Minimal nonergodic directions on genus 2 translation surfaces (2005)
It is well-known that on any Veech surface, the dynamics in any minimal direction is uniquely ergodic. In this paper it is shown that for any genus 2 translation surface which is not a Veech surface...
A divergent Teichmuller geodesic with uniquely ergodic vertical foliation (2005)
We construct an example of a quadratic differential whose vertical foliation is uniquely ergodic and such that the Teichmuller geodesic determined by the quadratic differential diverges in the moduli...
Plasma viremia as a sensitive indicator of the antiretroviral activity of L-697,661.
Davey, R T, Dewar, R L, Reed, G F, Vasudevachari, M B, Polis, M A, Kovacs, J A, ...
L-697,661 is a non-nucleoside analogue with potent, selective inhibitory activity against the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1). The present study evaluated the...
Davey, R T, Chaitt, D G, Reed, G F, Freimuth, W W, Herpin, B R, Metcalf, J A, ...
Delavirdine mesylate (DLV) is a potent nonnucleoside reverse transcriptase inhibitor with activity specific for human immunodeficiency virus type 1. In the present phase I/II study we evaluated the...
Polis, M A, Piscitelli, S C, Vogel, S, Witebsky, F G, Conville, P S, Petty, B, ...
The use of antiretroviral agents and drugs for the treatment and prophylaxis of opportunistic infections has lengthened the survival of persons with AIDS. In the era of multidrug therapy, drug...
Recent advances in the diagnosis, treatment, and prevention of Pneumocystis carinii pneumonia.
In summary, recent advances in our ability to diagnose, treat, and prevent recurrences of pneumocystis pneumonia have significantly improved the clinical management of this infection, especially in...
Bioavailability of oral trimetrexate in patients with acquired immunodeficiency syndrome.
Rogers, P, Allegra, C J, Murphy, R F, Drake, J C, Masur, H, Poplack, D G, ...
The combination of the lipophilic antifolate trimetrexate and the rescue agent leucovorin has shown promise in the treatment of Pneumocystis carinii pneumonia in patients with acquired...
Potent antipneumocystis and antitoxoplasma activities of piritrexim, a lipid-soluble antifolate.
Kovacs, J A, Allegra, C J, Swan, J C, Drake, J C, Parrillo, J E, Chabner, B A, ...
Piritrexim, a lipid-soluble antifolate, was evaluated for its activity against Pneumocystis carinii and Toxoplasma gondii. The concentration of piritrexim needed to inhibit 50% of the catalytic...
Horsburgh, C R, Cohn, D L, Roberts, R B, Masur, H, Miller, R A, Tsang, A Y, ...
Susceptibility testing and serotyping were performed on 57 isolates of Mycobacterium avium-M. intracellulare from patients with acquired immunodeficiency syndrome (AIDS) and 75 isolates from patients...
Histoenzymological study of selected dehydrogenase enzymes in Pneumocystis carinii.
Mazer, M A, Kovacs, J A, Swan, J C, Parrillo, J E, Masur, H
The metabolic activity of Pneumocystis carinii cysts was studied histochemically by a tetrazolium dye technique to assess substrate-specific dehydrogenase activity. Lactate dehydrogenase, succinate...
Gill, V J, Park, C H, Stock, F, Gosey, L L, Witebsky, F G, Masur, H
Patients with acquired immune deficiency syndrome may develop infection with mycobacteria, particularly Mycobacterium avium-M. intracellulare (MAI). These infections can frequently be associated with...
Gill, V J, Evans, G, Stock, F, Parrillo, J E, Masur, H, Kovacs, J A
A combination of three monoclonal antibodies, two prepared against human and one against rat Pneumocystis carinii, was used in an indirect fluorescent-antibody stain (IFA) to diagnose P. carinii in...
Interaction of sulfonamide and sulfone compounds with Toxoplasma gondii dihydropteroate synthase.
Allegra, C J, Boarman, D, Kovacs, J A, Morrison, P, Beaver, J, Chabner, B A, ...
