H. Mertsching

Human skin equivalent as an alternative to animal testing (2008)

Mertsching, H., Weimer, M., Kersen, S., Brunner, H.

3-D-Hautäquivalente sind physiologisch vergleichbar mit natürlicher Haut und deshalb eine Alternative zum Tierversuch. Das hoch differenzierte in-vitro Modell menschlicher Haut wird zur Prüfung...

Zellkulturtechniken, Zellmodelle und Tissue Engineering. Teil 2 (2008)

Wobus, A.M., Mertsching, H.

Die moderne Zell- und Molekularbiologie ist ohne den Einsatz von Zell- und Gewebekulturen nicht denkbar. Die "In-vitro-Zellbiologie" bildet heute die Grundlage für die Aufklärung...

Characterisation of biological and artificial matrix by Raman spectroscopy (2007)

Koch, S., Mertsching, H.

Development of a 3D vascularised human tumour model (2007)

Michaelis, J., Thude, S., Mertsching, H.

Generation of a vascularized biomatrix as a scaffold for tissue engineering (2007)

Schanz, J., Walles, T., Mertsching, H.

In vitro three-dimensional tubular trachea model (2007)

Brenner, M., Hansmann, J., Weimer, M., Brunner, H., Mertsching, H.

In vitro testing of different substances on a human 3D skin model (2007)

Weimer, M., Brunner, H., Mertsching, H.

Nanomaterials: Cytotoxic or biocompatible? (2007)

Peter, T., Pusch, K., Vohrer, U., Weimer, M., Mertsching, H.

Modified surfaces and culture conditions to optimize adult stem cell adhesion, proliferation, differentiation and function (2007)

Mertsching, H., Schweizer, P., Schanz, J., Weimer, M., Brunner, H.

Methods for the identification, characterization and isolation of adult stem cells (2007)

Thude, S., Koch, S., Rühl, M., Mertsching, H.

Studies of cell adhesion and cell differentiation by micro- and nanostructured surfaces (2007)

Schweizer, P., Weimer, M., Borchers, K., Sciarratta, V., Vohrer, U., Oehr, C., ...

Transplantation of myenteric and dorsal root neurones into acellular small intestinal submucous layer (2007)

Schäfer, K.H., Maas-Omlor, S., Rauch, U., Mertsching, H.

A vascularised matrix: Scaffold for the development of a vascularised liver cell module (2007)

Linke, K., Schanz, J., Mertsching, H.

Health risk versus benefit: Handling with nanomaterials: How safe - is safe enough? (2007)

Peter, T., Mertsching, H.

Over the last few years, the risk from exposure to ultrafine or nanoparticles (< 100 nm) for humans and the environment has constantly risen in line with the increasing market readiness of...

The potential of bioartificial tissues in oncology research and treatment (2007)

Walles, T., Weimer, M., Linke, K., Michaelis, J., Mertsching, H.

This review article addresses the relevance and potential of bioartificial tissues in oncologic research and therapy and reconstructive oncologic surgery. In order to translate the findings from...

Tissue engineering, regenerative medicine and in vitro test systems - the department of cell and tissue engineering of Fraunhofer Institute for Interfacial Engineering and Biotechnology in Stuttgart (2007)

Anadere, I., Mertsching, H.

Engineered liver-like tissue on a capillarized matrix for applied research (2007)

Linke, K., Schanz, J., Hansmann, J., Walles, T., Brunner, H., Mertsching, H.

Liver tissue that is functional and viable for several weeks in vitro represents an auspicious test system for basic and applied research. In this study, a coculture system for hepatocytes (HCs) and...

Neovaskularisation und Tissue Engineering vom komplexen Geweben (2007)

Mertsching, H.

Organ or tissue reconstruction and transplantation is a common therapy for failure or loss of organs and tissues. The goal of Tissue Engineering is the development of biological compatible...

Strategies for scaffold vascularization in tissue engineering (2007)

Walles, T., Mertsching, H.

GMP-Herstellung erfolgreich outsourcen: Herstellung klinischer Prüfware und Tissue Engineering nach GMP-Richtlinien (2006)

Anadere, I., Mertsching, H.

Klinische Prüfpräparate und Tissue Engineering Produkte sind gemäß AMG Arzneimittel. Deshalb muss für ihre Produktion eine Herstellungserlaubnis (Paragraph 13 AMG) vorliegen und sie müssen...

3D skin equivalent (2006)

Weimer, M., Mertsching, H., Brunner, H.

Ex vivo generation of vascularized organ-like structures based on a biological matrix (2006)

Mertsching, H., Schanz, J., Hausmann, J., Linke, K., Brunner, H.

Generation of a bioartificial fibromuscular tissue with autoregenerative capacities for surgical reconstruction (2006)

Biancosino, C., Zardo, P., Walles, T., Wildfang, I., Macchiarini, P., Mertsching, H.

Introduction Anecdotal clinical reports denote first tissue engineering applications entering medical practice. Currently it is still unknown, if these new types of implants will tolerate the...

