H. Kempski

Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia (2007)

Moulding, D.A., Blundell, M.P., Spiller, D.G., White, M.R.H., Cory, G.O., Calle, Y., ...

Specific mutations in the human gene encoding the Wiskott-Aldrich syndrome protein (WASp) that compromise normal auto-inhibition of WASp result in unregulated activation of the actin-related protein...

Five members of the CEBP transcription factor family are targeted by recurrent IgH-translocations in B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). (2007)

Akasaka, T., Balasas, T., Russell, L.J., Majid, A., Walewska, Renata, ...

Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) (2007)

Akasaka, T., Balasas, T., Russell, L.J., Sugimoto, K., Majid, A., Walewska, R., ...

CCAAT enhancer-binding protein (CEBP) transcription factors play pivotal roles in proliferation and differentiation, including suppression of myeloid leukemogenesis. Mutations of CEBPA are found in a...

Five members of the CEBP transcription factor family are targeted by recurrent IGH -translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) (2007)

Akasaka, T., Balasas, T., Russell, L. J., Sugimoto, K. J., Majid, A., Walewska, R., ...

Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia (2006)

Ancliff, P.J., Blundell, M.P., Cory, G.O., Calle, Y., Worth, A., Kempski, H., ...

Severe congenital neutropenia (SCN) is characterized by neutropenia, recurrent bacterial infections, and maturation arrest in the bone marrow. Although many cases have mutations in the ELA2 gene...

Characterization of the t(17;19) translocation by gene-specific fluorescent in situ hybridization-based cytogenetics and detection of the E2A-HLF fusion transcript and protein in patients' cells (2006)

Yeung, J., Kempski, H., Neat, M., Bailey, S., Smith, O., Brady, H.J.

This is the first report to comprehensively characterize the E2A-HLF fusion generated from the t(17;19)(q22;p13) translocation in childhood B-lineage acute lymphoblastic leukemia. E2A gene...

Generation of immunostimulatory dendritic cells from the malignant clone in patients with juvenile myelomonocytic leukemia (2003)

Nabarro, S., Thrasher, A.J., Kempski, H., Amrolia, P., Anderson, J.

Clinical features, cytogenetics and outcome in acute lymphoblastic and myeloid leukaemia of infancy: report from the MRC Childhood Leukaemia working party (2002)

Chessells, J.M., Harrison, C.J., Kempski, H., Webb, D.K., Wheatley, K., Hann, I.M., ...

The clinical features, cytogenetics and response to treatment have been examined in 180 infants (aged

Two categories of synovial sarcoma defined by divergent chromosome translocation breakpoints in Xp11.2, with implications for the histologic sub-classification of synovial sarcoma (1995)

Reeves, B R, Fletcher, C D, Kempski, H, ...

Molecular analysis of a new series of synovial sarcomas confirms that t(X;18)(p11.2;q11.2) breakpoints occur at two distinct regions on Xp designated SS1 and SS2. Breakpoint position correlates with...

Isolation and characterisation of a panel of cosmids which allows unequivocal identification of chromosome deletions involving the RB1 gene using fluorescence in situ hybridisation.

Cowell, J K, Jaju, R, Kempski, H

A series of cosmids covering the majority of the RB1 gene have been isolated from a flow sorted human chromosome 13 specific library. Using fluorescence in situ hybridisation these cosmids were all...

Neuroblastoma in monozygotic twins – a case of probable twin-to-twin metastasis

Anderson, J, Kempski, H, Hill, L, Rampling, D, Gordon, T, Michalski, A

Concordance for neuroblastoma in monozygotic twins has been reported only rarely, and the cause of the shared pathology has not been established. We describe a case of infant monozygotic twins...

Neuroblastoma in monozygotic twins – a case of probable twin to twin metastasis

Anderson, J, Kempski, H, Hill, L, Rampling, D, Gordon, T, Michalski, A

British Journal of Cancer (2002) 86, 1666–1666. DOI: 10.1038/sj/bjc/6600308 www.bjcancer.com