer across the human erythrocyte membrane was investigated by optical and isotopic techniques in intact erythrocytes.
Is repeated flushing of Hickman catheters necessary?
Gillies, H, Rogers, H J, Johnston, J, Harper, P G, Rudge, C J
Rifampicin reduces effectiveness and bioavailability of prednisolone.
McAllister, W A, Thompson, P J, Al-Habet, S M, Rogers, H J
Rifampicin is an inducer of hepatic drug metabolising enzymes. This results in interactions with several drugs including oral anticoagulants, hypoglycaemics, and contraceptives. Concurrent treatment...
Ferric iron and the antibacterial effects of horse 7S antibodies to Escherichia coli O111.
Previous work showed that the virulence of Escherichia coli O141 was related to its ability to secrete catechols capable of transporting iron from serum transferrin to the bacterial cell. E. coli...
Bacteriostatic effect of human milk on Escherichia coli: the role of IgA.
Previous work showed that lactoferrin was involved in the bacteriostatic effect of human milk on E. coli O111. Further experiments on the general nature of this effect have been carried out together...
Fractionated ifosfamide therapy produces a time-dependent increase in ifosfamide metabolism.
Lewis, L D, Fitzgerald, D L, Harper, P G, Rogers, H J
1. Fifteen patients received 1.5 g m-2 of ifosfamide intravenously over 0.5 h every day for 5 days. Twenty-one courses of treatment were studied. Plasma was assayed for ifosfamide by gas liquid...
The pharmacokinetics of ifosfamide given as short and long intravenous infusions in cancer patients.
Lewis, L D, Fitzgerald, D L, Mohan, P, Thatcher, N, Harper, P G, Rogers, H J
1. We investigated the pharmacokinetics of ifosfamide 5 g m-2 given by two regimens. Six patients (one female), median age 55 (range 40-71) years, all with lung cancer received 5 g m-2 ifosfamide...
Methylprednisolone pharmacokinetics after intravenous and oral administration.
1. The pharmacokinetics of methylprednisolone (MP) were studied in five normal subjects following intravenous doses of 20, 40 and 80 mg methylprednisolone sodium succinate (MPSS) and an oral dose of...
ORG 10172: a low molecular weight heparinoid anticoagulant with a long half-life in man.
Bradbrook, I D, Magnani, H N, Moelker, H C, Morrison, P J, Robinson, J, Rogers, H J, ...
ORG 10172 is a heparinoid with mean molecular weight 6500 daltons. Intravenous bolus injections of ORG 10172 were compared with placebo and heparin injections in 91 separate studies in 83 healthy...
Influence of age, sex and body weight on the dapsone acetylation phenotype.
Philip, P A, Gayed, S L, Rogers, H J, Crome, P
The acetylation of dapsone (DDS) was determined by estimation of the ratio of monoacetyldapsone (MADDS) to DDS concentrations in plasma following a single dose of DDS in 337 white British subjects...
James, C A, Mant, T G, Rogers, H J
The pharmacokinetics of mesna (sodium 2-mercaptoethane sulphonate) and its inactive disulphide, dimesna, were investigated using high performance liquid chromatography in six normal subjects...
Gillies, H C, Herriott, D, Liang, R, Ohashi, K, Rogers, H J, Harper, P G
The plasma pharmacokinetics of idarubicin (4-demethoxydaunorubicin) were studied in 20 patients with advanced malignant disease after intravenous (21 occasions) and oral (14 occasions)...
Determination of debrisoquine metabolic ratio from hourly urine collections in healthy volunteers.
Philip, P A, James, C A, Rogers, H J
The possibility of simplifying the regimen for the collection of urine samples in the determination of the debrisoquine metabolic ratio (DMR) was explored in 15 normal subjects. In the extensive...
Effects of single and multiple doses of ketoconazole on adrenal function in normal subjects.
Bradbrook, I D, Gillies, H C, Morrison, P J, Robinson, J, Rogers, H J, Spector, R G
The plasma cortisol response to 0.25 mg tetracosactrin given by intramuscular injection was suppressed by nine oral doses of 200 mg ketoconazole given 12 hourly to nine normal female subjects. No...
Bradbrook, I D, Babiker, M, Crome, P, Gillies, H C, Morrison, P J, Rogers, H J, ...
Oxprenolol in an Oros 8/130 sustained release osmotic pump system (equivalent to 120 mg oxprenolol hydrochloride in a conventional formulation and releasing 8 mg h-1) was given to eight normal young...
Decreased systemic clearance of caffeine due to cimetidine.
1 Five normal subjects received pre-treatment with cimetidine 200 mg three times daily and 400 mg at night for 6 days, or matching placebo. 2 Caffeine (300 mg) was given orally before any treatment...
Pharmacokinetics of single doses of sulphinpyrazone and its major metabolites in plasma and urine.
