H. Milting

K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum (2009)

Toischer, K., Lehnart, S., Tenderich, G., Milting, H., Körfer, R., Schmitto, J., ...

In heart failure, intracellular Ca2+ leak from cardiac ryanodine receptors (RyR2s) leads to a loss of Ca2+ from the sarcoplasmic reticulum (SR) potentially contributing to decreased function....

Combined tyrosine and serine/threonine kinase inhibition by sorafenib prevents progression of experimental pulmonary hypertension and myocardial remodeling (2008)

Klein, M., Schermuly, R.T., Ellinghaus, P., Milting, H., Riedl, B., Nikolova, S., ...

BACKGROUND: Inhibition of tyrosine kinases, including platelet-derived growth factor receptor, can reduce pulmonary arterial pressure in experimental and clinical pulmonary hypertension. We...

Prevention of pulmonary vascular and myocardial remodeling by the combined tyrosine and serine-/threonine kinase inhibitor, sorafenib, in pulmonary hypertension and right heart failure (2008)

M. Klein, R. T. Schermuly, P. Ellinghaus, H. Milting, B. Riedl, H. A. Ghofrani, ...

Inhibition of tyrosine kinases can reverse pulmonary hypertension but little is known about the role of serine-/threonine kinases in vascular and myocardial remodeling. We investigated the effects of...

Increased cardiac expression of TIMP-1 and TIMP-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart (2005)

Heymans, Stephane; U0011145, Schroen, B, Vermeersch, Pieter; U0035259, Milting, H, Herijgers, Paul; U0010444, Carmeliet, Peter; U0021003, ...

Increased cardiac expression of TIMP-1 and TIMP-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart (2005)

Heymans, Stephane; U0011145, Schroen, B, Milting, H, Herijgers, Paul; U0010444, Carmeliet, Peter; U0021003, Van De Werf, Frans; U0009589, ...

Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart (2005)

Heymans, Stephane; U0011145, Schroen, B, Vermeersch, Pieter; U0035259, Milting, H, Gao, FY, Kassner, A, ...

Background - Alterations in the balance of matrix metalloproteinases ( MMPs) and their specific tissue inhibitors (TIMPs) are involved in left ventricular (LV) remodeling. Whether their expression is...