Toxoplasma gondii is a common protozoan disease that often causes life-threatening disease, particularly among patients with the acquired immunodeficiency syndrome. This study demonstrates that the...
Effect of hydrocortisone on macrophage response to lymphokine.
Masur, H, Murray, H W, Jones, T C
To define the suppressive effects of corticosteroids on mononuclear phagocyte antiprotozoal activity, normal resident peritoneal macrophages were exposed to hydrocortisone (HC) before, during, and...
Potent in vitro and in vivo antitoxoplasma activity of the lipid-soluble antifolate trimetrexate.
Allegra, C J, Kovacs, J A, Drake, J C, Swan, J C, Chabner, B A, Masur, H
Trimetrexate, a highly lipid-soluble quinazoline antifolate now undergoing trials as an anticancer agent, was found to be a potent inhibitor of the dihydrofolate reductase (DHFR) isolated from...
Monocyte function in the acquired immune deficiency syndrome. Defective chemotaxis.
Smith, P D, Ohura, K, Masur, H, Lane, H C, Fauci, A S, Wahl, S M
The ineffective immune response in patients with the acquired immune deficiency syndrome (AIDS) contributes to severe and widespread infections and unrestricted growth by certain tumors. To determine...
Siegel, J P, Djeu, J Y, Stocks, N I, Masur, H, Gelmann, E P, Quinnan, G V
We studied the effects of sera from patients with the acquired immunodeficiency syndrome (AIDS) on interleukin-2 (IL-2) production to help elucidate the mechanism of immunodeficiency. Compared with...
Rook, A H, Masur, H, Lane, H C, Frederick, W, Kasahara, T, Macher, A M, ...
The recently described acquired immune deficiency syndrome (AIDS) is characterized by the occurrence of severe opportunistic infections and an aggressive form of Kaposi's sarcoma. A variety of...
Evaluation of abdominal pain in the AIDS patient.
Potter, D A, Danforth, D N, Macher, A M, Longo, D L, Stewart, L, Masur, H
Acquired immune deficiency syndrome (AIDS) is a recently recognized entity characterized by a deficiency in cell mediated immune response. The syndrome is manifested by the development of otherwise...
Plasma viremia as a sensitive indicator of the antiretroviral activity of L-697,661.
Davey, R T, Dewar, R L, Reed, G F, Vasudevachari, M B, Polis, M A, Kovacs, J A, ...
L-697,661 is a non-nucleoside analogue with potent, selective inhibitory activity against the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1). The present study evaluated the...
Davey, R T, Chaitt, D G, Reed, G F, Freimuth, W W, Herpin, B R, Metcalf, J A, ...
Delavirdine mesylate (DLV) is a potent nonnucleoside reverse transcriptase inhibitor with activity specific for human immunodeficiency virus type 1. In the present phase I/II study we evaluated the...
Polis, M A, Piscitelli, S C, Vogel, S, Witebsky, F G, Conville, P S, Petty, B, ...
The use of antiretroviral agents and drugs for the treatment and prophylaxis of opportunistic infections has lengthened the survival of persons with AIDS. In the era of multidrug therapy, drug...
Recent advances in the diagnosis, treatment, and prevention of Pneumocystis carinii pneumonia.
In summary, recent advances in our ability to diagnose, treat, and prevent recurrences of pneumocystis pneumonia have significantly improved the clinical management of this infection, especially in...
Bioavailability of oral trimetrexate in patients with acquired immunodeficiency syndrome.
Rogers, P, Allegra, C J, Murphy, R F, Drake, J C, Masur, H, Poplack, D G, ...
The combination of the lipophilic antifolate trimetrexate and the rescue agent leucovorin has shown promise in the treatment of Pneumocystis carinii pneumonia in patients with acquired...
Potent antipneumocystis and antitoxoplasma activities of piritrexim, a lipid-soluble antifolate.