Bradbrook, I D, John, V A, Morrison, P J, Rogers, H J, Spector, R G
1 High pressure liquid chromatographic assays for the estimation of sulphinpyrazone and its sulphide, sulphone and p-hydroxy metabolites in plasma and urine are described. 2 Five normal volunteers...
The hypotensive response to hydralazine, in triple therapy, is not related to acetylator phenotype.
Vandenburg, M J, Wright, P, Holmes, J, Rogers, H J, Ahmad, R A
Effect of pirprofen on glibenclamide kinetics and response.
Morrison, P J, Rogers, H J, Spector, R G, Bradbrook, I D, John, V A
Pirprofen (a new non-steroidal anti-inflammatory agent), 200 mg 8 hourly, or placebo was administered orally to eight normal volunteers to investigate its effect on the pharmacokinetics and glucose...
Pharmacokinetic observations on piroxicam in young adult, middle-aged and elderly patients.
Woolf, A D, Rogers, H J, Bradbrook, I D, Corless, D
Nineteen out of 21 patients with painful conditions of the locomotor system aged between 27 and 94 years completed a study in which they received 20 mg piroxicam daily for 14 days. Plasma piroxicam...
Morrison, P J, Bradbrook, I D, Rogers, H J
1 A quantitative thin layer chromatographic technique for the estimation of plasma prednisolone levels has been devised with a minimum level of estimation of 10 ng/ml. 2 A comparative study of the...
Morrison, P J, Bradbrook, I D, Rogers, H J
1 A gas chromatographic assay for the estimation of therapeutic concentrations of cinnarizine in plasma is described. 2 Cinnarizine (75 mg) was administered orally to twelve healthy subjects in the...
Comparison of the effect of drugs upon some commonly used measures of bowel transit time.
Rogers, H J, House, F R, Morrison, P J, Bradbrook, I D
1 To study the effect of drugs on methods of assessment of gut transit time a double-blind study of the effect of single doses of placebo, oxyphenisatin, anthracene purgatives, (+)-norpseudoephedrine...
Juma, F. D., Rogers, H. J., Trounce, J. R.
1 Plasma cyclophosphamide levels were estimated by gas-chromatography in seven patients following intravenous and oral cyclophosphamide administration. Plasma alkylating activity was determined by...
The kinetics of salivary elimination of cyclophosphamide in man.
Juma, F D, Rogers, H J, Trounce, J R
1 The concentrations of cyclophosphamide in plasma and saliva were determined in seven patients following administration of single doses of cyclophosphamide during chemotherapy for lymphoma. 2 The...
Effect of cimetidine on the absorption of orally administered tetracycline.
Fisher, P, House, F, Inns, P, Morrison, P J, Rogers, H J, Bradbrook, I D
1 Six healthy female subjects received orally two 250 mg tetracycline tablets either with 400 mg cimetidine or placebo. In a separate experiment six healthy female volunteers received 500 mg...
Juma, F. D., Rogers, H. J., Trounce, J. R.
1 Simple, accurate and specific gas-chromatographic methods for the estimation of derivatized phosphoramide and non-nitrogen mustards utilizing alkali-flame ionization detection are described.
Pharmacokinetics of intravenous and oral prednisolone.
1 Doses of 16, 32, 48 and 64 mg prednisolone were administered intravenously to normal volunteers who also received 100 prednisolone orally. Plasma prednisolone concentrations were estimated by...
Pharmacokinetics and protein binding interactions of dapsone and pyrimethamine.
1 Seven normal volunteers received oral doses of 100 mg dapsone (DDS), 25 mg pyrimethamine (PYR) singly or in combination in random order. 2 Plasma and salivary DDS and plasma monoacetyldapone...
A rapid method for determination of acetylation phenotype using dapsone.
Philip, P A, Roberts, M S, Rogers, H J
A rapid, simple one-stage protein precipitation method for the estimation of plasma dapsone (DDS) and monoacetyldapsone (MADDS) concentration by high-pressure liquid chromatography (h.p.l.c.) is...
The effect of acetylator phenotype on the disposition of aminoglutethimide.
Adam, A M, Rogers, H J, Amiel, S A, Rubens, R D
Aminoglutethimide (AG) 500 mg was administered orally to four normal volunteers and eight patients undergoing treatment for metastatic breast cancer. In each subject the acetylator phenotype was...
Bradbrook, I. D., John, V. A., Morrison, P. J., Rogers, H. J., Spector, R. G.
1 The absorption kinetics of oxprenolol have been investigated in eight healthy volunteers after single dosing with 16/260 Oros drug delivery systems. Oxprenolol disposition kinetics in individual...
Stuart-Harris, R., Bradbrook, I., Morrison, P., Smith, I. E., Rogers, H. J.
Serum aminoglutethimide (AG) and N-acetylaminoglutethimide (NAG) concentrations were measured by high pressure liquid chromatography (HPLC) in 24 postmenopausal women with advanced breast cancer...