Clinical application of tissue engineered human heart valves using autologous progenitor cells (2006)

Cebotari, S., Lichtenberg, A., Tudorache, I., Hilfiker, A., Mertsching, H., Leyh, R., ...

Tissue engineering of viable pulmonary arteries for surgical correction of congenital heart defects (2006)

Leyh, R.G., Wilhelmi, M., Rebe, P., Ciboutari, S., Haverich, A., Mertsching, H.

Isoliertes naturidentisches Kollagen (2006)

Xiong, X., Mertsching, H., Rupp, S., Brunner, H.

DE 102006026591 A1 UPAB: 20080102 NOVELTY - Isolating collagen from tissue comprises isolating collagen-containing fibers from the tissue, extracting collagen from the fibers by incubation with a...

Vaskularisierte Trägersysteme für in vitro Testsysteme (2006)

Mertsching, H., Hansmann, J., Schanz, J., Linke, K., Brenner, M., Michaelis, J., ...

Tissue Engineering gilt als vielversprechendes Verfahren zur Herstellung einfach organisierter Gewebe außerhalb des Körpers, die als in-vitro-Testsysteme im Bereich der Medikamentenentwicklung und...

Vorrichtung und Verfahren zur Analyse biologischer Proben (2006)

Mertsching, H., Sulz, G., Thielecke, H., Bolwien, C., Koch, S.

DE 102006053540 B3 UPAB: 20080421 NOVELTY - Optospectroscopic analysis of a biological sample in fluids, comprises: fixing the biological sample in a sample holding unit; categorizing the particles...

Verfahren zur Anreicherung von Melanozyten mittels modifizierter Oberflaechen (2006)

Mertsching, H., Schweizer, P., Brunner, H., Oehr, C., Sciarratta, V.

DE 102006057742 A1 UPAB: 20080815 NOVELTY - The method of obtaining melanocytes from an epidermal cell suspension and/or a cell suspension from a hair root, comprises cultivating the cell suspension...

Tissue remodeling in a bioartificial fibromuscular patch following transplantation in a human (2005)

Walles, T., Biancosino, C., Zardo, P., Macciarini, P., Gottlieb, J., Mertsching, H.

Neointima in vascular prostheses: The jury is still out: Reply (2005)

Walles, T., Mertsching, H.

Mit Schweinedarm geflickt (2005)

Mertsching, H.

Isolation of primary endothelial and stromal cell cultures of the corpus cavernosum penis for basic research and tissue engineering (2005)

Pilatz, A., Schultheiss, D., Gabouev, A.I., Schlote, N., Mertsching, H., Jonas, U., ...

In vitro viability of human cavernosal endothelial and fibroblastic cells after exposure to papaverine/phentolamine and prostaglandin E1 (2005)

Pilatz, A., Schultheiss, D., Gabouev, A.I., Schlote, N., Mertsching, H., Jonas, U., ...

Engineering of a vascularized scaffold for artificial tissue and organ generation (2005)

Mertsching, H., Walles, T., Hofmann, M., Schanz, J., Knapp, W.H.

Endothelialization and functional neointima on vascular grafts in humans: Reply (2005)

Walles, T., Mertsching, H.

Biological vascularized matrix for bladder tissue engineering: Matrix preparation, reseeding technique and short-term implantation in a porcine model (2005)

Schultheiss, D., Gabouev, A.I., Cebotari, S., Tudorache, I., Walles, T., Schlote, N., ...

Functional neointima characterization of vascular prostheses in human (2004)

Walles, T., Görler, H., Puschmann, C., Mertsching, H.

Expansion of chondrocytes in a three-dimensional matrix for tracheal tissue engineering (2004)

Walles, T., Giere, B., Macchiarini, P., Mertsching, H.

Experimental generation of a tissue-engineered functional and vascularized trachea (2004)

Walles, T., Giere, B., Hofmann, M., Schanz, J., Hofmann, F., Mertsching, H., ...

Biologische vaskularisierte Matrix (BioVaM). Ein Ansatz zur Lösung des Perfusionsproblems im Tissue Engineering (2004)

Schultheiss, D., Gabouev, A.I., Kaufmann, P.M., Schlote, N., Mertsching, H., Haverich, A., ...

A new technique is presented to harvest an acellular matrix from a porcine small bowel segment preserving the mesenteric arterial and venous pedicles. Reseeding of this biological vascularized matrix...

Replacement of the trachea with an autologous aortic graft (2004)

Mertsching, H., Walles, T., Macchiarini, P.

Expression of epidermal growth-factor receptor in lymphangiomatosis: A new therapeutic target? (2004)

Mertsching, H., Walles, T., Bakker, G., Wildfang, I., Macchiarini, P.

First human transplantation of a bioengineered airway tissue (2004)

Macchiarini, P., Walles, T., Biancosino, C., Mertsching, H.

Could 37 degrees C storage temperature extend homovital valve allograft viability? (2004)

Baric, D., Cebotari, S., Mertsching, H., Leyh, R., Haverich, A.