Kovacs, J A, Allegra, C J, Swan, J C, Drake, J C, Parrillo, J E, Chabner, B A, ...
Piritrexim, a lipid-soluble antifolate, was evaluated for its activity against Pneumocystis carinii and Toxoplasma gondii. The concentration of piritrexim needed to inhibit 50% of the catalytic...
Horsburgh, C R, Cohn, D L, Roberts, R B, Masur, H, Miller, R A, Tsang, A Y, ...
Susceptibility testing and serotyping were performed on 57 isolates of Mycobacterium avium-M. intracellulare from patients with acquired immunodeficiency syndrome (AIDS) and 75 isolates from patients...
Histoenzymological study of selected dehydrogenase enzymes in Pneumocystis carinii.
Mazer, M A, Kovacs, J A, Swan, J C, Parrillo, J E, Masur, H
The metabolic activity of Pneumocystis carinii cysts was studied histochemically by a tetrazolium dye technique to assess substrate-specific dehydrogenase activity. Lactate dehydrogenase, succinate...
Gill, V J, Park, C H, Stock, F, Gosey, L L, Witebsky, F G, Masur, H
Patients with acquired immune deficiency syndrome may develop infection with mycobacteria, particularly Mycobacterium avium-M. intracellulare (MAI). These infections can frequently be associated with...
Gill, V J, Evans, G, Stock, F, Parrillo, J E, Masur, H, Kovacs, J A
A combination of three monoclonal antibodies, two prepared against human and one against rat Pneumocystis carinii, was used in an indirect fluorescent-antibody stain (IFA) to diagnose P. carinii in...
Interaction of sulfonamide and sulfone compounds with Toxoplasma gondii dihydropteroate synthase.
Allegra, C J, Boarman, D, Kovacs, J A, Morrison, P, Beaver, J, Chabner, B A, ...
Toxoplasma gondii is a common protozoan disease that often causes life-threatening disease, particularly among patients with the acquired immunodeficiency syndrome. This study demonstrates that the...
Effect of hydrocortisone on macrophage response to lymphokine.
Masur, H, Murray, H W, Jones, T C
To define the suppressive effects of corticosteroids on mononuclear phagocyte antiprotozoal activity, normal resident peritoneal macrophages were exposed to hydrocortisone (HC) before, during, and...
Potent in vitro and in vivo antitoxoplasma activity of the lipid-soluble antifolate trimetrexate.
Allegra, C J, Kovacs, J A, Drake, J C, Swan, J C, Chabner, B A, Masur, H
Trimetrexate, a highly lipid-soluble quinazoline antifolate now undergoing trials as an anticancer agent, was found to be a potent inhibitor of the dihydrofolate reductase (DHFR) isolated from...
Monocyte function in the acquired immune deficiency syndrome. Defective chemotaxis.
Smith, P D, Ohura, K, Masur, H, Lane, H C, Fauci, A S, Wahl, S M
The ineffective immune response in patients with the acquired immune deficiency syndrome (AIDS) contributes to severe and widespread infections and unrestricted growth by certain tumors. To determine...
Siegel, J P, Djeu, J Y, Stocks, N I, Masur, H, Gelmann, E P, Quinnan, G V
We studied the effects of sera from patients with the acquired immunodeficiency syndrome (AIDS) on interleukin-2 (IL-2) production to help elucidate the mechanism of immunodeficiency. Compared with...
Rook, A H, Masur, H, Lane, H C, Frederick, W, Kasahara, T, Macher, A M, ...
The recently described acquired immune deficiency syndrome (AIDS) is characterized by the occurrence of severe opportunistic infections and an aggressive form of Kaposi's sarcoma. A variety of...
Evaluation of abdominal pain in the AIDS patient.
Potter, D A, Danforth, D N, Macher, A M, Longo, D L, Stewart, L, Masur, H
Acquired immune deficiency syndrome (AIDS) is a recently recognized entity characterized by a deficiency in cell mediated immune response. The syndrome is manifested by the development of otherwise...